fluoride varnish

ApprovedSmall molecule

TThe University of Hong Kong

fluoride varnish is one of 9 small molecule programs targeting Dental Caries. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Dental CariesActive, not recruiting

Dental CariesApproved

Active, not recruiting

Competition

Competitive Landscape

15 competitors in Dental Caries

#DrugCompanyPhaseTrials

Mycostatin

GGood Molecules, LLC

Approved

—2

Betadine

BBecton, Dickinson and Company

Zocor

Peridex

DDexcel Pharma Technologies Ltd.

Peridex

fluoride varnish

TThe University of Hong Kong

Approved

2 7

Calcium Hydroxide

MMansoura University

Phase 2

—8

Chlorhexidine Digluconate

GSK

Preclinical

1 9

Vancomycin Hydrochloride

WWake Forest University Health Sciences

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ANot yet recruiting

Dentinal Hypersensitivity

NCT07141576

Q4 2026

Phase 2Not yet recruiting

Silver Diamine Fluoride

NCT06797882

Q4 2027

N/AActive, not recruiting

Prevention

NCT06131957

Clinical

Trials by Indication[1]

White Spot Lesions3 trials

Effect of Curodont Repair on Color Change of White Spot Lesions

Unknown status·—·Phase 2·NCT02913885·64 enrolled

Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth

Not yet recruiting·—·Phase 2·NCT06932926·66 enrolled

Clinical Efficacy of Different Remineralizing Agents in Treatment of White Spot Lesions

Unknown status·—·N/A·NCT05064137·30 enrolled

Treatment2 trials

Early Treatments for Preventing Occlusal Caries Lesions

Active, not recruiting·HHue University of Medicine and Pharmacy·N/A·NCT05969756·114 enrolled

"Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children."

Active, not recruiting·SSacide Duman·N/A·NCT07112963·26 enrolled

Dental Caries2 trials

Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars

Completed·—·Phase 4·NCT02592278·180 enrolled

Fluoride Varnish in the Prevention of Dental Caries in Aboriginal and Non-aboriginal Children

Unknown status·UUniversity of Toronto·Phase 3·NCT00435500·1,320 enrolled

Prevention2 trials

Three Measures for the Prevention of Carious Lesions in Preschool Children

Unknown status·ZZhejiang University·Phase 3·NCT02341352·500 enrolled

Root Caries Prevention Using Fluoride Varnish Fortified With SBGC

Active, not recruiting·TThe University of Hong Kong·N/A·NCT06131957·540 enrolled

Dentin Hypersensitivity2 trials

Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions

Completed·—·N/A·NCT07063433·40 enrolled

Fluoride Varnish X Glass Ionomer Sealant on Cervical Dentin Hypersensitivity

Completed·UUniversity of Sao Paulo·Phase 3·NCT04591444·121 enrolled

11 more indications

Clinical Trial1 trial

Randomized Clinical Trial: Oral Health Package Law and Fluor Varnish Impact on Schoolchildren in Merida, Mexico

Unknown status·—·Phase 3·NCT05960110·900 enrolled

Hypersensitivity1 trial

Efficacy of Fluoride Varnish Containing Xylitol Coated Calcium Phosphate Versus Conventional Fluoride Varnish in Management of Hypersensitivity of Exposed Root Surfaces in Adult Patients

Completed·—·Phase 1·NCT04472182·105 enrolled

Pilot Study1 trial

Intensive Preventative Dental Program Pilot Study

Completed·WWake Forest University Health Sciences·Phase 1·NCT07218068·13 enrolled

Early Childhood Caries1 trial

Early Childhood Caries Prevention at a Pediatric Clinic

Completed·UUniversity of Maryland, Baltimore·N/A·NCT00497029·219 enrolled

Dentinal Hypersensitivity1 trial

Comparative Efficacy of Laser Systems and Fluoride in Managing Dentinal Hypersensitivity: RCT

Not yet recruiting·—·N/A·NCT07141576·96 enrolled

Randomized Controlled Trial1 trial

Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment

Unknown status·TThe University of Hong Kong·Phase 2·NCT04342858·99 enrolled

Pediatric Patients1 trial

Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients

Unknown status·—·Phase 1·NCT05202821·60 enrolled

Chemotherapy1 trial

Effect of Fluoride Varnish and CPP-ACP on Oral and Salivary Symptoms During Chemotherapy

Completed·—·Phase 2·NCT01737307·30 enrolled

Fluoride1 trial

Yakima Head Start Fluoride Varnish Study

Completed·UUniversity of Washington·Phase 3·NCT00067353·500 enrolled

CAR1 trial

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

Completed·AArwa Owais·Phase 1·NCT02604134·122 enrolled

Silver Diamine Fluoride1 trial

Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries

Not yet recruiting·NNational University of Malaysia·Phase 2·NCT06797882·99 enrolled

Sources

References

[1]
ClinicalTrials.gov — 22 trial records for fluoride varnish. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — fluoride varnish compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for fluoride varnish. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — The University of Hong Kong company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: TThe University of Hong Kong

fluoride varnish

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q4 2027

Trials by Indication[1]

White Spot Lesions3 trials

Treatment2 trials

Dental Caries2 trials

Prevention2 trials

Dentin Hypersensitivity2 trials

Clinical Trial1 trial

Hypersensitivity1 trial

Pilot Study1 trial

Early Childhood Caries1 trial

Dentinal Hypersensitivity1 trial

Randomized Controlled Trial1 trial

Pediatric Patients1 trial

Chemotherapy1 trial

Fluoride1 trial

CAR1 trial

Silver Diamine Fluoride1 trial

References

Drug Info

Quick Facts

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