Intrathecal Morphine

Phase 3Small molecule

Pacira Pharmaceuticals, Inc

Intrathecal Morphine is one of 278 small molecule programs targeting Metastasis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

277

Competitors

Pipeline

Status by Indication[3][1]

Indication

MetastasisActive, not recruiting

Obstructive Sleep ApneaActive, not recruiting

Chronic PainActive, not recruiting

HysterectomyActive, not recruiting

Post Operative PainNot yet recruiting

AnalgesiaRecruiting

Postoperative AnalgesiaNot yet recruiting

Epidural AnalgesiaNot yet recruiting

Caesarean SectionNot yet recruiting

MorphineRecruiting

MetastasisPreclinical

Active, not recruiting

Obstructive Sleep ApneaPreclinical

Active, not recruiting

Chronic PainPreclinical

Active, not recruiting

HysterectomyPreclinical

Active, not recruiting

Post Operative PainPreclinical

Not yet recruiting

AnalgesiaPhase 3

Recruiting

Postoperative AnalgesiaPhase 3

Not yet recruiting

Epidural AnalgesiaPhase 3

Not yet recruiting

Caesarean SectionPhase 3

Not yet recruiting

MorphinePreclinical

Recruiting

Showing 10 of 14 indications

Competition

Competitive Landscape

84 competitors in Cesarean Section

#DrugCompanyPhaseTrials

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Phase 3

5 2

Fentanyl-Morphine

SSeoul National University Hospital

Phase 3

2 3

Ondansetron, Dexamethasone

KKing Khaled Eye Specialist Hospital

Phase 3

1 4

Acetaminophen/ibuprofen

SSeoul National University Hospital

Phase 3

1 5

Morphine - .

RRambam Health Care Campus

Phase 3

1 6

Sebacoyl Dinalbuphine Ester

LLumosa Therapeutics Co., Ltd.

Phase 3

1 7

Dynastat

Pfizer

Preclinical

1 8

Proamatine

Takeda

Preclinical

1 9

Duragesic

CCephalon

Preclinical

6 10

Versed

CConrado Roberto Hoffmann Filho

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

PreclinicalRecruiting

Post Operative Pain

NCT07720739

Q1 2027

N/ARecruiting

Pancreaticoduodenectomy

NCT06761989

Post-ApprovalNot yet recruiting

Caesarean Section

NCT07377630

Q2 2027

ApprovedRecruiting

Caesarean Section

NCT06797973

Q3 2027

Phase 3Recruiting

Urinary Retention

NCT07050277

PreclinicalNot yet recruiting

Post Operative Pain

NCT07803133

Clinical

Trials by Indication[1]

Postoperative Analgesia5 trials

TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH

Active, not recruiting·MMinia University·Phase 1·NCT06882369·75 enrolled

Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia

Completed·—·Phase 4·NCT05338320·120 enrolled

Ropivacaine Continuous Wound Infusion Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery

Completed·SSaint-Joseph University·Phase 4·NCT03502642·60 enrolled

Show 2 more trials

Intrathecal Morphine for Postoperative Analgesia Following Laparoscopic Bariatric Surgery

Unknown status·—·Phase 2/3·NCT02731430·100 enrolled

Ultrasound-Guided Posterior Quadratus Lumborum Block With Bupivacaine and Dexmedetomidine Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery

Not yet recruiting·AAssiut University·Approved·NCT07807592·80 enrolled

Cesarean Section5 trials

Comparison of Three Different Doses of Intrathecal Morphine for Analgesia After Cesarean Section

Completed·OOndokuz Mayıs University·N/A·NCT05317572·150 enrolled

Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section

Completed·MMahidol University·N/A·NCT03199170·90 enrolled

TAP Catheters Versus Intrathecal Morphine for Cesarean Section

Unknown status·SStamford Anesthesiology Services, PC·N/A·NCT01593280·80 enrolled

Show 2 more trials

Intrathecal Hydromorphone for Pain Control After Cesarean Section

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02096003·80 enrolled

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02353754·12 enrolled

Morphine3 trials

Does Intrathecal Morphine Affect Outcomes in Spine Deformity Surgery

Unknown status·SSonoran Spine Research and Education Foundation·Phase 4·NCT05092828·40 enrolled

Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials

Completed·—··NCT00596609·36 enrolled

Intrathecal Morphine Versus Intrathecal Dexmedetomidine Compared to Placebo for Postoperative Pain Relief After Spine Fixation Surgeries: A Randomized Double-Blinded Study

Recruiting·TTanta University·Preclinical·NCT07777627·90 enrolled

Epidural Analgesia3 trials

Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery

Recruiting·MMeri Mirceta·Phase 4·NCT06935708·98 enrolled

Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery

Not yet recruiting·MMeri Mirceta·Phase 4·NCT06881563·98 enrolled

Quality of Labour Epidural Analgesia With Intrathecal Morphine as a Component of Combined Spinal Epidural

Recruiting·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06572241·182 enrolled

Caesarean Section3 trials

Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section

Not yet recruiting·IIstituto Giannina Gaslini·Phase 4·NCT07377630·100 enrolled

Transversus Abdominis Plane Block Versus Spinal Morphine After Caesarean Section : A Comparison Study

Completed·—·Phase 3·NCT03263689·130 enrolled

MOTHER Trial: Efficacy and Safety of Low-dose Intrathecal Morphine Following Planned Caesarean Section - a Randomised, Blinded, Clinical, Controlled, Multicentre Trial.

