Bupivacain

Phase 3Small molecule

IIstanbul University

Bupivacain is one of 253 small molecule programs targeting Post Operative Pain. It is currently in Phase 3.

Indications

Total Trials

Active Trials

252

Competitors

Pipeline

Status by Indication[3][1]

Indication

Post Operative PainUnknown status

Serratus Anterior Plane BlockRecruiting

Hip FractureActive, not recruiting

Chronic PainActive, not recruiting

Pain After SurgeryNot yet recruiting

SternotomyActive, not recruiting

BupivacaineCompleted

Total Knee ArthroplastyActive, not recruiting

Total Hip ArthroplastyActive, not recruiting

Atrial FibrillationActive, not recruiting

Post Operative PainPhase 3

Unknown status

Serratus Anterior Plane BlockPreclinical

Recruiting

Hip FracturePreclinical

Active, not recruiting

Chronic PainPreclinical

Active, not recruiting

Pain After SurgeryPreclinical

Not yet recruiting

SternotomyPhase 1

Active, not recruiting

BupivacainePhase 2

Completed

Total Knee ArthroplastyPreclinical

Active, not recruiting

Total Hip ArthroplastyPreclinical

Active, not recruiting

Atrial FibrillationPreclinical

Active, not recruiting

Showing 10 of 18 indications

Competition

Competitive Landscape

137 competitors in Atrial Fibrillation

#DrugCompanyPhaseTrials

Bupivacain

IIstanbul University

Phase 3

1 2

Calquence

AstraZeneca

Preclinical

1 3

Rituxan

Coumadin

3 5

Brukinsa

BBeOne Medicines

Preclinical

1 6

Imbruvica

PPharmacyclics LLC.

Preclinical

1 7

Versed

CConrado Roberto Hoffmann Filho

Preclinical

1 8

Ondexxya

UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Preclinical

1 9

Romazicon

CConrado Roberto Hoffmann Filho

Preclinical

1 10

Statin

Bristol-Myers Squibb

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Serratus Anterior Plane Block

NCT06856538

Phase 1Recruiting

Genicular Nerve Block

NCT06639503

Phase 1Not yet recruiting

Dexmedetomidine

NCT06668220

Post-ApprovalRecruiting

Mastectomy

NCT06574022

Post-ApprovalRecruiting

Liposomal Bupivacaine

NCT05972018

Phase 1Active, not recruiting

Sternotomy

NCT04985500

Clinical

Trials by Indication[1]

Post Operative Pain5 trials

Postoperative Pain After Bupivacaine Supplementation in Mandibular Fracture Surgery

Unknown status·UUniversity Tunis El Manar·Phase 4·NCT06243263·30 enrolled

Are There Differences in Postoperative Pain Between Bupivacaine and Lidocaine for Carpal Tunnel Release?

Completed·HHospital Italiano de Buenos Aires·N/A·NCT05697276·82 enrolled

Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use

Recruiting·MMediSys Health Network·Phase 4·NCT06719180·100 enrolled

Show 2 more trials

Bupivacaine Infiltration and Postoperative Pain

Unknown status·—·Phase 1·NCT04728308·300 enrolled

Quadratus Lumborum Block to Improve Postoperative Pain Management After Laparoscopic Myomectomies: a Double-blinded and Prospective Randomized Clinical Trial.

Recruiting·JJoseph Findley MD·Approved·NCT05979493·80 enrolled

Dexmedetomidine4 trials

Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia

Completed·SServices Institute of Medical Sciences, Pakistan·N/A·NCT06550414·165 enrolled

COMPARISON OF BUPIVACAINE WITH AND WITHOUT DEXMEDETOMIDINE IN CAUDAL BLOCK AMONG CHILDREN UNDERGOING INGUINAL HERNIOTOMY

Completed·—·Phase 1·NCT07140627·60 enrolled

Effect of Adding Different Concentrations of Dexmedetomidine to Bupivacaine in Caudal Block for Pediatrics

Not yet recruiting·—·Phase 1·NCT06668220·50 enrolled

Show 1 more trial

Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy

Completed·UUdayana University·Phase 4·NCT07292324·62 enrolled

Cesarean Section3 trials

Efficacy of Bupivacain Local Infiltration for the Management of Pain During Cesarean Section

