Esmeron
(rocuronium)ApprovedSmall molecule
Rocuronium is a muscle relaxant used during surgery and medical procedures to paralyze muscles, making it easier for doctors to perform operations and manage patients on breathing machines.[2] Esmeron is currently approved and in use across 37 indications[4].[1]
Esmeron is one of 536 small molecule programs targeting Hysterectomy. It is currently in Approved.
37
Indications
138
Total Trials
8
Active Trials
535
Competitors
3
FDA Applications
NDA/BLA/ANDA regulatory filings
1
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 34 indications
Competition
Competitive Landscape
348 competitors in Prostate Cancer
#DrugCompanyPhaseTrials
1Esmeron
FFresenius Kabi USA, LLC
Approved
Androgen Deprivation Therapy
Johnson & JohnsonPhase 3
Lipitor
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Phase 3
Acetylsalicylic Acid
BayerPhase 3
Lhrha
Johnson & JohnsonPhase 3
Piflufolastat
NovartisPhase 3
AAA817
NovartisPhase 3
Florastamin
HHTA Co., Ltd.
Phase 3
Trexall
Jazz PharmaceuticalsPreclinical
Botox
VVitae Pharmaceuticals Inc., an Allergan affiliate
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Neuromuscular Blockade13 trials
Show 10 more trials
Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?
Completed·—·Phase 4·NCT02484651·70 enrolled
Deep vs Moderate Neuromuscular Blockade With Rocuronium in Patients Undergoing Endolaryngeal Procedures
Completed·—·Phase 4·NCT02451202·102 enrolled
Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery
Unknown status·—·Phase 1·NCT05294926·88 enrolled
Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population
Completed·—·N/A·NCT02546843·66 enrolled
Rocuronium9 trials
Continuous Infusion and Bolus Doses of Rocuronium During Lumbal Discectomy, Muscle Strength and Patient Recovery
Completed·—·N/A·NCT04236050·80 enrolled
Effect of Esmolol on Pain Due to Rocuronium
Completed·—·Phase 4·NCT01824758·90 enrolled
Show 6 more trials
The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children
Unknown status·—·Phase 4·NCT02646709·60 enrolled
Pharmacokinetics of Rocuronium for Deep Block (DeepRocu)
Completed·—··NCT03545308·250 enrolled
Neuromuscular Block7 trials
Show 4 more trials
Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions
Unknown status·—·Phase 4·NCT02118844·92 enrolled
Laparoscopic Cholecystectomy6 trials
Rocuronium Effective Dose for Laparoscopic Cholecystectomy
Completed·—·Phase 3·NCT03043157·30 enrolled
Show 3 more trials
General Anesthesia5 trials
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
Completed·—·N/A·NCT05279898·70 enrolled
General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery
Completed·—·Phase 4·NCT04760912·60 enrolled
69 more indications
Sugammadex4 trials
Muscle Relaxants4 trials
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
Recruiting·—·N/A·NCT06707532·32 enrolled
Show 1 more trial
Muscle Relaxants on Efficacy of LMA Insertion
Completed·—·N/A·NCT03487003·128 enrolled
Anesthesia3 trials
Minimal Flow Anesthesia and Infection Risk
Active, not recruiting·—·N/A·NCT07092046·140 enrolled
Laparoscopic3 trials
Muscle Relaxation3 trials
Muscle Relaxation for Short Procedures
Completed·—·N/A·NCT01902641·105 enrolled
Sevoflurane3 trials
Ventilation3 trials
Cardiac Arrest3 trials
Safety and Efficacy2 trials
Hip Fracture2 trials
Tracheal Intubation2 trials
Premedication for Non-Emergency Endotracheal Intubation In the NICU
Completed·—·Phase 4·NCT01749501·45 enrolled
Neostigmine2 trials
Obese Patients2 trials
Neuromuscular Blocking Agents2 trials
Post Operative Sore Throat2 trials
Intravenous2 trials
The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing
Completed·—·N/A·NCT01532466·260 enrolled
Hemodynamic Stability2 trials
Cirrhosis1 trial
Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection
Completed·—·Phase 4·NCT02414880·60 enrolled
Erector Spinae Block1 trial
Abdominal Surgery1 trial
Ultrasound1 trial
Liver Transplant1 trial
Abdominal Surgeries1 trial
Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries
Not yet recruiting·—·N/A·NCT07464288·128 enrolled
Inguinal hernia1 trial
ISS1 trial
Comparison of Two Neuromuscular Transmission Monitors Based on Acceleromyography: TOF-Watch SX® and TOFScan®
Unknown status·—·N/A·NCT02880787·142 enrolled
Remifentanil1 trial
Critically Ill1 trial
The Use of Sugammadex in the Critically Ill
Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03791801·50 enrolled
Sedation1 trial
Intraocular Pressure1 trial
Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery
Completed·—·N/A·NCT07033442·60 enrolled
Prevention1 trial
Renal Impairment1 trial
Trial1 trial
The PATHFINDER Study: A Feasibility Trial
Completed·—·Phase 1·NCT04016740·22 enrolled
Chronic Kidney Disease1 trial
Pregnant Women1 trial
Anesthesia Induction1 trial
Hypoxemia1 trial
Poisoning1 trial
Hysterectomy1 trial
Coronary Artery Bypass1 trial
Induction Anesthesia1 trial
The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
Completed·—·Phase 4·NCT02709473·84 enrolled
Cesarean Section1 trial
Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Completed·—·Phase 4·NCT01941628·91 enrolled
Gynecologic Laparoscopic Surgery1 trial
Bronchoscopy1 trial
Elderly Patients1 trial
Effect of Dexmedetomidine on Recovery Profiles of Elderly Patients
Completed·—·N/A·NCT01851005·120 enrolled
Postoperative Analgesia1 trial
Effectiveness1 trial
Comparison of Effectiveness of Different Airway Management Methods During Percutaneous Tracheostomy
Unknown status·—·Phase 4·NCT04872881·52 enrolled
Urinary retention1 trial
Robotic Surgery1 trial
Muscle Relax Affects Outcomes of Robotic Surgery
Unknown status·—·N/A·NCT03726372·192 enrolled
Hemodynamic Response1 trial
Complication1 trial
Compare of Surgical Condition and Complications With Moderate and Deep NM Block
Unknown status·—·N/A·NCT02601508·80 enrolled
Suprascapular Nerve Block1 trial
Obstructive Sleep Apnea1 trial
Hemodynamic Instability1 trial
Unspecified2 trials
Stylet Use for McGrath Videolaryngoscope
Completed·—·Phase 4·NCT02642367·140 enrolled
Regulatory
FDA Approval Timeline[5]
Mar 17, 1994
ZEMURON
NDA NDA020214
Jun 9, 2025
ROCURONIUM BROMIDE
NDA NDA217472
Oct 24, 2025
ROCURONIUM BROMIDE
NDA NDA219108
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Esmeron drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for rocuronium. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Muscle-Type Nicotinic Acetylcholine Receptor Antagonist[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- FFresenius Kabi USA, LLC
Patent Landscape[6]
Patent Cliff
Jul 22, 2039
Earliest patent expiration — generic entry possible after this date
Patent #Expires
11998605Jul 22, 2039