antibiotics

Phase 3Small molecule

MMelinta Therapeutics, Inc.

antibiotics is one of 259 small molecule programs targeting Premature rupture of membranes. It is currently in Phase 3.

Indications

Total Trials

Active Trials

258

Competitors

Pipeline

Status by Indication[3][1]

Indication

Premature Rupture of MembranesActive, not recruiting

SinusitisActive, not recruiting

Lung CancerRecruiting

BronchiectasisActive, not recruiting

ErythemaActive, not recruiting

PneumoniaUnknown status

SepsisRecruiting

End Stage Liver DiseaseActive, not recruiting

Infectious DiseaseActive, not recruiting

EndometritisActive, not recruiting

Premature Rupture of MembranesPreclinical

Active, not recruiting

SinusitisPreclinical

Active, not recruiting

Lung CancerPhase 2

Recruiting

BronchiectasisPreclinical

Active, not recruiting

ErythemaPreclinical

Active, not recruiting

PneumoniaPhase 3

Unknown status

SepsisPhase 3

Recruiting

End Stage Liver DiseasePreclinical

Active, not recruiting

Infectious DiseasePreclinical

Active, not recruiting

EndometritisPreclinical

Active, not recruiting

Showing 10 of 15 indications

Competition

Competitive Landscape

199 competitors in Lung Cancer

#DrugCompanyPhaseTrials

Keytruda

Merck & Co.

Phase 3

32 2

Imfinzi

AstraZeneca

Phase 3

25 3

Yervoy

Bristol-Myers Squibb

Phase 3

10 4

Abraxane

Bristol-Myers Squibb

Phase 3

7 5

Alecensa

Roche

Phase 3

3 6

Zepzelca

Jazz Pharmaceuticals

Phase 3

3 7

DATROWAY

Daiichi Sankyo

Phase 3

2 8

Lynparza

AstraZeneca

Phase 3

2 9

Tarlatamab-Dznl

Amgen

Phase 3

2 10

Ilaris

Novartis

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Recruiting

Pneumonia

NCT07492771

Q1 2027

PreclinicalRecruiting

Periprosthetic Joint Infection

NCT06889701

Phase 3Recruiting

Urinary Tract Infection (diagnosis)

NCT07686055

Q2 2027

N/ARecruiting

Antibiotic Therapy

NCT07030673

N/ARecruiting

Bloodstream Infection

NCT06080698

Q3 2027

Phase 2Active, not recruiting

Pyelonephritis

NCT06672978

Clinical

Trials by Indication[1]

Antibiotics6 trials

Patterns of Antibiotics Resistance

Not yet recruiting·SSohag University··NCT06696859·100 enrolled

Clinical Evaluation of Smoker Periodontal Subjects After Lactobacillus-reuteri Probiotics and Antibiotics Therapy

Completed·—·Phase 3·NCT04209777·66 enrolled

Oral Versus Intravenous Antibiotics for the Treatment of Pleural Space Infection: a Randomized Controlled Pilot Trial

Unknown status·SSt. Joseph's Healthcare Hamilton·N/A·NCT04301869·40 enrolled

Show 3 more trials

Physician Administered Antibiotics in a Prehospital Setting

Completed·OOdense University Hospital··NCT03919851·117 enrolled

Reduction of Intravenous Antibiotics In Neonates

Completed·FFranciscus Gasthuis·Phase 4·NCT03247920·510 enrolled

Prenatal Antibiotics and Breast Milk / Neonatal IgA

Recruiting·FFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico··NCT05813184·82 enrolled

Treatment4 trials

Cholera Anti-Secretory Treatment Trial

Completed·PPATH·Phase 2·NCT04150250·47 enrolled

The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon

Completed·UUniversity of Aarhus·N/A·NCT04003181·64 enrolled

Glue Application in the Treatment of Low-Output Fistulas

Unknown status·JJinling Hospital, China·N/A·NCT01828892·30 enrolled

Show 1 more trial

Patient's Pretreatment Expectations About Post-Lyme Symptoms

Recruiting·UUniversity Medical Centre Ljubljana·N/A·NCT03462329·200 enrolled

Pneumonia4 trials

Nebulized Colistin for Hospital-Acquired Pneumonia

Unknown status·MMahidol University·Phase 3·NCT00920270·140 enrolled

Anaerobic Antibiotic Usage for Pneumonia in the Medical Intensive Care Unit

Completed·HHenry Ford Health System··NCT03046082·192 enrolled

Treatment of Coronavirus COVID-19 Pneumonia (Pathogen SARS-CoV-2) With Cryopreserved Allogeneic P_MMSCs and UC-MMSCs