Completed·SSaint Thomas Hospital, Panama·N/A·NCT05404490·202 enrolled

Compared With Different Method for Postcesarean Section Analgesia

Completed·—·N/A·NCT05405049·46 enrolled

Trans Abdominis Plane (TAP) Block in Patients With Cesarean Section

Unknown status·—·N/A·NCT04809532·60 enrolled

Erector Spinae Plane Block3 trials

Ketamine and Magnesium in Erector Spinae Plane Block

Completed·—·Phase 4·NCT05855798·60 enrolled

Erector Spinae Plane Block Impact on Quality of Recovery After Lumbar Spinal Decompression

Completed·—·Phase 4·NCT04943549·60 enrolled

U/s Guided Oblique Subcostal Transversus Abdominis Plane Block Versus Erector Spinae Plane Block as Preemptive Analgesia

Completed·—·Phase 4·NCT04941170·70 enrolled

Postoperative Analgesia3 trials

Adjuvants With Intrathecal Bupivacaine for Postoperative Analgesia

Unknown status·—·Phase 4·NCT06082232·90 enrolled

Caudal Block With Bupivacaine and Dexmedetomidine Versus TAP Block With Bupivacaine Alone for Postoperative Analgesia in Pediatric Undergoing Infraumbical Surgeries

Unknown status·SSohag University·Phase 2·NCT06183073·90 enrolled

ESP Block in Pediatric Patients for Postoperative Analgesia

Completed·—·Phase 4·NCT03627897·40 enrolled

53 more indications

Bupivacaine3 trials

Analgesic Effect of Bupivacaine Plus Ketamine Versus Bupivacaine Alone in Transversalis Fascia Plane Block

Not yet recruiting·—·Phase 1·NCT06935669·68 enrolled

Unilateral Intrathecal Bupivacaine Versus Prilocaine on Postoperative Spontaneous Voiding

Completed·TTheodor Bilharz Research Institute·Phase 4·NCT07262398·70 enrolled

The Rule of Bupivacaine Hydrochloride in Skin Graft Donor Site

Completed·MMinia University·Phase 2·NCT06766474·90 enrolled

Nerve Block2 trials

Ilioinguinal Nerve Block in Transcatheter Aortic Valve Implantation

Unknown status·—·Phase 4·NCT05220813·88 enrolled

Volume Dependent Effect of Pericapsular Nerve Block

Completed·SSisli Hamidiye Etfal Training and Research Hospital·N/A·NCT05256056·60 enrolled

Laparoscopic Cholecystectomy2 trials

Postoperative Pain After Instillation Of Bupivacaine During Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT07098429·60 enrolled

Adding Magnesium Sulfate to Bupivacaine in Ultrasound Guided Paravertebral Block for Laparoscopic Cholecystectomy

Completed·MMansoura University·N/A·NCT05099250·50 enrolled

Erector Spinae Block2 trials

Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery

Completed·—·Phase 2·NCT05475561·60 enrolled

Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block

Unknown status·—·Phase 4·NCT06231979·48 enrolled

Serratus Anterior Plane Block2 trials

Comparison of US-guided Single-dose Thoracic Paravertebral, Erector Spinae Plane and Serratus Anterior Plane Blocks

Unknown status·IIstanbul University·N/A·NCT05431062·60 enrolled

Rhomboid Intercostal Sub Serratus Plane Block Versus Serratus Anterior Plane Block in Thoractomy

Recruiting·YYasser S Mostafa, MD·N/A·NCT06856538·40 enrolled

Superficial Cervical Plexus Block2 trials

Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding Ketorolac to it.

