Namenda

(Memantine)

ApprovedSmall molecule

Memantine is used to treat moderate to severe Alzheimer's disease by helping to slow down memory loss and confusion. It works by regulating glutamate, a chemical in the brain involved in learning and memory.[2] Namenda is currently approved and in use across 48 indications[4].[1]

Namenda is one of 691 small molecule programs targeting Open-Angle Glaucoma. It is currently in Approved.

Indications

166

Total Trials

Active Trials

690

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Open-Angle GlaucomaApproved

Cocaine DependenceApproved

Fragile X SyndromeApproved

Mental DeteriorationApproved

AnxietyApproved

Central Nervous System NeoplasmApproved

SchizophreniaApproved

Glioblastoma MultiformeApproved

Depressive DisorderApproved

Breast CancerRecruiting

Open-Angle GlaucomaApproved

Approved

Cocaine DependenceApproved

Approved

Fragile X SyndromeApproved

Approved

Mental DeteriorationApproved

Approved

AnxietyApproved

Approved

Central Nervous System NeoplasmApproved

Approved

SchizophreniaApproved

Approved

Glioblastoma MultiformeApproved

Approved

Depressive DisorderApproved

Approved

Breast CancerPhase 2

Recruiting

Showing 10 of 46 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Namenda

AbbVie

Approved

2 2

Zolymbus

AbbVie

Preclinical

1 3

Blenoxane

Bristol-Myers Squibb

Preclinical

1 4

Lexiscan

Astellas

Preclinical

1 5

Voltaren

Novartis

Preclinical

1 6

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 8

Spravato

WWim Janssens

Preclinical

2 9

Duragesic-100

CCephalon

Preclinical

2 10

Acupan

YYonsei University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Metabolism

NCT06041789

Phase 1/2Recruiting

Glioblastoma

NCT05664464

Phase 1Recruiting

Psychosis

NCT04789915

Q2 2027

PreclinicalActive, not recruiting

Skin-Picking

NCT05796752

Phase 2Not yet recruiting

Cognitive Function

NCT06594172

Phase 1Recruiting

Major Depressive Disorder (MDD)

NCT07139834

Clinical

Trials by Indication[1]

Alzheimer's Disease14 trials

Delaying the Progression of Driving Impairment in Individuals With Mild Alzheimer's Disease

Completed·—·Phase 4·NCT00476008·60 enrolled

Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease

Completed·NNorthwell Health·Phase 4·NCT00551161·12 enrolled

The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease

Completed·—·Phase 4·NCT01921972·232 enrolled

Show 11 more trials

The Effect of Memantine on Brain Structure and Chemistry in Alzheimer's Disease Patients

Completed·SStanford University·Phase 3·NCT00255086·17 enrolled

Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease

Completed·SShanghai Mental Health Center·Phase 4·NCT00800709·26 enrolled

Memantine and Comprehensive, Individualized Management of Alzheimer's Disease and Caregiver Training

Completed·NNYU Langone Health·Phase 4·NCT00120874·20 enrolled

Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease

Active, not recruiting·UUniversity of California, San Diego·Phase 4·NCT03703856·53 enrolled

Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease

Completed·NNYU Langone Health·Phase 4·NCT00933608·17 enrolled

A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease

Completed·UUS Department of Veterans Affairs·Phase 3·NCT00235716·613 enrolled

SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

Completed·SSuven Life Sciences Limited·Phase 2·NCT02580305·564 enrolled

Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease

Completed·FForest Laboratories·Phase 4·NCT00469456·265 enrolled

Memantine Versus Donepezil in Early Stages of Alzheimer's Disease

Completed·UUnknown Sponsor·Phase 4·NCT00505167·64 enrolled

Memantine and Validation of a New Alzheimer's Disease Scale

Completed·MMerz Pharmaceuticals GmbH·Phase 3·NCT00804271·487 enrolled

Alzheimer's Disease - Input of Vitamin D With mEmantine Assay

Completed·UUniversity Hospital, Angers·Phase 3·NCT01409694·90 enrolled

Schizophrenia8 trials

Effect of Memantine on ERP in Early Schizophrenia and Healthy Subjects

Unknown status·NNational Taiwan University Hospital·N/A·NCT02233556·20 enrolled

Memantine add-on for Cognitive and Negative Symptoms of Schizophrenia

Unknown status·NNational Taiwan University Hospital·Phase 3·NCT02001103·120 enrolled

Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

Completed·UUniversity of California, San Diego·Phase 4·NCT03860597·42 enrolled

Show 5 more trials

Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms

Completed·HHospital de Clinicas de Porto Alegre·Phase 4·NCT00757978·22 enrolled

Memantine for the Prevention of Cognitive Dysfunction and Negative Symptoms in Patients With Acute Schizophrenia

Terminated·—·Phase 3·NCT00148590·24 enrolled

Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia

Completed·UUniversity of California, San Diego·Phase 1/2·NCT01555697·80 enrolled

Memantine Augmentation of Targeted Cognitive Training in Schizophrenia

Completed·UUniversity of California, San Diego·Phase 2/3·NCT04857983·62 enrolled

Memantine for the Treatment of Cognitive Dysfunction and Negative Symptoms in Patients With Chronic Schizophrenia

Terminated·—·Phase 3·NCT00148616·13 enrolled

Cognitive impairment6 trials

Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

Completed·MMayo Clinic·Phase 1·NCT04217694·18 enrolled

Effect of Memantine on Radiotherapy-related Cognitive Impairment

Unknown status·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2/3·NCT03342443·240 enrolled

Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia

Completed·JJohns Hopkins University·N/A·NCT00294554·20 enrolled

Show 3 more trials

Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT01876823·60 enrolled

Trial of Memantine for Cognitive Impairment in Multiple Sclerosis

Completed·OOregon Health and Science University·Phase 2/3·NCT00300716·82 enrolled

A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases

Completed·NNRG Oncology·Phase 3·NCT02360215·518 enrolled

Moderate to Severe Alzheimer's Disease5 trials

Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 4·NCT05430867·150 enrolled

Satisfaction With Orodispersible vs Conventional Memantine in Moderate to Severe Alzheimer's Disease

Completed·CCarnot Laboratories·Phase 4·NCT07417670·105 enrolled

Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease

Terminated· Lundbeck logo

Lundbeck·Phase 3·NCT00857649·369 enrolled

Show 2 more trials

Safety and Tolerability of Memantine in Moderate to Severe Alzheimer's Disease

Terminated· Lundbeck logo

Lundbeck·Phase 3·NCT00857233·297 enrolled

Donepezil and Memantine in Moderate to Severe Alzheimer's Disease

Unknown status·KKing's College London·Phase 4·NCT00866060·800 enrolled

Dementia5 trials

Corticolimbic Degeneration and Treatment of Dementia

Completed·WWashington University School of Medicine·Phase 4·NCT00768261·39 enrolled

Monitoring Anti-Dementia Drugs by Serum Levels

Completed·ZZealand University Hospital·Phase 4·NCT04117178·132 enrolled

Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)

Completed·HHelse Stavanger HF·Phase 2·NCT00630500·75 enrolled

Show 2 more trials

Memantine Versus Placebo in Parkinson's Disease Dementia or Dementia With Lewy Bodies

Completed· Lundbeck logo

Lundbeck·Phase 4·NCT00855686·199 enrolled

Double-blind, Parallel Group, Placebo-controlled Trial of the Efficacy and Tolerability of Memantine (20 mg) in Frontotemporal Dementia (FTD) Patients

Completed·NNantes University Hospital·Phase 2·NCT00200538·52 enrolled

87 more indications

Amyotrophic Lateral Sclerosis4 trials

Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)

Completed·UUniversity of Lisbon·Phase 2/3·NCT00353665·63 enrolled

Therapy in Amyotrophic Lateral Sclerosis (TAME)

