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local anesthetic

ApprovedSmall molecule

RRennes University Hospital

local anesthetic is one of 173 small molecule programs targeting Hernia. It is currently in Approved.

9

Indications

28

Total Trials

2

Active Trials

172

Competitors

Pipeline

Status by Indication[3][1]

Indication

BronchiectasisActive, not recruiting

Lateral EpicondylitisActive, not recruiting

HysterectomyActive, not recruiting

Frozen ShoulderActive, not recruiting

StrabismusActive, not recruiting

AnxietyActive, not recruiting

Back PainActive, not recruiting

Sensorineural Hearing LossActive, not recruiting

BronchiectasisApproved

Active, not recruiting

Lateral EpicondylitisPreclinical

Active, not recruiting

HysterectomyApproved

Active, not recruiting

Frozen ShoulderPreclinical

Active, not recruiting

StrabismusPreclinical

Active, not recruiting

AnxietyPreclinical

Active, not recruiting

Back PainPreclinical

Active, not recruiting

Sensorineural Hearing LossPhase 2/Phase 3

Active, not recruiting

Competition

Competitive Landscape

165 competitors in Anxiety

#DrugCompanyPhaseTrials

local anesthetic

RRennes University Hospital

Circadin

NNeurim Pharmaceuticals Ltd.

Centanafadine

Chamomile

HHams Hamed Abdelrahman

Celexa

Spravato

Campral

FForest Laboratories

Anerem

AAcacia Pharma Ltd

Luvox

SSolvay Pharmaceuticals

Andriol

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Post-ApprovalRecruiting

Bronchiectasis

NCT06209047

Clinical

Trials by Indication[1]

Thyroid Surgery1 trial

Ultrasound Guided Intermediate Cervical Plexus Block in Thyroid Surgery

Completed·—·N/A·NCT03731468·60 enrolled

Nitrous Oxide1 trial

QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study

Completed·RRennes University Hospital·N/A·NCT05178849·180 enrolled

Diagnosis1 trial

Marker for FAI Diagnosis

Completed·IIstituto Ortopedico Rizzoli··NCT02880085·20 enrolled

Ketamine1 trial

Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks

Unknown status·—·N/A·NCT04852484·90 enrolled

Back pain1 trial

Stem Cells vs. Steroids for Discogenic Back Pain

Withdrawn·JJohns Hopkins University·N/A·NCT04735185

23 more indications

Patient Satisfaction1 trial

Patient Satisfaction After Surgery for Otosclerosis Under Local ou General Anesthesia

Completed·RRennes University Hospital··NCT03888079·103 enrolled

Hernia1 trial

Predictive Factors for the Effectiveness of the Ilioinguinal Iliohypogastric Nerve Block for Hernia Surgery

Completed·UUniversity of Padova··NCT06121726·343 enrolled

Local Anesthesia1 trial

Local Anesthesia in Radial Catheterization

Unknown status·HHippocration General Hospital·Phase 4·NCT03072394·444 enrolled

Local Anesthetic1 trial

Local Anesthetic Infusion and Sternotomy

Terminated·UUniversity Hospital, Bordeaux·Phase 3·NCT00802048·21 enrolled

Strabismus1 trial

Effect of Dexmedetomedine in Subtenon's Block on Emergence Agitation in Pediatric Strabismus Surgery

Completed·SSameh Fathy·N/A·NCT04485273·100 enrolled

Intraperitoneal Chemotherapy1 trial

Four Quadrants Transverse Abdominus Plane (4Q-TAP) Block With Plain and Liposomal Bupivacaine vs. Thoracic Epidermal Analgesia (TEA) in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on an Enhanced Recovery Pathway

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT03359811·75 enrolled

Intratympanic Injection1 trial

Use of Vibration Anesthesia Device in Intratympanic Injections

Completed·YYuzuncu Yil University·N/A·NCT06885723·40 enrolled

Hysterectomy1 trial

Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy

Not yet recruiting·WWalter Reed National Military Medical Center·Phase 4·NCT06709716·76 enrolled

External Oblique Intercostal Plane Block1 trial

Bilateral External Oblique Intercostal Plane Block in Laparoscopic Cholecystectomy

Completed·TTheodor Bilharz Research Institute·Phase 4·NCT06541613·38 enrolled

Peripheral Nerve Block1 trial

Peripheral Nerve Blocks in Pediatric Orthopedic Patients

Terminated·UUniversity of Mississippi Medical Center·N/A·NCT02236130·49 enrolled

Sensorineural Hearing Loss1 trial

Assessment of The Efficacy of Intratympanic Platelet Rich Plasma for Treatment of Sensorineural Hearing Loss.

Unknown status·—·Phase 2/3·NCT05786378·23 enrolled

Bronchiectasis1 trial

Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis

Recruiting·—·Phase 4·NCT06209047·315 enrolled

Regional Anesthesia1 trial

Systemic Nalbuphine Versus Intravenous Regional Anesthesia

Completed·—·N/A·NCT03150732·82 enrolled

Thoracic Surgery1 trial

Analgesia After Video-Assisted Thoracic Surgery

Completed·—·Phase 2·NCT05094323·102 enrolled

Erector Spinae Plane Block1 trial

Ultrasound Guided Erector Spinae Plane Block in Breast Surgery

Unknown status·—·N/A·NCT03660020·60 enrolled

Bupivacaine1 trial

Assessment of Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion

Completed·FFondazione IRCCS Policlinico San Matteo di Pavia·Phase 4·NCT01229241·181 enrolled

Lateral Epicondylitis1 trial

Comparing Autologous Blood, Corticosteroid, and Their Combined Injection for Treating Lateral Epicondylitis

Completed·IIstanbul Training and Research Hospital·N/A·NCT06236178·119 enrolled

Effectiveness1 trial

Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations

Completed·UUniversity of Campinas, Brazil·Phase 1·NCT05267938·30 enrolled

Endodontic Treatment1 trial

Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

Completed·UUniversity of Washington·Phase 4·NCT05338671·35 enrolled

Pilot Study1 trial

Cryoneurolysis for TKA - a Pilot Study

Unknown status·UUnity Health Toronto·N/A·NCT05286996·20 enrolled

Frozen Shoulder1 trial

Percutaneous Interruption of the Coracohumeral Ligament for the Treatment of Frozen Shoulder

Completed·—·N/A·NCT04549051·46 enrolled

Observational Study1 trial

Serratus Intercostal Block Versus Epidural Analgesia in Eventration: Prospective Observational Study

Completed·HHospital del Rio Hortega··NCT06014749·80 enrolled

Anxiety1 trial

Pain and Anxiety Evaluation in Children Using Different Techniques of Local Anesthesia for Dental Treatment

Completed·UUniversidade Estadual de Ponta Grossa·N/A·NCT03176446·210 enrolled

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for local anesthetic. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — local anesthetic compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for local anesthetic. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Rennes University Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: RRennes University Hospital

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