Recruiting·AAnne Juul Wikkelsø·Approved·NCT06797973·1,312 enrolled

35 more indications

Analgesia3 trials

Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia

Recruiting·HHospital Central do Funchal·Phase 4·NCT07386353·120 enrolled

Wound Infusion vs Spinal Morphine for Post-caesarean Analgesia

Completed·DDr Madeleine Wilwerth·Phase 3·NCT02264821·192 enrolled

Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia

Recruiting·UUniversity of Ioannina·N/A·NCT07023497·100 enrolled

Post Operative Pain3 trials

Comparison of PENG Block and Intrathecal Morphine in Terms of Early Postoperative Quality of Recovery and Analgesic Efficacy in Patients Undergoing Elective Total Hip Arthroplasty: A Prospective Randomized Controlled Trial

Not yet recruiting·EErzincan Binali Yildirim Universitesi·Preclinical·NCT07803133·90 enrolled

Efficacy of Adding Intrathecal Morphine to Erector Spinae Plane Block for Postoperative Analgesia After Midline Laparotomy: A Prospective Randomized Study

Recruiting·SSohag University·Preclinical·NCT07720739·75 enrolled

Comparison of Ultrasound-Guided Transversalis Fascia Plane Block and Low-Dose Intrathecal Morphine for Postoperative Analgesia After Open Inguinal Hernia Repair: A Prospective Randomized Controlled Trial

Recruiting·HHitit University·Preclinical·NCT07695935·80 enrolled

Cesarean Delivery2 trials

Improving ObsQoR-11 With Continuous Wound Infusion Versus Intrathecal Morphine After Elective Cesarean Delivery

Withdrawn·CCiusss de L'Est de l'Île de Montréal·N/A·NCT05696678

Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery: a Randomized Clinical Trial

Completed·MMayo Clinic·Approved·NCT06826742·30 enrolled

Pancreaticoduodenectomy1 trial

Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy

Recruiting·SSeoul National University Hospital·N/A·NCT06761989·104 enrolled

Local Anesthetic1 trial

Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .

Completed·UUniversity Hospital, Lille·Phase 2/3·NCT03238430·186 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

The Quality of Recovery After Intrathecal Morphine or Adductor Canal Block in Anterior Cruciate Ligament Reconstruction

Unknown status·—·Phase 4·NCT05742958·70 enrolled

Laparoscopic Cholecystectomy1 trial

Analgesic Efficacy of Bupivacaine Infiltration, Erector Spinae Plane Block, and Intrathecal Morphine in Laparoscopic Cholecystectomy

Not yet recruiting·—·N/A·NCT07203794·132 enrolled

Total Knee Replacement1 trial

The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement

Unknown status·—·Phase 4·NCT01312415·42 enrolled

Obstructive Sleep Apnea1 trial

Spinal Morphine for Patients With Obstructive Sleep Apnea

Suspended·UUniversity Health Network, Toronto·N/A·NCT01790971·40 enrolled

Cardiac Surgery1 trial

Trial Comparing Intrathecal Morphine With Placebo In Patients Undergoing Robotic Cardiac Surgery

Completed·UUniversity of Chicago·Phase 4·NCT03241485·79 enrolled

Knee Arthroplasty1 trial

Intrathecal Morphine and Fentanyl for Knee Arthroplasty

Unknown status·KKeimyung University Dongsan Medical Center·N/A·NCT03365115·111 enrolled

Total Hip Arthroplasty1 trial

PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty

Completed·KKresimir Oremus, MD·Phase 4·NCT05308420·60 enrolled

Abdominoplasty1 trial

The Effect of Intravenous Nalbuphine on PONV With Intrathecal Morphine in Abdominoplasty.

Unknown status·—·N/A·NCT03786562·80 enrolled

Orthopedic Procedures1 trial

Does the Use of Intrathecal Morphine Increase the Length of Hospital Stay in Fast Track Orthopedic Procedures?