Completed·UUniversity of Kansas Medical Center·Phase 2·NCT02118727·89 enrolled

Memantine Therapy in Amyotrophic Lateral Sclerosis

Completed·PPhoenix Neurological Associates, LTD·Phase 2·NCT01020331·20 enrolled

Show 1 more trial

The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)

Completed·UUniversity of Alberta·Phase 2·NCT00409721·42 enrolled

Treatment4 trials

Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Completed·—·N/A·NCT00928954·10 enrolled

Memantine Treatment of Compulsive Buying

Completed·UUniversity of Minnesota·Phase 2·NCT00830375·10 enrolled

Treatment of Pendular Nystagmus in OPT

Completed·HHospices Civils de Lyon·Phase 4·NCT02466191·7 enrolled

Show 1 more trial

Memantine in the Treatment of Kleptomania

Completed·UUniversity of Chicago·Phase 2·NCT00880685·12 enrolled

Bipolar Disorder4 trials

Series Studies of Bipolar Disorder-Valproate add-on Memantine

Completed·NNational Cheng-Kung University Hospital·Phase 2/3·NCT01188148·219 enrolled

Memantine and Cognitive Dysfunction in Bipolar Disorder

Completed·MMassachusetts General Hospital·Phase 4·NCT00586066·72 enrolled

Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder

Unknown status·NNational Cheng-Kung University Hospital·Phase 3·NCT03039842·300 enrolled

Show 1 more trial

Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients

Unknown status·UUniversity of Sao Paulo·Phase 2·NCT02630888·44 enrolled

Memory4 trials

Investigation of Memantine in the Treatment of Memory, Concentration or Attention Problems

Completed·MMerz Pharmaceuticals GmbH·Phase 2·NCT01261741·299 enrolled

Memantine for Corticosteroid-Induced Mood and Declarative Memory Changes

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00280774·20 enrolled

Memantine or Riluzole Prophylaxis for Corticosteroid-induced Mood and Declarative Memory Changes

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00283309·20 enrolled

Show 1 more trial

The Influence of Glutamate on Memory in Humans

Completed·UUniversity Hospital, Bonn·N/A·NCT00980408·120 enrolled

Autism3 trials

Study of Pharmacokinetics, Safety, Efficacy, and Tolerability of Memantine in Children With Autism

Completed·FForest Laboratories·Phase 2·NCT00872898·124 enrolled

Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy

Completed·UUniversity of Missouri-Columbia·Phase 1·NCT02811627·10 enrolled

A Multi-site Double-blind Placebo-controlled Trial of Memantine Versus Placebo in Children With Autism (MEM)

Completed·EEvdokia Anagnostou·Phase 2·NCT01372449·23 enrolled

Neuropathic Pain3 trials

Study of NMDA Antagonists and Neuropathic Pain

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT01602185·7 enrolled

Memantine and Post-mastectomy Neuropathic Pain

Unknown status·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT03686774·150 enrolled

Preventing the Development of Neuropathic Pain Post-mastectomy/Tumorectomy by Pre-emptive or Post-operative Memantine Administration

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT01536314·43 enrolled

Parkinson's Disease3 trials

Parkinson's Disease Evaluated by PET and the Effect of Memantine

Completed·UUniversity of Aarhus·N/A·NCT00375778·12 enrolled

Study of Memantine for Gait Disorders And Attention Deficit In Parkinson's Disease

Completed·UUniversity Hospital, Lille·Phase 4·NCT01108029·28 enrolled

Namenda (Memantine) for Non-motor Symptoms in Parkinson's Disease

Completed·—·Phase 4·NCT00646204·40 enrolled

Cognition3 trials

Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI

Recruiting·TTata Memorial Centre·Phase 3·NCT06275035·101 enrolled

Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy

Withdrawn·UUniversity of California, Davis·N/A·NCT00986115

Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease

Unknown status·PPeking Union Medical College Hospital·Phase 2·NCT05538507·180 enrolled

