Prostigmin

(Neostigmine)

ApprovedSmall molecule

Neostigmine is used to treat myasthenia gravis, a condition where muscles become weak and tired easily, and to reverse the effects of certain anesthesia drugs after surgery.[2] Prostigmin is currently approved and in use across 26 indications[4].[1]

Prostigmin is one of 508 small molecule programs targeting Arrhythmia. It is currently in Approved.

Indications

114

Total Trials

Active Trials

507

Competitors

Pipeline

Status by Indication[4][1]

Indication

ArrhythmiaActive, not recruiting

Post Operative Nausea and VomitingActive, not recruiting

Liver TransplantActive, not recruiting

GlaucomaUnknown

Urinary RetentionActive, not recruiting

Shoulder PainActive, not recruiting

Obstructive Sleep ApneaActive, not recruiting

ParalysisActive, not recruiting

Kidney TransplantActive, not recruiting

Nausea and VomitingActive, not recruiting

ArrhythmiaPreclinical

Active, not recruiting

Post Operative Nausea and VomitingPhase 3

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

GlaucomaPreclinical

Unknown

Urinary RetentionPhase 2

Active, not recruiting

Shoulder PainApproved

Active, not recruiting

Obstructive Sleep ApneaApproved

Active, not recruiting

ParalysisApproved

Active, not recruiting

Kidney TransplantApproved

Active, not recruiting

Nausea and VomitingPhase 3

Active, not recruiting

Showing 10 of 23 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Prostigmin

Merck & Co.

Approved

1 2

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 3

MS Contin

Merck & Co.

Preclinical

2 4

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 5

Spravato

WWim Janssens

Preclinical

2 6

Chirocaine

PPurdue Pharma LP

Preclinical

1 7

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 8

Aquasol E

NNational Eye Institute (NEI)

Preclinical

—9

Vfend

PPrism Pharmaceuticals

Systemic Therapy

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Neuromuscular Blockade

NCT06112353

PreclinicalRecruiting

Residual Neuromuscular Block

NCT07309393

Q4 2026

Phase 2/3Not yet recruiting

Cesarean Section

NCT06513013

Q3 2027

Post-ApprovalRecruiting

Chronic Kidney Disease

NCT07203287

Q4 2027

Phase 2Recruiting

Headache

NCT05116930

Clinical

Trials by Indication[1]

Neostigmine20 trials

A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers

Completed·UUniversity of Nottingham·Phase 4·NCT01134848·10 enrolled

A Randomized Double Blind Controlled Trial Comparing Sugammadex and Neostigmine After Thoracic Anesthesia

Terminated·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 4·NCT02256280·70 enrolled

Neostigmine Versus Sugammadex on Renal Functions

Unknown status·MMenoufia University·Phase 4·NCT06081738·64 enrolled

Show 17 more trials

Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00825812·308 enrolled

Neostigmine Route for Acute Colonic Pseudo Obstruction

Unknown status·UUniversity of Southern California·Phase 4·NCT04951726·90 enrolled

Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular

Completed·TThe Cleveland Clinic·Phase 4·NCT03322657·69 enrolled

Cerebral Oxygenation and Metabolism After Reversal Of Rocuronium: Comparison Between Sugammadex Versus Neostigmine

Unknown status·MMansoura University·N/A·NCT02944175·40 enrolled

Comparison of Rocuronium and Org 25969 With Cisatracurium and Neostigmine (19.4.310)(P05931)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00451100·84 enrolled

Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00473694·182 enrolled

The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.

Unknown status·CCliniques universitaires Saint-Luc- Université Catholique de Louvain·N/A·NCT00407290·60 enrolled

Comparison of Sugammadex (Org 25969) With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 (P05960)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00451217·198 enrolled

Comparing Reversal With Neostigmine and Sugammadex in Paediatric

Completed·UUniversiti Sains Malaysia·N/A·NCT03137290·80 enrolled

Comparison of Sugammadex With Neostigmine as Reversal Agents for Rocuronium at Reappearance of T2 (Study P06101)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01050543·128 enrolled

Comparision of Different Dose of Neostigmine at Advanced Decurarization

Completed·—·Phase 3·NCT00847938·62 enrolled

Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)

Unknown status·YYonsei University·N/A·NCT04545099·84 enrolled

Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine.

