Lovenox

(Enoxaparin)

ApprovedSmall molecule

Enoxaparin is a blood thinner used to prevent and treat blood clots, including those that can cause strokes, heart attacks, or pulmonary embolism (a dangerous clot in the lungs).[2] Lovenox is currently approved and in use across 28 indications[4].[1]

Lovenox is one of 510 small molecule programs targeting Venous Thromboembolism. It is currently in Approved.

Indications

218

Total Trials

Active Trials

509

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Venous ThromboembolismTerminated

Intracerebral HemorrhageActive, not recruiting

Coronary Artery BypassActive, not recruiting

Morbid ObesityActive, not recruiting

Angina UnstableApproved

Nephrotic SyndromeApproved

Pancreatic NeoplasmApproved

Thrombotic DiseaseApproved

PsoriasisActive, not recruiting

Malignant Pancreatic NeoplasmApproved

Venous ThromboembolismApproved

Terminated

Intracerebral HemorrhageApproved

Active, not recruiting

Coronary Artery BypassApproved

Active, not recruiting

Morbid ObesityApproved

Active, not recruiting

Angina UnstableApproved

Approved

Nephrotic SyndromeApproved

Approved

Pancreatic NeoplasmApproved

Approved

Thrombotic DiseaseApproved

Approved

PsoriasisPreclinical

Active, not recruiting

Malignant Pancreatic NeoplasmApproved

Approved

Showing 10 of 28 indications

Competition

Competitive Landscape

449 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Lovenox

Sanofi

Approved

218 2

Apatinib

LLaNova Medicines Zhejiang Co., Ltd.

Phase 3

13 3

AK104

AAkeso

Phase 3

6 4

SHR-A1811

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

2 5

Remeron

OOrganon and Co

Preclinical

1 6

Valemetostat Tosylate

Daiichi Sankyo

Preclinical

1 7

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—8

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—9

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ANot yet recruiting

Growth

NCT07462182

Q4 2026

Phase 1Active, not recruiting

Anticoagulant

NCT06517563

Phase 2Recruiting

Efficacy and Safety

NCT07140523

Q1 2027

Post-ApprovalRecruiting

Thrombocytopenia

NCT05255003

Q3 2027

Post-ApprovalRecruiting

Anticoagulation

NCT06442267

Clinical

Trials by Indication[1]

Venous Thromboembolism19 trials

Postpartum Heparin Against Venous Thromboembolism: a Pilot Randomized Controlled Trial

Completed·UUniversity Hospital, Geneva·Phase 3·NCT05878899·77 enrolled

Evaluation of Chemical Venous Thromboembolism Prophylaxis in Trauma

Unknown status·MMethodist Health System··NCT06025162·100 enrolled

Prophylactic Enoxaparin Dosing for Prevention of Venous Thromboembolism in Pregnancy.

Completed·SStanford University·Phase 2/3·NCT00878826·11 enrolled

Show 16 more trials

BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 2·NCT01225822·1,973 enrolled

Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00152971·2,615 enrolled

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement Surgery

Completed· Astellas logo

Astellas·Phase 2/3·NCT00917254·369 enrolled

Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Hip Replacement Surgery

Completed· Astellas logo

Astellas·Phase 2/3·NCT00913120·610 enrolled

Bemiparin Versus Enoxaparin in the Prevention of Venous Thromboembolism Among ICU Patients

Completed·MMohamed Sayed Mohamed Abbas·N/A·NCT02795065·100 enrolled

Study of Prophylactic Effect of Rivaroxaban on Venous Thromboembolism in AECOPD

Unknown status·HHuashan Hospital·N/A·NCT03277001·438 enrolled

PREvention of VENous Thromboembolism In Hemorrhagic Stroke Patients

Terminated·UUniversity Of Perugia·Phase 3·NCT01573169·73 enrolled

Evaluation of Venous Thromboembolism Prevention in High-Risk Trauma Patients

Completed·UUniversity of Cincinnati·Phase 4·NCT02412982·103 enrolled

Weight-Adjusted vs Fixed Low Doses of Low Molecular Weight Heparin For Venous Thromboembolism Prevention in COVID-19

Completed·—·Phase 4·NCT04373707·1,000 enrolled

Dabigatran Etexilate in Extended Venous Thromboembolism (VTE) Prevention After Hip Replacement Surgery

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00168818·3,494 enrolled

Venous Thromboembolism Prophylaxis After Gynecological Pelvic Cancer Surgery With Rivaroxaban vs Enoxaparin

Unknown status·AAndré Luiz Malavasi Longo de Oliveira·Phase 3·NCT04999176·440 enrolled

Rivaroxaban Versus Enoxaparin for Prophylaxis of Venous Thromboembolism in Bariatric Surgery

Recruiting·—·N/A·NCT06689241·162 enrolled

Comparing Enoxaparin to Fondaparinux to Prevent Venous Thromboembolism (VTE) in Bariatric Surgical Patients

Completed·JJohns Hopkins University·Phase 1·NCT00894283·198 enrolled

Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome.

