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Other/Cognitive Function

Cognitive Function

8

Pipeline Programs↗

11

Active Trials↗

13

Companies Involved↗

Cognitive Function is an early-stage landscape with 8 programs across 13 companies.

Intelligence

Pipeline Metrics

Competitive Density

40/100

Pipeline Velocity

32/100

Mech. Concentration

20/100

Completion Rate

86/100

Attrition Rate

9/100

Pipeline

Programs by Phase

Preclinical4

Taurine

Third Military Medical University

Nattokinase

Second Affiliated Hospital, School of Medicine, Zhejiang University

Scopolamine

Baxter Healthcare Corporation

Desﬂurane

Zhejiang Cancer Hospital

Phase 12

Propranolol

Wyeth-Lederle Vaccines

Modafinil

Nuvo Research GmbH

Phase 22

Pioglitazone

Takeda

Memantine

AbbVie

Phase 3

No programs

Approved

No programs

Analysis

Modality Breakdown

88%

Small molecule

7 of 8 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 8 classified programs, each share of the total. Modality classified for 100% of 8 pipeline programs.

Analysis

Trial Status

85

clinical trials

Completed51 · 60%

Unknown status15 · 18%

Active, not recruiting6 · 7%

Terminated5 · 6%

Not yet recruiting4 · 5%

Withdrawn3 · 4%

Other1 · 1%

Clinical Trials

Trial Activity

85 trials

Cilostazol-Ginkgo for Cognitive Function in Elderly Diabetes

Recruiting·SSeoul National University Bundang Hospital·Phase 3·NCT06989697·80 enrolled

Does Park Golf Affect Working Memory?: An fNIRS-Based Randomized Controlled Trial in Community-Dwelling Older Adults

Active, not recruiting·Gwangju Health University·Preclinical·NCT07807631·36 enrolled

Radicle Clarity CNM™: A Randomized, Double-Blind, Placebo-Controlled Direct-to-Consumer Study Assessing the Impact of Health and Wellness Products on Cognitive Function and Related Health Outcomes Among E-Gamers

Active, not recruiting·RRadicle Science·Preclinical·NCT07386964·600 enrolled

Radicle Clarity DSTTM: A Randomized, Double-Blind, Placebo-Controlled Direct-to-Consumer Study Assessing the Impact of Health and Wellness Products on Mental Clarity and Related Health Outcomes

Active, not recruiting·RRadicle Science·Preclinical·NCT07342192·990 enrolled

Radicle Revive™: A Randomized, Double-Blind, Placebo-Controlled Direct-to-Consumer Study Assessing the Impact of Health and Wellness Products on Menopausal-Related Health Issues Associated Health Outcomes and Related Health Outcomes

Active, not recruiting·RRadicle Science·Preclinical·NCT07548307·990 enrolled

Modafinil and Cognitive Function in POTS

Active, not recruiting·VVanderbilt University Medical Center·Phase 1·NCT01988883·20 enrolled

Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide

Active, not recruiting·AAlliance Foundation Trials, LLC.·Phase 2·NCT04335682·111 enrolled

Effects of Adapted Argentine Tango Training Frequency Under Equal Weekly Exercise Volume on Dual-Task Walking and Executive Function in Adults Aged 55 to 60 Years: A Three-Arm Parallel Randomized Controlled Trial

Not yet recruiting·Xi'an Medical University·Preclinical·NCT07800494·270 enrolled

Research and Validation of an Artificial Intelligence-Based Cognitive Intervention Program

Not yet recruiting·National Research Center for Rehabilitation Technical Aids·Preclinical·NCT07766993·100 enrolled

A Randomized, Triple-blind, Placebo Controlled, Parallel Virtual Clinical Trial to Examine the Effect of Magnesium Choline Citrate on Cognitive Function and Anxiety in Healthy Adolescents and Adults

Not yet recruiting·NNutrisol, LLC·Preclinical·NCT07685613·200 enrolled

Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy

Not yet recruiting·—·Phase 2·NCT06594172·67 enrolled

Effect of a Specially Formulated Dietary Supplement With Pyrroloquinoline Quinone, γ-aminobutyric Acid, Caffeine and B-vitamins on Cognitive Function in Healthy Postmenopausal Women: a Randomized, Double-blind, Placebo-controlled Study

Completed·FFEMPHARMA Kft.·Preclinical·NCT06748989·70 enrolled

A Clinical Trial to Evaluate the Effects of Two Supplements on Cognitive Function, Cognitive Performance, and Mood

Completed·BBrainJuice·Preclinical·NCT07766564·30 enrolled

A Clinical Trial to Evaluate the Effects of a Supplement on Cognitive Function and Energy Levels

Completed·AArtah Nutrition Limited·Preclinical·NCT07755475·50 enrolled

A Randomized, Triple-blind, Placebo Controlled, Cross-over Clinical Trial to Assess the Efficacy of a Single Dose of AlphaWave® L-Theanine on Cognitive Function in Healthy Adults With Moderate Stress

Completed·EEthical Naturals, Inc.·Preclinical·NCT07004023·40 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)