Completed·—·Phase 1·NCT06982092·60 enrolled

A New Approach of Neostigmine in Unavoidable Post Operative Ileus

Completed·—·Phase 4·NCT00676377·3 enrolled

Epidural Neostigmine for Labor Pain

Completed·WWake Forest University·Phase 1·NCT00779467·200 enrolled

The Early Reversibility of Rocuronium After Different Doses of Neostigmine

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 4·NCT00001520·60 enrolled

Functional Respiratory Imaging After Neostigmine or Sugammadex

Completed·OOnze Lieve Vrouw Hospital·Phase 4·NCT02284412·13 enrolled

Neuromuscular Blockade14 trials

Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex

Completed·UUniversity Hospital, Antwerp·Phase 3·NCT01962298·75 enrolled

Diaphragm Function After Reversal of Rocuronium-induced Neuromuscular Blockade With Sugammadex or Neostigmine in Children

Completed·SSeoul National University Hospital·N/A·NCT05724550·73 enrolled

Effect of Neuromuscular Blockade and Reversal on Breathing

Completed·LLeiden University Medical Center·Phase 4·NCT02845375·46 enrolled

Show 11 more trials

Comparative Study of Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Morbidly Obese Patients

Unknown status·UUniversity of Patras·Phase 2/3·NCT01629394·120 enrolled

Comparison of Reversal of Neuromuscular Blockade With Sugammadex Versus Neostigmine Plus Glycopyrolate in Patients Undergoing Burn Surgery

Completed·UUniversity of Kansas Medical Center·Phase 3·NCT03513406·7 enrolled

The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery

Recruiting·TThe Fourth Affiliated Hospital of Zhejiang University School of Medicine·N/A·NCT06334562·80 enrolled

Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery

Completed·UUniversity of Missouri-Columbia·Phase 4·NCT03112993·40 enrolled

Reversal of Neuromuscular Blockade in Thoracic Surgical Patients

Completed·EEndeavor Health··NCT01837498·200 enrolled

Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade

Completed·OOnze Lieve Vrouw Hospital·Phase 4·NCT02403063·18 enrolled

Reversal With Sugammadex From Deep Neuromuscular Blockade Induced by Rocuronium in Children: Randomised Clinical Trial

Completed·FFundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia·Phase 3·NCT01809886·100 enrolled

The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

Completed·YYonsei University·N/A·NCT02109133·67 enrolled

Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00675792·100 enrolled

"Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"

Completed·—·Phase 4·NCT02375217·56 enrolled

Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection

Recruiting·UUniversity of California, Irvine·Phase 4·NCT06112353·128 enrolled

Laparoscopic Cholecystectomy5 trials

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy

Completed·KKasr El Aini Hospital·Phase 2·NCT04244097·56 enrolled

Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00724932·140 enrolled

Show 2 more trials

Comparison Between Intraperitoneal Versus Intramuscular Neostigmine on Pattern of Postoperative GIT Motility in Patients Undergoing Laparoscopic Cholecystectomy

Unknown status·—·Phase 4·NCT03505255·160 enrolled

Comparison of QoR-15 in Laparoscopic Cholecystectomy: Sugammadex vs. Neostigmine

Completed·SSeoul National University Bundang Hospital·Phase 4·NCT04332627·77 enrolled

Residual Neuromuscular Block4 trials

Sugammadex and Neostigmine at Residual Neuromuscular Blockade

Completed·TTechnical University of Munich··NCT01006720·99 enrolled

Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine

Completed·GGuangzhou General Hospital of Guangzhou Military Command··NCT03656614·121 enrolled

Monitoring of Postoperative Residual Neuromuscular Blockade in Laparoscopic Surgery

Completed·SSeoul National University Bundang Hospital·N/A·NCT03292965·80 enrolled

Show 1 more trial

Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function After Thoracoscopic Lung Resection: A Multicenter, Randomized, Double-Blind, Controlled Trial

Recruiting·SShanghai Pulmonary Hospital, Shanghai, China·Preclinical·NCT07309393·240 enrolled

Sugammadex3 trials

Study to Determine if Administration of Sugammadex Impacts Hospital Efficiency

Completed·UUniversity of South Florida·Phase 4·NCT02860507·50 enrolled

Sugammadex To IMprove Bowel Function

Completed·OOregon Health and Science University·Phase 4·NCT04546672·120 enrolled

Investigation of Sugammadex in Outpatient Urological Procedures

Completed·MM.D. Anderson Cancer Center·Phase 4·NCT03138967·54 enrolled

53 more indications

Headache3 trials

Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

Not yet recruiting·—·Phase 1/2·NCT06729047·330 enrolled

Comparison Of Different Doses Of Intrathecal Neostigmine In Prevention Of Post-Dural Puncture Headache

