VivoSeq
Other

Total Hip Arthroplasty

68

Pipeline Programs↗

15

Active Trials↗

31

Companies Involved↗

Total Hip Arthroplasty is a moderately active landscape with 68 programs across 31 companies. The most active players are Amgen, Moderna, Javelin Pharmaceuticals. 38 therapies are approved with 11 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

65/100

Pipeline Velocity

25/100

Mech. Concentration

14/100

Completion Rate

89/100

Attrition Rate

8/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Amgen logo

Amgen

1 program

Phase 1Moderna logo

Moderna

1 program

Phase 1J

Javelin Pharmaceuticals

1 program

Phase 1H

Hikma Pharmaceuticals LLC

2 programs

Phase 1UCB logo

UCB

1 program

Phase 2Eli Lilly logo

Eli Lilly

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical9

Dabigatran

Boehringer Ingelheim

Enoxaparin

Sanofi

Morphine

Hikma Pharmaceuticals LLC

Ketamine-Morphine

National University of Malaysia

Group (c)

Beijing Minhai Biotechnology Co., Ltd

Phase 14

Denosumab

Amgen

Active Comparator

Moderna

Pamidronate

Hikma Pharmaceuticals LLC

Ketorolac

Javelin Pharmaceuticals

Phase 26

Lacosamide

UCB

Du-176b

Daiichi Sankyo

Intravenous Administration of Oxytocin

Wake Forest University Health Sciences

Perfusion of Exacyl

Centre Hospitalier Universitaire de Saint Etienne

Dex

Seoul National University Hospital

Phase 311

Enoxaparin Sodium

Sanofi

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Nefopam

Yonsei University

Etoricoxib

Novartis

Edoxaban

Daiichi Sankyo

Approved38

Dexamethasone

Aspen Global Incorporated

Tranexamic Acid

Amring

Epinephrine

Samson Clinical Operations Pty Ltd

Acetaminophen

Kenvue Brands

Rivaroxaban

Wim Janssens

Analysis

Modality Breakdown

99%

Small molecule

99 of 100 classified programs — the dominant modality here.

1%ALL OTHERSMonoclonal antibody11%

Small molecule leads; the ring shows all 100 classified programs, each share of the total. Modality classified for 99% of 102 pipeline programs.

Analysis

Trial Status

103

clinical trials

Completed64 · 62%
Unknown status16 · 16%
Recruiting7 · 7%
Not yet recruiting6 · 6%
Terminated5 · 5%
Withdrawn3 · 3%
Other2 · 2%

Clinical Trials

Trial Activity

103 trials

Suzetrigine in Total Hip Arthroplasty
Recruiting·HHospital for Special Surgery, New York·Phase 3·NCT07226700·210 enrolled
The Pericapsular Nerve Block in Total Hip Arthroplasty
Recruiting·LLifeBridge Health·Phase 4·NCT04729686·78 enrolled
Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty
Recruiting·TTanta University·N/A·NCT06768580·135 enrolled
Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty
Recruiting·—·Phase 2·NCT06577155·60 enrolled
Quadratus Lumborum Block for Total Hip Arthroplasty
Recruiting·UUniversity of California, Los Angeles·Phase 1·NCT05247255·80 enrolled
Pericapsular Nerve Group and Lumbar Erector Spinae Plane Blocks for Geriatrics Undergoing Total Hip Arthroplasty
Recruiting·TTanta University·N/A·NCT06904703·120 enrolled
Magnesium Sulfate in Addition to Bupivacaine in Ultrasound-guided Transmuscular Quadratus Lumborum Block for Post-Operative Analgesia After Total Hip Arthroplasty
Recruiting·TTanta University·Phase 2/3·NCT06956950·70 enrolled
The Effect of Corticosteroids on Quality of Life Following Total Hip Arthroplasty: HIPSTER Study
Not yet recruiting·—·Phase 4·NCT07378215·224 enrolled
PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty
Not yet recruiting·PPoznan University of Medical Sciences·Phase 4·NCT07180979·90 enrolled
Effect of Local Pamidronate in Preventing Bone Loss After Total Hip Arthroplasty
Not yet recruiting·GGeneral and Teaching Hospital Celje·Phase 1·NCT00548288·40 enrolled
Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)
Not yet recruiting·UUniversity Hospital, Tours·Phase 3·NCT06349798·546 enrolled
Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)
Not yet recruiting·—·N/A·NCT07109388·50 enrolled
Peri-Operative Testosterone Administration in Primary Total Hip Arthroplasty
Not yet recruiting·AAmerican Hip Institute·Phase 4·NCT06608914·60 enrolled
Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty
Enrolling by invitation·MMayo Clinic·Phase 4·NCT07153003·560 enrolled
Efficacy of Intravenous Oxytocin to Speed Recovery After Total Hip Arthroplasty
Enrolling by invitation·WWake Forest University Health Sciences·Phase 2·NCT07430228·80 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)