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Neurology/Encephalopathy

Encephalopathy

41

Pipeline Programs↗

48

Active Trials↗

25

Companies Involved↗

Encephalopathy is a moderately active landscape with 41 programs across 25 companies. The most active players are Mario Negri Institute for Pharmacological Research. 8 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

63/100

Pipeline Velocity

47/100

Mech. Concentration

22/100

Completion Rate

77/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Mario Negri Institute for Pharmacological Research

1 program

Pipeline

Programs by Phase

Preclinical25

Thiamine

Universiti Kebangsaan Malaysia Medical Centre

Dexamethasone

Aspen Global Incorporated

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Standard Medical Therapy

Post Graduate Institute of Medical Education and Research, Chandigarh

Ibuprofen

Kenvue Brands

Phase 13

Fosigotifator

AbbVie

Citicoline Sodium

Armed Forces Hospital, Pakistan

Rifaximin、lactulose

Air Force Military Medical University, China

Phase 25

Dobutamine

Eli Lilly

RLS-0071

ReAlta Life Sciences, Inc.

Sildenafil ODT

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

GOCOVRI

Weill Medical College of Cornell University

Sovateltide

Pharmazz, Inc.

Phase 38

Nitazoxanide

Romark Laboratories L.C.

Erythropoietin

Wim Janssens

Citicoline

University of Texas Southwestern Medical Center

Levetiracetam IV

Assistance Publique - Hôpitaux de Paris

Rifaximin SSD

Bausch Health Americas, Inc.

Approved

No programs

Analysis

Modality Breakdown

95%

Small molecule

37 of 39 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 39 classified programs, each share of the total. Modality classified for 100% of 41 pipeline programs.

Analysis

Trial Status

186

clinical trials

Completed83 · 45%

Unknown status30 · 16%

Recruiting20 · 11%

Terminated15 · 8%

Active, not recruiting14 · 8%

Not yet recruiting12 · 6%

Other12 · 6%

Clinical Trials

Trial Activity

186 trials

Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia: A Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate Safety and Efficacy (Phase II Study)

Recruiting·—·Phase 2·NCT06098833·60 enrolled

Coil-Assisted Small-Diameter Covered-Stent Shunt Reduction for Refractory Hepatic Encephalopathy After TIPS: An Ambispective Cohort Study

Recruiting·AAir Force Military Medical University, China·Preclinical·NCT07799948·30 enrolled

Cerebral and Cognitive Modifications in Retired Female Professional Soccer Players as Compared to Non Exposed to Repeated Cranial Impacts Sportswomen : Transverse Analytic Study

Recruiting·UUniversity Hospital, Strasbourg, France·Preclinical·NCT06788262·80 enrolled

A Phase Ib/II First-in-human, Multicentre, Open-label, Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effect of Intrathecal S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Recruiting· Institut de Recherches Internationales Servier logo

Institut de Recherches Internationales Servier·Preclinical·NCT07227857·20 enrolled

A Multi-Center, Single-Arm Clinical Trial to Investigate the Efficacy and Safety of Elsunersen in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

Recruiting·PPraxis Precision Medicines·Phase 3·NCT07019922·40 enrolled

Effect of Supplemental Nightly Melatonin On REM and Cognition in Hepatic Encephalopathy (SNORE-HE) Trial

Recruiting·WWeill Medical College of Cornell University·Preclinical·NCT07046429·18 enrolled

Evaluating a Wireless NIRS Device in the Neonatal Intensive Care Unit: a Sub-study of the Wireless NICU Study

Recruiting·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Preclinical·NCT07732244·20 enrolled

Neonatal Neurological Observation With Video AI

Recruiting·AArtemis AI Labs·N/A·NCT07628829·200 enrolled

A Prospective Exploratory Study on Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery

Recruiting·AAir Force Military Medical University, China·Phase 1·NCT07683936·26 enrolled

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

Recruiting·UUniversity of Florida·Phase 1·NCT02621944·70 enrolled

Caffeine for Hypoxic Ischemic Encephalopathy (CHIME Trial)

Recruiting·NNICHD Global Network for Women's and Children's Health·Phase 3·NCT06855108·830 enrolled

Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose

Recruiting·—·Phase 4·NCT04073290·238 enrolled

Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

Recruiting·GGeneral Hospital of Shenyang Military Region·N/A·NCT06483737·174 enrolled

Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy

Recruiting·TTanta University·Phase 3·NCT04161053·60 enrolled

Darbepoetin in Neonatal Encephalopathy Trial

Recruiting·IImperial College London·Phase 2·NCT04432662·150 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)