VivoSeq
Other

Fracture

4

Pipeline Programs↗

11

Active Trials↗

8

Companies Involved↗

Fracture is an early-stage landscape with 4 programs across 8 companies. The most active players are Rhodes Pharmaceuticals, L.P., Amgen, Sanofi. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

35/100

Pipeline Velocity

19/100

Mech. Concentration

33/100

Completion Rate

60/100

Attrition Rate

24/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

R

Rhodes Pharmaceuticals, L.P.

1 program

PreclinicalAmgen logo

Amgen

0 programs

PreclinicalSanofi logo

Sanofi

0 programs

PreclinicalNovartis logo

Novartis

0 programs

PreclinicalGSK logo

GSK

0 programs

PreclinicalNovo Nordisk logo

Novo Nordisk

0 programs

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

38

clinical trials

Completed15 · 39%
Terminated5 · 13%
Recruiting5 · 13%
Withdrawn4 · 11%
Active, not recruiting3 · 8%
Unknown status2 · 5%
Other4 · 11%

Clinical Trials

Trial Activity

38 trials

Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)
Recruiting·UUniversity of Missouri-Columbia·Phase 4·NCT03652753·30 enrolled
Prospective, Randomized-control Trial Comparing Standard Intramedullary Tibial Fixation With Micromotion Tibial Intramedullary Fixation
Recruiting·UUniversity of Chicago·Preclinical·NCT06976801·372 enrolled
Primary Subtalar Arthrodesis for Calcaneal Fractures to Optimize Performance: A Randomized Clinical Trial
Recruiting·WWake Forest University Health Sciences·Preclinical·NCT06249126·218 enrolled
Intramedullary Calcium Sulfate Antibiotic Depot for Prevention of Open Fracture Related Infection: A Randomized Clinical Trial
Recruiting·WWake Forest University Health Sciences·Phase 3·NCT05766670·497 enrolled
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department: a Randomized Controlled Study
Recruiting·TThe Cooper Health System·Preclinical·NCT07430345·48 enrolled
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Active, not recruiting·MMcMaster University·Preclinical·NCT04947722·3,060 enrolled
Fragility Fractures of the Pelvis: Observational Outcome Study
Active, not recruiting·AAO Innovation Translation Center·N/A·NCT04182776·420 enrolled
Prospective Pilot Study With a Titanium Fusion Implant in Combination With Trans-iliac Screws for Insufficiency Fractures of the Pelvis
Active, not recruiting·UUniversity of Witten/Herdecke·Preclinical·NCT05367505·50 enrolled
Preventive Effect of 5% Lidocaine Plaster on the Development of Neuropathic Pain Following Osteoporotic Vertebral Fracture: A Proof-of-concept, Controlled, Randomized Trial
Not yet recruiting·UUniversity Hospital, Clermont-Ferrand·Approved·NCT07691359·30 enrolled
Bone Quality Assessment Following Application of Adipose Tissue Derived Autologous Mesenchymal Stem Cell Concentrate in the Management of Mandibular Fractures. A Randomized Clinical Trial
Not yet recruiting·CCairo University·Preclinical·NCT07671183·20 enrolled
Fracture Recovery for Returning to Duty (Teriparatide STRONG)
Enrolling by invitation·UUniversity of South Carolina·Phase 4·NCT04589819·183 enrolled
Study To Assess FRacTure Healing With SclerosTin Antibody - Hip
Completed·Amgen logoAmgen·Phase 2·NCT01081678·332 enrolled
SOLID-Effect of Risedronate Sodium at Distal Radius in Colle's Fracture.
Completed·Sanofi logoSanofi·Phase 4·NCT00460733·141 enrolled
RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
Completed·—·Phase 3·NCT00414700·118 enrolled
Non-steroid Antiinflammatory Drugs to Heal Colles Fracture
Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01606540·192 enrolled
Page 1 of 3

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)