Completed·SSohag University·Phase 2·NCT05180214·46 enrolled

Superficial Cervical Plexus Block With Dexmedetomidine Versus Without Adjuvant in Thyroid Surgery

Completed·UUdayana University·N/A·NCT07274670·58 enrolled

Liposomal Bupivacaine2 trials

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Recruiting·KKerry O'Rourke·Phase 3·NCT06284434·60 enrolled

Liposomal Bupivacaine/Bupivacaine in Rectus Sheath Blocks Versus Ropivacaine in Rectus Sheath Blocks And Catheters

Recruiting·HHartford Hospital·Phase 4·NCT05972018·14 enrolled

Spine Surgery2 trials

Thoracolumbar Interfascial Plane Block in Lumber Spine Surgery

Unknown status·—·N/A·NCT05880017·60 enrolled

The Effect of High-thoracic Erector Spinae Plane Block on Postoperative Pain and Diaphragmatic Function in Posterior Cervical Spine Surgery: a Randomized Controlled Trial

Completed·BBenha University·Phase 3·NCT06721832·50 enrolled

Mastectomy2 trials

Paravertebral Block Versus Erector Spinae Plane Block for Analgesia in Modified Radical Mastectomy

Completed·IIstanbul University·N/A·NCT05080985·86 enrolled

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks

Recruiting·UUniversity of Cincinnati·Phase 4·NCT06574022·100 enrolled

Adductor Canal Block2 trials

Comparison Between Adjuvants Added to Bupivacaine in Adductor Canal Block

Completed·—·Phase 2·NCT04892420·120 enrolled

Comparison Of Femoral Block And Middle Adductor Canal Block In Patients With Knee Arthroplasty

Unknown status·—·Phase 4·NCT04768764·52 enrolled

Pain Management2 trials

Comparison of Superior Hypogastric Plexus Block and Peritoneal Bupivacaine in Pain Management

Completed·EEnes Celik··NCT06954896·94 enrolled

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA

Completed·—·N/A·NCT06112548·80 enrolled

Laparoscopic2 trials

Efficacy of Modified Thoracoabdominal Nerves Block Through Perichondrial Approach in Total Laparoscopic Hysterectomies

Completed·—·N/A·NCT06116409·50 enrolled

Comparison of Paravertebral Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Nephrectomy

Completed·IIstanbul University·N/A·NCT05723341·91 enrolled

Spinal Anesthesia2 trials

Role of Pericapsular Nerve Block Using Dexmedetomidine and Bupivacaine in Improving the Outcome of Patients Undergoing Hip Surgery Under Spinal Anesthesia

Completed·—·Phase 1·NCT07149168·60 enrolled

The Effect of Spinal Column Flexion on Unilaterality of Spinal Anesthesia

Not yet recruiting·—·N/A·NCT06293404·60 enrolled

Postsurgical Analgesia1 trial

Bupivacaine Liposomal Injection (Exparel) for Postsurgical Analgesia in Patient Undergoing Laparoscopic Bariatric Surgery

Completed·TThe Cleveland Clinic·Phase 4·NCT02969187·126 enrolled

Atrial Fibrillation1 trial

Stellate Ganglion to Prevent Atrial Fibrillation

Withdrawn·RRush University Medical Center·N/A·NCT05656170

Prospective1 trial

Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study)

Recruiting·—·Phase 1/2·NCT06362915·52 enrolled

Hip Arthroplasty1 trial

The Effect of Fascia Iliaca Compartment Block (FICB) on QoR-15 Score in Partial Hip Arthroplasty Surgery

Completed·UUnknown Sponsor·N/A·NCT05965544·60 enrolled

Total Knee Arthroplasty1 trial

Continuous Infusion and Intermittent Bolus Adductor Canal Block for Total Knee Arthroplasty

Recruiting·NNational Cheng-Kung University Hospital·N/A·NCT05518513·66 enrolled

Local Anesthetic1 trial

Treatment Efficacy of Local Anesthetic/Steroid Mixture Injection for Patients With Odynophonia

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT05178485

Total Hip Arthroplasty1 trial

Comparison of Analgesic Efficacy of Quadratus Lumborum Type 3 and Suprainguinal Fascia Iliaca Compartment Block in Total Hip Arthroplasty Surgery

Completed·UUnknown Sponsor·N/A·NCT06838156·60 enrolled

Thoracic Erector Spinae Plane Block1 trial

The Efficacy of Thoracic Erector Spinae Plane Block For Perioperative Analgesia in Laparoscopic Bariatric Surgery for Super Obese Patients.

