Avastin

PreclinicalSmall molecule

Avastin is one of 81 small molecule programs targeting Proliferative Diabetic Retinopathy. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Proliferative Diabetic RetinopathyActive, not recruiting

Neovascular GlaucomaActive, not recruiting

Uveal MelanomaActive, not recruiting

Retinal Vein OcclusionActive, not recruiting

Diabetic Macular EdemaActive, not recruiting

Diabetic RetinopathyActive, not recruiting

Proliferative Diabetic RetinopathyPreclinical

Active, not recruiting

Neovascular GlaucomaPreclinical

Active, not recruiting

Uveal MelanomaPreclinical

Active, not recruiting

Retinal Vein OcclusionPreclinical

Active, not recruiting

Diabetic Macular EdemaPreclinical

Active, not recruiting

Diabetic RetinopathyPreclinical

Active, not recruiting

Competition

Competitive Landscape

32 competitors in Diabetic Retinopathy

#DrugCompanyPhaseTrials

Precose

Bayer

Approved

1 2

Avapro

Sanofi

Approved

1 3

Farxiga

Tricor

3 5

EGRIFTA WR

TTheratechnologies

Approved

1 6

Xalatan

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 7

Kenalog

BBassett Healthcare

Approved

—8

Rapamune

PPrism Pharmaceuticals

Approved

—9

Decadron

AAspen Global Incorporated

Approved

—10

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Non-Small Cell Lung Cancer7 trials

Efficacy and Safety of QL1101 and Avastin® Respectively Combined With Paclitaxel and Carboplatin in the First-line Treatment of Non-squamous Non-small Cell Lung Cancer

Completed· Qilu Pharmaceutical Co., Ltd. logo

Qilu Pharmaceutical Co., Ltd.·Phase 3·NCT03169335·535 enrolled

To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in Study of QL1101 and Avastin® in Patients With Non-squamous Non-small Cell Lung Cancer

Unknown status· Qilu Pharmaceutical Co., Ltd. logo

Qilu Pharmaceutical Co., Ltd.··NCT03195569·15 enrolled

A Study Exploring Efficacy of SIBP04 in Subjects With Non-squamous Non-small Cell Lung Cancer

Completed·SShanghai Institute Of Biological Products·Phase 3·NCT05318443·512 enrolled

Show 4 more trials

To Compare Efficacy and Safety of CT-P16 and European Union-Approved Avastin as First-Line Treatment for Metastatic or Recurrent Non-Squamous Non-Small Cell Lung Cancer

Completed·CCelltrion·Phase 3·NCT03676192·689 enrolled

A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)

Completed· Roche logo

Roche·Phase 2·NCT00095225·122 enrolled

Evaluation of FKB238 and Avastin in Patients With Advanced/Recurrent Non-squamous Non-small Cell Lung Cancer

Completed·CCentus Biotherapeutics Limited·Phase 3·NCT02810457·731 enrolled

Lower Dose Chemotherapy Given More Frequent With Avastin to Treat Advanced Non-Squamous Non-Small Cell Lung Cancer

Completed·UUniversity of Alabama at Birmingham·Phase 2·NCT00655850·39 enrolled

Metastatic Colorectal Cancer5 trials

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02776683·123 enrolled

A Randomized Trial of Avastin + Gemcitabine + 5-Fluorouracil (5FU)/Folinic Acid Versus Avastin + Oxaliplatin + 5FU/Folinic Acid in Metastatic Colorectal Cancer

Completed· Eli Lilly logo

Eli Lilly·Phase 2·NCT00192075·84 enrolled

A Study to Evaluate Avastin in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer

Completed· Roche logo

Roche·Phase 2·NCT00109226

Show 2 more trials

A Study to Compare Two Avastin-Based Treatment Regimens for the Treatment of Metastatic Colorectal Cancer

Terminated· Roche logo

Roche·Phase 4·NCT00114946·800 enrolled

A Study of Xeloda (Capecitabine) in Combination With Oxaliplatin in Patients With Metastatic Colorectal Cancer.