Terminated·MMilitary Institute od Medicine National Research Institute·Phase 2/3·NCT04558892·65 enrolled

Efficacy of Aspirin in Preventing Venous Thromboembolism

Completed·IInstituto de Seguridad y Servicios Sociales de los Trabajadores del Estado·Phase 4·NCT06635317·60 enrolled

Factor Xa Inhibitor for Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement

Completed· Astellas logo

Astellas·Phase 2·NCT00408239·367 enrolled

COVID-1914 trials

Enoxaparin in COVID-19 Moderate to Severe Hospitalized Patients

Completed·IIRCCS Azienda Ospedaliero-Universitaria di Bologna·Phase 2·NCT04427098·301 enrolled

Effect of the Use of Anticoagulant Therapy During Hospitalization and Discharge in Patients With COVID-19 Infection

Unknown status·—·N/A·NCT04508439·130 enrolled

Factor Xa Inhibitor Versus Standard of Care Heparin in Hospitalized Patients With COVID-19 (XACT)

Completed·SSt. David's HealthCare·Phase 2·NCT04640181·150 enrolled

Show 11 more trials

Enoxaparin for Primary Thromboprophylaxis in Ambulatory Patients With COVID-19

Terminated·UUniversity of Zurich·Phase 3·NCT04400799·475 enrolled

Full Dose Heparin Vs. Prophylactic Or Intermediate Dose Heparin in High Risk COVID-19 Patients

Completed·NNorthwell Health·Phase 3·NCT04401293·257 enrolled

Australasian COVID-19 Trial (ASCOT) ADAptive Platform Trial

Active, not recruiting·UUniversity of Melbourne·Phase 3·NCT04483960·2,200 enrolled

Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients

Terminated·—·Phase 3·NCT04492254·219 enrolled

Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19

Unknown status·MMassachusetts General Hospital·Phase 2·NCT04377997·300 enrolled

Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients

Completed·RRAAS Nutritionals, LLC·Phase 3·NCT05417997·71 enrolled

Effect of Prophylactic and Therapeutic Anticoagulants in Egyptian Patients With COVID-19

Completed·—··NCT04736901·90 enrolled

FREEDOM COVID-19 Anticoagulation Strategy

Completed·VValentin Fuster·Phase 4·NCT04512079·3,460 enrolled

Evaluating Dose Regimen of Intravenous Unfractionated Heparin and Low Molecular Weight Heparin in Critical Ill Patients Versus Critical Ill COVID-19 Patients Using Anti-Xa Levels.

Completed·UUniversity Hospital, Ghent··NCT05224388·813 enrolled

Comparison of Two Doses of Enoxaparin for Thromboprophylaxis in Hospitalized COVID-19 Patients

Completed·NNiguarda Hospital·Phase 3·NCT04366960·189 enrolled

Enoxaparin at Prophylactic or Therapeutic Doses in COVID-19

Completed·AASST Fatebenefratelli Sacco·Phase 3·NCT04646655·142 enrolled

Prophylaxis13 trials

Enoxaparin Thromboprophylaxis in Cancer Patients With Elevated Tissue Factor Bearing Microparticles

Completed·—·Phase 2·NCT00908960·70 enrolled

LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

Enrolling by invitation·MMassachusetts General Hospital·Phase 4·NCT03244020·2,868 enrolled

The SYMPTOMS - SYstematic Elderly Medical Patients Thromboprophylaxis: Efficacy on Symptomatic OutcoMeS - Study

Completed·UUniversity Hospital, Brest·Phase 3·NCT02379806·2,560 enrolled

Show 10 more trials

OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)

Completed·MMcMaster University·N/A·NCT01589393·52 enrolled

Terminated·YYale University·Phase 2·NCT03003390·51 enrolled

Aspirin and Compression Devices for VTE Prophylaxis in Orthopaedic Oncology

Completed·OOhio State University Comprehensive Cancer Center·N/A·NCT01696760·12 enrolled

Recruiting·YYale University·Phase 2/3·NCT04924322·258 enrolled

Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients

Completed· Bayer logo

Bayer·Phase 3·NCT00571649·8,101 enrolled

Oral Apixaban (Eliquis) Versus Enoxaparin (Lovenox) for Thromboprophylaxis in Women With Suspected Pelvic Malignancy

