Intrathecal Morphine

ApprovedSmall molecule

Pacira Pharmaceuticals, Inc

Intrathecal Morphine is one of 242 small molecule programs targeting Metastasis. It is currently in Approved.

Indications

Total Trials

Active Trials

241

Competitors

Pipeline

Status by Indication[3][1]

Indication

MetastasisActive, not recruiting

Urinary RetentionActive, not recruiting

Obstructive Sleep ApneaActive, not recruiting

Spinal FusionActive, not recruiting

Chronic PainActive, not recruiting

HysterectomyActive, not recruiting

Total Hip ArthroplastyActive, not recruiting

Post Operative PainRecruiting

Cesarean SectionActive, not recruiting

MetastasisPreclinical

Active, not recruiting

Urinary RetentionPhase 3

Active, not recruiting

Obstructive Sleep ApneaPreclinical

Active, not recruiting

Spinal FusionApproved

Active, not recruiting

Chronic PainPreclinical

Active, not recruiting

HysterectomyPreclinical

Active, not recruiting

Total Hip ArthroplastyApproved

Active, not recruiting

Post Operative PainPreclinical

Recruiting

Cesarean SectionPreclinical

Active, not recruiting

Competition

Competitive Landscape

230 competitors in Cesarean Section

#DrugCompanyPhaseTrials

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Approved

5 2

Marcaine

IInnocoll

Preclinical

21 3

Naropin

FFresenius Kabi Oncology Ltd.

Preclinical

12 4

Xylocaine

MMEDRx USA, Inc.

Preclinical

4 5

Ancef

BBaxter Healthcare Corporation

Preclinical

3 6

Nubain

AAultman Health Foundation

Preclinical

3 7

Glucophage

Boehringer Ingelheim

Preclinical

1 8

Imdur

OOmnivium

Preclinical

1 9

Bactroban

PPadagis LLC

Preclinical

1 10

Sufenta

LLeaf Vertical Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Analgesia

NCT07386353

Post-ApprovalNot yet recruiting

Epidural Analgesia

NCT06881563

N/ARecruiting

Analgesia

NCT07023497

Q4 2026

Post-ApprovalRecruiting

Epidural Analgesia

NCT06935708

PreclinicalRecruiting

Post Operative Pain

NCT07695935

Q1 2027

N/ARecruiting

Pancreaticoduodenectomy

NCT06761989

Clinical

Trials by Indication[1]

Cesarean Section5 trials

TAP Catheters Versus Intrathecal Morphine for Cesarean Section

Unknown status·SStamford Anesthesiology Services, PC·N/A·NCT01593280·80 enrolled

Intrathecal Hydromorphone for Pain Control After Cesarean Section

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02096003·80 enrolled

Comparison of Three Different Doses of Intrathecal Morphine for Analgesia After Cesarean Section

Completed·OOndokuz Mayıs University·N/A·NCT05317572·150 enrolled

Show 2 more trials

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02353754·12 enrolled

Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section

Completed·MMahidol University·N/A·NCT03199170·90 enrolled

Postoperative Analgesia4 trials

TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH

Active, not recruiting·MMinia University·Phase 1·NCT06882369·75 enrolled

Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia

Completed·—·Phase 4·NCT05338320·120 enrolled

Intrathecal Morphine for Postoperative Analgesia Following Laparoscopic Bariatric Surgery

Unknown status·—·Phase 2/3·NCT02731430·100 enrolled

Show 1 more trial

Ropivacaine Continuous Wound Infusion Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery

Completed·SSaint-Joseph University·Phase 4·NCT03502642·60 enrolled

Analgesia3 trials

Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia

Recruiting·HHospital Central do Funchal·Phase 4·NCT07386353·120 enrolled

Wound Infusion vs Spinal Morphine for Post-caesarean Analgesia

Completed·DDr Madeleine Wilwerth·Phase 3·NCT02264821·192 enrolled

Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia

Recruiting·UUniversity of Ioannina·N/A·NCT07023497·100 enrolled

Epidural Analgesia3 trials

Quality of Labour Epidural Analgesia With Intrathecal Morphine as a Component of Combined Spinal Epidural

