VivoSeq
Musculoskeletal

Frozen Shoulder

23

Pipeline Programs↗

7

Active Trials↗

14

Companies Involved↗

Frozen Shoulder is an emerging landscape with 23 programs across 14 companies. The most active players are Endo Pharmaceuticals, Matrizyme Pharma Corporation, Amphastar Pharmaceuticals, Inc.. 9 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

19/100

Mech. Concentration

43/100

Completion Rate

77/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Endo Pharmaceuticals logo

Endo Pharmaceuticals

1 program

Phase 2M

Matrizyme Pharma Corporation

1 program

Phase 2A

Amphastar Pharmaceuticals, Inc.

1 program

Phase 3AstraZeneca logo

AstraZeneca

1 program

ApprovedA

Averitas Pharma, Inc.

1 program

ApprovedM

Milestone Pharmaceuticals Inc.

1 program

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

88%

Small molecule

29 of 33 classified programs — the dominant modality here.

12%ALL OTHERSMonoclonal antibody26%Protein / enzyme26%

Small molecule leads; the ring shows all 33 classified programs, each share of the total. Modality classified for 94% of 36 pipeline programs.

Analysis

Trial Status

24

clinical trials

Completed10 · 42%
Recruiting5 · 21%
Unknown status4 · 17%
Terminated2 · 8%
Not yet recruiting2 · 8%
Withdrawn1 · 4%

Clinical Trials

Trial Activity

24 trials

Comparing HILT, Steroid Injection, and Manual Therapy for Frozen Shoulder
Recruiting·—·N/A·NCT06916650·180 enrolled
A Study to Determine the Safety and Efficacy of Bevacizumab Administered Via Injection Into the Shoulder Joint of Participants With Adhesive Capsulitis (Frozen Shoulder)
Recruiting·MMacquarie University, Australia·Phase 2·NCT06976671·28 enrolled
Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder
Recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT07416916·528 enrolled
Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder?
Recruiting·SShin Kong Wu Ho-Su Memorial Hospital·Preclinical·NCT06491745·94 enrolled
The Combined Effect of Mulligan Mobilization, Pain Neuroscience-Based Training, and Core Stabilization Exercises in Frozen Shoulder Patients
Recruiting·YYeditepe University·Preclinical·NCT07667556·36 enrolled
Frozen Shoulder and Hormone Replacement Therapy
Not yet recruiting·UUniversity of California, San Francisco·Phase 4·NCT07278323·60 enrolled
Comparison of Transcatheter Arterial Microembolization and Corticosteroid Injection and for Treatment of Frozen Shoulder
Not yet recruiting·SShin Kong Wu Ho-Su Memorial Hospital·Preclinical·NCT07696923·94 enrolled
Safety and Efficacy of EN3835 in Participants With Frozen Shoulder
Completed·Endo Pharmaceuticals logoEndo Pharmaceuticals·Phase 2·NCT04496167·198 enrolled
The Anti-Freaze-F Study- "Anti-TNF for Treatment of Frozen Shoulder - a Feasibility Study"
Completed·UUniversity of Oxford·Phase 2/3·NCT05299242·9 enrolled
Rotator Interval and Intra-articular Corticosteroid Injection for Frozen Shoulder
Completed·OOslo University Hospital·N/A·NCT00840229·122 enrolled
Oral Corticosteroids Versus Exercises On Treatment Of Frozen Shoulder,
Completed·IIstanbul University·N/A·NCT05212740·33 enrolled
Prolotherapy Intervention in Patient With Frozen Shoulder
Completed·—·Phase 4·NCT05131269·32 enrolled
Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder
Completed·—·Phase 4·NCT01087229·75 enrolled
Effects of App-assisted Home Exercise Program in Patients With Frozen Shoulder
Completed·—·N/A·NCT05980572·21 enrolled
Percutaneous Interruption of the Coracohumeral Ligament for the Treatment of Frozen Shoulder
Completed·—·N/A·NCT04549051·46 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)