Histamine Phosphate

(histamine)

PreclinicalSmall molecule

Eli Lilly

Histamine Phosphate is one of 133 small molecule programs targeting Allergic Rhinitis. It is currently in Preclinical.

Indications

Total Trials

Active Trials

132

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Allergic RhinitisActive, not recruiting

InteractionCompleted

ARTCompleted

MorphineCompleted

Allergic RhinitisPreclinical

Active, not recruiting

InteractionPreclinical

Completed

ARTPreclinical

Completed

MorphinePreclinical

Completed

Competition

Competitive Landscape

91 competitors in ART

#DrugCompanyPhaseTrials

Belamaf

GSK

Phase 3

3 2

Venclexta

AbbVie

Phase 3

2 3

Rituxan

Roche

Phase 3

1 4

Attruby

NNavire Pharma Inc., a BridgeBio company

Phase 3

1 5

Brukinsa

BBeOne Medicines

Phase 3

1 6

Treanda

AAzurity Pharmaceuticals

Phase 3

1 7

Toradol

JJavelin Pharmaceuticals

Phase 3

1 8

Cysteine Hydrochloride

Novartis

Phase 2

1 9

Noradrenaline

IInstitute of Liver and Biliary Sciences, India

Phase 3

1 10

Vyvgart

Argenx

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Allergic Rhinitis3 trials

Role of the Central Nervous System in Allergic Rhinitis

Terminated·UUniversitaire Ziekenhuizen KU Leuven·N/A·NCT01777464·14 enrolled

An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber

Completed·DDynavax Technologies Corporation·Phase 2·NCT00537355·271 enrolled

Leukotriene D4 Nasal Provocation Test in Allergic Rhinitis

Completed·GGuangzhou Institute of Respiratory Disease·N/A·NCT01963741·60 enrolled

Skin2 trials

Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen

Completed·AAnergis·Phase 1·NCT01719133·20 enrolled

Skin Prick Test of KeraStat® Cream

Completed·KKeraNetics, LLC·N/A·NCT04058054·22 enrolled

Morphine2 trials

A Relation of Morphine-induced Itch and Pain Processing

Completed·—·N/A·NCT04115462·24 enrolled

Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)

Completed·—·N/A·NCT04700007·26 enrolled

Interaction1 trial

Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

Completed·—·N/A·NCT04554888·20 enrolled

Osteoarthritis1 trial

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

Completed·AApimeds, Inc.·Phase 3·NCT01112722·363 enrolled

3 more indications

Acute Lymphoblastic Leukemia1 trial

Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP)

Completed·AAmphastar Pharmaceuticals, Inc.·Phase 2·NCT01689363·253 enrolled

ART1 trial

Substance P Challenge in Healthy Participants

Completed· GSK logo

GSK·N/A·NCT04676763·32 enrolled

Unspecified2 trials

Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch

Completed·—·N/A·NCT04588532·24 enrolled

TransMEM Gas Exchange -- Project 1, Aim 2

Completed·—·Phase 1·NCT01925729·84 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

HISTAMINE PHOSPHATE

NDA NDA000734

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for histamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — histamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for histamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA000734). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Eli Lilly company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: Eli Lilly

Histamine Phosphate

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Allergic Rhinitis3 trials

Skin2 trials

Morphine2 trials

Interaction1 trial

Osteoarthritis1 trial

Acute Lymphoblastic Leukemia1 trial

ART1 trial

Unspecified2 trials

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

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