Fresh Frozen Plasma

ApprovedBiologic

CSL Behring

Fresh Frozen Plasma is one of 216 biologic programs targeting Liver Transplant. It is currently in Approved.

Indications

Total Trials

Active Trials

215

Competitors

Pipeline

Status by Indication[3][1]

Indication

Liver TransplantActive, not recruiting

ThrombocytopeniaActive, not recruiting

Intracranial HemorrhageActive, not recruiting

Brain InjuryActive, not recruiting

SepsisActive, not recruiting

Progressive Supranuclear PalsyActive, not recruiting

Liver DiseaseActive, not recruiting

Valvular Heart SurgeryTerminated

Idiopathic Nephrotic SyndromeNot yet recruiting

Liver TransplantPreclinical

Active, not recruiting

ThrombocytopeniaPreclinical

Active, not recruiting

Intracranial HemorrhagePreclinical

Active, not recruiting

Brain InjuryPhase 2/Phase 3

Active, not recruiting

SepsisPhase 2

Active, not recruiting

Progressive Supranuclear PalsyPhase 1

Active, not recruiting

Liver DiseaseApproved

Active, not recruiting

Valvular Heart SurgeryApproved

Terminated

Idiopathic Nephrotic SyndromePreclinical

Not yet recruiting

Competition

Competitive Landscape

353 competitors in Liver Transplant

#DrugCompanyPhaseTrials

Fresh Frozen Plasma

CSL Behring

Approved

2 2

Octreotide

Johnson & Johnson

Preclinical

2 3

Lenvima

Eisai

Preclinical

2 4

Myfortic

Novartis

Preclinical

1 5

Beyfortus

BeiGene

Preclinical

1 6

Prostigmin

Merck & Co.

Preclinical

1 7

Myfortic

Novartis

Preclinical

6 8

Cyklokapron

AAmring

Preclinical

2 9

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 10

IC-Green

CCHX Technologies Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

PreclinicalNot yet recruiting

Idiopathic Nephrotic Syndrome

NCT07685093

Q4 2027

Phase 2Not yet recruiting

Sepsis

NCT07160426

Q2 2029

Phase 2/3Recruiting

Brain Injury

NCT06062888

Clinical

Trials by Indication[1]

Cardiac Surgery4 trials

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery

Terminated·IIRCCS Policlinico S. Donato·Phase 2·NCT04434001·40 enrolled

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery

Unknown status·KKonkuk University Medical Center·Phase 4·NCT06144125·152 enrolled

Fresh Frozen Plasma in Cardiac Surgery: Descriptive and Prognostic Study

Completed·UUniversity Hospital, Bordeaux··NCT00221741·1,497 enrolled

Show 1 more trial

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery

Unknown status·KKonkuk University Medical Center·Phase 4·NCT06144099·154 enrolled

Coagulopathy3 trials

An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure

Completed· CSL Behring logo

CSL Behring·Phase 3·NCT00803101·176 enrolled

Freeze-dried Plasma in the Initial Management of Coagulopathy in Trauma Patients

Completed·UUniversity Hospital, Lille·Phase 3·NCT02750150·42 enrolled

TEG (Thromboelastography) Based Versus Conventional Coagulation Parameters Based Correction of Coagulopathy in Non Variceal Bleed.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02689232·96 enrolled

Surgery2 trials

Fibrinogen as an Alternative to FFP in Aortic Surgery.

Completed·UUniversity of Edinburgh·Phase 4·NCT00994045·20 enrolled

Trial of PCC Versus FFP in Patients Undergoing Heart Surgery

Completed·QQueen Mary University of London·Phase 2·NCT03715348·50 enrolled

Intracranial Hemorrhage2 trials

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

Terminated·UUniversity of Utah·Phase 1·NCT00770718·2 enrolled

FFP Versus PCC in Intracranial Hemorrhage

Withdrawn·UUniversity of Utah·N/A·NCT02429453

Liver Transplant2 trials

Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery

Not yet recruiting·KKonkuk University Medical Center·Phase 4·NCT06144112·92 enrolled

Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Unknown status·—·N/A·NCT04107883·30 enrolled

20 more indications

Treatment2 trials

Treatment of Inherited Factor VII Deficiency

Completed·UUniversity of L'Aquila··NCT01269138·223 enrolled

Treatment of Congenital Factor VII Deficiency

Completed· Novo Nordisk logo

Novo Nordisk··NCT01779921·163 enrolled

Volume2 trials

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Withdrawn·MMontefiore Medical Center·Phase 2·NCT04109144

