BCG vaccine

Phase 3Vaccine

GGynecologic Oncology Group

BCG vaccine is one of 150 biologic programs targeting Urinary Bladder Carcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

149

Competitors

Pipeline

Status by Indication[3][1]

Indication

Urinary Bladder CarcinomaUnknown

Adverse EffectActive, not recruiting

Hepatitis BActive, not recruiting

DiphtheriaEnrolling by invitation

Alzheimer's DiseaseEnrolling by invitation

PreventionActive, not recruiting

VaccinesRecruiting

Urinary Bladder CarcinomaPreclinical

Unknown

Adverse EffectPreclinical

Active, not recruiting

Hepatitis BPreclinical

Active, not recruiting

DiphtheriaPhase 3

Enrolling by invitation

Alzheimer's DiseasePhase 1

Enrolling by invitation

PreventionPhase 3

Active, not recruiting

VaccinesPhase 3

Recruiting

Competition

Competitive Landscape

59 competitors in Alzheimer's Disease

#DrugCompanyPhaseTrials

Aricept

Eisai

Approved

31 2

Leqembi

Eisai

Phase 3

7 3

Nuplazid

AACADIA Pharmaceuticals Inc.

Ozempic

3 5

Qalsody

Biogen

Phase 3

1 6

Namenda

AbbVie

Phase 2

2 7

Niacor

AbbVie

Phase 2

1 8

Briviact

UCB

Phase 2

1 9

Leukine

Sanofi

Phase 2

1 10

BCG vaccine

GGynecologic Oncology Group

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Post-ApprovalRecruiting

Vaccines

NCT04899765

Q4 2028

ApprovedRecruiting

Vaccine Response Impaired

NCT06148025

Q3 2029

Post-ApprovalActive, not recruiting

Prevention

NCT05591339

Clinical

Trials by Indication[1]

COVID-199 trials

Bacillus Calmette-guérin Vaccination to Prevent COVID-19

Completed·HHellenic Institute for the Study of Sepsis·Phase 4·NCT04414267·301 enrolled

Reducing COVID-19 Related Hospital Admission in Elderly by BCG Vaccination

Unknown status·RRadboud University Medical Center·Phase 4·NCT04417335·2,014 enrolled

Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine

Completed·UUMC Utrecht·Phase 3·NCT04328441·1,511 enrolled

Show 6 more trials

BCG Vaccine for Health Care Workers as Defense Against COVID 19

Completed·TTexas A&M University·Phase 4·NCT04348370·659 enrolled

The Role of BCG Vaccine in the Clinical Evolution of COVID-19 and in the Efficacy of Anti-SARS-CoV-2 Vaccines

Active, not recruiting·OOswaldo Cruz Foundation·Phase 3·NCT05507671·556 enrolled

BCG Vaccination to Protect Healthcare Workers Against COVID-19

Completed·MMurdoch Childrens Research Institute·Phase 3·NCT04327206·6,828 enrolled

Use of BCG Vaccine as a Preventive Measure for COVID-19 in Health Care Workers

Unknown status·UUniversidade Federal do Rio de Janeiro·Phase 2·NCT04659941·752 enrolled

BCG Against Covid-19 for Prevention and Amelioration of Severity Trial (BAC to the PAST)

Withdrawn·HHarvard Medical School (HMS and HSDM)·Phase 3·NCT04534803

Prevention, Efficacy and Safety of BCG Vaccine in COVID-19 Among Healthcare Workers

Unknown status·HHospital Universitario Dr. Jose E. Gonzalez·Phase 3·NCT04461379·908 enrolled

Bladder Cancer7 trials

Radiation Therapy, Chemotherapy, or Observation in Treating Patients With Bladder Cancer

Completed·MMedical Research Council·Phase 3·NCT00002490

BCG Plus Interferon Alfa 2b in Treating Patients With Bladder Cancer

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00004122

AD 32 With or Without BCG After Surgery in Treating Patients With Newly Diagnosed or Recurrent Superficial Bladder Cancer

Completed·AAnthra Pharmaceuticals·Phase 2·NCT00003759

Show 4 more trials

The Impact of Intravesical Gemcitabine and 1/3 Dose Bacillus Calmette-Guerin on the Quality of Life in Superficial Bladder Cancer

Completed·AA.O.U. Città della Salute e della Scienza·Phase 2·NCT01697306·120 enrolled

BCG With or Without Mitomycin in Treating Patients With Bladder Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT00023842·97 enrolled

BCG With or Without Gefitinib in Treating Patients With High-Risk Bladder Cancer

Terminated·NNCIC Clinical Trials Group·Phase 3·NCT00352079·41 enrolled

Surgery and BCG in Treating Patients With Bladder Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002990·1,288 enrolled

Vaccination2 trials

BCG Revaccination in Children and Adolescents

Suspended·TTuberculosis Research Centre, India·Phase 3·NCT05330884·9,200 enrolled

Safety and Tuberculin Conversion Following BCG Vaccination

Completed·PPT Bio Farma·Phase 2·NCT05124340·220 enrolled

Small Cell Lung Cancer2 trials

Monoclonal Antibody Therapy Plus BCG in Treating Patients With Limited-Stage Small Cell Lung Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00006352·453 enrolled

Vaccination Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003279·500 enrolled

Tuberculosis2 trials

Immunization With BCG Vaccine to Prevent Tuberculosis Infection

Terminated·HHenry M. Jackson Foundation for the Advancement of Military Medicine·Phase 3·NCT04453293·16 enrolled

Phase I/II Randomized, Placebo-Controlled Study of the Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against Tuberculosis in Pre-Adolescents Living With and Without HIV in South Africa

Withdrawn·IInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group·Preclinical·NCT05539989

19 more indications

Vaccines2 trials

Live Vaccines and Innate Immune Training in COPD.

