Esmeron

(rocuronium)

ApprovedSmall molecule

Rocuronium is a muscle relaxant used during surgery and medical procedures to paralyze muscles, making it easier for doctors to perform operations and manage patients on breathing machines.[2] Esmeron is currently approved and in use across 27 indications[4].[1]

Esmeron is one of 477 small molecule programs targeting Muscle spasm. It is currently in Approved.

Indications

136

Total Trials

Active Trials

476

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Muscle SpasmActive, not recruiting

Cardiac ArrestActive, not recruiting

PoisoningActive, not recruiting

HypoxemiaActive, not recruiting

Liver TransplantActive, not recruiting

Hip FractureActive, not recruiting

Bone FractureApproved

Urinary RetentionActive, not recruiting

Organophosphate PoisoningApproved

Obstructive Sleep ApneaActive, not recruiting

Muscle SpasmApproved

Active, not recruiting

Cardiac ArrestPhase 3

Active, not recruiting

PoisoningPhase 2/Phase 3

Active, not recruiting

HypoxemiaApproved

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

Hip FractureApproved

Active, not recruiting

Bone FractureApproved

Approved

Urinary RetentionApproved

Active, not recruiting

Organophosphate PoisoningApproved

Approved

Obstructive Sleep ApneaPreclinical

Active, not recruiting

Showing 10 of 24 indications

Competition

Competitive Landscape

1399 competitors in Prostate Cancer

#DrugCompanyPhaseTrials

Esmeron

FFresenius Kabi Oncology Ltd.

Novantrone

5 3

Jatenzo

GGrupo Espanol de Tumores Neuroendocrinos

Preclinical

2 4

Duragesic

CCephalon

Preclinical

1 5

Viagra

VViatris Specialty LLC

Preclinical

1 6

Ranexa

MMenarini International Operations Luxembourg SA

Preclinical

1 7

Prednisone/prednisolone

Roche

Preclinical

3 8

Triptorelin Pamoate

Ipsen

Preclinical

2 9

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

—10

Naropin

FFresenius Kabi Oncology Ltd.

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Post-ApprovalRecruiting

Tracheal Intubation

NCT06564857

Q3 2027

Post-ApprovalRecruiting

Chronic Kidney Disease

NCT07203287

Clinical

Trials by Indication[1]

Neuromuscular Blockade12 trials

Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population

Completed·—·N/A·NCT02546843·66 enrolled

Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade.

Completed·MMassachusetts General Hospital·N/A·NCT02025075·37 enrolled

Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00675792·100 enrolled

Show 9 more trials

Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery

Completed·SStony Brook University·Phase 4·NCT02812186·79 enrolled

MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy

Unknown status·RRadboud University Medical Center·N/A·NCT03287388·8 enrolled

The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

Completed·YYonsei University·N/A·NCT02109133·67 enrolled

Mask Ventilation Before and After Neuromuscular Blockade

Completed·UUniversity of Washington·Phase 4·NCT02237443·210 enrolled

Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145)

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT03346057·344 enrolled

Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics

Completed·SSeoul St. Mary's Hospital·Phase 4·NCT02185339·61 enrolled

Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?

Completed·—·Phase 4·NCT02484651·70 enrolled

Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures

Completed·—·Phase 4·NCT02451202·102 enrolled

Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery

Unknown status·—·Phase 1·NCT05294926·88 enrolled

Rocuronium9 trials

Continuous Infusion and Bolus Doses of Rocuronium During Lumbal Discectomy, Muscle Strength and Patient Recovery

Completed·—·N/A·NCT04236050·80 enrolled

The Neuromuscular Effect of Rocuronium in Patient

Unknown status·GGo Eun Bae·N/A·NCT02657187·80 enrolled

Effect of Rocuronium on BIS Values

Completed·UUniversity of Padova··NCT05681611·8 enrolled

Show 6 more trials

The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children

Unknown status·—·Phase 4·NCT02646709·60 enrolled

Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study

Completed·UUniversity Hospital, Geneva·Phase 2·NCT01571908·280 enrolled

Intubating Conditions During Rapid Sequence Induction in Elderly With Either Suxamethonium 1.0 mg/kg or Rocuronium 1.0 mg/kg

Completed·MMatias Vested·Phase 4·NCT04868409·102 enrolled

Pharmacokinetics of Rocuronium for Deep Block (DeepRocu)

