Clomid

(Clomiphene citrate)

Phase 3Small molecule

Clomiphene citrate is used to help women become pregnant by stimulating the release of eggs from the ovaries. It's also sometimes used to treat low testosterone in men.[1] Clomid is currently being investigated across 11 indications[3], with its most advanced program in Phase 3.[1]

Clomid is one of 224 small molecule programs targeting Female Infertility. It is currently in Phase 3.

Indications

Total Trials

Active Trials

223

Competitors

Pipeline

Status by Indication[3][1]

Indication

Female InfertilityUnknown

AnovulationActive, not recruiting

HemorrhageUnknown

Polycystic Ovary SyndromeUnknown

Prostate CancerNot yet recruiting

TreatmentCompleted

Infertility, FemaleRecruiting

RandomizedRecruiting

In Vitro FertilizationCompleted

OvarianUnknown status

Female InfertilityPreclinical

Unknown

AnovulationPhase 3

Active, not recruiting

HemorrhagePreclinical

Unknown

Polycystic Ovary SyndromePreclinical

Unknown

Prostate CancerPhase 2

Not yet recruiting

TreatmentPreclinical

Completed

Infertility, FemalePhase 3

Recruiting

RandomizedPhase 2

Recruiting

In Vitro FertilizationPreclinical

Completed

OvarianPreclinical

Unknown status

Showing 10 of 11 indications

Competition

Competitive Landscape

332 competitors in Treatment

#DrugCompanyPhaseTrials

Clomid

Ferring

Phase 3

1 2

Biltricide

Bayer

Preclinical

3 3

Dexilant

Takeda

Preclinical

2 4

Niclocide

Bayer

Preclinical

1 5

Minipress

Pfizer

Preclinical

1 6

Alfenta

Jazz Pharmaceuticals

Preclinical

1 7

Intuniv

PPromius Pharma, LLC

Preclinical

1 8

Aurlumyn

BBTG International Inc.

Preclinical

1 9

Lotemax

PPharmos

Preclinical

1 10

Norpramin

VValidus Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 3Recruiting

Polycystic Ovarian Syndrome

NCT03059173

Q2 2028

ApprovedRecruiting

Infertility, Female

NCT06701071

Q1 2029

Phase 2Recruiting

Randomized

NCT04944836

Q1 2037

Phase 2Not yet recruiting

Prostate Cancer

NCT07882862

Clinical

Trials by Indication[1]

Polycystic Ovary Syndrome13 trials

Clomiphene Citrate Plus Cabergoline in Treatment of Polycystic Ovary Syndrome

Unknown status·WWoman's Health University Hospital, Egypt·Phase 2·NCT02644304·88 enrolled

Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome

Completed·NNational Center for Research Resources (NCRR)·N/A·NCT00005654·88 enrolled

Pregnancy in Polycystic Ovary Syndrome II

Completed·YYale University·Phase 3·NCT00719186·750 enrolled

Show 10 more trials

Extended Clomiphene Citrate Regimen in Women With Polycystic Ovary Syndrome

Completed·—·Phase 2/3·NCT02381184·160 enrolled

Minimal Stimulation or Clomiphene Citrate in Treatment of Polycystic Ovary Syndrome

Completed·MMansoura University·N/A·NCT01157312·113 enrolled

Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome

Completed·NNational Center for Research Resources (NCRR)·N/A·NCT00005104·99 enrolled

Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin

Withdrawn·CClinique Ovo·Phase 3·NCT01638988

Treatment of Infertility in Women With Polycystic Ovary Syndrome

Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 3·NCT00068861·678 enrolled

Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome

Completed·—·Phase 1·NCT03566225·400 enrolled

Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS)

