Hypertension Pipeline — VivoSeq

MOMENTOUS Study (iMpact Of an Ecg ai ModEl oN The Diagnosis Of pUlmonary hypertenSion)

Recruiting·TTempus AI·Preclinical·NCT06911632·900 enrolled

A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial Hypertension

Recruiting·National Institutes of Health Clinical Center (CC)·Phase 2·NCT01712620·70 enrolled

Genetics of Type 2 Diabetes in Diverse Populations

Recruiting·NNational Human Genome Research Institute (NHGRI)·N/A·NCT00837122·10,000 enrolled

A Phase 2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Sotatercept (MK-7962) in Children From 1 to Less Than 18 Years of Age With PAH on Standard of Care

Recruiting· Merck & Co. logo

Merck & Co.·Phase 2·NCT05587712·42 enrolled

A Double-blind, Randomised, 30-week Placebo-controlled Phase IV Study to Assess the Efficacy and Safety of Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's Syndrome

Recruiting·RRECORDATI GROUP·Approved·NCT07247162·63 enrolled

Comparison of the Efficacy and Safety of Dopamine, Norepinephrine and Epinephrine in the Treatment of Pulmonary Hypertensive Crisis Under Hemodynamic Monitoring

Recruiting·CChina National Center for Cardiovascular Diseases·Preclinical·NCT07667829·75 enrolled

Phase 1b/2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study Assessing the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of HS235 Added to Background Treatment in Adults With PAH

Recruiting·335Pharma Inc·Preclinical·NCT07143448·90 enrolled

Phase 1b/2, Multicenter, Double-Blind, Placebo-Controlled, Multiple Dose Study Assessing the Pharmacokinetics, Safety, Pharmacodynamics, and Efficacy of HS235 in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction

Recruiting·335Pharma Inc·Preclinical·NCT07123779·126 enrolled

Open-label, Single-arm, Non-controlled Trial to Evaluate Safety and Tolerability of Treprostinil Sodium in Children Below the Age of 18 Years Diagnosed With Pulmonary Arterial Hypertension (PAH)

Recruiting·AAOP Orphan Pharmaceuticals AG·Phase 3·NCT06350032·20 enrolled

Randomized Trial Comparing Efficacy and Safety of Initial Triple Therapy Including Parenteral Treprostinil to Initial Double Oral Therapy in Pulmonary Arterial Hypertension (PAH) Group I Patients (TripleTRE)

Recruiting·AAOP Orphan Pharmaceuticals AG·Approved·NCT06317805·110 enrolled

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Finding Trial to Evaluate the Efficacy and Safety of Orally Administered NS-863 in Participants With Pulmonary Arterial Hypertension (PAH)

Recruiting· NS Pharma logo

NS Pharma·Phase 2·NCT07441200·135 enrolled

Alabama Womb to Heart Solution: A Community-Based Cardiovascular Health Intervention After Hypertension in Pregnancy

Recruiting·UUniversity of Alabama at Birmingham·Preclinical·NCT07778966·174 enrolled

A Long-term Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder for Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease

Recruiting·IInsmed Incorporated·Phase 3·NCT07234032·344 enrolled

Effectiveness of Information-Motivation-Behavioral Skills -Based Intervention on Medication Adherence and Blood Pressure Control in North Ethiopia: A Cluster Randomized Controlled Trial

Recruiting·Bahir Dar University·Preclinical·NCT07894068·230 enrolled

Baveno VII Criteria-guided Initiation of Non-selective Beta Blocker in Patients With Compensated Advanced Chronic Liver Disease to Reduce Hepatic Decompensation: an Open-label Randomised Controlled Trial

Recruiting·CChinese University of Hong Kong·Approved·NCT06449339·474 enrolled

Hypertension

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