Completed· Roche logo

Roche·Phase 1·NCT00353262·36 enrolled

Breast Cancer4 trials

Predicting Response and Toxicity in Patients Receiving Paclitaxel and Avastin for Breast Cancer

Terminated·HHoosier Cancer Research Network··NCT00537173·11 enrolled

Carboplatin, Abraxane, Avastin as Neoadjuvant Therapy for Her2-Negative Breast Cancer

Completed·WWilliam Sikov MD·Phase 2·NCT00723125·60 enrolled

Abraxane, Avastin, and Gemcitabine as First-Line Therapy for Patients With Metastatic Breast Cancer

Completed·UUniversity of Miami·Phase 2·NCT00503906·30 enrolled

Show 1 more trial

A Study of Biweekly Gemcitabine, Paclitaxel, and Avastin in Patients With Metastatic Breast Cancer

Completed·BBarbara Ann Karmanos Cancer Institute·Phase 2·NCT00618826·14 enrolled

Bevacizumab3 trials

Study of Avastin (Bevacizumab) to Reverse Acquired Estrogen Independence in Previously Hormone Responsive Metastatic Breast Ca.

Completed·UUniversity of Alabama at Birmingham·Phase 2·NCT00240071·30 enrolled

A Pharmacokinetic Study Comparing PF-06439535 And Bevacizumab In Healthy Male Volunteers (REFLECTIONS B739-01)

Completed· Pfizer logo

Pfizer·Phase 1·NCT02031991·102 enrolled

Bioequivalence and Safety Study of Bevacizumab-biosimilar (RPH-001) Compared to Bevacizumab-innovator

Withdrawn·TTRPHARM·Phase 1·NCT03131700

Lymphoma3 trials

Avastin (Bevacizumab) Plus Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) for Advanced Stage Hodgkin Lymphoma

Terminated·MMassachusetts General Hospital·Phase 2·NCT00722865·25 enrolled

Avastin+ GemAOD As First-Line Treatment in NK/T Cell Lymphoma

Unknown status·SSun Yat-sen University·Phase 2·NCT01921790·30 enrolled

Avastin Plus Rituximab for Patients With B-Cell Non-Hodgkin's Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00081861·13 enrolled

47 more indications

Ovarian Cancer3 trials

Study of Bevacizumab/Doxil in Treatment of Platinum-Resistant/Refractory Ovarian Cancer (CA)

Completed·NNew Mexico Cancer Research Alliance·Phase 2·NCT00945139·46 enrolled

Study of Bevacizumab Followed by Bevacizumab Consolidation for Ovarian Cancer

Completed·UUniversity of Oklahoma·Phase 2·NCT00511992·20 enrolled

Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer (MK-4830-002)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT05446870·160 enrolled

Glioblastoma Multiforme3 trials

Gliadel, XRT, Temodar, Avastin Followed by Avastin, Temodar for Newly Diagnosed Glioblastoma Multiforme (GBM)

Terminated·—·Phase 2·NCT01186406·41 enrolled

Bevacizumab (Avastin) Into the Tumor Resection Cavity in Subjects With Glioblastoma Multiforme at First Recurrence

Terminated·BBrain & Spine Surgeons of New York·Phase 1·NCT01526837·1 enrolled

Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Completed·KKaty Peters·Phase 2·NCT00979017·41 enrolled

Diabetic Macular Edema2 trials

Analysis of Growth Factors in Patients Undergoing Lucentis or Avastin Injections for Diabetic Macular Edema and Exudative Macular Degeneration

Completed·VVitreo-Retinal Associates, Michigan·N/A·NCT01473251·16 enrolled

Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema

Completed·AAllegro Ophthalmics, LLC·Phase 2·NCT02348918·218 enrolled

Macular Degeneration2 trials

TAC-PF, Avastin® in Combination With Photodynamic Therapy to Treat Age Related Macular Degeneration