Completed·UUniversity of Colorado, Denver·Phase 2·NCT02366871·400 enrolled

Comparing Anti-XA Levels in Post-Cesarean Patients Undergoing Enoxaparin Thromboprophylaxis

Completed·MMemorialCare Health System·Phase 1·NCT02070237·90 enrolled

Safety of Fondaparinux as Routine VTE Prophylaxis in Medical ICU Patients

Terminated·—·Phase 3·NCT00493896·27 enrolled

PROphylaxis in NOn Major Orthopaedic Surgery

Terminated·—·Phase 3·NCT02401594·3,608 enrolled

Study Of Weight-Based Versus Standard Dose Enoxaparin Thromboprophylaxis In High-Risk Hospitalized Cancer Patients

Completed·—·Phase 2·NCT02706249·50 enrolled

Enoxaparin8 trials

Thrombelastography Based Dosing of Enoxaparin

Completed·OOregon Health and Science University·N/A·NCT00990236·185 enrolled

Tirofiban and Enoxaparin in High Risk Coronary Intervention

Completed·—·Phase 4·NCT00790387·60 enrolled

Aspirin and Enoxaparin for VTE in Trauma

Terminated·UUniversity of Miami·Phase 4·NCT02396732·31 enrolled

Show 5 more trials

Taxotere-Enoxaparin-(ENOXA)-Study

Terminated·HHannover Medical School·Phase 3·NCT01058759·14 enrolled

Study of Pharmacodynamic Equivalence of Enoxaparin Rovi to Clexane®, in Healthy Volunteers

Completed·RRovi Pharmaceuticals Laboratories·Phase 1·NCT03363477·46 enrolled

Heparin or Enoxaparin in Patients With Cancer

Completed·NNorthwestern University··NCT00004875·6 enrolled

PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin

Completed·AAMAG Pharmaceuticals, Inc.·Phase 1/2·NCT02206100·40 enrolled

Weight-Based Enoxaparin Dosing and Real-Time Dose Adjustment in Orthopaedic Trauma

Completed·UUniversity of Utah·Phase 2·NCT03339349·80 enrolled

Low Molecular Weight Heparin6 trials

Low Molecular Weight Heparin or no Treatment Following Cesarean Delivery

Completed·UUniversity of Utah·Phase 2·NCT06118957·64 enrolled

Comparison of 2 Low Molecular Weight Heparin as a Thromboprophylaxis Postpartum

Completed·HHawler Medical University·N/A·NCT01588171·7,020 enrolled

Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis

Unknown status·MMonash Medical Centre·Phase 4·NCT01252420·330 enrolled

Show 3 more trials

Low Molecular Weight Heparin vs Unfractionated Heparin at Cardiac Surgery

Completed·GG. d'Annunzio University·N/A·NCT00420667·43 enrolled

Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients.

Unknown status·—·Phase 4·NCT01970280·26 enrolled

ABRIDGE: Low Molecular Weight Heparin in Bridging Patients After Mechanical Valve Replacement

Completed·TThe Cleveland Clinic·Phase 4·NCT00298285·100 enrolled

80 more indications

Pulmonary Embolism6 trials

Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach

Completed· Sanofi logo

Sanofi·Phase 3·NCT00345618·3,202 enrolled

Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thromboembolism (DVT) and Pulmonary Embolism (PE). A Study of BAY59-7939 in the Prevention of Venous Thrombo Embolism (VTE) in Subjects Undergoing Elective Total Knee Replacement.

Completed· Bayer logo

Bayer·Phase 3·NCT00362232·3,148 enrolled

Low-Dose Tenecteplase in Covid-19 Diagnosed With Pulmonary Embolism

Terminated·—·Phase 4·NCT04558125·2 enrolled

Show 3 more trials

Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1/2·NCT02923115·134 enrolled

Adjuvant Treatment of Pulmonary Embolism With Drotrecogin Alfa (Activated): Phase II Exploratory Study

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00191724·47 enrolled

Once Daily Enoxaparin for Outpatient Treatment of Acute DVT and/or Pulmonary Embolism

Completed·—·N/A·NCT00413374·40 enrolled

Knee Replacement Surgery5 trials

A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT03891524·1,242 enrolled

BMS-562247 in Subjects Undergoing Elective Total Knee Replacement Surgery

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2/3·NCT00097357·1,238 enrolled

A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants

Completed· Regeneron logo

Regeneron·Phase 2·NCT05618808·373 enrolled

Show 2 more trials

New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00074828·511 enrolled

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00452530·3,221 enrolled

Total Hip Replacement5 trials

Dose-Ranging Study of BAY 59-7939 on the Prevention of VTE in Patients Undergoing Elective Total Hip Replacement