Recruiting·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06572241·182 enrolled

Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery

Recruiting·MMeri Mirceta·Phase 4·NCT06935708·98 enrolled

Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery

Not yet recruiting·MMeri Mirceta·Phase 4·NCT06881563·98 enrolled

Morphine3 trials

Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery

Unknown status·SSonoran Spine Research and Education Foundation·Phase 4·NCT05092828·40 enrolled

Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials

Completed·—··NCT00596609·36 enrolled

Intrathecal Morphine for Recovery and Outcomes After VATS

Recruiting·—·N/A·NCT07231926·52 enrolled

32 more indications

Cesarean Delivery2 trials

Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery

Withdrawn·CCiusss de L'Est de l'Île de Montréal·N/A·NCT05696678

Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery

Completed·MMayo Clinic·Phase 4·NCT06826742·30 enrolled

Caesarean Section2 trials

Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section

Not yet recruiting·IIstituto Giannina Gaslini·Phase 4·NCT07377630·100 enrolled

Transversus Abdominis Plane Block Versus Spinal Morphine After Caesarean Section : A Comparison Study

Completed·—·Phase 3·NCT03263689·130 enrolled

Hysterectomy2 trials

Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy

Recruiting·—·N/A·NCT07232108·64 enrolled

Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy

Recruiting·—·N/A·NCT06837506·80 enrolled

Total Knee Replacement1 trial

The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement

Unknown status·—·Phase 4·NCT01312415·42 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

The Quality of Recovery After Intrathecal Morphine or Adductor Canal Block in Anterior Cruciate Ligament Reconstruction

Unknown status·—·Phase 4·NCT05742958·70 enrolled

Knee Arthroplasty1 trial

Intrathecal Morphine and Fentanyl for Knee Arthroplasty

Unknown status·KKeimyung University Dongsan Medical Center·N/A·NCT03365115·111 enrolled

Total Hip Arthroplasty1 trial

PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty

Completed·KKresimir Oremus, MD·Phase 4·NCT05308420·60 enrolled

Abdominoplasty1 trial

The Effect of Intravenous Nalbuphine on PONV With Intrathecal Morphine in Abdominoplasty.

Unknown status·—·N/A·NCT03786562·80 enrolled

Orthopedic Procedures1 trial

Does the Use of Intrathecal Morphine Increase the Length of Hospital Stay in Fast Track Orthopedic Procedures?

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT05105074·104 enrolled

Side Effects1 trial

Side Effects of a Single Shot Intrathecal Morphine in Clinical Practice, a Retrospective Analysis

Active, not recruiting·UUniversitaire Ziekenhuizen KU Leuven··NCT07238179·600 enrolled

Laparoscopic Cholecystectomy1 trial

Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy

Not yet recruiting·—·N/A·NCT07203794·132 enrolled

Randomized Controlled Trial1 trial

Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural

Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT02666794·50 enrolled

Obese Women1 trial

TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia

Withdrawn·NNorthwestern University·Phase 4·NCT03282669

Supra-inguinal Fascia Iliaca Block1 trial

The Efficacy of Pain Control After Total Hip Replacement Between Ultrasound Guided Supra-inguinal Fascia Iliaca Block and Intrathecal Morphine

Unknown status·MMahidol University·N/A·NCT04104204·98 enrolled

Abdominal Surgeries1 trial

Effect of Intrathecal Morphine in Children Undergoing Major Abdominal Surgeries,

Unknown status·—·N/A·NCT03158584·45 enrolled

Pediatric1 trial

ITM vs QL for Pediatric Open Lower Abdominal Procedures

Terminated·MMedical University of South Carolina·Phase 4·NCT05506930·14 enrolled

Metastasis1 trial

Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery

Completed·SSamsung Medical Center·N/A·NCT05742438·114 enrolled

Pancreaticoduodenectomy1 trial

Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy

Recruiting·SSeoul National University Hospital·N/A·NCT06761989·104 enrolled

Obstructive Sleep Apnea1 trial

Spinal Morphine for Patients With Obstructive Sleep Apnea

Suspended·UUniversity Health Network, Toronto·N/A·NCT01790971·40 enrolled

Cardiac Surgery1 trial

Trial Comparing Intrathecal Morphine With Placebo In Patients Undergoing Robotic Cardiac Surgery

Completed·UUniversity of Chicago·Phase 4·NCT03241485·79 enrolled

Abdominal Cancer Surgery1 trial

intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain

Completed·—·Phase 2/3·NCT02726828·90 enrolled

Local Anesthetic1 trial

Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .