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Withdrawn·MMontefiore Medical Center·Phase 4·NCT03202524

Anticoagulant Therapy1 trial

Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy

Completed· CSL Behring logo

CSL Behring·Phase 3·NCT00708435·216 enrolled

Neurosurgical Patients1 trial

CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients

Completed·FFondation Ophtalmologique Adolphe de Rothschild·Phase 4·NCT02777424·18 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Progressive Supranuclear Palsy1 trial

Young Plasma Transfusions for Progressive Supranuclear Palsy

Completed·UUniversity of California, San Francisco·Phase 1·NCT02460731·6 enrolled

Liver Disease1 trial

Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease

Completed·UUniversity of Colorado, Denver·Phase 4·NCT02366845·50 enrolled

Intraoperative1 trial

Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

Completed·NNational Cancer Institute, Egypt·N/A·NCT04683614·60 enrolled

Invasive Procedure1 trial

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Completed· Octapharma logo

Octapharma·Phase 3·NCT00618098·200 enrolled

Brain Injury1 trial

FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

Recruiting·NNorthwestern University·Phase 2/3·NCT06062888·357 enrolled

Injury1 trial

Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28)

Completed·RRigshospitalet, Denmark·Phase 4·NCT02253082·44 enrolled

Thrombocytopenia1 trial

Efficacy of Fresh Frozen Plasma (FFP) in Treating Thrombocytopenia in Dengue Patients

Active, not recruiting·SSheikh Hasina National Institute of Burn and Plastic Surgery·N/A·NCT06642493·300 enrolled

Sepsis1 trial

Study of Protection And Repair of Endothelial-glycocalyx in Sepsis

Not yet recruiting·—·Phase 2·NCT07160426·45 enrolled

Clinical Trial1 trial

Clinical Trial Assessing Non-Inferiority of Freeze Dried Plasma to Fresh Frozen Plasma in Reversing Warfarin

Withdrawn·VVascular Solutions LLC·Phase 2·NCT04794348

Cardiopulmonary Bypass1 trial

PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding

Completed·MMayo Clinic·Phase 4·NCT02557672·106 enrolled

Longevity1 trial

The Effect of Prophylactic FFP Administration on ECMO Circuit Longevity

Completed·—·N/A·NCT01903863·31 enrolled

Pediatric1 trial

Albumin vs. Plasma for PEdiAtric pRiming Trial

Completed·IIRCCS Policlinico S. Donato·Phase 4·NCT02738190·80 enrolled

Idiopathic Nephrotic Syndrome1 trial

Comparison of Efficacy and Safety of Albumin Versus Fresh Frozen Plasma in Managing Diuretic Resistant Edema in Children With Idiopathic Nephrotic Syndrome

Not yet recruiting·QQamar Shafiq·Preclinical·NCT07685093·56 enrolled

Valvular Heart Surgery1 trial

Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery, Compared With Fresh Frozen Plasma: Study Protocol for a Non-inferiority, Randomized Controlled Trial

Terminated·SSHI Jia·Approved·NCT04244981·476 enrolled

Unspecified1 trial

Ascending Doses of Autologous FDP vs FFP

Completed·UU.S. Army Medical Research and Development Command·Phase 1·NCT02930226·30 enrolled

Sources

References

[1]
ClinicalTrials.gov — 35 trial records for Fresh Frozen Plasma. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Fresh Frozen Plasma compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Fresh Frozen Plasma. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — CSL Behring company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Biologic[2]
Highest Phase: Approved[1]
Company: CSL Behring

Fresh Frozen Plasma

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q4 2027

Q2 2029

Trials by Indication[1]

Cardiac Surgery4 trials

Coagulopathy3 trials

Surgery2 trials

Intracranial Hemorrhage2 trials

Liver Transplant2 trials

Treatment2 trials

Volume2 trials

Anticoagulant Therapy1 trial

Neurosurgical Patients1 trial

Blood Pressure1 trial

Progressive Supranuclear Palsy1 trial

Liver Disease1 trial

Intraoperative1 trial

Invasive Procedure1 trial

Brain Injury1 trial

Injury1 trial

Thrombocytopenia1 trial

Sepsis1 trial

Clinical Trial1 trial

Cardiopulmonary Bypass1 trial

Longevity1 trial

Pediatric1 trial

Idiopathic Nephrotic Syndrome1 trial

Valvular Heart Surgery1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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