Methadone Hydrochloride

ApprovedSmall molecule

NNational Institute of Allergy and Infectious Diseases (NIAID)

Methadone Hydrochloride is one of 117 small molecule programs targeting Cleft Palate. It is currently in Approved.

Indications

Total Trials

Active Trials

116

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cleft PalateActive, not recruiting

Hip FractureActive, not recruiting

Cancer PainActive, not recruiting

Spinal FusionActive, not recruiting

Cleft PalateApproved

Active, not recruiting

Hip FractureApproved

Active, not recruiting

Cancer PainPhase 1

Active, not recruiting

Spinal FusionApproved

Active, not recruiting

Competition

Competitive Landscape

116 competitors in Hip Fracture

#DrugCompanyPhaseTrials

Lovenox

Sanofi

Phase 3

1 2

Crestor

AstraZeneca

Phase 3

1 3

Prolia

Amgen

Phase 3

1 4

Zometa

Pfizer

Phase 3

1 5

Xarelto

WWim Janssens

Phase 3

2 6

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

2 7

Arixtra

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Phase 3

2 8

Deltavit

HHyundai Pharmaceutical Co., LTD.

Phase 3

1 9

PROCRIT

WWim Janssens

Phase 3

1 10

Fosamax

OOrganon and Co

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 3Recruiting

Methadone

NCT07226076

Q3 2027

Phase 1Recruiting

Study completion

NCT06877858

Post-ApprovalRecruiting

Cleft Palate

NCT06962306

Clinical

Trials by Indication[1]

Methadone6 trials

Methadone in TKA for Post-op Pain and Opioid Reduction

Recruiting·MMedical University of South Carolina·Phase 3·NCT07226076·162 enrolled

Methadone Effects on Zidovudine (ZDV, AZT) Disposition

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000800·15 enrolled

A Study of Azidothymidine Plus Methadone in Patients With AIDS and AIDS Related Complex (ARC)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00001008·18 enrolled

Show 3 more trials

Epidural Methadone in Healthy Volunteers

Completed·Ssimon.haroutounian·Phase 1·NCT03525509·13 enrolled

A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000788·24 enrolled

Methadone, Morphine, or Oxycodone in Treating Pain in Patients With Cancer

Terminated·MM.D. Anderson Cancer Center·N/A·NCT00726830·1 enrolled

Spinal Fusion2 trials

Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients

Terminated·MMontefiore Medical Center·Phase 4·NCT02989597·10 enrolled

Methadone vs Magnesium in Spinal Fusion

Completed·NNationwide Children's Hospital·Phase 2·NCT01795495·63 enrolled

Head and Neck Cancer1 trial

Gabapentin, Methadone Hydrochloride, and Oxycodone Hydrochloride in Improving Quality of Life in Patients With Stage II-IV Head and Neck Cancer During Chemoradiation

Completed·RRoswell Park Cancer Institute·Phase 1·NCT02531906·60 enrolled

Intraoperative1 trial

Intraoperative Methadone in Children Undergoing Surgery

Terminated·UUniversity of Aarhus·Phase 3·NCT04680286·60 enrolled

Hip Fracture1 trial

Perioperative Methadone Compared to Placebo in Elderly Hip Fracture Patients

Completed·UUniversity of Southern Denmark·Phase 4·NCT06086171·129 enrolled

6 more indications

Cleft Palate1 trial

Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

Recruiting·—·Phase 4·NCT06962306·60 enrolled

Effectiveness1 trial

Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions

Unknown status·TThe Methodist Hospital Research Institute·Phase 1·NCT04112550·150 enrolled

Interaction1 trial

Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000906·12 enrolled

Post Operative Pain1 trial

Intraoperative Methadone for the Prevention of Postoperative Pain

Recruiting·—·Phase 3·NCT05831345·80 enrolled

Cancer Pain1 trial

Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain

Terminated·NNCIC Clinical Trials Group·Phase 1·NCT00930332·8 enrolled

Unspecified1 trial

MethaLoad Dose-Finding Study

Recruiting·UUniversity of Pennsylvania·Phase 1·NCT06877858·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 17 trial records for Methadone Hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Methadone Hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Methadone Hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — National Institute of Allergy and Infectious Diseases (NIAID) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: NNational Institute of Allergy and Infectious Diseases (NIAID)

Methadone Hydrochloride

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q3 2027

Trials by Indication[1]

Methadone6 trials

Spinal Fusion2 trials

Head and Neck Cancer1 trial

Intraoperative1 trial

Hip Fracture1 trial

Cleft Palate1 trial

Effectiveness1 trial

Interaction1 trial

Post Operative Pain1 trial

Cancer Pain1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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