Completed·—··NCT03545308·250 enrolled

Optimal Dose of Succinylcholine and Rocuronium for Electroconvulsive Therapy (ECT)

Completed·MMassachusetts General Hospital·N/A·NCT01441960·45 enrolled

Effect of Esmolol on Pain Due to Rocuronium

Completed·—·Phase 4·NCT01824758·90 enrolled

Neuromuscular Block7 trials

Effect of Deep Neuromuscular Block on Surgical Conditions in Morbidly Obese Patients

Completed·LLeiden University Medical Center·Phase 4·NCT02553629·109 enrolled

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

Completed·UUniversity of California, San Francisco·Phase 4·NCT01199237·107 enrolled

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Unknown status·UUniversity of Florence·Phase 4·NCT02698969·58 enrolled

Show 4 more trials

Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.

Completed·AAZ Sint-Jan AV·Phase 4·NCT01930747·50 enrolled

Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions

Unknown status·—·Phase 4·NCT02118844·92 enrolled

Neuromuscular Block and Anesthetic Depth Monitoring

Completed·SSeoul National University Bundang Hospital·N/A·NCT02575443·60 enrolled

Influence of Neuromuscular Block on Mask Ventilation

Completed·KKreiskrankenhaus Dormagen·N/A·NCT01849211·120 enrolled

Laparoscopic Cholecystectomy6 trials

Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00724932·140 enrolled

Rocuronium Effective Dose for Laparoscopic Cholecystectomy

Completed·—·Phase 3·NCT03043157·30 enrolled

The Effect of Deep Neuromuscular Blockade on Postoperative Shoulder Tip Pain After Laparoscopic Cholecystectomy

Completed·YYonsei University·Phase 4·NCT02036827·108 enrolled

Show 3 more trials

Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia

Unknown status·FFederal University of São Paulo·Phase 4·NCT02953210·40 enrolled

A Study Comparing the Use of Deep or Standard Neuromuscular Blockade in Combination With Low or Standard Insufflation Pressures in Participants Undergoing Laparoscopic Cholecystectomy (P07982)

Completed· Merck & Co. logo

Merck & Co.·Phase 4·NCT01728584·127 enrolled

Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

Completed·—·Phase 2·NCT02469831·40 enrolled

General Anesthesia5 trials

Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia

Terminated·HHopital Foch·Phase 4·NCT01579864·6 enrolled

General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Completed·—·Phase 4·NCT04760912·60 enrolled

Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia

Unknown status·TTang-Du Hospital·Phase 4·NCT02141737·272 enrolled

Show 2 more trials

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Completed·—·N/A·NCT05279898·70 enrolled

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Completed·TTianjin Medical University General Hospital·N/A·NCT02711917·175 enrolled

68 more indications

Muscle Relaxants4 trials

Muscle Relaxants on Efficacy of LMA Insertion

Completed·—·N/A·NCT03487003·128 enrolled

The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)

Recruiting·—·N/A·NCT06707532·32 enrolled

Interaction of Statins and Nondepolarizing Muscle Relaxants

Unknown status·HHuang-wei LV··NCT02222519·60 enrolled

Show 1 more trial

Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures

Completed·HHarbin Medical University·N/A·NCT07035301·153 enrolled

Sugammadex4 trials

Rocuronium Plus Sugammadex Versus Succinylcholine Alone in Participants Undergoing Short Surgical Procedures (19.4.319)(P05700 AM2)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00751179·161 enrolled

A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part B: Caucasian Participants (P05971)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00552617·100 enrolled

Investigation of Sugammadex in Outpatient Urological Procedures

Completed·MM.D. Anderson Cancer Center·Phase 4·NCT03138967·54 enrolled

Show 1 more trial

Comparison of Recovery From Rocuronium 1.2 mg/kg Followed by Sugammadex (Org 25969) 16 mg/kg at 3 Minutes With Recovery From Succinylcholine 1.0 mg/kg (19.4.303)(P05946)(MK-8616-026)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00474253·115 enrolled

Cardiac Arrest3 trials

Neuromuscular Blockade for Post-Cardiac Arrest Care

Completed·—·Phase 2·NCT02260258·83 enrolled

Influence of Skeletal Muscle Paralysis on Metabolism in Hypothermic Patients After Cardiac Arrest

