atorvastatin calcium

ApprovedSmall molecule

atorvastatin calcium is a small molecule that works as a HMG-Coa Reductase Inhibitor.[2] It is being used across 27 indications, with its most advanced program in Approved.[1]

atorvastatin calcium is one of 638 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

Total Trials

Active Trials

637

Competitors

Pipeline

Status by Indication[3][1]

Indication

Coronary Artery DiseaseUnknown

Metabolic SyndromeActive, not recruiting

Disorder of Lipid MetabolismActive, not recruiting

Ischemic CardiomyopathyActive, not recruiting

Cardiovascular DiseaseActive, not recruiting

HyperlipidemiaUnknown

Abnormal Circulating Lipid ConcentrationUnknown

StrokeUnknown

IGA GlomerulonephritisActive, not recruiting

Angina PectorisUnknown

Coronary Artery DiseasePreclinical

Unknown

Metabolic SyndromePreclinical

Active, not recruiting

Disorder of Lipid MetabolismPhase 3

Active, not recruiting

Ischemic CardiomyopathyApproved

Active, not recruiting

Cardiovascular DiseasePhase 3

Active, not recruiting

HyperlipidemiaPreclinical

Unknown

Abnormal Circulating Lipid ConcentrationPreclinical

Unknown

StrokePreclinical

Unknown

IGA GlomerulonephritisPhase 2

Active, not recruiting

Angina PectorisPreclinical

Unknown

Showing 10 of 27 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

atorvastatin calcium

Merck & Co.

Approved

1 2

MS Contin

Merck & Co.

Preclinical

2 3

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 4

Chantix

PPrism Pharmaceuticals

Preclinical

1 5

Fentanyl Citrate

IINSYS Therapeutics Inc

Preclinical

2 6

Conventional Chemotherapy

SShanghai Jiao Tong University School of Medicine

Preclinical

1 7

Vit D

PPost Graduate Institute of Medical Education and Research, Chandigarh

Preclinical

1 8

Beta Blocker

WWeill Medical College of Cornell University

Preclinical

1 9

Recombinant Human Chorionic Gonadotropin

Merck & Co.

Preclinical

1 10

Citalopram Hydrobromide

TTorrent Pharmaceuticals Limited

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Active, not recruiting

Ulcerative Colitis

NCT04767984

Post-ApprovalRecruiting

Ischemic Stroke

NCT03753555

Q2 2027

Post-ApprovalNot yet recruiting

Intracranial Hemorrhage

NCT05589454

Q3 2027

Post-ApprovalRecruiting

Cholesterol

NCT05641753

Clinical

Trials by Indication[1]

Atorvastatin6 trials

Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00335504·85 enrolled

A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin

Completed·NNewAmsterdam Pharma·Phase 1·NCT06081166·74 enrolled

Drug-durg Interaction of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin

Active, not recruiting·GGuangdong Raynovent Biotech Co., Ltd·Phase 1·NCT07362030·32 enrolled

Show 3 more trials

Actual Use Trial of Atorvastatin Calcium 10 mg

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT01964326·1,311 enrolled

Bioequivalence Study of Atorvastatin Calcium Tablets, 80 mg of Dr. Reddy's Under Fed Conditions

Completed·—·Phase 1·NCT01645423·77 enrolled

Bioequivalence Study of Atorvastatin Calcium Tablets, 40 mg of Dr. Reddy's Under Fed Conditions

Completed·—·Phase 1·NCT01645410·71 enrolled

Coronary Artery Disease2 trials

Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization

Unknown status·JJun Li·Phase 4·NCT03072121·440 enrolled

Curative Effect Evaluation of Danlou Tablet on Coronary Artery Disease Not Amenable to Revascularization

Unknown status·JJun Li·Phase 4·NCT03072082·440 enrolled

Fasting Conditions2 trials

Bioequivalence Study of Atorvastatin Calcium Tablets, 40 mg Under Fasting Conditions

Completed·—·Phase 1·NCT01645384·69 enrolled

Bioequivalence Study of Atorvastatin Calcium Tablets, 80 mg of Dr. Reddy's Under Fasting Conditions

Completed·—·Phase 1·NCT01645449·77 enrolled

Angina Pectoris1 trial

Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Unknown status·GGuang'anmen Hospital of China Academy of Chinese Medical Sciences·Phase 4·NCT04661709·502 enrolled

Statin1 trial

To Investigate the Role of Upstream High Dose Statin in STEMI

Completed·TThe Western Pennsylvania Hospital·Phase 4·NCT01050348·120 enrolled

22 more indications

Ulcerative Colitis1 trial

Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis

Active, not recruiting·NNorthwestern University·Phase 2·NCT04767984·42 enrolled

Breast Cancer1 trial

A Phase I Prevention Study of Atorvastatin in Women at Increased Risk for Breast Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00637481·66 enrolled