Unknown status·IInstitute of Cell Therapy·Phase 1/2·NCT04461925·30 enrolled

Show 1 more trial

A Randomized, Double-blind, Placebo-controlled Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of MP101 in Adult Patients With Acute Pseudomonas Aeruginosa Pneumonia

Recruiting·MMicrobiotiX Co., Ltd·Phase 1·NCT07492771·18 enrolled

Urinary Tract Infection3 trials

Probiotics and Multi-Drug Resistant Urinary Tract Infection

Completed·OOchsner Health System·N/A·NCT03644966·25 enrolled

Bacteriophages for Treating Urinary Tract Infections in Patients Undergoing Transurethral Resection of the Prostate

Completed·—·Phase 2/3·NCT03140085·97 enrolled

Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women

Completed·MMegan Bradley·Phase 4·NCT05726318·70 enrolled

Cystitis2 trials

Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis

Completed·FFundação Educacional Serra dos Órgãos·Phase 4·NCT03379389·284 enrolled

Efficacy of Oxybutynin in Paediatric Cystitis

Completed·UUniversity of Calgary·Phase 4·NCT03877289·81 enrolled

50 more indications

Sepsis2 trials

Dendritic Cells-Derived Exosomes in Human Sepsis

Unknown status·JJinling Hospital, China··NCT02957279·50 enrolled

Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics Therapy for Preterm Neonates At-risk of Early-onset Sepsis: a Multicentric, Randomized, Controlled, Non-inferiority Trial (the SAUNA Trial)

Recruiting·IIndian Council of Medical Research·Phase 3·NCT06377397·1,500 enrolled

End Stage Liver Disease2 trials

A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study)

Unknown status·TTongji Hospital··NCT03363451·2,000 enrolled

A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIP Study)

Unknown status·TTongji Hospital··NCT03362632·400 enrolled

Antibiotic Prophylaxis2 trials

Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders

Completed·SSociété Française d'Endoscopie Digestive··NCT03944863·252 enrolled

Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study

Unknown status·NNational Cheng-Kung University Hospital·N/A·NCT04146883·800 enrolled

Pyelonephritis2 trials

Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00136656·700 enrolled

A Multi-Center, Open-Label, Single-Arm, Phase 2 Study To Evaluate The Safety, Tolerability, And Pharmacokinetics Of Vabomere (Meropenem-Vaborbactam) In The Treatment Of Children With Complicated Urinary Tract Infection, Including Acute Pyelonephritis

Active, not recruiting·MMelinta Therapeutics, Inc.·Phase 2·NCT06672978·66 enrolled

Appendicitis2 trials

The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis)

Recruiting·—·Phase 3·NCT03688295·1,476 enrolled

Non-operative vs. Operative Management of Acute Appendicitis in Vulnerable Patient Populations

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT05724628

Bowel Preparation2 trials

Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs: A Propensity Analysis

Completed·TThird Affiliated Hospital, Sun Yat-Sen University··NCT04258098·806 enrolled

Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

Active, not recruiting·HHelsinki University Central Hospital·Phase 4·NCT04281667·604 enrolled

Osteomyelitis2 trials

Patients Response to Early Switch To Oral:Osteomyelitis Study

Terminated·JJulio Ramirez·Phase 1·NCT02099240·11 enrolled

Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis

Unknown status·—·N/A·NCT06084754·20 enrolled

Clostridium Difficile Infection1 trial

Penn Microbiome Therapy (PMT) for Severe-Clostridium Difficile Infection (CDI)

Terminated·UUniversity of Pennsylvania·Phase 2·NCT03970200·15 enrolled

Premature rupture of membranes1 trial

The Value of Amniopatch in Preterm Premature Rupture of Membranes

Completed·—·N/A·NCT03473210·100 enrolled

Bronchiectasis1 trial

Sputum Microbiota and the Association With Clinical Parameters in Steady-state, Acute Exacerbation and Convalescence of Bronchiectasis

Unknown status·GGuangzhou Institute of Respiratory Disease·N/A·NCT02315547·120 enrolled

Antibiotic1 trial

Antibiotic "Dysbiosis" in Preterm Infants

Completed·UUniversity of Florida·Phase 2·NCT02784821·98 enrolled

Antibody Response1 trial

Treatment of Deficient Subclass or Anti-polysaccharide Antibody Response

Completed·PProthya Biosolutions·Phase 4·NCT00522821·55 enrolled

Allergic Asthma1 trial

C1-inhibitor in Allergic ASThma Patients

Terminated·TT. van der Poll·Phase 4·NCT03051698·37 enrolled

Septic Shock1 trial

The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation

Completed·—·N/A·NCT03020407·211 enrolled

Gut Microbiome1 trial

Effects of IAP-EOGBSD on Offspring's Gut Microbiome and Immunity.

