Calcium folinate

Phase 3Small molecule

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Calcium folinate is one of 381 small molecule programs targeting Gastrointestinal Cancer. It is currently in Phase 3.

Indications

Total Trials

Active Trials

380

Competitors

Pipeline

Status by Indication[3][1]

Indication

Gastrointestinal CancerRecruiting

LymphomaRecruiting

Liver Metastases From Colorectal Cancer (mcrc)Enrolling by invitation

Gastroesophageal AdenocarcinomaRecruiting

First-Line TreatmentNot yet recruiting

Advanced Solid TumorsRecruiting

Safety and EfficacyRecruiting

Spastic ParaplegiaRecruiting

Metastatic Colorectal CancerActive, not recruiting

Colorectal CancerUnknown status

Gastrointestinal CancerPreclinical

Recruiting

LymphomaPhase 2

Recruiting

Liver Metastases From Colorectal Cancer (mcrc)Phase 2

Enrolling by invitation

Gastroesophageal AdenocarcinomaPhase 2

Recruiting

First-Line TreatmentPhase 2

Not yet recruiting

Advanced Solid TumorsPhase 1

Recruiting

Safety and EfficacyPhase 2

Recruiting

Spastic ParaplegiaPhase 1

Recruiting

Metastatic Colorectal CancerPhase 2

Active, not recruiting

Colorectal CancerPhase 3

Unknown status

Showing 10 of 13 indications

Competition

Competitive Landscape

401 competitors in Lymphoma

#DrugCompanyPhaseTrials

Calcium folinate

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Phase 3

1 2

Zofran

Novartis

Preclinical

2 3

Norvir

AbbVie

Preclinical

1 4

Cabenuva

GSK

Preclinical

1 5

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 6

Kenalog

BBausch Health Americas, Inc.

Preclinical

1 7

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

—8

Decadron

QQuince Therapeutics S.p.A.

Preclinical

—9

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Preclinical

—10

R-CHOP

IIncyte Biosciences Japan GK

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Pancreatic Cancer

NCT06531278

Q2 2027

Phase 2Recruiting

Metastatic Colorectal Cancer

NCT06493760

PreclinicalRecruiting

Gastrointestinal Cancer

NCT07056777

Q3 2027

Phase 1/2Recruiting

Solid Tumors

NCT06703177

Phase 2Recruiting

Safety and Efficacy

NCT06313801

Q4 2027

Phase 1Recruiting

Advanced Solid Tumors

NCT06544655

Clinical

Trials by Indication[1]

Metastatic Colorectal Cancer4 trials

Study of Bevacizumab Plus Chemotherapy in Patients With Metastatic Colorectal Cancer

Unknown status·CChinese Academy of Medical Sciences·Phase 2·NCT01679327·100 enrolled

mFOLFOX6 Combined With Dalpiciclib in Patients With Metastatic Colorectal Cancer

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 2·NCT05480280·18 enrolled

A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients

Recruiting·SSunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.·Phase 2·NCT06493760·130 enrolled

Show 1 more trial

Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer

Active, not recruiting·VVejle Hospital·Phase 2·NCT04245865·83 enrolled

Pancreatic Cancer3 trials

Adebelimab Combined With Irinotecan Liposomal Injection, Oxaliplatin, Fluorouracil and Calcium Folinate Are Used in the First-line Treatment of Pancreatic Cancer Liver Metastasis Efficacy and Safety

Recruiting·JJiang Long·Phase 2·NCT06531278·40 enrolled

Adebrelimab in Combination With NALIRIFOX in Locally Advanced Pancreatic Cancer

Recruiting·FFudan University·Phase 2·NCT06475326·87 enrolled

NEO-adjuvant Chemo-immunotherapy in Pancreatic Cancer

Active, not recruiting·AAustralasian Gastro-Intestinal Trials Group·Phase 2·NCT06094140·20 enrolled

