Citicoline
ApprovedSmall molecule
Citicoline is used to help improve memory and thinking ability, particularly in patients recovering from stroke or experiencing age-related cognitive decline. It works by supporting brain cell function and protecting brain tissue from damage.[2] Citicoline is currently approved and in use across 20 indications[4].[1]
Citicoline is one of 452 small molecule programs targeting Neurodegenerative Disease. It is currently in Approved.
20
Indications
23
Total Trials
4
Active Trials
451
Competitors
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 19 indications
Competition
Competitive Landscape
1931 competitors in COVID-19
#DrugCompanyPhaseTrials
1Citicoline
UUniversity of Texas Southwestern Medical Center
Approved
COVID-19 Vaccine
ModernaPreclinical
Biaxin
AbbViePreclinical
Singulair
AstraZenecaPreclinical
Angiomax
BBaxter Healthcare Corporation
Preclinical
Benadryl
PParkedale
Preclinical
Nitrostat
VViatris Specialty LLC
Preclinical
Low-Molecular-Weight Heparin
Daiichi SankyoPreclinical
Piperacillin/tazobactam
PfizerPreclinical
Orap
TevaPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Brain Injury3 trials
Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT)
Terminated·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 3·NCT00545662·1,213 enrolled
Ischemic stroke2 trials
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.
Completed·—·Phase 3·NCT01388738·30 enrolled
Citicoline in Ischemic Stroke
Unknown status·—·Phase 3·NCT05154903·200 enrolled
Major Depressive Disorder1 trial
Encephalopathy1 trial
Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy
Unknown status·—·Phase 3·NCT03181646·50 enrolled
15 more indications
Marijuana1 trial
Optic Nerve Disease1 trial
Anterior Ischemic Optic Neuropathy1 trial
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Citicoline drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Citicoline. EMBL-EBI & Wellcome Sanger Institute.
- [5]
Details