Unknown status·ZZhujiang Hospital··NCT05738460·180 enrolled

Injury1 trial

Antibiotic Use in Facial Fracture Post Injury

Recruiting·MMethodist Health System··NCT04925531·1,000 enrolled

Immunogenicity1 trial

Phase I Study of Safety and Immunogenicity of ADU-623

Completed·PProvidence Health & Services·Phase 1·NCT01967758·11 enrolled

Infectious Disease1 trial

Real World Study of Classic Infectious Disease

Recruiting·HHuashan Hospital··NCT04020536·10,000 enrolled

Sinusitis1 trial

The Effect of Facial Effleurage on Acute Rhinosinusitis

Completed·—·N/A·NCT04642989·138 enrolled

Infective Endocarditis1 trial

Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis

Terminated·CCarmen Olmos Blanco·Phase 4·NCT04222257·20 enrolled

Renal Replacement Therapy1 trial

Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)

Completed·HHospital Universitari de Bellvitge··NCT04033029·20 enrolled

Cardiovascular Disease1 trial

CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease

Active, not recruiting·TThe Cleveland Clinic·Phase 1·NCT01731236·100 enrolled

Surgical Site Infection1 trial

Surgical Site Infection After Episiotomy Repair Related to Routine Use of Antibiotic Prophylaxis in Low-Risk Population

Completed·—··NCT06154720·200 enrolled

Azithromycin1 trial

Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes

Unknown status·—·N/A·NCT05328817·240 enrolled

Surgical Site Infections1 trial

The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.

Withdrawn·YYale University··NCT03982810

Glucocorticoid1 trial

Personalized Variable Versus Fixed Dose Glucocorticoid Therapy in AECOPD

Completed·—·N/A·NCT02147015·248 enrolled

Lung Cancer1 trial

Fecal Microbiota Transplantation With Immune Checkpoint Inhibitors in Lung Cancer

Recruiting·SSoroka University Medical Center·Phase 2·NCT05502913·80 enrolled

Antibiotic Therapy1 trial

Early Discontinuation of Antibiotic Therapy in Elderly Patients Hospitalized for a Viral Infection

Recruiting·—·N/A·NCT07030673·256 enrolled

Hypophosphatemia1 trial

Levels of 'Hypophosphatemia Affect Outcome of Septic Patients in ICU

Unknown status·—·Phase 4·NCT04519762·100 enrolled

Inflammatory Bowel Disease1 trial

Microbial Restoration in Inflammatory Bowel Diseases

Recruiting·SSt Vincent's Hospital Melbourne·Phase 1/2·NCT04970446·120 enrolled

Bone and Joint Infection1 trial

Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J)

Completed·OOxford University Hospitals NHS Trust·Phase 4·NCT00974493·1,054 enrolled

Erythema1 trial

Erythema Migrans in Elderly

Completed·UUniversity Medical Centre Ljubljana··NCT03371563·1,220 enrolled

Pregnant Women1 trial

Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women

Completed·IInnovacion y Desarrollo de Estrategias en Salud·N/A·NCT03362697·150 enrolled

Endometritis1 trial

RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis

Completed·—·N/A·NCT02648698·120 enrolled

Lyme disease1 trial

Study and Treatment of Post Lyme Disease (STOP-LD)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000937·55 enrolled

Pulmonary Nodules1 trial

Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making

Unknown status·GGuiBin Qiao··NCT04857333·1,800 enrolled

Corneal Ulcer1 trial

Steroids for Corneal Ulcers Trial

Completed·TThomas M. Lietman·Phase 4·NCT00324168·500 enrolled

Hemodialysis1 trial

Intradialytic Drug Removal by Short-daily Hemodialysis

Completed·IIndiana University School of Medicine·N/A·NCT00596167·6 enrolled

HNSCC1 trial

Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT

Completed·MMemorial Sloan Kettering Cancer Center·Phase 3·NCT01931150·11 enrolled