Completed·MMedical University of Vienna·N/A·NCT01683006·43 enrolled

Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest

Completed·MMedical University of Vienna·Phase 3·NCT01719770·60 enrolled

Muscle Relaxation3 trials

Muscle Relaxation for Short Procedures

Completed·—·N/A·NCT01902641·105 enrolled

The Muscle Relaxation-study

Completed·HHerlev Hospital·Phase 4·NCT01523886·49 enrolled

Muscle Relaxation for Pediatric Adenotonsillectomy

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT06225466·172 enrolled

Sevoflurane3 trials

Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00559468·52 enrolled

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium

Completed·MMaharashtra University of Health Sciences·Phase 4·NCT02785653·60 enrolled

Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children

Completed·IIstanbul University·N/A·NCT03795259·148 enrolled

Laparoscopic3 trials

Atropine in Laparoscopic Gynaecological Surgery

Unknown status·CClinica Santa Maria·Phase 4·NCT02769325·150 enrolled

Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy

Completed·—·Phase 4·NCT02320734·66 enrolled

Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis

Completed·FFudan University·Phase 4·NCT02194855·100 enrolled

Ventilation3 trials

Supported Ventilation in ARDS Patients

Completed·UUniversity Medical Center Nijmegen·N/A·NCT02064140·12 enrolled

Optimal Inspiratory Pressure for Facemask Pressure-controlled Ventilation in Children

Completed·SSeoul National University Hospital·N/A·NCT02471521·120 enrolled

The Necessity of Routine Mask Ventilation in Adults

Completed·YYonsei University·N/A·NCT02400931·288 enrolled

Anesthesia3 trials

Minimal Flow Anesthesia and Infection Risk

Active, not recruiting·—·N/A·NCT07092046·140 enrolled

Rocuronium Dose Finding Study After Single-shot or Steady-state Propofol Anesthesia

Completed·TTechnical University of Munich·N/A·NCT02054468·82 enrolled

Use of Sugammadex at the End of Case in Routine Anesthesia (MK-8616-023)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00298831·224 enrolled

Hip Fracture2 trials

Regional vs General Anesthesia in Patients With Hip Fracture Under Treatment With Clopidogrel

Unknown status·LLarissa University Hospital·N/A·NCT03596060·150 enrolled

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture

Withdrawn·LLoyola University·Phase 4·NCT03226080

Neuromuscular Blocking Agents2 trials

Neuromuscular Blocking Agents in the Elderly

Completed·RRigshospitalet, Denmark··NCT03857750·32 enrolled

Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals

Completed·JJakob Louis Thomsen··NCT02914119·30,430 enrolled

Hemodynamic Stability2 trials

Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients

Completed·HHebei Medical University Fourth Hospital·N/A·NCT07064408·230 enrolled

Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients

Completed·SSeoul National University Hospital·N/A·NCT05423951·106 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 2·NCT07404579·90 enrolled

Safety and Efficacy of Sugammadex (Org 25969, MK-8616) in Participants With or Having a Past History of Pulmonary Disease (19.4.308) (P05932) (MK-8616-017)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00475215·86 enrolled

General Anaesthesia2 trials

Serum Tryptase Concentration During General Anaesthesia With Rocuronium

Completed·MMedical University of Bialystok·N/A·NCT04035707·126 enrolled

Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia

Completed·AAzienda Ospedaliera di Padova·Phase 4·NCT01651572·120 enrolled

Intravenous2 trials

Protocol for Eslax Intravenous Drug Use Investigation (Study P06082)

Completed· Merck & Co. logo

Merck & Co.··NCT00902070·3,969 enrolled

The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing

Completed·—·N/A·NCT01532466·260 enrolled

Post Operative Sore Throat2 trials

Effect of Intraoperative Muscle Relaxation Depth on Postoperative Sore Throat and Hoarseness After General Anesthesia

Unknown status·SSMG-SNU Boramae Medical Center·N/A·NCT03391700·206 enrolled

Effect of Intraoperative Neuromuscular Blockade on Postoperative Sore Throat and Hoarseness

Completed·SSMG-SNU Boramae Medical Center··NCT03397797·117 enrolled

Obese Patients2 trials

Pharmacodynamic Trial on Rocuronium in Obese Patients

Completed·RRigshospitalet, Denmark·Phase 4·NCT00540085·51 enrolled

Preoxygenation With Optiflow™ in Morbidly Obese Patients is Superior to Face Mask

Withdrawn·MMontefiore Medical Center·N/A·NCT03009877

Neostigmine2 trials

Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)