Completed· Bayer logo

Bayer·Phase 2·NCT00398905·726 enrolled

Dose-confirmatory Bridging Study in Total Hip Replacement

Completed· Bayer logo

Bayer·Phase 3·NCT01205932·402 enrolled

Regulation of Coagulation in Orthopedic Surgery to Prevent DVT and PE, a Controlled, Double-blind, Randomized Study of BAY 59-7939 in the Extended Prevention of VTE in Patients Undergoing Elective Total Hip Replacement

Completed· Bayer logo

Bayer·Phase 3·NCT00332020·2,457 enrolled

Show 2 more trials

Dose-ranging Study of Once-daily Regimen of BAY 59-7939 in the Prevention of VTE in Patients Undergoing Elective Total Hip Replacement

Completed· Bayer logo

Bayer·Phase 2·NCT00396786·877 enrolled

Rivaroxaban (10mg) Given Once Daily in Patients Undergoing Total Hip Replacement Compared to Enoxaparin

Completed· Bayer logo

Bayer·Phase 3·NCT00329628·4,541 enrolled

Total Knee Arthroplasty5 trials

Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty

Unknown status·—·Phase 4·NCT02865174·90 enrolled

Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty

Completed· Ionis Pharmaceuticals logo

Ionis Pharmaceuticals·Phase 2·NCT01713361·315 enrolled

FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty

Completed· Bayer logo

Bayer·Phase 2·NCT03276143·813 enrolled

Show 2 more trials

Clinical Study on the Efficacy and Safety of Multiple Oral Administrations of SHR2285 Tablets in Patients Undergoing Elective Total Knee Arthroplasty

Terminated· Shanghai Hengrui Pharmaceutical Co., Ltd. logo

Shanghai Hengrui Pharmaceutical Co., Ltd.·Phase 2·NCT05203705·64 enrolled

Factor XI inhibiTion for the Prevention of Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty

Active, not recruiting·SSuzhou Alphamab Co., Ltd.·Phase 2·NCT06180889·241 enrolled

Total Knee Replacement4 trials

Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement

Completed·TTetherex Pharmaceuticals Corporation·Phase 2·NCT03812328·207 enrolled

Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement

Completed· Takeda logo

Takeda·Phase 2·NCT00641732·1,045 enrolled

Safety and Efficacy of TeaRx Xa Factor Direct Inhibitor Versus Enoxaparin as a Venous Thromboembolic Events (VTE) Prevention Following Total Knee Replacement

Completed·TTeaRx LLC·Phase 2·NCT03088358·200 enrolled

Show 1 more trial

Dose-confirmatory Bridging Study in Total Knee Replacement

Completed· Bayer logo

Bayer·Phase 3·NCT01206972·302 enrolled

Total Hip Arthroplasty4 trials

Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty

Completed·SSamsung Medical Center·Phase 4·NCT02379663·639 enrolled

Comparison of Blood Loss Following Total Hip Arthroplasty With the Use of Three Thromboprophylactic Regimes: Dabigatran, Enoxaparin and Rivaroxaban.

Unknown status·CCentre of Postgraduate Medical Education·N/A·NCT02085824·60 enrolled

Dabigatran Etexilate Compared With Enoxaparin in Prevention of Venous Thromboembolism (VTE) Following Total Hip Arthroplasty

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00657150·2,055 enrolled

Show 1 more trial

Deep Vein Thrombosis (DVT) Prevention in Total Hip Arthroplasty: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)

Completed·MMedical Compression Systems·N/A·NCT00358735·411 enrolled

Anticoagulation4 trials

Catheter-Directed Thrombolysis Versus Anticoagulation Monotherapy in Intermediate-High Risk PE

Terminated·RRajaie Cardiovascular Medical and Research Center·Phase 3·NCT05172115·94 enrolled

Anticoagulation Post Laparoscopic Splenectomy

Terminated·UUniversity of Alberta·Phase 2·NCT00769873·35 enrolled

Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI

Completed·—·Phase 4·NCT03664180·2,989 enrolled

Show 1 more trial

Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support

Recruiting·MMedical University of Vienna·Phase 4·NCT06442267·90 enrolled

Acute Coronary Syndrome4 trials

Safety and Efficacy of LMWH Versus Rivaroxaban in Chinese Patients Hospitalized With Acute Coronary Syndrome

Completed·SSecond Xiangya Hospital of Central South University·Phase 4·NCT03363035·2,055 enrolled

SYNERGY: Open Study of Enoxaparin Versus Unfractionated Heparin in Patients With Acute Coronary Syndromes

Completed· Sanofi logo

Sanofi·Phase 3·NCT00043784·8,000 enrolled

Patients With High-risk Acute Coronary Syndrome Without ST-segment Elevation

Terminated·EEurofarma Laboratorios S.A.·Phase 3·NCT01356992·62 enrolled

Show 1 more trial

Enoxaparin Bioequivalence Study in Acute Coronary Syndrome Patients

Completed·UUniversity of Monastir·Phase 1·NCT04552067·172 enrolled

Deep Vein Thrombosis4 trials

Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). A Study of BAY 59-7939 in the Prevention of VTE in Subjects Undergoing Elective Total Knee Replacement.

