VivoSeq
Other

Adverse Effect

42

Pipeline Programs↗

3

Active Trials↗

20

Companies Involved↗

Adverse Effect is a moderately active landscape with 42 programs across 20 companies. The most active players are Vitae Pharmaceuticals Inc., an Allergan affiliate, Hikma Pharmaceuticals LLC, Pfizer's Upjohn has merged with Mylan to form Viatris Inc.. 13 therapies are approved with 1 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

6/100

Mech. Concentration

18/100

Completion Rate

84/100

Attrition Rate

9/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2H

Hikma Pharmaceuticals LLC

1 program

ApprovedP

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

ApprovedNovartis logo

Novartis

1 program

ApprovedS

Salix

1 program

ApprovedP

Protega

1 program

Approved

Pipeline

Programs by Phase

Analysis

Modality Breakdown

95%

Small molecule

42 of 44 classified programs — the dominant modality here.

5%ALL OTHERSProtein / enzyme12%Vaccine12%

Small molecule leads; the ring shows all 44 classified programs, each share of the total. Modality classified for 100% of 48 pipeline programs.

Analysis

Trial Status

32

clinical trials

Completed16 · 50%
Unknown status10 · 31%
Recruiting3 · 9%
Withdrawn2 · 6%
Terminated1 · 3%

Clinical Trials

Trial Activity

32 trials

Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects
Recruiting·—·N/A·NCT07264309·140 enrolled
Effect of Vitamin D Supplementation on the Efficacy and Adverse Effects of Neoadjuvant Therapy in Patients with Breast Cancer
Recruiting·—·N/A·NCT06642428·140 enrolled
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Recruiting·RRajaie Cardiovascular Medical and Research Center·N/A·NCT06541691·3,000 enrolled
New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects
Completed·SSociety for Applied Studies·Phase 4·NCT00490932·27,966 enrolled
Prophylactic TCM for Mitigation of EGFR-TKI Related Dermatological Adverse Effect
Completed·—·Phase 3·NCT05204758·30 enrolled
Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response.
Completed·HHadassah Medical Organization·N/A·NCT00421369·35 enrolled
Relationship Between Serum Vitamin D Levels and Musculoskeletal Adverse Effects in Patients Using Isotretinoin
Completed·—·N/A·NCT04204304·177 enrolled
Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection
Completed·UUniversity of Cincinnati·Phase 4·NCT00885664·60 enrolled
A Clinical Trial Evaluating the Role of Systemic Antihistamine Therapy in the Reduction of Adverse Effects Associated With Topical 5-aminolevulinic Acid Photodynamic Therapy
Completed·GGoldman, Butterwick, Fitzpatrick and Groff·N/A·NCT02451579·20 enrolled
Correlation of Genetic Polymorphism of Azathioprine Metabolizing Enzymes and Correlation to Clinical Adverse Effects
Completed·NNational Taiwan University Hospital·N/A·NCT00525473·166 enrolled
Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 mcg BID
Completed·—·Phase 4·NCT00235053·13 enrolled
Study of Adverse Effects Occuring in Patients Receiving an Antibiotic Treatment With Temocillin
Completed·—·N/A·NCT03599999·26 enrolled
A Study To Assess the Adverse Effects and Change in Condition of OnabotulinumtoxinA X Injection in Adult Participants With Forehead Lines
Completed·AbbVie logoAbbVie·Phase 2·NCT05152576·124 enrolled
Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients
Completed·—·Phase 4·NCT03582332·64 enrolled
Efficacy and Adverse Effects of Prapchompoothaweep Remedy and Loratadine for Treatment in AR Patients
Completed·TThammasat University·Phase 2·NCT03640273·72 enrolled
Page 1 of 3

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)