Completed·UUniversity Magna Graecia·Phase 4·NCT01004068·96 enrolled

Adding L-Carnitine to Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome

Completed·—·Phase 4·NCT03630341·150 enrolled

L-Carnitine and Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome

Completed·—·N/A·NCT03476356·106 enrolled

Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome

Completed·MMansoura University·N/A·NCT01910766·110 enrolled

Ovulation Induction8 trials

Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOS

Completed·MMohamed Sayed Abdelhafez·Phase 4·NCT02436226·300 enrolled

Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs

Completed·—·Phase 4·NCT02479256·600 enrolled

Comparison of Clomiphene Citrate and Gonadotropins in Ovulation Induction Cycles

Completed·UUniversitair Ziekenhuis Brussel·Phase 4·NCT00835744·40 enrolled

Show 5 more trials

Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS

Completed·—·Phase 4·NCT02352597·150 enrolled

Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )

Unknown status·Mmostafa gomaa hamid halawa·Phase 2·NCT02551367·110 enrolled

Sildenafil Effect After Ovulation Induction

Unknown status·—·Phase 4·NCT02890238·100 enrolled

BMI Effect on the Response to Ovulation Induction in Letrozole vs Clomid

Unknown status·—·Phase 4·NCT04331197·160 enrolled

Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction

Completed·YYuzuncu Yil University·N/A·NCT07398924·90 enrolled

Infertility7 trials

Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility

Unknown status·EElham Raafat·Phase 1·NCT03681197·170 enrolled

Cost-effective Treatment of Unexplained Infertility

Completed·—·Phase 4·NCT06178523·900 enrolled

Treatment of Anovulatory Infertility in PCOS Patients

Completed·UUniversity Magna Graecia·Phase 4·NCT00471523·80 enrolled

Show 4 more trials

Effect of Endometrial Injury in Couples With Unexplained Infertility

Unknown status·—·N/A·NCT03398993·100 enrolled

Letrozole vs. Clomiphene Citrate in Patients With Anovulatory Infertility

Completed· Sun Pharmaceutical Industries Limited logo

Sun Pharmaceutical Industries Limited·Phase 3·NCT00610077·55 enrolled

Effect of Sildenafil Citrate Compared to Estrogen as Adjuvant Therapy for Unexplained Infertility

Completed·—·Phase 4·NCT05753098·148 enrolled

Cabergoline As An Adjuvant To Clomiphene Citrate For Management Of Unexplained Infertility

Unknown status·—·Phase 2/3·NCT03549741·120 enrolled

Polycystic Ovarian Syndrome4 trials

Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome

Completed·HHospital de Clinicas de Porto Alegre·Phase 3·NCT00427700·82 enrolled

Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome

Completed·SServices Institute of Medical Sciences, Pakistan·Phase 2/3·NCT05702957·220 enrolled

The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.

Completed·—··NCT07419776·90 enrolled

Show 1 more trial

Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome

Recruiting·UUniversity Hospital, Lille·Phase 3·NCT03059173·276 enrolled

PCOS3 trials

NAC in CC Resistant PCOS After LOD

Completed·—·Phase 2/3·NCT02775734·144 enrolled

Myo-inositol Versus Clomiphene Citrate in PCOS

Terminated·UUniversity Hospital, Ghent·Phase 4·NCT04306692·12 enrolled

Clomiphene Citrate in Infertile PCOS Patients

Withdrawn·UUniversity Magna Graecia·Phase 4·NCT00501839

34 more indications

Ovarian Stimulation3 trials

Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.

Unknown status·UUniversity of Athens·Phase 2/3·NCT02237755·50 enrolled

Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation

Completed·YYale University·Phase 3·NCT01044862·900 enrolled

Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate

Recruiting·PPAEC General Hospital, Islamabad·Phase 4·NCT07462065·62 enrolled

Pregnancy2 trials

The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women

Completed·559th Medical Wing·Phase 3·NCT00413179·56 enrolled

Effect of Local Endometrial Injury on Pregnancy Outcomes During Ovulation Induction Cycles

Unknown status·—·N/A·NCT02345837·160 enrolled

Hypogonadism2 trials

Clomiphene Citrate for the Treatment of Obesity Related Male Hypogonadism

Completed·UUniversity of Sao Paulo·Phase 2·NCT02380755·78 enrolled

Clomiphene in Males With Prolactinomas and Persistent Hypogonadism

Completed·FFederal University of São Paulo·Phase 2·NCT00697814·15 enrolled

Efficacy and Safety2 trials

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH

Completed· Ferring logo

Ferring·Phase 2/3·NCT00296465·132 enrolled

Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Delivered From a Iontophoretic Patch Compared to Oral Treatment With Clomiphene or Placebo in Infertile Females