Obsessive-Compulsive Disorder3 trials

Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder

Completed·NNew York State Psychiatric Institute·Phase 2·NCT00956085·12 enrolled

Memantine Augmentation in Obsessive-Compulsive Disorder

Completed·SStanford University·Phase 1/2·NCT00264238·15 enrolled

Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder

Completed·UUniversity of California, Los Angeles·Phase 3·NCT00674219·17 enrolled

Brain Injury3 trials

Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury

Terminated·UUniversity of Missouri-Columbia·Phase 4·NCT00462228·11 enrolled

Memantine as an Additive Therapy in Patients With Traumatic Brain Injury

Not yet recruiting·MMansoura University·Phase 2/3·NCT06914310·80 enrolled

Memantine for Neuroprotection and Cognitive Enhancement Following Traumatic Brain Injury

Completed·IIndiana University·N/A·NCT02240589·11 enrolled

Autism Spectrum Disorder3 trials

A Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders

Completed·MMassachusetts General Hospital·Phase 4·NCT01333865·25 enrolled

Memantine in Adult Autism Spectrum Disorder

Terminated·JJohns Hopkins University·N/A·NCT01078844·4 enrolled

Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder

Completed·MMassachusetts General Hospital·Phase 3·NCT01972074·84 enrolled

Agitation3 trials

Memantine on Aggression and Agitation of Alzheimer's Disease (AD)

Unknown status·PPeking University·N/A·NCT00703430·50 enrolled

Memantine for Agitation in Dementia

Completed·—·Phase 4·NCT00371059·153 enrolled

Memantine for Agitation and Aggression in Severe Alzheimer's Disease

Completed·SSunnybrook Health Sciences Centre·Phase 4·NCT00401167·31 enrolled

Down syndrome3 trials

Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome

Completed·UUniversity of Colorado, Denver·Phase 4·NCT01112683·42 enrolled

Down Syndrome Memantine Follow-up Study

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 2·NCT02304302·160 enrolled

Phase 1B Trial on Escalating Doses of Memantine in Down Syndrome

Not yet recruiting·UUniversity Hospitals Cleveland Medical Center·Phase 1·NCT07531940·25 enrolled

MPA2 trials

Comparison of Once Daily and Twice Daily Dosing on Safety and Tolerability of Memantine in Patients With Alzheimer

Completed· Lundbeck logo

Lundbeck·Phase 4·NCT02553928·62 enrolled

Impact of Persistent Conductances on Motor Unit Firing in SCI

Unknown status·SShirley Ryan AbilityLab·N/A·NCT02136823·50 enrolled

Aphasia2 trials

Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial

Unknown status·GGabinete Berthier y Martínez·Phase 4·NCT00196703·30 enrolled

Memantine and Intensive Speech-Language Therapy in Aphasia

Completed·GGabinete Berthier y Martínez·Phase 4·NCT00640198·28 enrolled

Multiple Sclerosis2 trials

Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis

Completed·HHospices Civils de Lyon·Phase 2·NCT01744444·10 enrolled

Memantine Therapy for Multiple Sclerosis

Terminated·—·Phase 2·NCT00638833·20 enrolled

Breast Cancer2 trials

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

Recruiting·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT06727773·90 enrolled

Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT04033419·55 enrolled

Brain Metastases2 trials

NTS-WBRT in Brain Metastases

Recruiting·MMassachusetts General Hospital·Phase 2·NCT05013892·41 enrolled

A Randomized Phase 2 Trial of Memory Avoidance Whole Brain Radiotherapy Versus Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Recruiting·CCase Comprehensive Cancer Center·Phase 2·NCT07248228·90 enrolled

Single Dose2 trials

Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge

Active, not recruiting·—·Phase 2·NCT05418049·45 enrolled

A Study of the Effect of Memantine on Pharmacokinetics, Safety and Tolerability of Single Dose RO5313534 in Healthy Volunteers, and the Effect of RO5313534 on Safety and Tolerability of Steady State Memantine

