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Other/Hemorrhage

Hemorrhage

105

Pipeline Programs↗

124

Active Trials↗

43

Companies Involved↗

Hemorrhage is a highly competitive landscape with 105 programs across 43 companies. 12 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

77/100

Pipeline Velocity

72/100

Mech. Concentration

8/100

Completion Rate

74/100

Attrition Rate

13/100

Pipeline

Programs by Phase

Preclinical73

Clomiphene Citrate

Ferring

Diclofenac Sodium

Novartis

Eltrombopag

GSK

Sodium Nitroprusside

Exela Pharma Sciences, LLC.

Medroxyprogesterone Acetate

Eli Lilly

Phase 13

Tocilizumab

Celltrion

Avacopan

Amgen

24 Hours Antibiotics

Montefiore Medical Center

Phase 217

Deferoxamine

Jazz Pharmaceuticals

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Methylprednisolone Sodium Succinate

Massachusetts Eye and Ear Infirmary

Deuterated Oxytocin (d5ot)

University of Chicago

Febuxostat

Takeda

Phase 312

Carbetocin

ACADIA Pharmaceuticals Inc.

Calcium Gluconate

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Tachosil

Takeda

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Anticoagulants

Sanofi

Approved

No programs

Analysis

Modality Breakdown

93%

Small molecule

92 of 99 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 99 classified programs, each share of the total. Modality classified for 98% of 105 pipeline programs.

Analysis

Trial Status

413

clinical trials

Completed160 · 39%

Unknown status73 · 18%

Recruiting66 · 16%

Not yet recruiting48 · 12%

Terminated33 · 8%

Withdrawn21 · 5%

Other12 · 3%

Clinical Trials

Trial Activity

413 trials

Minimally Invasive Neuroendoscopic Ultra-Early Targeted ICH Evacuation (MINUTE) Trial

Recruiting·WWeill Medical College of Cornell University·Preclinical·NCT07260916·300 enrolled

PELE IDE Clinical Study, Peripheral Onyx™ Liquid Embolic Safety and Effectiveness of The Onyx™ LES for Embolization of Arterial Hemorrhage in the Peripheral Vasculature

Recruiting·—·Preclinical·NCT06742801·119 enrolled

TrIal of Early Minimally Invasive Catheter Evacuation With Thrombolysis in IntraCerebral Hemorrhage (TIME-ICH): A Prospective, Multi-center, Open-label, Adaptive, Randomized Controlled Trial

Recruiting·XXuanwu Hospital, Beijing·Preclinical·NCT07187687·750 enrolled

Impact of Neuromuscular Stimulation and High Protein Nutritional Supplementation on Long-term Recovery After Aneurysmal Subarachnoid Hemorrhage.

Recruiting·UUniversity of Maryland, Baltimore·Preclinical·NCT03201094·30 enrolled

A Prospective, Multicenter, Global Registry Evaluating Minimally Invasive Surgery for the Treatment of Acute Spontaneous Supratentorial Intracerebral Hemorrhage.

Recruiting·EEmory University·N/A·NCT07651631·2,500 enrolled

Pharmacokinetics and Pharmacodynamics of Oxytocin in Cesarean Delivery

Recruiting·UUniversity of Chicago·Phase 2·NCT05488457·100 enrolled

Recombinant Factor VIIa (rFVIIa) for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial - Part 2

Recruiting·JJoseph Broderick, MD·Phase 3·NCT07227246·350 enrolled

The Effect of Transcutaneous Vagal Nerve Stimulation (tVNS) on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

Recruiting·—·Preclinical·NCT07131696·10 enrolled

Are Long Term Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

Recruiting·MMontefiore Medical Center·Phase 1·NCT05001750·84 enrolled

Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

Recruiting·ZZeenat Qureshi Stroke Institute·N/A·NCT06402968·1,018 enrolled

Pharmacokinetics Of Emulsified Avacopan In ANCA-associated Vasculitis With Severe Diffuse Alveolar Hemorrhage

Recruiting·MMayo Clinic·Phase 1·NCT07556484·6 enrolled

A Prospective Interventional Study Evaluating the Effect of Simulation-Based Postpartum Hemorrhage Training on Team Performance and Crisis Resource Management Skills Among Senior Anesthesiology Residents

Recruiting·—·Preclinical·NCT07519252·36 enrolled

Safety and Efficacy of Chronic Subdural Hematoma Embolization With Detachable Coils

Recruiting·IIcahn School of Medicine at Mount Sinai·N/A·NCT07291427·150 enrolled

Logistic Regression Prediction Model vs. Standard of Care for Prediction of Postpartum Hemorrhage - A Pragmatic Randomized Controlled Trial

Recruiting·—·Preclinical·NCT06513351·12,500 enrolled

Administration of Calcium Gluconate for the Reduction of Blood Loss During Vaginal Delivery: A Randomized, Double-Blind, Placebo-Controlled Trial

Recruiting·RRambam Health Care Campus·Preclinical·NCT07714902·710 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)