Bloodstream Infection1 trial

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

Recruiting·JJohns Hopkins University·N/A·NCT06080698·1,030 enrolled

Diabetic Foot1 trial

Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics

Unknown status·KKing's College Hospital NHS Trust·Phase 4·NCT01418456·166 enrolled

Low back pain1 trial

Low Back Pain and Antibiotic Treatment

Withdrawn·—·Phase 1·NCT00285493

Sarcopenia1 trial

Understanding Acute Sarcopenia

Unknown status·UUniversity of Birmingham·N/A·NCT03858192·168 enrolled

Osteonecrosis1 trial

Best Treatment Choice for Osteonecrosis of the Jaw

Unknown status·TTim Van den Wyngaert·Phase 4·NCT04512638·125 enrolled

Complicated Appendicitis1 trial

Optimal Care of Complicated Appendicitis

Completed·UUniversity of Michigan·Phase 4·NCT03159754·40 enrolled

Urinary Tract Infection (Diagnosis)1 trial

Precision Management of Urinary Tract Symptoms in Older Women: A Randomized Trial to Reduce Overtreatment

Recruiting·MMegan Bradley·Phase 3·NCT07686055·90 enrolled

Periprosthetic Joint Infection1 trial

A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in Participants With Early or Acute Hematogenous PJI Requiring or Not Requiring DAIR After TKA, or Requiring Long-term Antibiotic Therapy

Recruiting·TTenNor Therapeutics Inc.·Preclinical·NCT06889701·33 enrolled

Physical Abilities1 trial

Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans

Recruiting·AAssaf Harofeh MC·Preclinical·NCT05024188·70 enrolled

Duchenne Muscular Dystrophy1 trial

Phase 4 Study to Evaluate the Safety and Effectiveness of ELEVIDYS in Patients With Duchenne Muscular Dystrophy Treated in a Post-Marketing Setting (ENHANCE)

Recruiting· Sarepta Therapeutics logo

Sarepta Therapeutics·Approved·NCT07542314·20 enrolled

Unspecified1 trial

Intrauterine Stent Placement Following Hysteroscopic Septum Resection

Not yet recruiting·WWeill Medical College of Cornell University·N/A·NCT07032506·320 enrolled

Sources

References

[1]
ClinicalTrials.gov — 76 trial records for antibiotics. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — antibiotics compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for antibiotics. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Melinta Therapeutics, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMelinta Therapeutics, Inc.

antibiotics

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q3 2027

Trials by Indication[1]

Antibiotics6 trials

Treatment4 trials

Pneumonia4 trials

Urinary Tract Infection3 trials

Cystitis2 trials

Sepsis2 trials

End Stage Liver Disease2 trials

Antibiotic Prophylaxis2 trials

Pyelonephritis2 trials

Appendicitis2 trials

Bowel Preparation2 trials

Osteomyelitis2 trials

Clostridium Difficile Infection1 trial

Premature rupture of membranes1 trial

Bronchiectasis1 trial

Antibiotic1 trial

Antibody Response1 trial

Allergic Asthma1 trial

Septic Shock1 trial

Gut Microbiome1 trial

Injury1 trial

Immunogenicity1 trial

Infectious Disease1 trial

Sinusitis1 trial

Infective Endocarditis1 trial

Renal Replacement Therapy1 trial

Cardiovascular Disease1 trial

Surgical Site Infection1 trial

Azithromycin1 trial

Surgical Site Infections1 trial

Glucocorticoid1 trial

Lung Cancer1 trial

Antibiotic Therapy1 trial

Hypophosphatemia1 trial

Inflammatory Bowel Disease1 trial

Bone and Joint Infection1 trial

Erythema1 trial

Pregnant Women1 trial

Endometritis1 trial

Lyme disease1 trial

Pulmonary Nodules1 trial

Corneal Ulcer1 trial

Hemodialysis1 trial

HNSCC1 trial

Bloodstream Infection1 trial

Diabetic Foot1 trial

Low back pain1 trial

Sarcopenia1 trial

Osteonecrosis1 trial

Complicated Appendicitis1 trial

Urinary Tract Infection (Diagnosis)1 trial

Periprosthetic Joint Infection1 trial

Physical Abilities1 trial

Duchenne Muscular Dystrophy1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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