Completed·UUniversity Hospital, Lille·Phase 2/3·NCT03238430·186 enrolled

Intraoperative1 trial

Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01201499·140 enrolled

Spinal Fusion1 trial

Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion

Completed·UUniversity of Colorado, Denver·Phase 4·NCT00880607·84 enrolled

Postoperative Pain Management1 trial

Efficacy and Safety of Intrathecal Morphine for Postoperative Pain Management Following Planned Caesarean Section

Recruiting·AAnne Juul Wikkelsø·Phase 4·NCT06797973·1,312 enrolled

Quadratus Lumborum Block1 trial

Quadratus Lumborum Block for Post-Cesarean Analgesia

Terminated·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT02339766·8 enrolled

Chronic pain1 trial

Comparative Study on the Effect of Quadratus Lumborum Block Versus Intrathecal Morphine on the Incidence of Chronic Pain Post Caesarean Section in a University Hospital of Middle-income Country

Completed·MMenoufia University·N/A·NCT05602038·100 enrolled

Urinary retention1 trial

Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine

Recruiting·UUniversity of Toronto·Phase 3·NCT07050277·50 enrolled

Total Hip Replacement1 trial

The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement

Unknown status·—·Phase 4·NCT01312077·50 enrolled

Erector Spinae Plane Block1 trial

Comparison of the Erector Spinae Plane Block Versus Intrathecal Morphine on Post-Cesarean Delivery Analgesia

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT04256642·160 enrolled

Spinal Surgery1 trial

The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery

Completed·UUniversity of Calgary·Phase 4·NCT01053039·150 enrolled

Post Operative Pain1 trial

Comparison of Ultrasound-Guided Transversalis Fascia Plane Block and Low-Dose Intrathecal Morphine for Postoperative Analgesia After Open Inguinal Hernia Repair: A Prospective Randomized Controlled Trial

Recruiting·HHitit University·Preclinical·NCT07695935·80 enrolled

Sources

References

[1]
ClinicalTrials.gov — 53 trial records for Intrathecal Morphine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intrathecal Morphine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intrathecal Morphine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pacira Pharmaceuticals, Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pacira Pharmaceuticals, Inc

Intrathecal Morphine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Trials by Indication[1]

Cesarean Section5 trials

Postoperative Analgesia4 trials

Analgesia3 trials

Epidural Analgesia3 trials

Morphine3 trials

Cesarean Delivery2 trials

Caesarean Section2 trials

Hysterectomy2 trials

Total Knee Replacement1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Knee Arthroplasty1 trial

Total Hip Arthroplasty1 trial

Abdominoplasty1 trial

Orthopedic Procedures1 trial

Side Effects1 trial

Laparoscopic Cholecystectomy1 trial

Randomized Controlled Trial1 trial

Obese Women1 trial

Supra-inguinal Fascia Iliaca Block1 trial

Abdominal Surgeries1 trial

Pediatric1 trial

Metastasis1 trial

Pancreaticoduodenectomy1 trial

Obstructive Sleep Apnea1 trial

Cardiac Surgery1 trial

Abdominal Cancer Surgery1 trial

Local Anesthetic1 trial

Intraoperative1 trial

Spinal Fusion1 trial

Postoperative Pain Management1 trial

Quadratus Lumborum Block1 trial

Chronic pain1 trial

Urinary retention1 trial

Total Hip Replacement1 trial

Erector Spinae Plane Block1 trial

Spinal Surgery1 trial

Post Operative Pain1 trial

References

Drug Info

Quick Facts

Related News