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Other/Fracture

Fracture

45

Pipeline Programs↗

118

Active Trials↗

36

Companies Involved↗

Fracture is a moderately active landscape with 45 programs across 36 companies. 5 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

70/100

Pipeline Velocity

74/100

Mech. Concentration

27/100

Completion Rate

65/100

Attrition Rate

20/100

Pipeline

Programs by Phase

Preclinical35

Buprenorphine

Indivior Inc.

Hydromorphone

Rhodes Pharmaceuticals, L.P.

Enoxaparin Sodium

Sanofi

Romosozumab

Amgen

Clopidogrel

Sanofi

Phase 12

LYN101

Shanghai TTM-Bio Technology Co., Ltd

Metformin

EMD Serono

Phase 23

Lidocaine IV

MEDRx USA, Inc.

Acetylsalicylic Acid

Bayer

Isomyosamine

TNF Pharmaceuticals, Inc.

Phase 35

Antibiotic Cement Bead Pouch

University of Maryland, Baltimore

Vancomycin (VAN) Treatment

University Hospital, Montpellier

Rivaroxaban

Wim Janssens

Cryoablation

Fudan University

PENG Block and Cryoablation

University of Minnesota

Approved

No programs

Analysis

Modality Breakdown

98%

Small molecule

42 of 43 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 43 classified programs, each share of the total. Modality classified for 100% of 45 pipeline programs.

Analysis

Trial Status

394

clinical trials

Completed145 · 37%

Recruiting60 · 15%

Unknown status52 · 13%

Terminated46 · 12%

Not yet recruiting42 · 11%

Withdrawn32 · 8%

Other17 · 4%

Clinical Trials

Trial Activity

394 trials

Assessment of the Verus Frame as a Support for the Leg in Orthopaedic Surgery (Intramedullary Nailing) of Tibial Fracture in Adults. A Prospective, Single-arm, Interventional Post-market Clinical Investigation With AO Foundation Approved Acceptance Criteria and a Retrospective Registry Control Group.

Recruiting·—·Preclinical·NCT07362121·25 enrolled

Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries

Recruiting·JJohns Hopkins University·Preclinical·NCT06293469·356 enrolled

Assessment of Bone Displacement Under Loading Following Periprosthetic Fracture Repair With Weight-Bearing CT

Recruiting·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Preclinical·NCT06525610·21 enrolled

An Open Label, Multi-Center, Retrospective and Prospective Evaluation of Equinoxe Proximal Humerus Fracture Plates Clinical and Radiographic Outcomes

Recruiting·EExactech·N/A·NCT05703958·151 enrolled

A Randomized Controlled Trial Comparing Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy for the Management of Severe Open Tibia Fracture Wounds

Recruiting·UUniversity of Maryland, Baltimore·Phase 3·NCT05615844·312 enrolled

Immediate vs Delayed Weight-bearing After Surgical Treatment of Malleolar Fractures: a Randomized Controlled Trial

Recruiting·EEnte Ospedaliero Cantonale, Bellinzona·Preclinical·NCT04429217·100 enrolled

Periarticular Administration of Dexamethasone to Improve Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Hip Arthroplasty - A Randomized Trial

Recruiting·EEnte Ospedaliero Cantonale, Bellinzona·Approved·NCT05023369·110 enrolled

Improving Intramedullary Nailing of Proximal Femoral Fractures Through a Navigation Assisted Technique: a Double Blinded Randomized Control Trial

Recruiting·—·Preclinical·NCT04494672·96 enrolled

Musculoskeletal Adaptive Platform Trial (MAPT): Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

Recruiting·UUniversity of Southern California·Preclinical·NCT07244211·600 enrolled

Treatment of Olecranon Fractures in the Elderly, a Randomised Controlled Trial Comparing Surgical and Conservative Treatment

Recruiting·EEnte Ospedaliero Cantonale, Bellinzona·Preclinical·NCT07400692·84 enrolled

Influence of Cemented Cephalic Augmentation on the Outcome of Osteosynthesis Using Intramedullary Nailing in the Surgical Treatment of Pertrochanteric Hip Fractures in the Elderly

Recruiting·DDiego Matías Domínguez Prado·Preclinical·NCT06634290·314 enrolled

The With Or Without Olecranon K-wire (WOW OK) Trial of Tension Band Wire Fixation Versus Cerclage Fixation Without K-wires in Displaced Stable Olecranon Fractures

Recruiting·—·Preclinical·NCT05657899·200 enrolled

Continuous Compartment Pressure Monitoring in Adolescent Tibia Fractures

Recruiting·BBoston Children's Hospital·Preclinical·NCT07674043·50 enrolled

Elastic Stable Intramedullary Nailing Supplemented by Kirschner Wires Versus Plate Fixation in the Treatment of Distal Tibial Metaphyseal-diaphyseal Junction Fractures in Adolescents

Recruiting·SSohag University·Preclinical·NCT07783529·60 enrolled

Open Reduction and Internal Fixation of Humeral Midshaft Fracture: Anterior Versus Posterior Plate Fixation

Recruiting·—·Preclinical·NCT07775690·150 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)