Completed· Roche logo

Roche·Phase 1·NCT01196065·16 enrolled

Systemic Lupus Erythematosus2 trials

Memantine in Systemic Lupus Erythematosus

Completed·JJohns Hopkins University·N/A·NCT00181298·61 enrolled

Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus

Active, not recruiting·VVanderbilt University Medical Center·Phase 2·NCT03527472·111 enrolled

Glaucoma2 trials

Memantine in Patients With Chronic Glaucoma

Completed· AbbVie logo

AbbVie·Phase 3·NCT00141882·1,119 enrolled

Memantine in Patients With Chronic Glaucoma

Completed· AbbVie logo

AbbVie·Phase 3·NCT00168350·1,179 enrolled

Post Operative Pain2 trials

Memantine for Post-Operative Pain Control

Unknown status·UUniversity of Washington·Phase 4·NCT01041313·120 enrolled

Memantine and Postoperative Pain

Terminated·—·Phase 4·NCT01032759·77 enrolled

Glioblastoma2 trials

Memantine for Recurrent Glioblastoma

Terminated·UUniversity of Rochester·Phase 2·NCT01260467·4 enrolled

Glutamate Inhibitors in Glioblastoma

Recruiting·UUniversity of Zurich·Phase 1/2·NCT05664464·120 enrolled

Whole-Brain Radiotherapy2 trials

Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery

Terminated·NNRG Oncology·Phase 3·NCT04588246·19 enrolled

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Recruiting·CCanadian Cancer Trials Group·Phase 3·NCT03550391·206 enrolled

Relapse1 trial

Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3

Completed·NNew York State Psychiatric Institute·Phase 1·NCT00136786·25 enrolled

Huntington's Disease1 trial

Study of Memantine to Treat Huntington's Disease

Completed·—·Phase 4·NCT00652457·50 enrolled

Alzheimer disease1 trial

A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy

Completed· Roche logo

Roche·Phase 2·NCT01677754·542 enrolled

Refractory1 trial

Memantine for Refractory OCD Patients

Unknown status·UUniversity of Roma La Sapienza·Phase 3·NCT05015595·20 enrolled

Cognitive Function1 trial

Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy

Not yet recruiting·—·Phase 2·NCT06594172·67 enrolled

Steroid1 trial

Attenuation of Corticosteroid Induced Hippocampal Changes

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT01656187·46 enrolled

Spasticity1 trial

Memantine for Spasticity in MS Patients

Completed·UUniversity of Rochester·Phase 4·NCT00638027·21 enrolled

Fed1 trial

Study in Healthy Subjects to Compare Two Tablet Formulations of Memantine (Ebixa®) in Fasted and Fed Conditions

Completed· Lundbeck logo

Lundbeck·Phase 1·NCT03670095·64 enrolled

Radiation Therapy1 trial

Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain

Not yet recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 2·NCT07470606·108 enrolled

Antidepressants1 trial

Memantine Augmentation of Antidepressants

Completed·UUniversity of Massachusetts, Worcester·Phase 4·NCT00344682·31 enrolled

Heroin Dependence1 trial

Memantine as a Supplement to Naltrexone in Treating Heroin Dependence

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT00476242·82 enrolled

PET1 trial

Memantine in Body Focused Repetitive Behaviors

Completed·UUniversity of Chicago·Phase 2·NCT04792645·100 enrolled

Partial Epilepsy1 trial

Does Memantine Improve Verbal Memory Task Performance in Subjects With Partial Epilepsy and Memory Dysfunction?

Completed·AAmerican Academy of Neurology·N/A·NCT01054599·29 enrolled

Orthostatic Intolerance1 trial

Treatment of Orthostatic Intolerance

Active, not recruiting·SSatish R. Raj·Phase 1/2·NCT00262470·150 enrolled

Essential Tremor1 trial

A Pilot Clinical Trial Of Memantine for Essential Tremor

Completed·VVA Greater Los Angeles Healthcare System·Phase 4·NCT00439699·16 enrolled

