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Other/Post Operative Pain

Post Operative Pain

49

Pipeline Programs↗

128

Active Trials↗

39

Companies Involved↗

Post Operative Pain is a moderately active landscape with 49 programs across 39 companies. The most active players are TLC Biopharmaceuticals, Inc., Sustained Therapeutics Inc., Chengdu Kanghong Pharmaceutical Group Co., Ltd.. 11 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

71/100

Pipeline Velocity

87/100

Mech. Concentration

33/100

Completion Rate

89/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

TLC Biopharmaceuticals, Inc.

1 program

Sustained Therapeutics Inc.

1 program

Chengdu Kanghong Pharmaceutical Group Co., Ltd.

1 program

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.

1 program

Pipeline

Programs by Phase

Preclinical34

Sufentanil Citrate

West China Hospital

Calcium Hydroxide Intracanal Medication

Ankara University

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Diclofenac

Novartis

HL-1186

Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.

Phase 12

Zynrelef

Washington University School of Medicine

KHN702

Chengdu Kanghong Pharmaceutical Group Co., Ltd.

Phase 22

ST-01

Sustained Therapeutics Inc.

Esketamine

Wim Janssens

Phase 311

Bupivacain

Istanbul University

TLC590

TLC Biopharmaceuticals, Inc.

Carbocaine

Assistance Publique - Hôpitaux de Paris

Methadone Hydrochloride

National Institute of Allergy and Infectious Diseases (NIAID)

ESP Block With Bupivacaine

Yale University

Approved

No programs

Analysis

Trial Status

476

clinical trials

Completed242 · 51%

Unknown status77 · 16%

Recruiting74 · 16%

Not yet recruiting40 · 8%

Terminated16 · 3%

Withdrawn12 · 3%

Other15 · 3%

Clinical Trials

Trial Activity

476 trials

Randomized Controlled Trial on the Effects of Transcutaneous Electroacupuncture on Brain Functional Connectivity in Postoperative Pain Patients Based on Electroencephalography

Recruiting·BBeijing Chao Yang Hospital·Preclinical·NCT07819630·90 enrolled

Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block in Breast Surgery in Terms of Ease of Application and Patient Comfort

Recruiting·SSakarya University·Preclinical·NCT07561853·64 enrolled

Quadratus Lumborum Block to Improve Postoperative Pain Management After Laparoscopic Myomectomies: a Double-blinded and Prospective Randomized Clinical Trial.

Recruiting·JJoseph Findley MD·Approved·NCT05979493·80 enrolled

Impact of Cross-Sectional Design in Single-File Rotary System on Apical Debris Extrusion and Postoperative Pain Following Single-Visit Root Canal Treatment: An In Vitro and Randomized Clinical Study

Recruiting·MMinia University·Preclinical·NCT07808684·30 enrolled

Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol in the Non -Surgical Retreatment of Maxillary Anterior Teeth in Type II Diabetic Patients: A Randomized Clinical Trial

Recruiting·MMinia University·Preclinical·NCT07800403·28 enrolled

Quadratus Lumborum Block Versus External Oblique Plane Block for Analgesia After Open Nephrectomy: A Prospective Randomized Clinical Trial

Recruiting·CCairo University·Preclinical·NCT07787221·54 enrolled

Impact of Preemptive Analgesia on Postoperative Pain in Patients Undergoing Orthognathic Surgery: A Randomized Controlled Trial.

Recruiting·UUniversity of Puerto Rico·Approved·NCT07571252·72 enrolled

Comparison Between Low-volume Versus Standard-volume Ultrasound-guided Bilateral Intermediate Cervical Plexus Block for Patients Undergoing Thyroidectomy: A Randomized Controlled Trial.

Recruiting·AAssiut University·Approved·NCT07789548·60 enrolled

The Effect of Acupressure on Postoperative Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair: A Prospective Three-Arm Randomized Sham-Controlled Clinical Trial

Recruiting·MMedipol University·Preclinical·NCT07787871·90 enrolled

The Effect of Video-Based Preoperative Patient Education on Physician Trust, Postoperative Pain, and Anxiety Levels in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Recruiting·Sanliurfa Education and Research Hospital·Preclinical·NCT07767344·62 enrolled

Influence of Irrigant Delivery Systems on the Incidence of Postoperative Discomfort in Oval Canals : A Randomized Clinical Trial

Recruiting·MMinia University·Preclinical·NCT07788027·32 enrolled

Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions: A Randomized Clinical Study

Recruiting·MMinia University·Preclinical·NCT07785973·30 enrolled

Effect of Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block on Opioid Consumption After Reduction Mammaplasty: A Prospective Randomized Controlled Trial

Recruiting·Cumhuriyet University Hospital·Preclinical·NCT07657949·80 enrolled

Effectiveness of Serratus Posterior Superior Intercostal Plane Block Administered With Different Volumes of 0.25% Bupivacaine for Postoperative Analgesia in Breast Surgery: A Prospective, Randomized, Double-Blind Study

Recruiting·BBursa City Hospital·Preclinical·NCT07783386·90 enrolled

Comparison of Deep Subgluteal Block and Pericapsular Nerve Group Block Combined With Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia After Hip Arthroplasty: A Randomized Prospective Study

Recruiting·MMedipol University·Preclinical·NCT07770932·60 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)