Completed· Ferring logo

Ferring·Phase 2·NCT00796289·350 enrolled

Endometrial2 trials

Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)

Terminated·UUniversity of Illinois at Chicago·N/A·NCT01718444·27 enrolled

Effect of Oral Sildenafil Citrate on Improvement of Endometrial Thickness

Completed·—·Phase 2/3·NCT05846906·130 enrolled

Growth2 trials

The Effect Of Vitamin D Replacement Therapy On Serum Leptin And Follicular Growth Pattern In Women With Resistant Polycystic Ovary

Unknown status·—·Phase 4·NCT03806036·100 enrolled

Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction

Completed· EMD Serono logo

EMD Serono·Phase 2·NCT00213148·271 enrolled

Efficacy2 trials

Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate

Completed·—·Phase 2·NCT05231980·120 enrolled

Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate

Completed·—·Phase 2·NCT03674385·60 enrolled

Infertility, Female2 trials

One-Shot Ovarian Stimulation Protocol: A Pilot Study Investigating the Endocrine Profile

Completed·FFundación Santiago Dexeus Font·Preclinical·NCT06635538·20 enrolled

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation in Patients With Diminished Ovarian Reserve Undergoing In-vitro Fertilization: a Randomized Controlled Trial

Recruiting·UUniversity of Southern California·Approved·NCT06701071·120 enrolled

Tics1 trial

Pharmacokinetics and Hepatic Safety of EGCG

Completed·YYale University·Phase 1·NCT04177693·39 enrolled

Randomized1 trial

Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial

Recruiting·UUniversity of Utah·Phase 2·NCT04944836·58 enrolled

SMA1 trial

Autologous Platelet-rich Plasma for Clomiphene Citrate-induced Thin Endometrium

Completed·—·Phase 2/3·NCT03770026·30 enrolled

Flare up1 trial

Mild Stimulation Protocol Versus Microdose Gonadotropin-releasing Hormone Agonist Flare up Protocol in Poor Responders

Completed·—·Phase 4·NCT01213147·159 enrolled

IVF Outcome1 trial

Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women

Unknown status·UUmm Al-Qura University·N/A·NCT05106712·700 enrolled

Women1 trial

Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle

Unknown status·SShaare Zedek Medical Center·N/A·NCT00449514·100 enrolled

Steroid1 trial

Incremental Clomiphene Citrate Doses in Successive Cycles and FSH, LH and Steroid Hormone Levels

Completed·—·Phase 4·NCT04210765·50 enrolled

In Vitro Fertilization1 trial

Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization

Completed·NNew Hope Fertility Center·N/A·NCT02865681·4 enrolled

Testosterone1 trial

Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration

Completed·WWeill Medical College of Cornell University·Phase 2·NCT01880086·13 enrolled

Infertile Patients1 trial

Parameters Declaring PCO Infertile Patients Either Sensitive or Resistant to Different Doses of Clomiphene Citrate.

Unknown status·—··NCT04887402·100 enrolled

Luteinizing Hormone (LH)1 trial

Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to Low Dose Clomiphene Citrate in Normally Menstruating Fertile Women

Completed·MMilton S. Hershey Medical Center·Phase 1/2·NCT01340521·25 enrolled

Concentration1 trial

Pharmacokinetic Evaluation of Serum Testosterone Concentrations After Administration of Clomiphene Citrate

Withdrawn·WWeill Medical College of Cornell University·Phase 2·NCT05096169

Function1 trial

Anastrazole and Clomiphene to Evaluate Hypogonadal Symptoms and Erectile Function