Completed·AAmany Ahmed Eissa·N/A·NCT06377605·60 enrolled

Sedation1 trial

Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation

Completed·—·Phase 2·NCT06034873·42 enrolled

Agitation1 trial

Effect of Caudal Nalbuphine on Postoperative Emergence Agitation in Pediatrics Undergoing Infra-umbilical Surgeries

Unknown status·—·Phase 1·NCT05245721·80 enrolled

Ketorolac1 trial

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 2·NCT04646967·100 enrolled

Effectiveness1 trial

Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction

Completed·UUniversity of Virginia·Phase 4·NCT04777591·117 enrolled

Breast Reconstruction1 trial

Pain Study Using Intermittent Bupivacain Injections After Breast Reconstruction With DIEP Flap

Completed·UUllevaal University Hospital·Phase 2·NCT00804674·47 enrolled

Hemodynamic Stability1 trial

Low Dose Bupivacaine Versus Prilocaine Regarding Hemodynamic Stability and Safety in Geriatrics

Completed·FFayoum University Hospital·Phase 1/2·NCT06382220·100 enrolled

Quadratus Lumborum Block1 trial

Regional Midazolam in Quadratus Lumborum Block

Unknown status·—·N/A·NCT05261672·60 enrolled

Vomiting1 trial

Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia

Unknown status·MMohamed Youssef Mohamed·N/A·NCT05474001·90 enrolled

Abdominal Surgeries1 trial

Combined Ketorolac Bupivacaine Versus Bupivacaine Alone for TAP Block in Children Undergoing Lower Abdominal Surgeries

Completed·SSohag University·Phase 2·NCT06267820·90 enrolled

Knee Arthroscopy1 trial

Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl

Completed·ZZagazig University·N/A·NCT04442906·45 enrolled

Perioperative Pain Management1 trial

Perioperative Pain Management for Cleft Lip in Children

Unknown status·—·N/A·NCT04614259·76 enrolled

Pediatrics1 trial

Unilateral Transversus Abdominis Plane Block in Pediatrics

Completed·MMinia University·N/A·NCT04539314·90 enrolled

Hysterectomy1 trial

Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy

Completed·PPreben Kjolhede·Phase 4·NCT00527332·180 enrolled

Genicular Nerve Block1 trial

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

Recruiting·UUniversity of Chicago·Phase 1·NCT06639503·38 enrolled

Thoracoscopic Surgery1 trial

Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients

Completed·JJannie Bisgaard Stæhr··NCT04633850·45 enrolled

CAR1 trial

Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.

Completed·UUnited States Naval Medical Center, San Diego·Phase 1·NCT06499181·86 enrolled

Breast Cancer1 trial

Analgesic Effect of Serratus Plane Block With Adjuvant Agents in Breast Cancer Surgery

Completed·SSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey·Phase 2·NCT07081581·75 enrolled

Intrathecal Dexmedetomidine1 trial

Intrathecal Dexmedetomidine vs Midazolame

Completed·NNational Cancer Institute, Egypt·Phase 4·NCT06315634·75 enrolled

Fibromyalgia1 trial

Phrenic Nerve Infiltration in Fibromyalgia

Completed·UUniversity of Seville·Phase 4·NCT05792774·60 enrolled

Rib Fracture1 trial

Vital Capacity in Ultrasound Guided Serratus Plane Block in ED Patients With Multiple Rib Fractures

Terminated·AAntonios Likourezos·Phase 4·NCT04530149·3 enrolled

Arthroscopic Shoulder Surgeries1 trial

Comparison Between Dexametidomedine\Bupivacaine and Plain Bupivacaine in Superior Trunk Block for Arthroscopic Shoulder Surgeries

Completed·—·N/A·NCT07046325·40 enrolled

Rectus Sheath Block1 trial

The Effect of Bilateral Rectus Sheath Block Versus Wound Infiltration in Gynecooncological Patients

Completed·—··NCT06095908·30 enrolled

Concentration1 trial

Effect of Bupivacaine Concentration on Ultrasound Guided Pericapsular Group Nerve Block Efficacy in Hip Surgery Patients

Completed·—·Phase 4·NCT05788458·135 enrolled

Endometrial Cancer1 trial

Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer

Completed·TTufts Medical Center·Phase 3·NCT05763667·15 enrolled

Postsurgical Pain Management1 trial

Phase 2/3 Study of TLC590 for Postsurgical Pain Management

Not yet recruiting·TTaiwan Liposome Company·Phase 2/3·NCT05161637·415 enrolled

Perioperative Pain1 trial

Use of Perioperative Pain Blocks In Urological Surgery

Completed·IIcahn School of Medicine at Mount Sinai·Phase 3·NCT04426500·148 enrolled

Hip Fracture1 trial

Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients.