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT05105074·104 enrolled

Side Effects1 trial

Side Effects of a Single Shot Intrathecal Morphine in Clinical Practice, a Retrospective Analysis

Active, not recruiting·UUniversitaire Ziekenhuizen KU Leuven··NCT07238179·600 enrolled

Quadratus Lumborum Block1 trial

Quadratus Lumborum Block for Post-Cesarean Analgesia

Terminated·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT02339766·8 enrolled

Randomized Controlled Trial1 trial

Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural

Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT02666794·50 enrolled

Obese Women1 trial

TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia

Withdrawn·NNorthwestern University·Phase 4·NCT03282669

Hysterectomy1 trial

Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy

Recruiting·—·N/A·NCT07232108·64 enrolled

Abdominal Cancer Surgery1 trial

intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain

Completed·—·Phase 2/3·NCT02726828·90 enrolled

Supra-inguinal Fascia Iliaca Block1 trial

The Efficacy of Pain Control After Total Hip Replacement Between Ultrasound Guided Supra-inguinal Fascia Iliaca Block and Intrathecal Morphine

Unknown status·MMahidol University·N/A·NCT04104204·98 enrolled

Abdominal Surgeries1 trial

Effect of Intrathecal Morphine in Children Undergoing Major Abdominal Surgeries,

Unknown status·—·N/A·NCT03158584·45 enrolled

Urinary retention1 trial

Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine

Recruiting·UUniversity of Toronto·Phase 3·NCT07050277·50 enrolled

Total Hip Replacement1 trial

The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement

Unknown status·—·Phase 4·NCT01312077·50 enrolled

Erector Spinae Plane Block1 trial

Comparison of the Erector Spinae Plane Block Versus Intrathecal Morphine on Post-Cesarean Delivery Analgesia

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 3·NCT04256642·160 enrolled

Spinal Surgery1 trial

The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery

Completed·UUniversity of Calgary·Phase 4·NCT01053039·150 enrolled

Intraoperative1 trial

Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT01201499·140 enrolled

Spinal Fusion1 trial

Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion

Completed·UUniversity of Colorado, Denver·Phase 4·NCT00880607·84 enrolled

Pediatric1 trial

ITM vs QL for Pediatric Open Lower Abdominal Procedures

Terminated·MMedical University of South Carolina·Phase 4·NCT05506930·14 enrolled

Metastasis1 trial

Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery

Completed·SSamsung Medical Center·N/A·NCT05742438·114 enrolled

Pain Management1 trial

Postoperative Pain Control After Cesarean Delivery: Intrathecal Morphine With or Without Adjunctive Fascial Levobupivacaine Infiltration. A Prospective Observational Cohort Study

Not yet recruiting·FFundación Santa Fe de Bogota··NCT07859956·336 enrolled

Lumbar Fusion Surgery1 trial

Intrathecal Morphine vs Intrathecal Morphine Combined With Clonidine for 1-2 Level Lumbar Fusion

Not yet recruiting·MMaineHealth·Phase 3·NCT07846657·70 enrolled

Postoperative Pain Management1 trial

The Effects of Intrathecal Morphine in Addition to Serratus Anterior Plane Block and Dexmedetomidine on Postoperative Recovery (QoR-15) and Systemic Inflammation in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial

Completed·AAtaturk University·Preclinical·NCT07231926·64 enrolled

Pain1 trial

Quadratus Lumborum Block Versus Intrathecal Morphine for Prevention of Chronic Post-Caesarean Pain: A Four-Arm Randomised Controlled Trial

Completed·MMenoufia University·Preclinical·NCT05602038·100 enrolled

Ultrasound1 trial

Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy: A Randomized Trial

Completed·AAin Shams University·Preclinical·NCT06837506·80 enrolled

Sources

References

[1]
ClinicalTrials.gov — 59 trial records for Intrathecal Morphine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intrathecal Morphine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intrathecal Morphine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pacira Pharmaceuticals, Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pacira Pharmaceuticals, Inc

Intrathecal Morphine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q3 2027

Trials by Indication[1]

Postoperative Analgesia5 trials

Cesarean Section5 trials

Morphine3 trials

Epidural Analgesia3 trials

Caesarean Section3 trials

Analgesia3 trials

Post Operative Pain3 trials

Cesarean Delivery2 trials

Pancreaticoduodenectomy1 trial

Local Anesthetic1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Laparoscopic Cholecystectomy1 trial

Total Knee Replacement1 trial

Obstructive Sleep Apnea1 trial

Cardiac Surgery1 trial

Knee Arthroplasty1 trial

Total Hip Arthroplasty1 trial

Abdominoplasty1 trial

Orthopedic Procedures1 trial

Side Effects1 trial

Quadratus Lumborum Block1 trial

Randomized Controlled Trial1 trial

Obese Women1 trial

Hysterectomy1 trial

Abdominal Cancer Surgery1 trial

Supra-inguinal Fascia Iliaca Block1 trial

Abdominal Surgeries1 trial

Urinary retention1 trial

Total Hip Replacement1 trial

Erector Spinae Plane Block1 trial

Spinal Surgery1 trial

Intraoperative1 trial

Spinal Fusion1 trial

Pediatric1 trial

Metastasis1 trial

Pain Management1 trial

Lumbar Fusion Surgery1 trial

Postoperative Pain Management1 trial

Pain1 trial

Ultrasound1 trial

References

Drug Info

Quick Facts

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