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Flunarizine

Phase 3Small molecule

AAspartes Pharmaceuticals, Inc.

Flunarizine is one of 36 small molecule programs targeting Migraine. It is currently in Phase 3.

1

Indications

12

Total Trials

6

Active Trials

35

Competitors

Pipeline

Status by Indication[3][1]

Indication

MigraineNot yet recruiting

MigrainePhase 3

Not yet recruiting

Competition

Competitive Landscape

105 competitors in Migraine

#DrugCompanyPhaseTrials

Zonegran

AAzurity Pharmaceuticals

Elismetrep

Flunarizine

AAspartes Pharmaceuticals, Inc.

BAT7104

Tizanidine Hydrochloride

EElan Pharmaceuticals

Bayer Aspirin

Cymbalta

Jazz Pharmaceuticals

Adempas

Cervidil

Nitrostat

VViatris Specialty LLC

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalNot yet recruiting

Migraine

NCT06499116

Q2 2027

ApprovedNot yet recruiting

Migraine Prophylaxis

NCT07655700

Q2 2029

Phase 2Not yet recruiting

Migraine

NCT07751497

Clinical

Trials by Indication[1]

Migraine9 trials

Comparative Efficacy of Flunarizine and Propanolol in Pediatric Migraine

Recruiting·MMuhammad Aamir Latif·N/A·NCT07354126·44 enrolled

Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care

Not yet recruiting·FFundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina·Phase 4·NCT06499116·460 enrolled

Decoding Pain Sensitivity in Migraine With Multimodal Brainstem-based Neurosignature

Unknown status·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT04702971·600 enrolled

Show 6 more trials

Evaluation of Efficacy and Safety of add-on Alpha-lipoic Acid on Migraine Prophylaxis in Adolescent Population

Completed·—·Phase 4·NCT04064814·60 enrolled

Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis

Unknown status·—·N/A·NCT06162819·84 enrolled

Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine

Completed·—·N/A·NCT03712917·120 enrolled

Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis

Completed·TTaipei Veterans General Hospital, Taiwan·Phase 4·NCT02639598·62 enrolled

Childhood Migraine Treatment Noninvasive Pulsed Radiofrequency vs Flunarizine

Active, not recruiting·DDamla Yürük··NCT06753825·60 enrolled

A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention: Rimegepant Versus Flunarizine Non-inferiority Study

Not yet recruiting·SSecond Affiliated Hospital, Zhejiang University, School of Medicine·Phase 2·NCT07751497·400 enrolled

Schizophrenia1 trial

Efficacy and Tolerability of Flunarizine for the Treatment of Schizophrenia: Comparison With Haloperidol

Completed·AAmbulatório de Bipolaridade·Phase 4·NCT00740259·70 enrolled

Migraine Prophylaxis1 trial

Comparative Efficacy of Propranolol, Flunarizine, and Their Combination in Migraine Prophylaxis: An Open-label Parallel-arm Randomized Controlled Trial

Not yet recruiting·CChittagong Medical College·Approved·NCT07655700·177 enrolled

Unspecified1 trial

An Open Label Pharmacokinetic Study of ASP-001 Formulations in Healthy Volunteers

Not yet recruiting·AAspartes Pharmaceuticals, Inc.·Phase 1·NCT07445464·12 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Flunarizine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Flunarizine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Flunarizine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Aspartes Pharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: AAspartes Pharmaceuticals, Inc.

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