Terminated·NNational Eye Institute (NEI)·Phase 2·NCT00464347·100 enrolled

Pilot Study to Evaluate the Safety and Efficacy of Treatment With ORA102 Combined With Avastin (Bevacizumab) Versus Avastin Alone, in Patients With Neovascular Age Related Macular Degeneration (AMD)

Unknown status·OOra Bio Ltd.·Phase 1/2·NCT00745511·96 enrolled

Lung Cancer2 trials

Avastin and Tarceva for Locally Advanced or Metastatic Non-Squamous Non-Small-Cell Lung Cancer

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00043823·41 enrolled

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT02272413·671 enrolled

Malignant Glioma2 trials

AMG 102 and Avastin for Recurrent Malignant Glioma

Completed·KKaty Peters·Phase 2·NCT01113398·36 enrolled

Phase II Avastin + Bortezomib for Patients With Recurrent Malignant Glioma

Completed·—·Phase 2·NCT00611325·56 enrolled

Retinal Vein Occlusion2 trials

Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion

Completed·MMaturi, Raj K., M.D., P.C.·Phase 4·NCT01085734·30 enrolled

Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)

Completed·LLong Island Vitreoretinal Consultants·N/A·NCT01231633·27 enrolled

Immunogenicity2 trials

Pharmacokinetic Characteristics, Safety, Tolerability and Immunogenicity of LY01008 and Avastin in Healthy Chinese Male Subjects

Completed·SShandong Boan Biotechnology Co., Ltd·Phase 1·NCT05110118·112 enrolled

Compare IBI305 and Bevacizumab on Pharmacokinetics/Safety/Immunogenicity on Healthy Male

Completed· Innovent Biologics (Suzhou) Co. Ltd. logo

Innovent Biologics (Suzhou) Co. Ltd.·Phase 1·NCT03083990·100 enrolled

Safety and Efficacy2 trials

A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival

Completed·RReza Dana, MD·Phase 1/2·NCT01996826·75 enrolled

Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival

Completed·RReza Dana, MD·Phase 1/2·NCT01072357·30 enrolled

Chemoradiation2 trials

Preop Chemoradiation Resectable Pancreas

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00336648·11 enrolled

Neoadjuvant Chemoradiation With RHUMAB VEGF (Avastin) for Rectal Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00113230·25 enrolled

Cancer2 trials

A Study to Evaluate Avastin in Patients Treated in a Previous Genentech-Sponsored Cancer Study

Completed· Roche logo

Roche·Phase 3·NCT00096967·100 enrolled

An Extension Study to Evaluate Avastin in Patients Treated in a Previous Genentech-Sponsored Cancer Study

Completed· Roche logo

Roche·Phase 2·NCT00109057·56 enrolled

Colorectal Cancer2 trials

A Study to Evaluate Avastin in Combination With Standard Chemotherapy to Treat Colorectal Cancer

Completed· Roche logo

Roche·Phase 3·NCT00109070

Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal Cancer

Terminated·HHellenic Oncology Research Group·Phase 2·NCT00681876·16 enrolled

Age-Related Macular Degeneration2 trials

Combination Therapy for Age-Related Macular Degeneration.

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2·NCT00376701·103 enrolled

An Open-Label Investigator Sponsored Trial to Investigate the Safety, Tolerability and Development of Subfoveal Fibrosis By Intravitreal Administration of Altering Regimens of Fovista and Anti-VEGF Therapy in Subjects With Neovascular Age-Related Macular Degeneration

Completed·RRetinal Consultants of Arizona·Phase 1·NCT02591914·30 enrolled

Gliosarcoma1 trial

Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas

Completed·—·Phase 2·NCT00612339·41 enrolled

HIES1 trial

Intravitreal Avastin in Proliferative Retinopathies

Completed·OOphthalmological Association Edelweiss·Phase 2·NCT00564148·100 enrolled

Neoadjuvant Chemotherapy1 trial

Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00506155·60 enrolled

Biomarkers1 trial

Profile of Soluble and Cellular Biomarkers and of Functional Imaging During Antiangiogenic Therapies in Cancer Patients

