Lidocaine IV

ApprovedSmall molecule

KKasr El Aini Hospital

Lidocaine IV is one of 286 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

Total Trials

Active Trials

285

Competitors

Pipeline

Status by Indication[3][1]

Indication

Coronary Artery DiseaseActive, not recruiting

Chronic PancreatitisActive, not recruiting

MetastasisActive, not recruiting

Rib FractureActive, not recruiting

DeliriumActive, not recruiting

Chronic PainActive, not recruiting

Total Knee ArthroplastyActive, not recruiting

Abdominal PainActive, not recruiting

Pancreatic CancerActive, not recruiting

Intravenous LidocaineNot yet recruiting

Coronary Artery DiseasePreclinical

Active, not recruiting

Chronic PancreatitisPhase 2

Active, not recruiting

MetastasisPreclinical

Active, not recruiting

Rib FracturePhase 2

Active, not recruiting

DeliriumPhase 3

Active, not recruiting

Chronic PainPhase 1/Phase 2

Active, not recruiting

Total Knee ArthroplastyApproved

Active, not recruiting

Abdominal PainApproved

Active, not recruiting

Pancreatic CancerPreclinical

Active, not recruiting

Intravenous LidocainePhase 3

Not yet recruiting

Showing 10 of 12 indications

Competition

Competitive Landscape

1063 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Lidocaine IV

KKasr El Aini Hospital

Approved

1 2

MS Contin

Merck & Co.

Preclinical

1 3

Medrol

Pfizer

Preclinical

1 4

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 5

ABI-007

Bristol-Myers Squibb

Preclinical

2 6

Active Comparator

Moderna

Preclinical

1 7

LDE225

Novartis

Preclinical

1 8

Sulfonylureas

Eli Lilly

Preclinical

1 9

Thiazolidinediones

Sanofi

Preclinical

1 10

Alpha-Glucosidase Inhibitors

Sanofi

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 3Recruiting

Intravenous Lidocaine

NCT07661758

Q3 2027

Phase 3Not yet recruiting

Digestive System Disease

NCT07076641

Phase 3Recruiting

Delirium

NCT05010148

Clinical

Trials by Indication[1]

Intravenous Lidocaine7 trials

Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.

Terminated·JJeremy Kearns·Phase 4·NCT04208516·17 enrolled

Intravenous Lidocaine in Open Lung Resection Surgery

Completed·SSaint-Joseph University·Phase 4·NCT04480281·60 enrolled

Effect of Intravenous Lidocaine on Propofol Requirements

Completed·GGeneral Hospital of Ningxia Medical University·N/A·NCT04633577·40 enrolled

Show 4 more trials

Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Recruiting·UUniversity Tunis El Manar·N/A·NCT06272461·50 enrolled

Evaluation of Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia (ELSA Trial)

Unknown status·IInstituto Nacional de Cancer, Brazil·Phase 2/3·NCT04741880·66 enrolled

Comparison of Intraoperative Intravenous Lidocaine Infusion and Transversus Abdominis Plane (TAP) Block for Post-operative Analgesia Following Laproscopic Cholecystectomy

Completed·—·N/A·NCT05231941·90 enrolled

Pre-emptive Single Intravenous Lidocaine Dose to Prevent Post-Fundal Pressure Headache During Cesarean Section: The LID-HEAD Multi-center Randomized Controlled Trial

Recruiting·TTanta University·Phase 3·NCT07661758·680 enrolled

Dexmedetomidine3 trials

Opioid Sparing Analgesia: Dexmedetomidine Versus Lidocaine for Intracranial Surgeries in Children

Completed·ZZagazig University·Phase 1/2·NCT04535089·64 enrolled

Dexmedetomidine Versus Lidocaine in Attenuating Airway Reflexes During Recovery of Thyroidectomy Patients

Unknown status·—·N/A·NCT05657028·140 enrolled

Dexmedetomidine in IVRA

Completed·MMenoufia University·Phase 4·NCT05123170·90 enrolled

Post Operative Pain3 trials

Comparison of the Effect of Lidocaine Infusion Applied at Different Doses During Lumbar Spinal Surgery on Hemodynamics and Postoperative Pain

Unknown status·—·N/A·NCT05936190·80 enrolled

Effect of Lidocaine Versus Magnesium on Postoperative Pain in Spine Surgery

Unknown status·HHaitham Mohammad Ahmad Mohammad·Phase 4·NCT04776369·60 enrolled

Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery

Unknown status·UUniversity of Athens·Phase 2/3·NCT03363425·60 enrolled

Lidocaine Infusion1 trial

Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy

Completed·RRhode Island Hospital·Phase 4·NCT03902314·70 enrolled

Laparoscopic Cholecystectomy1 trial

Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT05788393·64 enrolled

28 more indications

Hemodynamic Stability1 trial

Lidocaine Versus Fentanyl for Hemodynamic Stability

Completed·TTheodor Bilharz Research Institute·Phase 4·NCT06557473·40 enrolled

Abdominal pain1 trial

High Dose IV Lidocaine vs Hydromorphone for Abdominal Pain in the Emergency Department

Terminated·HHennepin Healthcare Research Institute·Phase 4·NCT04398316·4 enrolled

Pancreatic Cancer1 trial

Lidocaine Infusion With ERAS Protocol for Pancreatic Cancer Surgery: Effect on Pain and Patient Immunity.

