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Thiamine

ApprovedSmall molecule

UUniversiti Kebangsaan Malaysia Medical Centre

Thiamine is a B vitamin used to treat or prevent thiamine deficiency, which can cause weakness, nerve damage, and heart problems. It's also used to help the body process carbohydrates and maintain healthy nerves and muscles.[2] Thiamine is currently approved and in use across 23 indications[4].[1]

Thiamine is one of 432 small molecule programs targeting Beriberi. It is currently in Approved.

23

Indications

25

Total Trials

1

Active Trials

431

Competitors

Pipeline

Status by Indication[4][1]

Indication

BeriberiUnknown

Cardiac ArrestActive, not recruiting

Respiratory FailureActive, not recruiting

Acute Respiratory FailureActive, not recruiting

Peripheral NeuropathyActive, not recruiting

HyperthyroidismActive, not recruiting

Huntington DiseaseActive, not recruiting

Thiamine DeficiencyUnknown

DeliriumActive, not recruiting

SepsisActive, not recruiting

BeriberiPreclinical

Unknown

Cardiac ArrestPhase 2

Active, not recruiting

Respiratory FailurePhase 2

Active, not recruiting

Acute Respiratory FailurePreclinical

Active, not recruiting

Peripheral NeuropathyPreclinical

Active, not recruiting

HyperthyroidismPreclinical

Active, not recruiting

Huntington DiseasePhase 2

Active, not recruiting

Thiamine DeficiencyPreclinical

Unknown

DeliriumPreclinical

Active, not recruiting

SepsisPhase 3

Active, not recruiting

Showing 10 of 22 indications

Competition

Competitive Landscape

687 competitors in Heart Failure

#DrugCompanyPhaseTrials

Thiamine

UUniversiti Kebangsaan Malaysia Medical Centre

Amidate

Medrol

Monoferric

PPharmacosmos A/S

Bystolic

VVitae Pharmaceuticals Inc., an Allergan affiliate

Activase

Zemplar

Xifaxan

Zoloft

VViatris Specialty LLC

Coumadin

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Recruiting

Coronary Artery Bypass

NCT06326996

Clinical

Trials by Indication[1]

Septic Shock5 trials

Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients

Unknown status·UUniversiti Kebangsaan Malaysia Medical Centre·N/A·NCT03649009·72 enrolled

Thiamine Supplementation in Patients With Septic Shock

Withdrawn·TThe Cleveland Clinic·Phase 1·NCT03122678

Thiamine as a Metabolic Resuscitator in Septic Shock

Completed·—·Phase 1/2·NCT01070810·88 enrolled

Show 2 more trials

The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock

Terminated·UUniversity Medical Centre Ljubljana·Phase 4·NCT03335124·5 enrolled

The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

Completed·—·Phase 2·NCT03333278·216 enrolled

Heart Failure2 trials

Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy

Completed·MMashhad University of Medical Sciences·Phase 3·NCT01115504·50 enrolled

Thiamine and Acute Decompensated Heart Failure: Pilot Study

Completed·—·Phase 2·NCT00680706·131 enrolled

Cardiac Arrest2 trials

Vitamin C in Post-cardiac Arrest

Completed·AAmsterdam UMC, location VUmc·Phase 2·NCT03509662·270 enrolled

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

Terminated·—·Phase 2·NCT02974257·41 enrolled

Critical Illness2 trials

The Effect of Thiamine vs. Placebo on VO2 in Critical Illness

Completed·—·Phase 2·NCT01985685·66 enrolled

Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

Completed·—·N/A·NCT01462279·20 enrolled

Sepsis2 trials

Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

Completed·—·Phase 2·NCT03422159·140 enrolled

Vitamin C, Thiamine, and Steroids in Sepsis

Completed·EEmory University·Phase 3·NCT03509350·501 enrolled

10 more indications

Delirium2 trials

High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT03263442·66 enrolled

Thiamine Administration and Prevalence of Delirium in the Intensive Care Unit: A Before-after Study

Completed·MMeir Medical Center··NCT04214106·1,000 enrolled

Fatigue2 trials

PBC Induced Fatigue Treated With Thiamine

Unknown status·HHenning Grønbæk·Phase 4·NCT04893993·36 enrolled

Thiamin Against Robust IBD Fatigue

Completed·UUniversity of Aarhus·Phase 4·NCT03634735·40 enrolled

Hyperthyroidism1 trial

Thiamine Supplement in Patients With Severe Hyperthyroidism

Completed·RRamathibodi Hospital·N/A·NCT02767245·12 enrolled

Peripheral Neuropathy1 trial

Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy

Withdrawn·LLoma Linda University·N/A·NCT00279266

Congenital Heart Disease1 trial

The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease

Completed·UUniversitas Sumatera Utara·Phase 1·NCT06298344·86 enrolled

Cardiac Surgery1 trial

Thiamine as an Adjunctive Therapy in Cardiac Surgery

Completed·—·Phase 2·NCT02322892·64 enrolled

Congestive Heart Failure1 trial

Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure

Completed·LLuzerner Kantonsspital·N/A·NCT00770107·12 enrolled

Coronary Artery Bypass1 trial

Thiamine Intervention and Coronary Artery Bypass Grafting

Recruiting·UUniversity of California, Los Angeles·Phase 1·NCT06326996·52 enrolled

Intraoperative1 trial

Investigating Oral Agents for Urine Staining to Facilitate Intraoperative Observation of Ureteral Jets

Completed·TTexas Tech University Health Sciences Center·Phase 1·NCT03432572·120 enrolled

After Cardiac Surgery1 trial

The Thiamine Administration After Cardiac Surgery Trial

Completed·SSarah Saxena·Phase 4·NCT04641104·200 enrolled

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for Thiamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Thiamine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Thiamine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Thiamine. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Universiti Kebangsaan Malaysia Medical Centre company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: UUniversiti Kebangsaan Malaysia Medical Centre

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