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Other/Mortality

Mortality

37

Pipeline Programs↗

20

Active Trials↗

17

Companies Involved↗

Mortality is a moderately active landscape with 37 programs across 17 companies. 6 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

58/100

Pipeline Velocity

25/100

Mech. Concentration

20/100

Completion Rate

84/100

Attrition Rate

10/100

Pipeline

Programs by Phase

Preclinical30

Methylprednisolone

Pfizer

Dexamethasone

Aspen Global Incorporated

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Everolimus

Novartis

Zinc

American Regent, Inc.

Phase 1

No programs

Phase 21

Metformin

EMD Serono

Phase 36

Empagliflozin

Boehringer Ingelheim

Progesterone

Ferring

Combination of Antibiotics

Assistance Publique - Hôpitaux de Paris

BCG Solvent

Bandim Health Project

Azithromycin to Pregnant Women

University of Maryland, Baltimore

Approved

No programs

Analysis

Modality Breakdown

97%

Small molecule

33 of 34 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 34 classified programs, each share of the total. Modality classified for 97% of 37 pipeline programs.

Analysis

Trial Status

107

clinical trials

Completed62 · 58%

Recruiting13 · 12%

Unknown status13 · 12%

Terminated9 · 8%

Active, not recruiting4 · 4%

Not yet recruiting3 · 3%

Other3 · 3%

Clinical Trials

Trial Activity

107 trials

Scale-up Implementation Approaches to Ending Pregnancy-related and -Associated Morbidity and Mortality (MIRACLE Center Project 3)

Recruiting·MMichigan State University·Preclinical·NCT06541951·600 enrolled

BIO-FUNCTION for NRM Prediction in SCTCT: Assessing Biological and Functional Reserve to Predict Non-Relapse Mortality in Stem Cell Transplant and Cell Therapy

Recruiting·HHenry Ford Health System·N/A·NCT07769151·124 enrolled

Mortality and Muscle Mass Loss in Critically Ill Patients: A Prospective, Observational, Multicenter Study.

Recruiting·BBrno University Hospital·N/A·NCT07280039·386 enrolled

Longevity Metrics AI/ML Development Study: A Standing Data Library and Model-Development Platform for Predicting and Validating Health Measurements, Longevity, and Disease

Recruiting·LLongevity Metrics, Inc.·N/A·NCT07808619·1,000,000 enrolled

The Human Observatory: A Prospective Individual and Population-Level Study of Aging, Health, and Longevity

Recruiting·LLongevity Metrics, Inc.·N/A·NCT07646782·1,000,000 enrolled

PRophylaxis Against Early VENTilator-associated Infections to Reduce Mortality in Mechanically Ventilated Intensive Care Unit (ICU) Patients With Acute Brain Injuries: a Phase 3 Randomised, Double Blind, Parallel Group, Placebo-controlled Two-side Superiority Trial

Recruiting·TThe George Institute·Phase 3·NCT06819592·3,300 enrolled

Azithromycine Pour la Vie Des Enfants au Niger II

Recruiting·UUniversity of California, San Francisco·Approved·NCT06358872·3,300,000 enrolled

Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function.

Recruiting·—·Phase 3·NCT05879276·164 enrolled

Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)

Recruiting·PPopulation Health Research Institute·Phase 3·NCT05580666·8,000 enrolled

Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality

Recruiting·UUniversity Hospital, Montpellier·N/A·NCT07273643·30 enrolled

Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection and Mortality Rates

Recruiting·FFondazione IRCCS Policlinico San Matteo di Pavia·N/A·NCT07473999·200 enrolled

Effect of Early Use of Levosimendan Versus Placebo on Top of a Conventional Strategy of Inotrope Use on a Combined Morbidity-mortality Endpoint in Patients With Cardiogenic Shock

Recruiting·PPr Bruno LEVY·Phase 3·NCT04020263·610 enrolled

ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients

Recruiting·—·Phase 3·NCT04588311·2,500 enrolled

NIH-AARP Diet and Health Secondary Research Study Based on OH95CN025 Data

Active, not recruiting·National Cancer Institute (NCI)·N/A·NCT04750915·566,398 enrolled

Sauver Avec l'Azithromycine en Traitant Les Femmes Enceintes et Les Enfants (SANTE)

Active, not recruiting·UUniversity of Maryland, Baltimore·Approved·NCT03909737·99,700 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)