Withdrawn· Merck & Co. logo

Merck & Co.·Phase 4·NCT02410590

Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00473694·182 enrolled

Tracheal Intubation2 trials

Remifentanil Versus Rocuronium for Optimizing Video Laryngoscopy-assisted Tracheal Intubation

Recruiting·NNordsjaellands Hospital·Phase 4·NCT06564857·2,648 enrolled

Premedication for Non-Emergency Endotracheal Intubation In the NICU

Completed·—·Phase 4·NCT01749501·45 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Bladder Cancer1 trial

Neuromuscular Blockade During Transurethral Resection of Bladder Cancer

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT03039543·108 enrolled

Cognitive Functions1 trial

Cognitive Functions After TIVA With Dexmedetomidine

Completed·UUludag University·Phase 4·NCT02631135·40 enrolled

Hemodynamic Response1 trial

Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02464722·50 enrolled

Laparoscopy1 trial

Deep NMB in Ambulatory Gynecological Laparoscopy

Completed·WWahba bakhet·Phase 4·NCT04105764·80 enrolled

MPA1 trial

Comparison of Methods to Facilitate Rapid Sequence Intubation

Completed·SSeoul National University Bundang Hospital·N/A·NCT01479751·110 enrolled

Pregnant Women1 trial

Comparison of Onset and Duration of Rocuronium Between 2nd Trimester Pregnant and Non-pregnant Women

Completed·HHallym University Kangnam Sacred Heart Hospital··NCT02797860·90 enrolled

Complication1 trial

Compare of Surgical Condition and Complications With Moderate and Deep NM Block

Unknown status·—·N/A·NCT02601508·80 enrolled

Anesthesia Induction1 trial

Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

Completed·UUniversity of Rostock·N/A·NCT01591031·60 enrolled

Surgical1 trial

Effect of NMBA on Surgical Conditions in THR

Withdrawn·AAlgemeen Ziekenhuis Maria Middelares·Phase 4·NCT03369782

Cirrhosis1 trial

Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection

Completed·—·Phase 4·NCT02414880·60 enrolled

Bariatric Surgery1 trial

Surgical Conditions During Laparoscopic Bariatric Surgery

Completed·UUniversity of Missouri-Columbia·Phase 4·NCT02703909·144 enrolled

Erector Spinae Block1 trial

Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane Block

Completed·TTanta University·N/A·NCT05596227·180 enrolled

Abdominal Surgery1 trial

Validation of Subjective Rating Scales Used to Assess Surgical Conditions in Abdominal Surgery

Completed·HHerlev Hospital·Phase 4·NCT02079337·14 enrolled

Suprascapular Nerve Block1 trial

Postoperative Analgesia of Magnesium Sulfate in Suprascapular Nerve Block Following Shoulder Arthroscopy

Unknown status·MMansoura University·N/A·NCT03602469·60 enrolled

Skin1 trial

Measurement of the Skin Sympathetic Nerve Activity

Completed·SSeoul National University Hospital·N/A·NCT03658057·20 enrolled

Nephrectomy1 trial

QLB After Nephrectomy

Completed·MMedical University of Lublin·N/A·NCT03529201·105 enrolled

Inguinal hernia1 trial

Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway

Completed·MMaltepe University·N/A·NCT02696837·80 enrolled

Propofol1 trial

Desflurane Versus Propofol in the Sitting Position

Completed·GGachon University Gil Medical Center·N/A·NCT01436799·40 enrolled

Remimazolam1 trial

Remimazolam Phase II Cardiac Anesthesia Study

Completed·PPaion UK Ltd.·Phase 2·NCT01937767·90 enrolled

Poisoning1 trial

A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning

Completed·UUniversity of Edinburgh·Phase 2/3·NCT02147054·45 enrolled

Hysterectomy1 trial

Recovery After Laparoscopic Hysterectomy With Deep Neuromuscular Blockade and Low Intra-abdominal Pressure

Completed·HHerlev Hospital·Phase 4·NCT01722097·110 enrolled

Coronary Artery Bypass1 trial

Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery

Completed·WWest Virginia University·Phase 4·NCT03939923·84 enrolled

Postoperative Analgesia1 trial

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Unknown status·HHuazhong University of Science and Technology·Phase 4·NCT03135795·100 enrolled

Intraocular Pressure1 trial

Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery

Completed·—·N/A·NCT07033442·60 enrolled

Sedation1 trial

Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways

Unknown status·PPeking University·N/A·NCT04924621·42 enrolled

Chronic Kidney Disease1 trial

Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease

Recruiting·TThe University of Texas Medical Branch, Galveston·Phase 4·NCT07203287·490 enrolled