Unknown status·—·Phase 2/3·NCT04905953·274 enrolled

Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture

Recruiting·MMayo Clinic·Phase 2·NCT05116930·18 enrolled

Urinary retention3 trials

Postoperative Urinary Retention After Reversal of Neuromuscular Block by Neostigmine Versus Sugammadex

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT05794503·235 enrolled

Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery

Enrolling by invitation·UUniversity of Missouri-Columbia·Phase 4·NCT05887375·118 enrolled

Acupuncture for Postoperative Urinary Retention After Hemorrhoidectomy: a Randomized Controlled Trial

Completed·—·Phase 2·NCT05898919·92 enrolled

Paralysis3 trials

Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy

Completed·WWest Virginia University·Phase 4·NCT03111121·79 enrolled

Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine

Completed·KKartal Kosuyolu Yuksek Ihtisas Education and Research Hospital·Phase 4·NCT05066035·113 enrolled

To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.

Completed·ZZiauddin University·Phase 1/2·NCT07097441·100 enrolled

Complication3 trials

The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications

Completed·OOregon Health and Science University·Phase 4·NCT02861131·200 enrolled

Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications

Completed·UUniversity Health Network, Toronto·Phase 4·NCT03679611·120 enrolled

Does Residual Muscular Weakness Lead to an Increase in Respiratory Complications in Bariatric Patients?

Completed·CCoastal Anesthesiology Consultants·N/A·NCT02037516·330 enrolled

Obstructive Sleep Apnea2 trials

Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine

Completed·UUniversity of California, San Diego·Phase 4·NCT04570150·90 enrolled

Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea

Completed·—·Phase 4·NCT02160223·74 enrolled

Neuromuscular Block2 trials

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Unknown status·UUniversity of Florence·Phase 4·NCT02698969·58 enrolled

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

Completed·UUniversity of California, San Francisco·Phase 4·NCT01199237·107 enrolled

Efficacy and Safety2 trials

Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage

Completed·UUS Department of Veterans Affairs·Phase 4·NCT00745095·360 enrolled

Efficacy and Safety of Sugammadex in High-Risk Ambulatory Surgeries

Withdrawn·MMontefiore Medical Center·Phase 4·NCT03944473

Nausea and vomiting2 trials

Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery

Completed·KKK Women's and Children's Hospital·Phase 3·NCT02666014·184 enrolled

Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.

Completed·OOrdu University·Phase 4·NCT02286752·98 enrolled

Effectiveness2 trials

Effectiveness of Sugammadex in LMS Surgery

Unknown status·KKorea University Anam Hospital·Phase 4·NCT02329964·80 enrolled

A Double-blind, Randomized, Parallel Design Study to Compare the Effectiveness of Sugammadex Versus Neostigmine in Improving Surgical Condition in Subjects Undergoing Laryngeal Microsurgery

Completed·YYonsei University·N/A·NCT01980069·72 enrolled

Critically Ill Patients2 trials

Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

Completed·ZZulekha Hospitals··NCT06687187·3 enrolled

Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

Recruiting·SSeoul National University Hospital·N/A·NCT05993390·30 enrolled

Remifentanil2 trials

Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Female

Completed·—·N/A·NCT04407078·40 enrolled

Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Male

Completed·—·N/A·NCT03583021·42 enrolled

Local Anesthetic1 trial

Comparative Study Between Dexmedetomidine & Neostigmine as an Adjuvant to Local Anesthetic Mixture in Peribulbar Block in Vitreoretinal Surgeries

Completed·—·Phase 1·NCT06501352·81 enrolled

Adductor Canal Block1 trial

Neostigmine and Dexamethasone in Adductor Canal Block

Completed·—·N/A·NCT04565301·90 enrolled

Kidney Transplant1 trial

Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade at the End of Kidney Transplantation Surgery

Completed·UUniversity of Colorado, Denver·Phase 4·NCT03923556·84 enrolled

Anesthesia1 trial

Study of Sugammadex Versus Usual Care on Incidence of Residual Blockade at Post Anesthesia Care Unit Admission (P07981)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01479764·154 enrolled

Cognitive Function1 trial

Quality of Awakening and Impact on Cognitive Function After Administration of Sugammadex in Robotic Radical Cystectomy

Completed·RRegina Elena Cancer Institute·N/A·NCT02454504·120 enrolled

Pediatric1 trial

Different Reversal Agents in Pediatric Day-case Cancer Surgery

Unknown status·NNational Cancer Institute, Egypt·Phase 4·NCT03996655·80 enrolled

Bariatric Surgery1 trial

Sugammadex on Laparoscopic Bariatric Surgery

Not yet recruiting·SShanxi Bethune Hospital·N/A·NCT06678451·60 enrolled

Septic Shock1 trial

Adjuvant Use of Neostigmine in Sepsis and Septic Shock.