Mixed Dyslipidemia1 trial

A Year 2, Safety Extension Study of the Combination of ABT-335 and Statin Therapy for Subjects With Mixed Dyslipidemia

Completed·AAbbott·Phase 3·NCT00491530·310 enrolled

Hematological Malignancies1 trial

Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT01527045·47 enrolled

Hypertension1 trial

China Protection Trial of Glucose Metabolism by Pitavastatin in Patients With Prediabetes and Hypertension

Unknown status·JJun Tao·Phase 4·NCT03532620·396 enrolled

Prostate Cancer1 trial

Atorvastatin Calcium and Celecoxib in Treating Patients With Rising PSA Levels After Local Therapy for Prostate Cancer

Completed·RRutgers, The State University of New Jersey·Phase 2·NCT01220973·27 enrolled

Ischemic stroke1 trial

The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques

Recruiting·GGeneral Hospital of Shenyang Military Region·Phase 4·NCT03753555·100 enrolled

Brain Injury1 trial

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

Enrolling by invitation·UUniversity of California, San Francisco·Phase 2·NCT05826912·672 enrolled

Peripheral Blood Stem Cell Transplantation1 trial

Donor Atorvastatin Treatment for Preventing Severe Acute Graft-Versus-Host Disease in Patients Undergoing Myeloablative Peripheral Blood Stem Cell Transplantation

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT01525407·83 enrolled

Metabolic Syndrome1 trial

Atorvastatin Calcium in Preventing Metabolic Syndrome in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy

Withdrawn·UUniversity of Nebraska·N/A·NCT01555632

Allogeneic Hematopoietic Cell Transplant1 trial

Atorvastatin as GVHD Prophylaxis for Allogeneic Hematopoietic Cell Transplantation

Completed·MMehdi Hamadani·Phase 2·NCT01665677·69 enrolled

Drug1 trial

The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00017758·56 enrolled

Hypercholesterolemia1 trial

A Study of MK-6213 Co-Administered With Atorvastatin in Participants With Hypercholesterolemia (MK-6213-006)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00687271·334 enrolled

Interaction1 trial

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000941·56 enrolled

Periodontitis1 trial

Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment

Completed·MMisr University for Science and Technology·Phase 1·NCT05583643·24 enrolled

Ischemic Cardiomyopathy1 trial

Statin Therapy for Ischemic and Nonischemic Cardiomyopathy

Completed·PPhilip Binkley·Phase 4·NCT00701220·9 enrolled

Alzheimer's Disease1 trial

Lipitor as a Treatment for Alzheimer's Disease

Completed·IInstitute for the Study of Aging (ISOA)·Phase 2·NCT00024531·98 enrolled

Cholesterol1 trial

Cholesterol Lowering and Residual Risk in Diabetes, Type 1

Recruiting·NNYU Langone Health·Phase 4·NCT05641753·125 enrolled

Intracranial Hemorrhage1 trial

Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds

Not yet recruiting·SSichuan Provincial People's Hospital·Phase 4·NCT05589454·344 enrolled

Dyslipidemia1 trial

Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes

Completed·—·Phase 4·NCT05238012·392 enrolled

Transplantation1 trial

Atorvastatin for the Prophylaxis of Acute GVHD in Patients Undergoing Matched Sibling Allogeneic Transplantation

Completed·WWest Virginia University·Phase 2·NCT01175148·60 enrolled

Unspecified1 trial

Weak Pulse at Yang and Wiry Pulse at Yin Theory

Completed·XXikun Li·N/A·NCT07378228·70 enrolled

Sources

References

[1]
ClinicalTrials.gov — 34 trial records for atorvastatin calcium. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — atorvastatin calcium compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for atorvastatin calcium. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: HMG-Coa Reductase Inhibitor[2]
Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Merck & Co.

atorvastatin calcium

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Q3 2027

Trials by Indication[1]

Atorvastatin6 trials

Coronary Artery Disease2 trials

Fasting Conditions2 trials

Angina Pectoris1 trial

Statin1 trial

Ulcerative Colitis1 trial

Breast Cancer1 trial

Mixed Dyslipidemia1 trial

Hematological Malignancies1 trial

Hypertension1 trial

Prostate Cancer1 trial

Ischemic stroke1 trial

Brain Injury1 trial

Peripheral Blood Stem Cell Transplantation1 trial

Metabolic Syndrome1 trial

Allogeneic Hematopoietic Cell Transplant1 trial

Drug1 trial

Hypercholesterolemia1 trial

Interaction1 trial

Periodontitis1 trial

Ischemic Cardiomyopathy1 trial

Alzheimer's Disease1 trial

Cholesterol1 trial

Intracranial Hemorrhage1 trial

Dyslipidemia1 trial

Transplantation1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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