Strabismus1 trial

Peribulbar Rocuronium in Adult Strabismus Surgery

Completed·TTanta University·N/A·NCT04821817·52 enrolled

Ultrasound1 trial

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block

Unknown status·TTanta University·N/A·NCT05543109·85 enrolled

Prevention1 trial

Median Effective Dose of Rocuronium for the Prevention of Myofibrillation Caused by the Injection of Succinylcholine

Completed·YYangzhou University·N/A·NCT05909696·60 enrolled

Liver Transplant1 trial

SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation

Completed·UUniversity Health Network, Toronto··NCT01404793·28 enrolled

Renal Impairment1 trial

Dialysis of Sugammadex in Participants With Severe Renal Impairment (Study 19.4.333) (P05773)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00656799·6 enrolled

Intensive Care1 trial

Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care

Completed·UUniversity Hospital, Basel, Switzerland·Phase 4·NCT00355368·420 enrolled

Remifentanil1 trial

The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children

Completed·HHallym University Medical Center·N/A·NCT02486926·102 enrolled

Critically Ill1 trial

The Use of Sugammadex in the Critically Ill

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03791801·50 enrolled

Cesarean Section1 trial

Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine

Completed·—·Phase 4·NCT01941628·91 enrolled

Obstructive Sleep Apnea1 trial

Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea

Completed·MMalin Jonsson Fagerlund·N/A·NCT01672606·11 enrolled

Abdominal Surgeries1 trial

Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries

Not yet recruiting·—·N/A·NCT07464288·128 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

ISS1 trial

Comparison of Two Neuromuscular Transmission Monitors Based on Acceleromyography: TOF-Watch SX® and TOFScan®

Unknown status·—·N/A·NCT02880787·142 enrolled

Hypoxemia1 trial

Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX)

Unknown status·FFondation Ophtalmologique Adolphe de Rothschild·Phase 4·NCT02589691·412 enrolled

Robotic Surgery1 trial

Muscle Relax Affects Outcomes of Robotic Surgery

Unknown status·—·N/A·NCT03726372·192 enrolled

Induction Anesthesia1 trial

The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia

Completed·—·Phase 4·NCT02709473·84 enrolled

Gynecologic Laparoscopic Surgery1 trial

Optimizing Surgical Conditions During Gynecologic Laparoscopic Surgery With Deep Neuromuscular Blockade

Completed·HHerlev Hospital·Phase 4·NCT01933425·14 enrolled

Bronchoscopy1 trial

Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy

Completed·ZZhejiang Cancer Hospital·Phase 4·NCT05468671·34 enrolled

Regional Anesthesia1 trial

Regional Anesthesia Versus General Anesthesia

Completed·IIRCCS Azienda Ospedaliero-Universitaria di Bologna·N/A·NCT03830086·28 enrolled

Effectiveness1 trial

Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy

Unknown status·—·Phase 4·NCT04872881·52 enrolled

Urinary retention1 trial

Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery

Enrolling by invitation·UUniversity of Missouri-Columbia·Phase 4·NCT05887375·118 enrolled

Elderly Patients1 trial

Effect of Dexmedetomidine on Recovery Profiles of Elderly Patients

Completed·—·N/A·NCT01851005·120 enrolled

Unspecified2 trials

Stylet Use for McGrath Videolaryngoscope

Completed·—·Phase 4·NCT02642367·140 enrolled

A Study of Residual Curarization Incidence in China

Unknown status·PPeking University First Hospital·Phase 4·NCT01690338·6,090 enrolled

Regulatory

FDA Approval Timeline[5]

Mar 17, 1994

ZEMURON

NDA NDA020214

Jun 9, 2025

ROCURONIUM BROMIDE

NDA NDA217472

Oct 24, 2025

ROCURONIUM BROMIDE

NDA NDA219108

Sources

References

[1]
ClinicalTrials.gov — 136 trial records for rocuronium. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Esmeron drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — rocuronium compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for rocuronium. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA219108). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Esmeron. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Fresenius Kabi Oncology Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Muscle-Type Nicotinic Acetylcholine Receptor Antagonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: FFresenius Kabi Oncology Ltd.

Patent Landscape[6]

Patent Cliff

Jul 22, 2039

Earliest patent expiration — generic entry possible after this date

Patent #Expires

11998605Jul 22, 2039