Completed·MMansoura University·Phase 2·NCT04130230·50 enrolled

Shoulder pain1 trial

Neuromuscular Blockade on Shoulder Pain of Elderly

Completed·MM.D. Anderson Cancer Center·Phase 4·NCT03210376·100 enrolled

Laparotomy1 trial

Role of Curarization During Anesthesia for Gynecologic Surgical Laparotomy Procedures

Unknown status·—·Phase 2·NCT03519724·100 enrolled

Breast Cancer1 trial

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

Completed·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 2·NCT02839668·120 enrolled

Postoperative Quality of Recovery1 trial

Comparison the Postoperative Quality of Recovery Between Neostigmine and Sugammadex in Elderly Patients Undergoing Trans Pars Plana Vitrectomy With General Anesthesia -Randomized Controlled Trial-

Completed·YYonsei University·N/A·NCT03108989·90 enrolled

Myasthenia Gravis1 trial

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis

Completed·—·N/A·NCT06436768·62 enrolled

Regional Anaesthesia1 trial

Regional Anaesthesia

Completed·RReham Ali Abdelhaleem Abdelrahman·N/A·NCT06055101·54 enrolled

Coronary Artery Bypass1 trial

Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery

Completed·WWest Virginia University·Phase 4·NCT03939923·84 enrolled

Local Anesthesia1 trial

Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia

Completed·—·Phase 2/3·NCT03021772·60 enrolled

Gastrectomy1 trial

A Study to Compare Neostigmine vs Sugammadex in Length of PACU Stay in Patients Undergoing Sleeve Gastrectomy Surgery

Terminated·VVirtua Health, Inc.·Phase 4·NCT03276026·68 enrolled

Postoperative Recovery1 trial

Effect of Neuromuscular Reversal With Sugammadex on Postoperative Recovery Profile

Completed·LLeiden University Medical Center·Phase 4·NCT02243943·100 enrolled

Adverse Events1 trial

Perioperative Respiratory Adverse events_sugammadex

Completed·SSeoul National University Hospital·Phase 4·NCT05354466·174 enrolled

Spinal Anesthesia1 trial

IM Neostigmine for Accelerating Bladder Emptying After CS by Spinal Anesthesia

Completed·MMansoura University·Phase 4·NCT04364607·100 enrolled

Extubation1 trial

Ability to Maintain Saturation Levels Without Oxygen Supplementation as a Extubation Criteria Without TOF Monitoring Equipment

Enrolling by invitation·—·N/A·NCT06275542·240 enrolled

Cirrhosis1 trial

Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection

Completed·—·Phase 4·NCT02414880·60 enrolled

Cesarean Section1 trial

MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section

Not yet recruiting·—·Phase 2/3·NCT06513013·68 enrolled

Neuromuscular Blocking Agents1 trial

Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals

Completed·JJakob Louis Thomsen··NCT02914119·30,430 enrolled

Ondansetron1 trial

Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron

Completed·TTanta University·Phase 2·NCT05342818·90 enrolled

Bupivacaine1 trial

Addition of Neostigmine to Levobupivacaine

Completed·—·N/A·NCT04492319·112 enrolled

Hysterectomy1 trial

Role of Curarization During Anesthesia for Laparoscopic Hysterectomy

Completed·—·Phase 2·NCT03519633·238 enrolled

Liver Transplant1 trial

Sugammadex/Neostigmine and Liver Transplantation

Completed·AAzienda Ospedaliera S. Maria della Misericordia·N/A·NCT02697929·40 enrolled

Laparoscopic Surgery1 trial

Deep Neuromuscular Block for Laparoscopic Surgery

Completed·UUniversity of Melbourne·Phase 4·NCT03034577·350 enrolled

Major Abdominal Surgery1 trial

Effects of Neuromuscular Block Reversal With Sugammadex vs Neostigmine on Postoperative Respiratory Outcomes After Major Abdominal Surgery

Completed·EEnrique Alday Muñoz·Phase 4·NCT02361060·130 enrolled

Postoperative Analgesia1 trial

Efficacy of Intra-articular Neostigmine Versus Ketamine for Postoperative Analgesia in Arthroscopic Knee Surgery

Completed·—·Phase 2/3·NCT03248648·100 enrolled

Quality of Recovery1 trial

Quality of Recovery After Reversal With Neostigmine or Sugammadex.

