Magnesium

ApprovedSmall molecule

SSpherium Biomed

Magnesium is one of 510 small molecule programs targeting Total Joint Arthroplasty. It is currently in Approved.

Indications

Total Trials

Active Trials

509

Competitors

Pipeline

Status by Indication[3][1]

Indication

Total Joint ArthroplastyActive, not recruiting

ArrhythmiaActive, not recruiting

Low Back PainActive, not recruiting

Cerebral PalsyActive, not recruiting

Migraine DisorderApproved

Atrial Heart Septal DefectActive, not recruiting

Liver TransplantActive, not recruiting

ToxicityActive, not recruiting

Cholestatic Liver DiseaseActive, not recruiting

Autistic BehaviorActive, not recruiting

Total Joint ArthroplastyPhase 1

Active, not recruiting

ArrhythmiaPhase 3

Active, not recruiting

Low Back PainPreclinical

Active, not recruiting

Cerebral PalsyPreclinical

Active, not recruiting

Migraine DisorderApproved

Approved

Atrial Heart Septal DefectPreclinical

Active, not recruiting

Liver TransplantApproved

Active, not recruiting

ToxicityApproved

Active, not recruiting

Cholestatic Liver DiseasePhase 1

Active, not recruiting

Autistic BehaviorPreclinical

Active, not recruiting

Showing 10 of 27 indications

Competition

Competitive Landscape

1050 competitors in Asthma

#DrugCompanyPhaseTrials

Magnesium

SSpherium Biomed

Approved

3 2

Xolair

Roche

Preclinical

25 3

Singulair

AstraZeneca

Preclinical

17 4

Nucala

GGlaxo Dba Glaxosmithkline

Preclinical

35 5

Dupixent

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

30 6

Arcoxia

Aciphex

2 8

Paracetamol

GSK

Preclinical

1 9

Aclidinium Bromide

AstraZeneca

Preclinical

—10

Vit D

PPost Graduate Institute of Medical Education and Research, Chandigarh

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalActive, not recruiting

Shoulder Arthroplasty

NCT05488847

Q4 2026

Phase 2Recruiting

Bladder Spasms

NCT05806996

Q2 2027

Phase 3Recruiting

Migraine

NCT06904287

Clinical

Trials by Indication[1]

Migraine3 trials

Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Recruiting·WWake Forest University Health Sciences·Phase 3·NCT06904287·100 enrolled

Acetaminophen and Ibuprofen With and Without Magnesium and Primary Migraine in Childhood

Completed·UUniversity of Catanzaro·Phase 4·NCT01756209·160 enrolled

Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

Not yet recruiting·FFayoum University·Phase 3·NCT07147972·100 enrolled

Asthma3 trials

Lung Function of Asthmatic Children by Nebulized MgSO4

Completed·—·N/A·NCT01799109·90 enrolled

Oral Intake of Mg in Controlled Asthmatic Patients

Active, not recruiting·ZZagazig University·Phase 2/3·NCT06721247·166 enrolled

Magnesium and Asthma - Clinical Trials

Completed·NNational Center for Complementary and Integrative Health (NCCIH)·Phase 2·NCT00029510·240 enrolled

Alcohol Withdrawal2 trials

Magnesium After Alcohol Withdrawal Treatment

Completed·FFinnish Foundation for Alcohol Studies·Phase 4·NCT00325299·178 enrolled

MAGnesium Adjunction in Alcohol Withdrawal Syndrome: a Multicenter Assessment (MAGMA)

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT03033823·105 enrolled

Agitation2 trials

Effect of Preoperative Oral Magnesium on Emergence Agitation

Recruiting·TTanta University·N/A·NCT07082894·120 enrolled

Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics

Unknown status·—·Phase 1/2·NCT06077539·100 enrolled

Temporomandibular Joint Disorder1 trial

Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).

Completed·SSpherium Biomed·Phase 1/2·NCT02602483·96 enrolled

29 more indications

Spinal Surgery1 trial

The Comparison of Analgesia Methods Used for Spinal Surgery

Unknown status·IIstanbul University·N/A·NCT04603638·82 enrolled

Bariatric Surgery1 trial

Use of MgSO4 for Pain After Bariatric Surgery

Completed·YYeditepe University Hospital·N/A·NCT03355807·80 enrolled

Tonsillectomy1 trial

Magnesium vs Placebo for Tonsillectomy

Completed·—·Phase 2/3·NCT02218424·60 enrolled

Postoperative Recovery1 trial

The Effect of Magnesium Supplementation During General Anesthesia on the Quality of Postoperative Recovery in Children

Completed·SSeoul National University Hospital·N/A·NCT03132701·66 enrolled

Vaccine1 trial

Magnesium Injection Ensures Steroid Avoidance During Vaccine, Viremia or Immunocompromise

Recruiting·SSalem Anaesthesia Pain Clinic··NCT05862454·150 enrolled

Postoperative Analgesia1 trial

Magnesium Sulfate Improves Postoperative Analgesia in Laparoscopic Gynecologic Surgeries