Completed·—·Phase 2·NCT03933618·24 enrolled

Endometriosis1 trial

Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest

Unknown status·—·Phase 4·NCT02575248·310 enrolled

Treatment1 trial

Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium

Completed·—·N/A·NCT02710981·42 enrolled

Randomized Controlled Trial1 trial

Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial

Unknown status·—·Phase 1·NCT02024984·90 enrolled

GnRH Antagonist1 trial

Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF

Unknown status·BBioroma·Phase 4·NCT02201914·250 enrolled

Outcome1 trial

Coenzyme q 10 and Fertility Outcome in Women With Clomiphene Resistant PCOS

Completed·—·Phase 4·NCT04302532·149 enrolled

Insulin Resistant1 trial

Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant

Terminated·SSemnan University of Medical Sciences·Phase 2·NCT02523898·388 enrolled

Anovulation1 trial

Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation

Active, not recruiting·RRachel Mejia·Phase 4·NCT05206448·190 enrolled

Acromegaly1 trial

Clomiphene Citrate for Treatment of Acromegaly

Completed·FFelipe Henning Gaia Duarte·Phase 2·NCT02274311·16 enrolled

Ovarian1 trial

Anti-Mullerian Hormone as Predictor of Ovarian Responce to Clomiphene Citrate in PCOS

Unknown status·—·N/A·NCT03316469·40 enrolled

Oligoasthenozoospermia1 trial

Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia

Completed·SShakeela Ishrat·Phase 3·NCT06564961·50 enrolled

Prostate Cancer1 trial

HRT-PC Trial: Hormone Recovery After Treatment for Prostate Cancer Trial. An Open-label Phase II Study of Clomiphene Citrate in Patients With Persistent Hypogonadism After ADT for Treatment of Localized Prostate Cancer

Not yet recruiting·UUniversity of Nebraska·Phase 2·NCT07882862·83 enrolled

Polycystic Ovarian Syndrome (PCOS)1 trial

Comparison of Clomiphene Citrate Alone Versus Clomiphene Citrate Plus Sildenafil Citrate for Ovulation Induction in Women With Polycystic Ovarian Syndrome

Completed·NNishtar Medical University·Approved·NCT07769476·98 enrolled

Unspecified3 trials

Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist

Completed·YYazd Research & Clinical Center for Infertility·Phase 4·NCT00830492·200 enrolled

Clomiphene Citrate Stair-Step Protocol

Unknown status·—·N/A·NCT03178500·60 enrolled

Traditional Clomiphene Citrate Administration vs. Stair-step Approach

Completed·UUniversity of Oklahoma·Phase 3·NCT01008319·120 enrolled

Sources

References

[1]
ClinicalTrials.gov — 80 trial records for Clomiphene citrate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Clomiphene citrate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Clomiphene citrate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Ferring company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Estrogen Receptor Alpha Modulator[2]
Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Ferring

Clomid

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q2 2028

Q1 2029

Q1 2037

Trials by Indication[1]

Polycystic Ovary Syndrome13 trials

Ovulation Induction8 trials

Infertility7 trials

Polycystic Ovarian Syndrome4 trials

PCOS3 trials

Ovarian Stimulation3 trials

Pregnancy2 trials

Hypogonadism2 trials

Efficacy and Safety2 trials

Endometrial2 trials

Growth2 trials

Efficacy2 trials

Infertility, Female2 trials

Tics1 trial

Randomized1 trial

SMA1 trial

Flare up1 trial

IVF Outcome1 trial

Women1 trial

Steroid1 trial

In Vitro Fertilization1 trial

Testosterone1 trial

Infertile Patients1 trial

Luteinizing Hormone (LH)1 trial

Concentration1 trial

Function1 trial

Endometriosis1 trial

Treatment1 trial

Randomized Controlled Trial1 trial

GnRH Antagonist1 trial

Outcome1 trial

Insulin Resistant1 trial

Anovulation1 trial

Acromegaly1 trial

Ovarian1 trial

Oligoasthenozoospermia1 trial

Prostate Cancer1 trial

Polycystic Ovarian Syndrome (PCOS)1 trial

Unspecified3 trials

References

Drug Info

Quick Facts

Related News