Completed·SStony Brook University·Phase 4·NCT02909439·80 enrolled

Chronic Kidney Disease1 trial

Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease

Recruiting·TThe University of Texas Medical Branch, Galveston·Phase 4·NCT07203287·490 enrolled

Thyroid Surgery1 trial

Feasibility of Neostigmine for Intraoperative Neuromonitoring in Thyroid Surgery

Completed·SSeoul National University Hospital·N/A·NCT04873531·44 enrolled

Intraoperative1 trial

Effect of Sugammadex for Muscle Motor Response and Awareness in Intraoperative Wakeup

Completed·—·Phase 4·NCT02390817·60 enrolled

Arrhythmia1 trial

Reversal of Neuromuscular Blockade and Perioperative Arrhythmias

Completed·UUnknown Sponsor·N/A·NCT04720573·80 enrolled

Muscle Relaxant1 trial

Effectiveness of Sugammadex on Muscle Relaxant Reversal in Preterm Neonates

Unknown status·—·N/A·NCT04566796·60 enrolled

Drug1 trial

The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow

Unknown status·UUniversity Hospital, Linkoeping·N/A·NCT04777383·90 enrolled

Critically Ill1 trial

The Use of Sugammadex in the Critically Ill

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03791801·50 enrolled

Knee Arthroscopy1 trial

Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study)

Completed·—·Phase 2/3·NCT03212495·100 enrolled

Enhanced Recovery After Surgery1 trial

Enhanced Recovery After Surgery for Anterior Cervcial Spine Surgeries in Elderly Patients

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT04161508·100 enrolled

Unspecified1 trial

Use of High Resolution Colonic Manometry in Studying Motility

Withdrawn·JJames J. Peters Veterans Affairs Medical Center·Phase 1·NCT02574611

Sources

References

[1]
ClinicalTrials.gov — 114 trial records for Neostigmine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Prostigmin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Neostigmine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Neostigmine. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Acetylcholinesterase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Merck & Co.

Prostigmin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q3 2027

Q4 2027

Trials by Indication[1]

Neostigmine20 trials

Neuromuscular Blockade14 trials

Laparoscopic Cholecystectomy5 trials

Residual Neuromuscular Block4 trials

Sugammadex3 trials

Headache3 trials

Urinary retention3 trials

Paralysis3 trials

Complication3 trials

Obstructive Sleep Apnea2 trials

Neuromuscular Block2 trials

Efficacy and Safety2 trials

Nausea and vomiting2 trials

Effectiveness2 trials

Critically Ill Patients2 trials

Remifentanil2 trials

Local Anesthetic1 trial

Adductor Canal Block1 trial

Kidney Transplant1 trial

Anesthesia1 trial

Cognitive Function1 trial

Pediatric1 trial

Bariatric Surgery1 trial

Septic Shock1 trial

Shoulder pain1 trial

Laparotomy1 trial

Breast Cancer1 trial

Postoperative Quality of Recovery1 trial

Myasthenia Gravis1 trial

Regional Anaesthesia1 trial

Coronary Artery Bypass1 trial

Local Anesthesia1 trial

Gastrectomy1 trial

Postoperative Recovery1 trial

Adverse Events1 trial

Spinal Anesthesia1 trial

Extubation1 trial

Cirrhosis1 trial

Cesarean Section1 trial

Neuromuscular Blocking Agents1 trial

Ondansetron1 trial

Bupivacaine1 trial

Hysterectomy1 trial

Liver Transplant1 trial

Laparoscopic Surgery1 trial

Major Abdominal Surgery1 trial

Postoperative Analgesia1 trial

Quality of Recovery1 trial

Chronic Kidney Disease1 trial

Thyroid Surgery1 trial

Intraoperative1 trial

Arrhythmia1 trial

Muscle Relaxant1 trial

Drug1 trial

Critically Ill1 trial

Knee Arthroscopy1 trial

Enhanced Recovery After Surgery1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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