Completed· Bayer logo

Bayer·Phase 3·NCT00361894·2,531 enrolled

Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00643201·5,614 enrolled

Re-STOP DVT: Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users

Unknown status·HHallym University Medical Center·Phase 4·NCT01063426·180 enrolled

Show 1 more trial

Identification and Treatment of Clinically Silent Catheter-Related Deep Vein Thrombosis in Children With Cancer

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT00633061·136 enrolled

Stroke3 trials

Enoxaparin and/or Minocycline in Acute Stroke

Terminated·NNYU Langone Health·N/A·NCT00836355·6 enrolled

Enoxaparin Versus Aspirin in Patients With Cancer and Stroke

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT01763606·20 enrolled

Study of the Efficacy, Safety and Tolerability of Low Molecular Weight Heparin vs. Unfractionated Heparin in Stroke

Unknown status·SShiraz University of Medical Sciences·Phase 2·NCT02159287·80 enrolled

Pancreatic Cancer3 trials

Chemotherapy With or Without Enoxaparin in Pancreatic Cancer

Completed·CCONKO-Studiengruppe·Phase 2/3·NCT00785421·312 enrolled

Docetaxel and Liposomal Doxorubicin Chemotherapy With Enoxaparin in Patients With Advanced Pancreatic Cancer

Terminated·UUniversity of Iowa·Phase 2·NCT00426127·2 enrolled

PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Participants With Stage IV Untreated Pancreatic Cancer

Completed·HHalozyme Therapeutics·Phase 2·NCT01839487·279 enrolled

Percutaneous Coronary Intervention3 trials

The STREAM Percutaneous Coronary Intervention Anticoagulant Sub-study

Completed·RRobert Welsh·Phase 3·NCT00882635·44 enrolled

Prolonged Enoxaparin in Primary Percutaneous Coronary Intervention

Completed·SSheffield Teaching Hospitals NHS Foundation Trust·Phase 4·NCT03568838·100 enrolled

Prolonged Enoxaparin In Primary Percutaneous Coronary Intervention; A Pilot Pharmacodynamic Study

Completed·SSheffield Teaching Hospitals NHS Foundation Trust·Phase 4·NCT03146858·22 enrolled

Pregnant Women3 trials

Use of Warfarin After the First Trimester in Pregnant Women With APS

Unknown status·MMohamed Sayed Abdelhafez·Phase 4·NCT02303171·100 enrolled

Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial

Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT02600260·7,212 enrolled

Timing of Initiation of LMWH Administration in Pregnant Women With APS

Completed·MMohamed Sayed Abdelhafez·Phase 4·NCT02326051·100 enrolled

Pregnancy3 trials

Effect of Low Molecular Heparin on Pregnancy Outcome With Protein S Deficiency

Not yet recruiting·PPeking University People's Hospital·Phase 2·NCT06531525·48 enrolled

Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome

Completed·HHaEmek Medical Center, Israel·N/A·NCT01068795·144 enrolled

Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI

Unknown status·—·Phase 4·NCT02696330·150 enrolled

Venous thrombosis3 trials

Comparison of Subcutaneous Heparin and Enoxaparin for Deep Venous Thrombosis (DVT) Prophylaxis in Surgical Intensive Care Patients

Withdrawn·LLisa Louwers·N/A·NCT01325779

Enoxaparin in Children With Asymptomatic Venous Thrombosis After Pediatric Cardiac Surgery

Withdrawn·TThe Hospital for Sick Children·Phase 3·NCT01474902

Efficacy of Apixaban in Malignancy With Deep Venous Thrombosis

Unknown status·—·Phase 3·NCT04462003·100 enrolled

Anticoagulant3 trials

Comparative Analysis of Injectable Anticoagulants for Thromboprophylaxis Post Cancer-related Surgery

Completed· GSK logo

GSK··NCT01444612·4,068 enrolled

Variability of Whole Blood Clotting Time Measurements in Ex Vivo Human Blood Samples Spiked With Anticoagulants

Completed·AAMAG Pharmaceuticals, Inc.··NCT03296982·12 enrolled

Effects of VMX-C001 on the Anticoagulant Effect of Different Forms of Heparin

Active, not recruiting·VVarmX B.V.·Phase 1·NCT06517563·16 enrolled

Brain Injury2 trials

Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1·NCT01014403·62 enrolled

The Use of Low Molecular Weight Heparin in Traumatic Brain Injury

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT00170378·300 enrolled

Bariatric Surgery2 trials

Thromboprophylaxis and Bariatric Surgery

Unknown status·UUniversity Hospital, Strasbourg, France·Phase 4·NCT00444652·300 enrolled

Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study

Unknown status·MMansoura University·Phase 1/2·NCT02128178·700 enrolled

Hip Replacement Surgery2 trials

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00423319·5,407 enrolled

A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery

Completed· Astellas logo

Astellas·Phase 2/3·NCT00902928·1,992 enrolled

Complication2 trials

Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy

Completed·HHospital Universitari Vall d'Hebron Research Institute·Phase 3·NCT01388322·361 enrolled

Preventing COVID-19 Complications With Low- and High-dose Anticoagulation

Terminated·UUniversity Hospital, Geneva·Phase 3·NCT04345848·160 enrolled

Pneumonia2 trials

Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection

Unknown status·MMassimo Girardis·Phase 3·NCT04528888·210 enrolled

High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy

Unknown status·AAzienda Ospedaliero-Universitaria di Modena·Phase 3·NCT04408235·300 enrolled

Growth2 trials

Impact of Enoxaparin Therapy on Fetal Outcomes in Intrauterine Growth Restriction

Not yet recruiting·MMuhammad Aamir Latif·N/A·NCT07462182·108 enrolled

Low-molecular-weight Heparin in Constituted Vascular Intrauterine Growth Restriction

Completed·—·Phase 3·NCT02672566·82 enrolled

Knee Surgery2 trials

Evaluation of PD 0348292 for Preventing Blood Clots in the Lungs or Deep Leg Veins of Patients After Knee Surgery

Completed· Pfizer logo

Pfizer·Phase 2·NCT00306254·1,225 enrolled

RE-MODEL Dabigatran Etexilate 150mg or 220mg Once Daily (o.d.) Versus (v.s.) Enoxaparin 40mg o.d. for Prevention of Thrombosis After Knee Surgery

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00168805·2,101 enrolled

TED2 trials

Etude (Study) Phase I Enox - UnFractionated Heparin (UFH)

Completed· Sanofi logo

Sanofi·Phase 1·NCT00622115·72 enrolled

Pilot Feasibility and Safety of Administering Weight Adjusted Fixed LMWH Dose

Unknown status·HHamilton Health Sciences Corporation·Phase 3·NCT02486666·20 enrolled

Prevention2 trials

Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)

Completed·PPortola Pharmaceuticals·Phase 3·NCT01583218·7,513 enrolled

Study of Apixaban for the Prevention of Thrombosis-related Events in Patients With Acute Medical Illness

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 3·NCT00457002·6,758 enrolled

Pilot Study2 trials

LV Thrombus Pilot Study for Comparing Enoxaparin Vs. Warfarin

Completed·CCorewell Health East·N/A·NCT00321009·60 enrolled

OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage - Pilot Study

Unknown status·MMcMaster University·N/A·NCT02260908·300 enrolled

Acute Myocardial Infarction2 trials

A Trial on Efficacy and Safety of Full Dose Tenecteplase Combined With Unfractionated Heparin (UFH) or Enoxaparin in Acute Myocardial Infarction (AMI) in the Prehospital Setting

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02181998·1,606 enrolled

Full Dose Tenecteplase (TNK-tPA) Together With Heparin Sodium, Full Dose Tenecteplase With Enoxaparin, Half Dose Tenecteplase Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction (AMI)

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02181985·5,989 enrolled

Orthopedic2 trials

Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures

Terminated·VValleywise Health·Phase 4·NCT05081375·6 enrolled

Echo-Doppler Assessment of the Occurrence of Asymptomatic DVT in Orthopedic Replacement Surgery Under Enoxaparin

Completed·LLes Laboratoires des Médicaments Stériles·Phase 4·NCT01354704·153 enrolled

Efficacy and Safety2 trials

Efficacy and Safety for Different Regimen of VTE Pharmacoprophylaxis Among Severely Burn Patients

Completed·KKing Abdullah International Medical Research Center·N/A·NCT05237726·20 enrolled

A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA

Recruiting·SSirius Therapeutics Co., Ltd.·Phase 2·NCT07140523·450 enrolled

Factor Xa Inhibitor1 trial

Factor Xa Inhibitor, PRT054021, Against Enoxaparin for the Prevention of Venous Thromboembolic Events (EXPERT)