Terminated·MMedical University Innsbruck··NCT01507740·60 enrolled

Unknown status·UUniversity Medical Center Groningen·Phase 2·NCT05745857·25 enrolled

Melanoma1 trial

Abraxane and Avastin as Therapy for Patients With Malignant Melanoma, a Phase II Study

Completed·—·Phase 2·NCT00462423·50 enrolled

Fluorouracil1 trial

Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00507585·63 enrolled

Tics1 trial

A Study to Compare the Pharmacokinetics and Safety of QL1101 and EU-Avastin® in Healthy Volunteers

Completed· Qilu Pharmaceutical Co., Ltd. logo

Qilu Pharmaceutical Co., Ltd.·Phase 1·NCT06232902·84 enrolled

Hemangioblastoma1 trial

Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease

Terminated·—·Phase 1·NCT01015300·1 enrolled

Neovascular AMD1 trial

Safety Study of Zimura in Combination With Anti-VEGF Therapy in Patients With Neovascular AMD

Terminated·UUnknown Sponsor·Phase 2·NCT05571267·1 enrolled

Locally Advanced1 trial

Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00609765·1 enrolled

Gemcitabine1 trial

Cisplatin/Paclitaxel/Gemcitabine +/- Avastin in Patients With Unknown Primary Tumor

Withdrawn·RRigshospitalet, Denmark·Phase 2·NCT00458315

First-line Treatment1 trial

Bioequivalence Study Bevacizumab Biosimilar (BEVZ92) Versus Bevacizumab (AVASTIN®) in First-line Treatment mCRC Patients

Completed·MmAbxience Research S.L.·Phase 1·NCT02069704·142 enrolled

Papilloma1 trial

Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP)

Completed·MMassachusetts General Hospital·Phase 1·NCT01020747·20 enrolled

Renal Cell Carcinoma1 trial

A Study Evaluating Tarceva in Combination With Avastin Versus Avastin Alone in Treating Metastatic Renal Cell Carcinoma

Completed· Roche logo

Roche·Phase 2·NCT00081614·100 enrolled

Proliferative Diabetic Retinopathy1 trial

Avastin for PDR (Proliferative Diabetic Retinopathy)

Completed·UUniversity of Southern California·N/A·NCT01270542·20 enrolled

Diabetic Retinopathy1 trial

Effect of Intravitreal Bevacizumab on Focal Edema With Hard Exudates Secondary to Diabetic Retinopathy

Unknown status·SSeoul St. Mary's Hospital·N/A·NCT01422018·10 enrolled

Pancreatic Cancer1 trial

QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer

Withdrawn·NNantPharma, LLC·Phase 1/2·NCT03127124

Clinical Trial1 trial

Intravitreal Bevasizumab VS Sham Treatment in Acute BRVO: A Randomized Clinical Trial

Completed·SShahid Beheshti University of Medical Sciences·Phase 3·NCT00370851·82 enrolled

Pancreas Cancer1 trial

Efficacy of Neoadjuvant Chemoradiation for Potentially Resectable Pancreas Cancer

Completed·AAmer Zureikat·Phase 2·NCT00557492·59 enrolled

Diabetic Macular Oedema1 trial

Trial of Switching Between Intravitreal Bevacizumab (Avastin®)& Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema

Completed·UUniversity of Sydney·Phase 2·NCT01787669·19 enrolled

Chemotherapy1 trial

Avastin in Combination With Chemotherapy for RAS Mutant Unresectable Colorectal Liver-limited Metastases

Completed·XXu jianmin·Phase 4·NCT01972490·241 enrolled

Glioblastoma1 trial

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Completed·—·Phase 2·NCT00597402·125 enrolled

Neuroendocrine Carcinoma1 trial

Avastin (Bevacizumab) and RAD001 (Everolimus) in Advanced Low or Intermediate Grade Neuroendocrine Carcinoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00607113·41 enrolled

