Calcium folinate

Phase 3Small molecule

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Calcium folinate is one of 285 small molecule programs targeting Gastroesophageal Junction Adenocarcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

284

Competitors

Pipeline

Status by Indication[3][1]

Indication

Gastroesophageal Junction AdenocarcinomaCompleted

Spastic ParaplegiaActive, not recruiting

Central Nervous System LymphomaActive, not recruiting

LymphomaRecruiting

OsteosarcomaActive, not recruiting

Intestinal CancerActive, not recruiting

AdenocarcinomaActive, not recruiting

Metastatic Colorectal CancerActive, not recruiting

Colorectal CancerActive, not recruiting

Pancreatic CancerActive, not recruiting

Gastroesophageal Junction AdenocarcinomaPhase 3

Completed

Spastic ParaplegiaPhase 1

Active, not recruiting

Central Nervous System LymphomaPhase 2

Active, not recruiting

LymphomaPhase 2

Recruiting

OsteosarcomaPhase 1/Phase 2

Active, not recruiting

Intestinal CancerPhase 1/Phase 2

Active, not recruiting

AdenocarcinomaPhase 3

Active, not recruiting

Metastatic Colorectal CancerPhase 2

Active, not recruiting

Colorectal CancerPhase 3

Active, not recruiting

Pancreatic CancerPhase 2

Active, not recruiting

Showing 10 of 11 indications

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

Calcium folinate

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

1 2

Blenoxane

SSequus Pharmaceuticals

Preclinical

25 3

Oncaspar

SServier

Preclinical

15 4

Zofran

Novartis

Preclinical

2 5

Wellcovorin

GGlaxo Dba Glaxosmithkline

Preclinical

4 6

Tafasitamab

Incyte

Preclinical

7 7

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 8

Nuvigil

NNuvo Research GmbH

Preclinical

1 9

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

—10

Decadron

QQuince Therapeutics S.p.A.

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1/2Active, not recruiting

Colorectal Cancer

NCT05846867

Q4 2026

Phase 2Recruiting

Pancreatic Cancer

NCT06531278

Q2 2027

Phase 2Recruiting

Metastatic Colorectal Cancer

NCT06493760

PreclinicalRecruiting

Gastrointestinal Cancer

NCT07056777

Q3 2027

Phase 1/2Recruiting

Solid Tumors

NCT06703177

Phase 2Recruiting

Safety and Efficacy

NCT06313801

Clinical

Trials by Indication[1]

Metastatic Colorectal Cancer4 trials

Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer

Active, not recruiting·VVejle Hospital·Phase 2·NCT04245865·83 enrolled

A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients

Recruiting·SSunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.·Phase 2·NCT06493760·130 enrolled

Study of Bevacizumab Plus Chemotherapy in Patients With Metastatic Colorectal Cancer

Unknown status·CChinese Academy of Medical Sciences·Phase 2·NCT01679327·100 enrolled

Show 1 more trial

mFOLFOX6 Combined With Dalpiciclib in Patients With Metastatic Colorectal Cancer

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 2·NCT05480280·18 enrolled

Colorectal Cancer3 trials

A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer

Unknown status·MMulticenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group·Phase 3·NCT00385970·380 enrolled

Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 3·NCT02785146·230 enrolled

A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

Active, not recruiting·AAkeso·Phase 1/2·NCT05846867·170 enrolled

Pancreatic Cancer3 trials

Adebelimab Combined With Irinotecan Liposomal Injection, Oxaliplatin, Fluorouracil and Calcium Folinate Are Used in the First-line Treatment of Pancreatic Cancer Liver Metastasis Efficacy and Safety

Recruiting·JJiang Long·Phase 2·NCT06531278·40 enrolled

NEO-adjuvant Chemo-immunotherapy in Pancreatic Cancer

Active, not recruiting·AAustralasian Gastro-Intestinal Trials Group·Phase 2·NCT06094140·20 enrolled