Completed·PPortola Pharmaceuticals·Phase 2·NCT00375609·215 enrolled

Thrombocytopenia1 trial

STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis

Recruiting·TTzu-Fei Wang·Phase 4·NCT05255003·50 enrolled

Obesity1 trial

Enoxaparin Dosing in Obesity

Completed·EEmory University·Phase 4·NCT01798550·62 enrolled

Toxicity1 trial

Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity

Completed·UUniversity of Magdeburg·Phase 2·NCT01149304·22 enrolled

Ovarian Cancer1 trial

Pilot Study of Rosuvastatin and Enoxaparin Thromboprophylaxis Following Ovarian Cancer Surgery (O-STAT Study)

Completed·—·Phase 2·NCT03532139·24 enrolled

Venous Thromboembolic Disease1 trial

Enoxaparin in Acute Venous Thromboembolic Disease

Completed· Sanofi logo

Sanofi·Phase 4·NCT00265993·251 enrolled

Myocardial Infarction1 trial

STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00623623·1,899 enrolled

Rivaroxaban1 trial

Comparative Efficacy of Rivaroxaban and Enoxaparin in Post-Laparotomy DVT Prevention

Recruiting·—·Phase 4·NCT07243080·212 enrolled

Morbid Obesity1 trial

Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT01970202·55 enrolled

Prevention of Thromboembolic Events1 trial

Prevention of Thromboembolic Events in Total Knee Replacement Patients

Withdrawn· Novartis logo

Novartis·Phase 2·NCT03393481

Impaired Renal Function1 trial

Enoxaparin 20mg Versus 30mg Subcutaneously Once Daily in Elderly Patients With Impaired Renal Function

Completed·LLebanese American University·Phase 4·NCT03158792·32 enrolled

Laparoscopic1 trial

D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy

Not yet recruiting·GGeneral Committee of Teaching Hospitals and Institutes, Egypt·N/A·NCT06049758·80 enrolled

Abdominal Cancer Surgery1 trial

Japanese Efficacy and Safety Study of Enoxaparin in Patients With Curative Abdominal Cancer Surgery

Completed· Sanofi logo

Sanofi·Phase 3·NCT00723216·151 enrolled

Severe Acute Respiratory Syndrome1 trial

Nebulized Heparin in Severe Acute Respiratory Syndrome COVID-19

Unknown status·CClinica San Camilo, Argentina·Phase 4·NCT04530578·200 enrolled

Staphylococcus Aureus1 trial

Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT01911624·94 enrolled

Ischemia1 trial

Ischemia Driven Enoxaparin Therapy in ACS Presenting as Low Risk (IDEAL)

Terminated·—·Phase 4·NCT00518245·11 enrolled

Cataract1 trial

Clinical Trial on Anti-inflammatory Effect of Low-Molecular Weight Heparin in Pediatric Cataract Surgery

Completed·IIladevi Cataract and IOL Research Center·Phase 4·NCT00986076·23 enrolled

Esophageal Cancer1 trial

Overall Survival of Inoperable Gastric/GastroOesophageal Cancer Subjects on Treating With LMWH + Chemotherapy(CT) vs Standard CT

Completed·—·Phase 3·NCT00718354·740 enrolled

Cancer1 trial

Comparison of Two Different Dosages of Low-molecular Weight Heparin in Cancer Patients

Completed·MMedical University of Vienna·Phase 3·NCT00375076

Echocardiography1 trial

Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)

Completed·TThe Cleveland Clinic·Phase 4·NCT00289042·200 enrolled

Anti-Xa Activity1 trial

Residual Anti-Xa Activity After Last Treatment Dose of Enoxaparin

Terminated·WWake Forest University Health Sciences·Phase 4·NCT03296033·122 enrolled

Adult1 trial

A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants

Completed· Regeneron logo

Regeneron·Phase 2·NCT06454630·179 enrolled

Portal vein thrombosis1 trial

Compare the Efficacy and Safety of Dabigatran and Enoxaparin in Patients With Portal Vein Thrombosis With Cirrhosis

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·Phase 2/3·NCT06818279·120 enrolled

Chronic Kidney Disease1 trial

The Effect of Prophylactic Anticoagulation on Major Bleeding Events in Hospitalized Chronic Kidney Disease and Lower Limb Fracture Patients.