Completed·SSahlgrenska University Hospital·N/A·NCT05101291·15 enrolled

Intraperitoneal1 trial

Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy

Recruiting·SSardar Umer Rehman·Phase 1·NCT07429448·60 enrolled

Back pain1 trial

Analgesic Requirement for Post-Operative Pain Control in Elective 1-3 Level Transforaminal Lumbar Interbody Fusion: Comparison of Thoracolumbar Interfascial Plane Block With Exparel to Bupivacaine HCl

Enrolling by invitation·FFoundation for Orthopaedic Research and Education·Preclinical·NCT06350981·76 enrolled

Colorectal Cancer1 trial

Comparison of the Effectiveness of Bupivacaine and Bupivacaine+Dexmedetomidine Combination in Transversus Abdominis Plane* Block in Colorectal Cancer Surgery

Completed·DDr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital··NCT06370949·84 enrolled

Sternotomy1 trial

Erector Spinae Plane Block vs. Pecto-intercostal Fascial Plane Block vs. Control for Sternotomy: A Prospective Randomized Trial

Active, not recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT04985500·225 enrolled

Pain After Surgery1 trial

Reduction of Post-surgery Pelvic Pain by Bupivacaine Injection During TVT/ TVT-O Procedure

Not yet recruiting·HHadassah Medical Organization·Preclinical·NCT07429019·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 85 trial records for Bupivacain. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Bupivacain compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Bupivacain. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Istanbul University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: IIstanbul University

Bupivacain

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Post Operative Pain5 trials

Dexmedetomidine4 trials

Cesarean Section3 trials

Erector Spinae Plane Block3 trials

Postoperative Analgesia3 trials

Bupivacaine3 trials

Nerve Block2 trials

Laparoscopic Cholecystectomy2 trials

Erector Spinae Block2 trials

Serratus Anterior Plane Block2 trials

Superficial Cervical Plexus Block2 trials

Liposomal Bupivacaine2 trials

Spine Surgery2 trials

Mastectomy2 trials

Adductor Canal Block2 trials

Pain Management2 trials

Laparoscopic2 trials

Spinal Anesthesia2 trials

Postsurgical Analgesia1 trial

Atrial Fibrillation1 trial

Prospective1 trial

Hip Arthroplasty1 trial

Total Knee Arthroplasty1 trial

Local Anesthetic1 trial

Total Hip Arthroplasty1 trial

Thoracic Erector Spinae Plane Block1 trial

Sedation1 trial

Agitation1 trial

Ketorolac1 trial

Effectiveness1 trial

Breast Reconstruction1 trial

Hemodynamic Stability1 trial

Quadratus Lumborum Block1 trial

Vomiting1 trial

Abdominal Surgeries1 trial

Knee Arthroscopy1 trial

Perioperative Pain Management1 trial

Pediatrics1 trial

Hysterectomy1 trial

Genicular Nerve Block1 trial

Thoracoscopic Surgery1 trial

CAR1 trial

Breast Cancer1 trial

Intrathecal Dexmedetomidine1 trial

Fibromyalgia1 trial

Rib Fracture1 trial

Arthroscopic Shoulder Surgeries1 trial

Rectus Sheath Block1 trial

Concentration1 trial

Endometrial Cancer1 trial

Postsurgical Pain Management1 trial

Perioperative Pain1 trial

Hip Fracture1 trial

Intraperitoneal1 trial

Back pain1 trial

Colorectal Cancer1 trial

Sternotomy1 trial

Pain After Surgery1 trial

References

Drug Info

Quick Facts

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