Colorectal Cancer3 trials

A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer

Unknown status·MMulticenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group·Phase 3·NCT00385970·380 enrolled

A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

Active, not recruiting·AAkeso·Phase 1/2·NCT05846867·170 enrolled

Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 3·NCT02785146·230 enrolled

First-line Treatment2 trials

The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy

Not yet recruiting·FFujian Cancer Hospital·Phase 2·NCT05640726·30 enrolled

Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

Not yet recruiting·HHarbin Medical University·Phase 2·NCT06648525·68 enrolled

Spastic paraplegia1 trial

Calcium Folinate Treatment of Spastic Paraplegia 56

Recruiting·SShanghai 6th People's Hospital·Phase 1·NCT06478238·10 enrolled

12 more indications

Osteosarcoma1 trial

Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.

Completed·IIsofol Medical AB·Phase 1/2·NCT01987102·18 enrolled

Solid Tumors1 trial

A Study of SHR-1826 for Injection in Combination With Other Antitumor Therapies in Subjects With Solid Tumors

Recruiting· Suzhou Suncadia Biopharmaceuticals Co., Ltd. logo

Suzhou Suncadia Biopharmaceuticals Co., Ltd.·Phase 1/2·NCT06703177·876 enrolled

Patients With Solid Tumors1 trial

A Study of SHR-4375 Injection in Combination With Other Antitumor Therapies in Patients With Solid Tumors

Not yet recruiting· Suzhou Suncadia Biopharmaceuticals Co., Ltd. logo

Suzhou Suncadia Biopharmaceuticals Co., Ltd.·Phase 1/2·NCT07298772·198 enrolled

Advanced Solid Tumors1 trial

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT06544655·213 enrolled

Microsatellite Instability1 trial

Neoadjuvant/Adjuvant AK104 in Microsatellite Instability-high or Mismatch Repair-deficient, Resectable Colon Cancer

Not yet recruiting·AAkeso·Phase 3·NCT07412613·386 enrolled

Recruiting· AstraZeneca logo

AstraZeneca·Phase 2·NCT07069712·100 enrolled

Liver Metastases From Colorectal Cancer (mCRC)1 trial

Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer Who Failed Standard Two or Three-line Therapy

Enrolling by invitation·FFudan University·Phase 2·NCT07441369·16 enrolled

Gastroesophageal Junction Adenocarcinoma1 trial

RACE-trial: Neoadjuvant Radiochemotherapy Versus Chemotherapy for Patients With Locally Advanced, Potentially Resectable Adenocarcinoma of the Gastroesophageal Junction (GEJ) A Randomized Phase III Joint Study of the AIO, ARO and DGAV

Completed·UUniversitätsmedizin Mannheim·Phase 3·NCT04375605·342 enrolled

Gastrointestinal Cancer1 trial

A Phase Ib/IIa Clinical Trial Evaluating the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Tumors

Recruiting·ZZhejiang Doer Biologics Co., Ltd.·Preclinical·NCT07056777·186 enrolled

Unspecified1 trial

Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects

Completed· GSK logo

GSK·Phase 1·NCT03258762·14 enrolled

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for Calcium folinate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Calcium folinate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Calcium folinate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Suzhou Suncadia Biopharmaceuticals Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Calcium folinate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q2 2027

Q3 2027

Q4 2027

Trials by Indication[1]

Metastatic Colorectal Cancer4 trials

Pancreatic Cancer3 trials

Colorectal Cancer3 trials

First-line Treatment2 trials

Spastic paraplegia1 trial

Osteosarcoma1 trial

Solid Tumors1 trial

Patients With Solid Tumors1 trial

Advanced Solid Tumors1 trial

Microsatellite Instability1 trial

Safety and Efficacy1 trial

Lymphoma1 trial

Gastroesophageal Adenocarcinoma1 trial

Liver Metastases From Colorectal Cancer (mCRC)1 trial

Gastroesophageal Junction Adenocarcinoma1 trial

Gastrointestinal Cancer1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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