Completed·HHospital Civil de Guadalajara·Phase 2·NCT06795698·61 enrolled

Catheter Infection1 trial

Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients

Recruiting·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT03083184·400 enrolled

Ischemic stroke1 trial

Edoxaban for the Treatment of Coagulopathy in Patients With Active Cancer and Acute Ischemic Stroke: a Pilot Study. (ENCHASE Study)

Unknown status·SSamsung Medical Center·Phase 2/3·NCT03570281·40 enrolled

Mortality1 trial

Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin

Completed· Sanofi logo

Sanofi·Phase 4·NCT00622648·8,329 enrolled

Direct Oral Anticoagulants (DOACs)1 trial

Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer

Completed·AAlliance Foundation Trials, LLC.·N/A·NCT02744092·811 enrolled

Islet Transplantation1 trial

B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure

No longer available·NNational Institute of Allergy and Infectious Diseases (NIAID)··NCT01049633

Psoriasis1 trial

Low-Dose Enoxaparin in Psoriasis

Not yet recruiting·ZZagazig University·N/A·NCT06416566·30 enrolled

Fetal Growth Restriction1 trial

LMWH for Treatment of Early Fetal Growth Restriction (HepaGrowth)

Enrolling by invitation·—·Phase 3·NCT04762992·12 enrolled

Hip Fracture1 trial

Japanese Safety and Efficacy Study of Enoxaparin in Patients With Hip Fracture Surgery

Completed· Sanofi logo

Sanofi·Phase 3·NCT00685958·54 enrolled

Intensive Care1 trial

Pharmacokinetics of Enoxaparin in Intensive Care Patients

Completed·TTampere University Hospital·Phase 4·NCT02095509·39 enrolled

Intracerebral Hemorrhage1 trial

Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage

Unknown status·UUniversity of Oulu·Phase 4·NCT00699465·320 enrolled

End Stage Renal Disease (ESRD)1 trial

A Study to Evaluate Safety of Single Doses of BMS-986177 in Patients With End Stage Renal Disease (ESRD) Treated With Hemodialysis

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1/2·NCT03000673·32 enrolled

Breast Reconstruction1 trial

Apixaban vs Enoxaparin Following Microsurgical Breast Reconstruction-An RCT

Completed·SStanford University·Phase 1/2·NCT04504318·82 enrolled

In Vitro Fertilization1 trial

Effect of Prophylatic Use of Enoxaparin in Women Undergoing in Vitro Fertilization Treatment

Completed·FFaculdade de Medicina do ABC··NCT05225155·104 enrolled

Phase II1 trial

ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial

Completed· Bayer logo

Bayer·Phase 2·NCT00839826·641 enrolled

Heart Attack1 trial

Which Therapy for Acute Heart Attacks? (The WEST Study)

Completed·UUniversity of Alberta·Phase 2/3·NCT00121446·300 enrolled

Atrial Fibrillation1 trial

Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Nonvalvular Atrial Fibrillation (NVAF)

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 3·NCT02072434·2,199 enrolled

Coronary Artery Bypass1 trial

: Pharmacokinetics of Enoxaparin After Coronary Artery Bypass Graft Surgery

Completed·TTampere University Hospital·Phase 4·NCT02474212·85 enrolled

Ultrasound1 trial

Feasibility of ExAblate MRI Guided High Intensity Focused Ultrasound Tx of Soft Tissue Tumors

Terminated·PPejman Ghanouni·N/A·NCT01965002·5 enrolled

Thromboembolism1 trial

Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Elective Knee Replacement Surgery

Completed· Sanofi logo

Sanofi·Phase 3·NCT00718224·1,150 enrolled

Intravenous Administration1 trial

Single Intravenous Administration of TB-402 for the Prophylaxis of Venous Thromboembolic Events (VTE) After Total Knee Replacement Surgery

Completed·TThromboGenics·Phase 2·NCT00793234·316 enrolled

Head and Neck Cancer1 trial

Apixaban or Enoxaparin After Head and Neck Cancer Surgery

Recruiting·KKiranya Arnold·Phase 4·NCT07189897·76 enrolled

Coronary Artery Disease1 trial

Effects of Low Molecular Weight Heparin Versus Dabigatran on Platelet Aggregation in Patients With Stable Coronary Artery Disease

Completed·UUniversity of Sao Paulo General Hospital·Phase 4·NCT02389582·29 enrolled

Obese Patients1 trial

Adjusted Value of Thromboprophylaxis in Hospitalized Obese Patients: A Comparative Study of Two Regimens of Enoxaparin

Completed·UUniversity Hospital, Rouen·Phase 3·NCT01707732·92 enrolled

Intravenous1 trial

STEMI Treated With Primary Angioplasty and Intravenous Lovenox or Unfractionated Heparin (UFH)

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00718471·910 enrolled

Diffuse Large B-Cell Lymphoma1 trial

Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT02589145·8 enrolled

Metabolism1 trial

Enoxaparin Metabolism in Reconstructive Surgery Patients

Completed·UUniversity of Utah·Phase 2·NCT02411292·110 enrolled

Unspecified2 trials

Patients Preference With Self-Injection: The PRISM Study

Completed·HHamilton Health Sciences Corporation·Phase 4·NCT00253396·100 enrolled

Michelangelo - Oasis 5

Completed· GSK logo

GSK·Phase 3·NCT00139815·20,078 enrolled

Regulatory