Completed·JJosefin Eklöf·Phase 4·NCT06257212·60 enrolled

Measles and BCG Vaccines for Mother and Child

Recruiting·BBandim Health Project·Phase 4·NCT04899765·2,400 enrolled

Hepatitis B1 trial

A Trial Investigating the Influence of BCG and Hepatitis B Immunisation at Birth on Neonatal Immune Responses: The Early Life Vaccines and Immunity Study

Completed·MMurdoch Childrens Research Institute·N/A·NCT02444611·185 enrolled

Prostate Cancer1 trial

Vaccine Therapy in Treating Patients With Stage D0 Prostate Cancer

Unknown status·KKael-GemVax Co., Ltd.·Phase 2·NCT00514072·54 enrolled

Immune Response1 trial

Effects of BCG on Immune Response

Completed·RRadboud University Medical Center·Phase 2/3·NCT02085590·20 enrolled

Colon Cancer1 trial

Fluorouracil, Semustine, and Vincristine Compared With BCG in Treating Patients With Dukes' B or Dukes' C Colon Cancer That Has Been Removed By Surgery

Completed·NNSABP Foundation Inc·Phase 3·NCT00427570

Breast Cancer1 trial

Vaccine Therapy in Treating Women With Metastatic Breast Cancer

Completed·PProvidence Cancer Center, Earle A. Chiles Research Institute·Phase 1·NCT00003184

Diphtheria1 trial

BCG Revaccination With the Third Dose of Diphtheria-tetanus-pertussis Vaccine and Infant Mortality in Africa

Enrolling by invitation·BBandim Health Project·Phase 4·NCT07005726·6,000 enrolled

Monoclonal1 trial

Monoclonal Antibody A1G4 Plus BCG in Treating Patients With Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT00003023·24 enrolled

Stage III Colon Cancer1 trial

Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery

Completed·IIntracel·Phase 1/2·NCT00016133

Melanoma1 trial

Vaccine Therapy Compared With Interferon Alfa in Treating Patients With Stage III Melanoma

Terminated·AAVAX Technologies·Phase 2·NCT00003715·425 enrolled

Stage IV Ovarian Epithelial Cancer1 trial

Vaccine Therapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer

Terminated·GGynecologic Oncology Group·Phase 2·NCT00003386

Respiratory Infection1 trial

Prevention of Acute Respiratory Infection in Taiwanese Institutionalized Elderly

Withdrawn·HHarvard Medical School (HMS and HSDM)·Phase 2/3·NCT04938323

Bladder Carcinoma1 trial

Pilot Study of BC-819/PEI and BCG in Patients With Superficial Transitional Cell Bladder Carcinoma

Completed·AAnchiano Therapeutics Israel Ltd.·Phase 1·NCT01878188·38 enrolled

Prevention1 trial

Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau

Active, not recruiting·BBandim Health Project·Phase 4·NCT05591339·200 enrolled

Mortality1 trial

BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots

Completed·TTuberculosis Research Centre, India·Phase 3·NCT04475302·2,175 enrolled

Alzheimer's Disease1 trial

Does BCG Vaccination Reduce Biomarkers of Alzheimer's Disease?

Enrolling by invitation·TTamir Ben-Hur·Phase 1·NCT06078891·60 enrolled

Adverse Effect1 trial

BCG Vaccination Scar Formation in Children Under Five Years :Factors Affecting Its Formation and Subsequent Adverse Effects .

Unknown status·—·N/A·NCT03548233·100 enrolled

Metastatic Colorectal Cancer1 trial

Monoclonal Antibody Therapy and/or Vaccine Therapy in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer

Unknown status·OOnyvax·Phase 1/2·NCT00007826

Vaccine Response Impaired1 trial

A Human Experimental Medicine Study to Assess Whether the Gut Microbiota Regulates Specific and Non-specific Immune Responses to Vaccination

Recruiting·SSouth Australian Health and Medical Research Institute·Approved·NCT06148025·348 enrolled

Sources

References

[1]
ClinicalTrials.gov — 42 trial records for BCG vaccine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — BCG vaccine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for BCG vaccine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Gynecologic Oncology Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Vaccine[2]
Highest Phase: Phase 3[1]
Company: GGynecologic Oncology Group

BCG vaccine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q4 2028

Q3 2029

Trials by Indication[1]

COVID-199 trials

Bladder Cancer7 trials

Vaccination2 trials

Small Cell Lung Cancer2 trials

Tuberculosis2 trials

Vaccines2 trials

Hepatitis B1 trial

Prostate Cancer1 trial

Immune Response1 trial

Colon Cancer1 trial

Breast Cancer1 trial

Diphtheria1 trial

Monoclonal1 trial

Stage III Colon Cancer1 trial

Melanoma1 trial

Stage IV Ovarian Epithelial Cancer1 trial

Respiratory Infection1 trial

Bladder Carcinoma1 trial

Prevention1 trial

Mortality1 trial

Alzheimer's Disease1 trial

Adverse Effect1 trial

Metastatic Colorectal Cancer1 trial

Vaccine Response Impaired1 trial

References

Drug Info

Quick Facts

Related News