Completed·IInstituto do Cancer do Estado de São Paulo·Phase 4·NCT02508857·60 enrolled

Magnesium Sulfate1 trial

Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth

Completed·UUniversity Hospital, Rouen·Phase 4·NCT00120588·700 enrolled

Intravenous Lidocaine1 trial

Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery

Completed·YYonsei University·N/A·NCT02018276·135 enrolled

Pancreatitis1 trial

EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic Pancreatitis

Completed·UUniversity Medicine Greifswald·Phase 3·NCT00142233·295 enrolled

Low back pain1 trial

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Completed·IIstanbul University·N/A·NCT04626063·240 enrolled

Delayed Onset Muscle Soreness1 trial

COMBOPROFEN for Treatment of Muscular Pain Associated With Delayed Onset Muscle Soreness (DOMS)

Completed·SSpherium Biomed·Phase 2·NCT03223519·74 enrolled

Cerebral Palsy1 trial

Effect of Oral Magnesium Therapy on Constipation on Cerebral Palsy Children

Unknown status·—··NCT03471312·50 enrolled

Toxicity1 trial

Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity

Completed·MMahidol University·Phase 4·NCT02481518·30 enrolled

Scoliosis1 trial

The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery

Completed·TThe Hospital for Sick Children·Phase 2·NCT01148888·5 enrolled

Effectiveness1 trial

Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments

Unknown status·UUniversity College, London·Phase 4·NCT05149820·100 enrolled

Coronary Artery Bypass1 trial

Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery

Completed·—·Phase 2·NCT00041392·389 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Active, not recruiting·HHenry Ford Health System·Phase 4·NCT05488847·83 enrolled

Intravenous1 trial

Tocolytics Trial: Intravenous (IV) Magnesium Versus Oral Nifedpine in Fetal Fibronectin (FFN) Postive Population

Terminated·MMemorialCare·Phase 3·NCT00641784·200 enrolled

Arrhythmia1 trial

MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery

Terminated·UUniversity of British Columbia·Phase 3·NCT00250965·927 enrolled

Total Joint Arthroplasty1 trial

Improving Sleep Quality After Total Joint Arthroplasty ( TJA)

Withdrawn·SStanford University·Phase 1·NCT03879707

Muscle Cramp1 trial

Topical Magnesium and Muscle Cramps in Dialysis Patients.

Unknown status·SSir Charles Gairdner Hospital·Phase 2·NCT03082625·40 enrolled

Total Intravenous Anesthesia1 trial

Total Intravenous Anesthesia in Patients Undergoing Craniotomy

Recruiting·ZZagazig University·N/A·NCT07105618·108 enrolled

Laparoscopic Cholecystectomy1 trial

Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients

Completed·ZZiauddin University·Phase 1/2·NCT07079514·60 enrolled

Critically Ill Patients1 trial

Magnesium Replacement Therapy to Prevent Acute Renal Failure in Critically Ill Patients

Completed·UUniversidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude·N/A·NCT01700998·140 enrolled

Local Anesthetic1 trial

Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection

Unknown status·FFayoum University·Phase 1·NCT04532775·100 enrolled

Bone Loss1 trial

Magnesium Supplementation to Prevent Bone Loss

Completed·UUniversity of Tennessee·Phase 1·NCT00346658·74 enrolled

Liver Transplant1 trial

Magnesium Administration in Liver Transplantation and Reperfusion Injury

Completed·TThe Catholic University of Korea·Phase 4·NCT00994981·61 enrolled

Bladder Spasms1 trial

Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Recruiting·MMayo Clinic·Phase 2·NCT05806996·120 enrolled

Unspecified1 trial

Magnesium in Coronaries (MAGIC)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000610

Sources

References

[1]
ClinicalTrials.gov — 40 trial records for Magnesium. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Magnesium compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Magnesium. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Spherium Biomed company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: SSpherium Biomed

Magnesium

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Trials by Indication[1]

Migraine3 trials

Asthma3 trials

Alcohol Withdrawal2 trials

Agitation2 trials

Temporomandibular Joint Disorder1 trial

Spinal Surgery1 trial

Bariatric Surgery1 trial

Tonsillectomy1 trial

Postoperative Recovery1 trial

Vaccine1 trial

Postoperative Analgesia1 trial

Magnesium Sulfate1 trial

Intravenous Lidocaine1 trial

Pancreatitis1 trial

Low back pain1 trial

Delayed Onset Muscle Soreness1 trial

Cerebral Palsy1 trial

Toxicity1 trial

Scoliosis1 trial

Effectiveness1 trial

Coronary Artery Bypass1 trial

Shoulder Arthroplasty1 trial

Intravenous1 trial

Arrhythmia1 trial

Total Joint Arthroplasty1 trial

Muscle Cramp1 trial

Total Intravenous Anesthesia1 trial

Laparoscopic Cholecystectomy1 trial

Critically Ill Patients1 trial

Local Anesthetic1 trial

Bone Loss1 trial

Liver Transplant1 trial

Bladder Spasms1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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