Ovarian Carcinoma1 trial

Pilot Study of Taxol, Carboplatin, and Bevacizumab in Advanced Stage Ovarian Carcinoma Patients

Completed·GGynecologic Oncology Associates·Phase 2·NCT00127920·20 enrolled

Pancreatic Adenocarcinoma1 trial

Phase I/II Trial of Radiation, Avastin and Tarceva for Pancreatic Adenocarcinoma

Completed·—·Phase 1·NCT00735306·12 enrolled

Gastroesophageal Junction1 trial

Erlotinib and Avastin in Patients With Cancer of the Esophagus or Gastroesophageal Junction

Terminated·WWashington University School of Medicine·Phase 2·NCT00442507·6 enrolled

Fallopian Tube1 trial

Avastin in Combination With Docetaxel in Ovarian/Fallopian Tube/Peritoneum Carcinoma

Completed·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00504257·45 enrolled

Uveal Melanoma1 trial

Treatment With Intravitreal Avastin for Large Uveal Melanomas

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT00596362·1 enrolled

Recurrent1 trial

Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers

Completed·—·Phase 2·NCT00545792·21 enrolled

Intraperitoneal1 trial

Intraperitoneal Paclitaxel and Carboplatin With IV Avastin Therapy in Patients With Carcinomas of Mullerian Origin

Unknown status·MMassachusetts General Hospital·Phase 1·NCT00652119·46 enrolled

Unspecified3 trials

Pharmacokinetic Equivalence and Safety Study of RPH-001 and Avastin®

Completed·RR-Pharm·Phase 1·NCT03659305·80 enrolled

French Evaluation Group Avastin Versus Lucentis

Completed·HHospices Civils de Lyon·Phase 3·NCT01170767·501 enrolled

A Phase I, Double-blind, Randomised, Single-dose, Parallel Group Study to Demonstrate the Equivalent Pharmacokinetic Properties of a Single Intravenous Dose of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects

Completed·PPrestige Biopharma Limited·Phase 1·NCT03390673·119 enrolled

Sources

References

[1]
ClinicalTrials.gov — 86 trial records for Avastin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Avastin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Avastin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Roche company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: Roche

Avastin

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Non-Small Cell Lung Cancer7 trials

Metastatic Colorectal Cancer5 trials

Breast Cancer4 trials

Bevacizumab3 trials

Lymphoma3 trials

Ovarian Cancer3 trials

Glioblastoma Multiforme3 trials

Diabetic Macular Edema2 trials

Macular Degeneration2 trials

Lung Cancer2 trials

Malignant Glioma2 trials

Retinal Vein Occlusion2 trials

Immunogenicity2 trials

Safety and Efficacy2 trials

Chemoradiation2 trials

Cancer2 trials

Colorectal Cancer2 trials

Age-Related Macular Degeneration2 trials

Gliosarcoma1 trial

HIES1 trial

Neoadjuvant Chemotherapy1 trial

Biomarkers1 trial

Neovascular Glaucoma1 trial

Doxorubicin1 trial

Esophageal Adenocarcinoma1 trial

Melanoma1 trial

Fluorouracil1 trial

Tics1 trial

Hemangioblastoma1 trial

Neovascular AMD1 trial

Locally Advanced1 trial

Gemcitabine1 trial

First-line Treatment1 trial

Papilloma1 trial

Renal Cell Carcinoma1 trial

Proliferative Diabetic Retinopathy1 trial

Diabetic Retinopathy1 trial

Pancreatic Cancer1 trial

Clinical Trial1 trial

Pancreas Cancer1 trial

Diabetic Macular Oedema1 trial

Chemotherapy1 trial

Glioblastoma1 trial

Neuroendocrine Carcinoma1 trial

Ovarian Carcinoma1 trial

Pancreatic Adenocarcinoma1 trial

Gastroesophageal Junction1 trial

Fallopian Tube1 trial

Uveal Melanoma1 trial

Recurrent1 trial

Intraperitoneal1 trial

Unspecified3 trials

References

Drug Info

Quick Facts

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