Completed·—·N/A·NCT05470166·30 enrolled

Bariatric Surgery1 trial

Lidocaine Versus ESP - After Bariatric Surgery

Completed·JJagiellonian University·N/A·NCT05700214·279 enrolled

Extubation1 trial

Bolus vs. Continuous IV Lidocaine Against Post-Extubation Cough in Post-Thyroidectomy Patients

Completed·UUniversitas Padjadjaran·Phase 2·NCT06040034·40 enrolled

Outcome1 trial

Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial

Terminated·PPeter MacCallum Cancer Centre, Australia·Phase 3·NCT04316013·254 enrolled

Headache1 trial

The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache

Unknown status·—·Phase 2·NCT06109389·80 enrolled

Analgesia1 trial

Neural Correlates of Lidocaine Analgesia

Completed·KKeith M Vogt·Phase 1·NCT05501600·30 enrolled

Chronic Pancreatitis1 trial

Intravenous Lidocaine for Pain Associated With Pancreatic Cancer and Chronic Pancreatitis

Completed·—·Phase 2·NCT05906615·30 enrolled

Sickle Cell Crisis1 trial

Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis

Unknown status·—·Phase 2·NCT04614610·100 enrolled

Coronary Artery Disease1 trial

A Comparison Between Ketamine-lidocaine Versus Ketamine-fentanyl for Induction on the Hemodynamic Effects in Patients With Coronary Artery Disease

Unknown status·KKasr El Aini Hospital·N/A·NCT05502211·100 enrolled

Hemodynamic Changes1 trial

Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels

Completed·AArsil Radiansyah·Phase 1·NCT06516861·30 enrolled

Hemodynamic Response1 trial

Dexmedetomidine or Lidocaine for Lessening the Hemodynamic Responses to Laryngoscopy and Intubation

Completed·ZZagazig University·N/A·NCT05941767·100 enrolled

Cancer1 trial

Long Acting Neuraxial Peri-prostatic Block in Cancer

Active, not recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT06703437·12 enrolled

Anesthesia1 trial

Opioid-based Versus Lidocaine-based Induction of Anesthesia With Propofol in Elderly

Unknown status·KKasr El Aini Hospital·Phase 4·NCT05051007·100 enrolled

Rib Fracture1 trial

Comparison of Continuous Intravenous Lidocaine Infusion Versus ESP Block for Rib Fracture Analgesia

Not yet recruiting·SStanford University·Phase 2·NCT04707183·160 enrolled

Laparoscopic Surgery1 trial

Lidocaine as an Anesthetic Adjuvant in Liver and Gastric Laparoscopic Surgery

Completed·IInstitut d'Investigació Biomèdica de Girona Dr. Josep Trueta·Phase 4·NCT04584749·96 enrolled

Cesarean Section1 trial

Effect of Intraoperative Intravenous Lidocaine on Postoperative Pain and Return of Bowel Function After Cesarean Sections

Completed·—·Phase 2·NCT06433713·60 enrolled

Postoperative Pain Control1 trial

Postoperative Pain Control Following Hysteroscopy

Completed·—·N/A·NCT06423456·150 enrolled

Delirium1 trial

A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain

Recruiting·UUniversity of California, San Francisco·Phase 3·NCT05010148·278 enrolled

Chronic pain1 trial

Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.

Recruiting·—·Phase 1/2·NCT06431165·69 enrolled

Pruritus1 trial

Intravenous Lidocaine for Treating Intrathecal Fentanyl Induced Pruritus

Unknown status·—·Phase 1·NCT06243120·54 enrolled

Total Knee Arthroplasty1 trial

Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty

Completed·RRhode Island Hospital·Phase 4·NCT04828083·120 enrolled

Smooth Emergence1 trial

The Effect of Lidocaine on Smooth Emergence With Double Lumen Tube

Unknown status·—·N/A·NCT04455711·80 enrolled

Functional Endoscopic Sinus Surgery1 trial

Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery

Active, not recruiting·TThe Second People's Hospital of Huai'an·Phase 1/2·NCT06457100·60 enrolled

Metastasis1 trial

Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery

Completed·SSamsung Medical Center·N/A·NCT05742438·114 enrolled

Blood-Brain Barrier1 trial

Modulating Surgery-Induced Blood-Brain Barrier Disruption in Elderly

Recruiting·SSamsung Medical Center·N/A·NCT06090955·108 enrolled

Digestive System Disease1 trial

Phase III, Randomized, Double-blind Study to Assess the Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Analgesic Morphine Rachi Anesthesia for Major Digestive or Abdominal Surgery by Laparotomy.

Not yet recruiting·GGCS Ramsay Santé pour l'Enseignement et la Recherche·Phase 3·NCT07076641·76 enrolled

Sources

References

[1]
ClinicalTrials.gov — 43 trial records for Lidocaine IV. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Lidocaine IV compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Lidocaine IV. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Kasr El Aini Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: KKasr El Aini Hospital

Lidocaine IV

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q3 2027

Trials by Indication[1]

Intravenous Lidocaine7 trials

Dexmedetomidine3 trials

Post Operative Pain3 trials

Lidocaine Infusion1 trial

Laparoscopic Cholecystectomy1 trial

Hemodynamic Stability1 trial

Abdominal pain1 trial

Pancreatic Cancer1 trial

Bariatric Surgery1 trial

Extubation1 trial

Outcome1 trial

Headache1 trial

Analgesia1 trial

Chronic Pancreatitis1 trial

Sickle Cell Crisis1 trial

Coronary Artery Disease1 trial

Hemodynamic Changes1 trial

Hemodynamic Response1 trial

Cancer1 trial

Anesthesia1 trial

Rib Fracture1 trial

Laparoscopic Surgery1 trial

Cesarean Section1 trial

Postoperative Pain Control1 trial

Delirium1 trial

Chronic pain1 trial

Pruritus1 trial

Total Knee Arthroplasty1 trial

Smooth Emergence1 trial

Functional Endoscopic Sinus Surgery1 trial

Metastasis1 trial

Blood-Brain Barrier1 trial

Digestive System Disease1 trial

References

Drug Info

Quick Facts

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