VivoSeq
Other

Oral Ulcer

14

Pipeline Programs↗

2

Active Trials↗

10

Companies Involved↗

Oral ulcer is an emerging landscape with 14 programs across 10 companies. The most active players are Merck & Co., Eli Lilly, Kenvue Brands. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

41/100

Pipeline Velocity

0/100

Mech. Concentration

13/100

Completion Rate

80/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Merck & Co. logo

Merck & Co.

1 program

Phase 1Eli Lilly logo

Eli Lilly

1 program

Phase 1K

Kenvue Brands

2 programs

Phase 2N

Nobel Pharmaceuticals

1 program

Phase 2Alnylam Pharmaceuticals logo

Alnylam Pharmaceuticals

1 program

Phase 2V

Validus Pharmaceuticals

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Modality Breakdown

90%

Small molecule

18 of 20 classified programs — the dominant modality here.

10%ALL OTHERSProtein / enzyme210%

Small molecule leads; the ring shows all 20 classified programs, each share of the total. Modality classified for 100% of 21 pipeline programs.

Analysis

Trial Status

15

clinical trials

Completed8 · 53%
Unknown status3 · 20%
Recruiting2 · 13%
Withdrawn1 · 7%
Suspended1 · 7%

Clinical Trials

Trial Activity

15 trials

Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
Recruiting·Amgen logoAmgen·Phase 3·NCT04528082·60 enrolled
Lenalidomide in the Treatment of Mucosal Behçet's Syndrome
Recruiting·PPeking Union Medical College Hospital·Preclinical·NCT05449548·42 enrolled
Aloe Vera and Chlorhexidine Against Traumatic Oral Ulcers
Completed·UUniversity of Santiago de Compostela·Phase 4·NCT03633292·140 enrolled
Evaluation of Low Level Laser Therapy and Lidocaine Versus Chlorhexidine for the Management of Traumatic Oral Ulcers in Children
Completed·NNational Research Centre, Egypt·N/A·NCT07138586·30 enrolled
Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease
Completed·NNobel Pharmaceuticals·Phase 2·NCT00483184·84 enrolled
Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial
Completed·UUniversity of Texas at Austin·Phase 2·NCT03241030·102 enrolled
PRF in Management of Chronic Multiple Oral Ulcers
Completed·—·Phase 1·NCT03878771·804 enrolled
Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture
Completed·MMedical University of Silesia·N/A·NCT06531720·27 enrolled
Topical Mebo Versus Lidocane in Healing Time of Traumatic Oral Ulcer
Completed·OOctober 6 University·N/A·NCT06184282·28 enrolled
Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
Completed·IIpekyolu Ilac Ltd. Sti·Phase 2·NCT03888846·41 enrolled
Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous)
Suspended·HHadassah Medical Organization·Phase 2·NCT00281723·50 enrolled
The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer
Withdrawn·XXijing Hospital of Digestive Diseases·Phase 3·NCT02769494
Diode Laser Versus Topical Corticosteroids in Management of Oral Ulcers in Behcet's Disease
Unknown status·—·N/A·NCT03771768·38 enrolled
Therapeutic Effect of Folic Acid in Healing of Oral Ulcers
Unknown status·—·Phase 1·NCT04989049·75 enrolled
Evaluation of Topical Rebamipide Versus Topical Betamethasone for Management of Oral Ulcers in Behcet's Disease
Unknown status·—·Phase 1/2·NCT06084624·40 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)