Bulimia Nervosa1 trial

An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder

Completed·MMclean Hospital·N/A·NCT01038128·5 enrolled

Ataxia1 trial

Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome

Completed·UUniversity of California, Davis·N/A·NCT00584948·94 enrolled

Peripheral Neuropathy1 trial

The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy

Unknown status·MMendel AI·Phase 2/3·NCT04737967·60 enrolled

Alcohol Dependence1 trial

A Placebo-Controlled Trial of Memantine for Alcohol Dependence

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT00246415·90 enrolled

Adult1 trial

A Study to Examine the, Safety, Tolerability and Pharmacokinetics Co-Administered Baclofen and Memantine in Obese and Lean, Otherwise Healthy Adults

Completed·GGedeon Richter Plc.·Phase 1·NCT02001584

CHOP1 trial

Psychopharmacotherapy in Multiple Substances Abuse

Completed·NNational Cheng-Kung University Hospital·Phase 3·NCT01189214·200 enrolled

Antipsychotics1 trial

Memantine and Antipsychotics Use

Terminated·MMerz Pharmaceuticals GmbH·Phase 4·NCT00649220·19 enrolled

Depression1 trial

Treatment Resistant Geriatric Depression in Primary Care

Completed·MMclean Hospital·Phase 1·NCT01392287·12 enrolled

Neurodegenerative Disease1 trial

Prediction of Cognitive Properties of Memantine for Neurodegenerative Diseases

Unknown status·UUniversity Hospital, Lille·Phase 1·NCT02288000·30 enrolled

Monotherapy1 trial

Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction

Unknown status·NNational Cheng-Kung University Hospital·Phase 2/3·NCT04687566·120 enrolled

Alcoholism1 trial

Memantine in Bipolar Patients With Alcoholism

Unknown status·NNational Cheng-Kung University Hospital·Phase 3·NCT03043001·60 enrolled

Metabolism1 trial

Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

Recruiting·—·Phase 2·NCT06041789·45 enrolled

Migraine1 trial

Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine.

Completed·UUniversidad Autonoma de San Luis Potosí·Phase 3·NCT04698525·33 enrolled

Brain Metastases From Solid Tumors1 trial

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

Completed· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 3·NCT00566852·554 enrolled

Cognitive Functions1 trial

Effects of Donepezil and Memantine on Cognitive Functions After a Sleep Deprivation Challenge in Healthy Volunteers

Completed·QQualissima·Phase 1·NCT01461174·36 enrolled

Huntington disease1 trial

A Trial of Memantine as Symptomatic Treatment for Early Huntington Disease

Completed·UUniversity of British Columbia·Phase 2·NCT01458470·19 enrolled

AIN1 trial

The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?

Withdrawn·JJerrry L Lewis·N/A·NCT00988663

Rehabilitation1 trial

Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults

Completed·EEric Lenze·Phase 4·NCT00183729·35 enrolled

Ischemic stroke1 trial

Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome

Completed·MMazandaran University of Medical Sciences·Phase 3·NCT02535611·47 enrolled

Post-Traumatic Stress Disorder1 trial

An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder

Completed·SSriram Ramaswamy·Phase 4·NCT02258828·26 enrolled

Neuroimaging1 trial

Functional Neuroimaging of Alcoholism Vulnerability (PIT)

Completed·YYale University·Phase 2·NCT01585168·71 enrolled

Bipolar Depression1 trial

Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression

Completed·IIndiana University School of Medicine·Phase 4·NCT00305578·29 enrolled

Atrophy1 trial

A Clinical Study Evaluating the Effects of Memantine on Brain Atrophy in Patients With Alzheimer's Disease

Completed· Lundbeck logo

Lundbeck·Phase 4·NCT00862940·277 enrolled

CLE1 trial

Inhibition of α-synuclein Cell-cell Transmission by NMDAR Blocker, Memantine

Unknown status·WWayne State University·Phase 3·NCT03858270·50 enrolled

Transcranial Magnetic Stimulation1 trial

The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

Completed·IIstanbul Medipol University Hospital·N/A·NCT05102045·27 enrolled

Cognitive Deficit1 trial

Memantine to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Major Depression