Adebrelimab in Combination With NALIRIFOX in Locally Advanced Pancreatic Cancer

Recruiting·FFudan University·Phase 2·NCT06475326·87 enrolled

First-line Treatment2 trials

The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy

Not yet recruiting·FFujian Cancer Hospital·Phase 2·NCT05640726·30 enrolled

Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

Not yet recruiting·HHarbin Medical University·Phase 2·NCT06648525·68 enrolled

Safety and Efficacy1 trial

Comparing the Safety and Efficacy of First-line Polychemotherapy and Polychemotherapy in Combination With PIPAC Sessions

Recruiting·NNizhny Novgorod Regional Clinical Oncology Center·Phase 2·NCT06313801·106 enrolled

11 more indications

Spastic paraplegia1 trial

Calcium Folinate Treatment of Spastic Paraplegia 56

Recruiting·SShanghai 6th People's Hospital·Phase 1·NCT06478238·10 enrolled

Osteosarcoma1 trial

Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.

Completed·IIsofol Medical AB·Phase 1/2·NCT01987102·18 enrolled

Microsatellite Instability1 trial

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Not yet recruiting·AAkeso·Phase 3·NCT07412613·386 enrolled

Patients With Solid Tumors1 trial

A Study of SHR-4375 Injection in Combination With Other Antitumor Therapies in Patients With Solid Tumors

Not yet recruiting· Suzhou Suncadia Biopharmaceuticals Co., Ltd. logo

Suzhou Suncadia Biopharmaceuticals Co., Ltd.·Phase 1/2·NCT07298772·198 enrolled

Solid Tumors1 trial

A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With Solid Tumors

Recruiting· Suzhou Suncadia Biopharmaceuticals Co., Ltd. logo

Suzhou Suncadia Biopharmaceuticals Co., Ltd.·Phase 1/2·NCT06703177·876 enrolled

Advanced Solid Tumors1 trial

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT06544655·213 enrolled

Liver Metastases1 trial

Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer

Enrolling by invitation·FFudan University·Phase 2·NCT07441369·16 enrolled

Gastroesophageal Junction Adenocarcinoma1 trial

RACE-trial: Neoadjuvant Radiochemotherapy Versus Chemotherapy for Patients With Locally Advanced, Potentially Resectable Adenocarcinoma of the Gastroesophageal Junction (GEJ) A Randomized Phase III Joint Study of the AIO, ARO and DGAV

Completed·UUniversitätsmedizin Mannheim·Phase 3·NCT04375605·342 enrolled

Lymphoma1 trial

The CAROLYN Trial: Lisocabtagene Maraleucel as First-Line Therapy for Primary Central Nervous System Lymphoma (PCNSL) in Transplant-Ineligible Patients

Recruiting·JJuno Therapeutics, Inc., a Bristol-Myers Squibb Company·Phase 2·NCT07015242·65 enrolled

Gastrointestinal Cancer1 trial

A Phase Ib/IIa Clinical Trial Evaluating the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Tumors

Recruiting·ZZhejiang Doer Biologics Co., Ltd.·Preclinical·NCT07056777·186 enrolled

Unspecified1 trial

Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects

Completed· GSK logo

GSK·Phase 1·NCT03258762·14 enrolled

Sources

References

[1]
ClinicalTrials.gov — 24 trial records for Calcium folinate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Calcium folinate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Calcium folinate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Suzhou Suncadia Biopharmaceuticals Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Calcium folinate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Q3 2027

Trials by Indication[1]

Metastatic Colorectal Cancer4 trials

Colorectal Cancer3 trials

Pancreatic Cancer3 trials

First-line Treatment2 trials

Safety and Efficacy1 trial

Spastic paraplegia1 trial

Osteosarcoma1 trial

Microsatellite Instability1 trial

Patients With Solid Tumors1 trial

Solid Tumors1 trial

Advanced Solid Tumors1 trial

Liver Metastases1 trial

Gastroesophageal Junction Adenocarcinoma1 trial

Lymphoma1 trial

Gastrointestinal Cancer1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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