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Thiamine

Phase 2Small molecule

UUniversiti Kebangsaan Malaysia Medical Centre

Thiamine is a B vitamin used to treat or prevent thiamine deficiency, which can cause weakness, nerve damage, and heart problems. It's also used to help the body process carbohydrates and maintain healthy nerves and muscles.[1] Thiamine is currently being investigated across 15 indications[3], with its most advanced program in Phase 2.[1]

Thiamine is one of 214 small molecule programs targeting Beriberi. It is currently in Phase 2.

15

Indications

28

Total Trials

4

Active Trials

213

Competitors

Pipeline

Status by Indication[3][1]

Indication

BeriberiUnknown

Acute Respiratory FailureActive, not recruiting

Peripheral NeuropathyActive, not recruiting

HyperthyroidismActive, not recruiting

Thiamine DeficiencyUnknown

Anemia (phenotype)Unknown

EncephalopathyUnknown

Congestive Heart FailureActive, not recruiting

Chronic Kidney DiseaseUnknown

Alcohol Use DisorderNot yet recruiting

BeriberiPreclinical

Unknown

Acute Respiratory FailurePreclinical

Active, not recruiting

Peripheral NeuropathyPreclinical

Active, not recruiting

HyperthyroidismPreclinical

Active, not recruiting

Thiamine DeficiencyPreclinical

Unknown

Anemia (phenotype)Preclinical

Unknown

EncephalopathyPreclinical

Unknown

Congestive Heart FailurePreclinical

Active, not recruiting

Chronic Kidney DiseasePreclinical

Unknown

Alcohol Use DisorderPhase 2

Not yet recruiting

Showing 10 of 15 indications

Competition

Competitive Landscape

169 competitors in Chronic Kidney Disease

#DrugCompanyPhaseTrials

Thiamine

UUniversiti Kebangsaan Malaysia Medical Centre

Efepoetin Alfa

PPT Kalbe Genexine Biologics

Uloric

Glucotrol

Lorelco

Vemlidy

Sovaldi

Activase

Flomax

Januvia

ZZydus Therapeutics Inc.

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 2Not yet recruiting

Alcohol Use Disorder

NCT07844720

Q1 2029

Phase 2Not yet recruiting

Major Depressive Disorder (MDD)

NCT07793071

Q4 2031

Phase 2Not yet recruiting

Meningitis

NCT07868679

Clinical

Trials by Indication[1]

Septic Shock5 trials

Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients

Unknown status·UUniversiti Kebangsaan Malaysia Medical Centre·N/A·NCT03649009·72 enrolled

Thiamine Supplementation in Patients With Septic Shock

Withdrawn·TThe Cleveland Clinic·Phase 1·NCT03122678

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

Terminated·UUniversity Medical Centre Ljubljana·Phase 4·NCT03335124·5 enrolled

Show 2 more trials

The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

Completed·—·Phase 2·NCT03333278·216 enrolled

Thiamine as a Metabolic Resuscitator in Septic Shock

Completed·—·Phase 1/2·NCT01070810·88 enrolled

Heart Failure2 trials

Thiamine and Acute Decompensated Heart Failure: Pilot Study

Completed·—·Phase 2·NCT00680706·131 enrolled

Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy

Completed·MMashhad University of Medical Sciences·Phase 3·NCT01115504·50 enrolled

Sepsis2 trials

Vitamin C, Thiamine, and Steroids in Sepsis

Completed·EEmory University·Phase 3·NCT03509350·501 enrolled

Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

Completed·—·Phase 2·NCT03422159·140 enrolled

Cardiac Arrest2 trials

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

Terminated·—·Phase 2·NCT02974257·41 enrolled

Vitamin C in Post-cardiac Arrest

Completed·AAmsterdam UMC, location VUmc·Phase 2·NCT03509662·270 enrolled

Fatigue2 trials

PBC Induced Fatigue Treated With Thiamine

Unknown status·HHenning Grønbæk·Phase 4·NCT04893993·36 enrolled

Thiamin Against Robust IBD Fatigue

Completed·UUniversity of Aarhus·Phase 4·NCT03634735·40 enrolled

13 more indications

Delirium2 trials

Thiamine Administration and Prevalence of Delirium in the Intensive Care Unit: A Before-after Study

Completed·MMeir Medical Center··NCT04214106·1,000 enrolled

High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT03263442·66 enrolled

Critical Illness2 trials

Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

Completed·—·N/A·NCT01462279·20 enrolled

The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Completed·—·Phase 2·NCT01985685·66 enrolled

Cardiac Surgery1 trial

Thiamine as an Adjunctive Therapy in Cardiac Surgery

Completed·—·Phase 2·NCT02322892·64 enrolled

Hyperthyroidism1 trial

Thiamine Supplement in Patients With Severe Hyperthyroidism

Completed·RRamathibodi Hospital·N/A·NCT02767245·12 enrolled

Congestive Heart Failure1 trial

Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure

Completed·LLuzerner Kantonsspital·N/A·NCT00770107·12 enrolled

Intraoperative1 trial

Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets

Completed·TTexas Tech University Health Sciences Center·Phase 1·NCT03432572·120 enrolled

After Cardiac Surgery1 trial

The Thiamine Administration After Cardiac Surgery Trial

Completed·SSarah Saxena·Phase 4·NCT04641104·200 enrolled

Congenital Heart Disease1 trial

The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease

Completed·UUniversitas Sumatera Utara·Phase 1·NCT06298344·86 enrolled

Peripheral Neuropathy1 trial

Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy

Withdrawn·LLoma Linda University·N/A·NCT00279266

Meningitis1 trial

THiamine for Recovery In Vulnerable Early-life Infections

Not yet recruiting·MMilton S. Hershey Medical Center·Phase 2·NCT07868679·240 enrolled

Alcohol Use Disorder1 trial

Randomised Open-label Pilot Study on Thiamine Supplementation to REduce braiN Injury Associated With Chronic Alcohol Use in Outpatients With Alcohol Use Disorder

Not yet recruiting·IInstitut National de la Santé Et de la Recherche Médicale, France·Phase 2·NCT07844720·60 enrolled

Major Depressive Disorder (MDD)1 trial

An Open-Label Clinical Trial Conducted Via Telepsychiatry of Oral Thiamine for the Treatment of Depression In Youth

Not yet recruiting·MMassachusetts General Hospital·Phase 2·NCT07793071·40 enrolled

Coronary Heart Disease1 trial

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

Recruiting·UUniversity of California, Los Angeles·Phase 1·NCT06326996·52 enrolled

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for Thiamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Thiamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Thiamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Universiti Kebangsaan Malaysia Medical Centre company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: UUniversiti Kebangsaan Malaysia Medical Centre

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