Completed·SStanford University·N/A·NCT00186498·11 enrolled

AIDS dementia1 trial

A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000867·120 enrolled

Brain Aging1 trial

Brain Aging and Treatment Response in Geriatric Depression

Completed·UUniversity of California, Los Angeles·Phase 4·NCT01902004·115 enrolled

Tension-type headache1 trial

Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Completed·DDanish Headache Center·Phase 3·NCT00315666·40 enrolled

Executive Dysfunction1 trial

Memantine Monotherapy for Executive Dysfunction and ADHD

Withdrawn·MMassachusetts General Hospital·N/A·NCT01844427

Eating Disorder1 trial

An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder

Completed·MMclean Hospital·Phase 4·NCT00330655·15 enrolled

Opioid Dependence1 trial

Memantine and Naltrexone Treatment for Opioid Dependence

Completed·NNew York State Psychiatric Institute·Phase 2·NCT00125515·81 enrolled

Women1 trial

A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03988803·16 enrolled

Acute1 trial

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

Completed·NNew York State Psychiatric Institute·Phase 1·NCT00136747·45 enrolled

Mild to Moderate Alzheimer's Disease1 trial

A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil ± Memantine) for the Treatment of Participants With Mild to Moderate Alzheimer's Disease

Withdrawn· AbbVie logo

AbbVie·Phase 1·NCT03316898

Frontotemporal Dementia1 trial

Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia

Completed·UUniversity of California, San Francisco·Phase 4·NCT00545974·81 enrolled

Buprenorphine1 trial

Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults

Completed·UUniversity of Massachusetts, Worcester·Phase 2/3·NCT01052662·87 enrolled

Alcohol Consumption1 trial

Family History Study of Alcohol Consumption Using Memantine

Completed·YYale University·Phase 2·NCT00630955·111 enrolled

Cocaine-dependent1 trial

Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2

Completed·NNew York State Psychiatric Institute·Phase 2·NCT00134901·81 enrolled

Fibromyalgia1 trial

Randomised Controlled Trial of Memantine in Fibromyalgia

Unknown status·—·Phase 3·NCT01653457·60 enrolled

Trial1 trial

A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration

Completed·UUniversity of California, San Francisco·Phase 4·NCT00187525

Neurotoxicity1 trial

Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Unknown status·MMansoura University·Phase 1/2·NCT05834231·60 enrolled

Psychosis1 trial

Add-on MEmaNtine to Dopamine Modulation to Improve Negative Symptoms at First Psychosis

Recruiting·—·Phase 1·NCT04789915·46 enrolled

Cognitive Disorder1 trial

Study on Cognitive Disorders of Multiple Sclerosis

Completed·UUniversity Hospital, Caen·Phase 3·NCT01074619·90 enrolled

Major Depressive Disorder (MDD)1 trial

Examining the Effects of Escitalopram and Memantine on Pattern Separation in Major Depressive Disorder

Recruiting·JJeffrey Miller·Phase 1·NCT07139834·30 enrolled

Skin-Picking1 trial

Single-Group Crossover Trial Comparing Behavioral Treatment to Memantine in Body Focused Repetitive Behaviors

Active, not recruiting·UUniversity of Chicago·Preclinical·NCT05796752·26 enrolled

Glioma of Brain1 trial

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors: A Pilot Study

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT03194906·41 enrolled

Unspecified1 trial

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 16, 2003

NAMENDA

NDA NDA021487

Apr 18, 2005

NAMENDA

NDA NDA021627

Jun 21, 2010

NAMENDA XR

NDA NDA022525

Sources

References

[1]
ClinicalTrials.gov — 166 trial records for Memantine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Namenda drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Memantine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Memantine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022525). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Namenda. U.S. Food & Drug Administration.
[7]
SEC EDGAR — AbbVie company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glutamate [NMDA] Receptor Negative Allosteric Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: AbbVie

Patent Landscape[6]

Patent Cliff

Mar 24, 2029

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8039009Mar 24, 2029

8039009*PEDSep 24, 2029