VivoSeq
Other

Premature Rupture of Membranes

19

Pipeline Programs↗

3

Active Trials↗

9

Companies Involved↗

Premature rupture of membranes is an emerging landscape with 19 programs across 9 companies. The most active players are The Central and Eastern European Gynecologic Oncology Group, Pfizer's Upjohn has merged with Mylan to form Viatris Inc., Azurity Pharmaceuticals. 3 therapies are approved with 8 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

0/100

Mech. Concentration

25/100

Completion Rate

90/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

The Central and Eastern European Gynecologic Oncology Group

3 programs

Phase 3P

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

2 programs

Phase 3A

Azurity Pharmaceuticals

1 program

Phase 3O

Omnivium

1 program

ApprovedPfizer logo

Pfizer

3 programs

ApprovedF

Fresenius Kabi Oncology Ltd.

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

16

clinical trials

Completed9 · 56%
Unknown status3 · 19%
Recruiting2 · 13%
Withdrawn1 · 6%
Not yet recruiting1 · 6%

Clinical Trials

Trial Activity

16 trials

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation
Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT03976063·850 enrolled
TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden
Recruiting·TThe Central and Eastern European Gynecologic Oncology Group·Phase 3·NCT07107477·138 enrolled
Magnesium Sulphate in Premature Rupture of Membranes
Not yet recruiting·—·N/A·NCT05134688·124 enrolled
The Value of Amniopatch in Preterm Premature Rupture of Membranes
Completed·—·N/A·NCT03473210·100 enrolled
Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin
Completed·EErzincan Military Hospital·Phase 3·NCT01099280·225 enrolled
Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM)
Completed·—·N/A·NCT03491826·1,011 enrolled
Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes
Completed·YYuzuncu Yil University·N/A·NCT07148622·40 enrolled
Cervical Ripening in Premature Rupture of Membranes
Completed·MMontefiore Medical Center·N/A·NCT02314728·230 enrolled
Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant Management
Completed·RRambam Health Care Campus·N/A·NCT02825641·458 enrolled
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
Completed·—·Phase 4·NCT00355303·932 enrolled
Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term
Completed·—·Phase 4·NCT00355966·212 enrolled
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes
Completed·—·Phase 2·NCT04807543·100 enrolled
Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes
Withdrawn·IIndiana University·Phase 3·NCT01556334
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Unknown status·HHadassah Medical Organization·N/A·NCT00247104·200 enrolled
Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes
Unknown status·Ssammour.rami·N/A·NCT04143685·200 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)