Toradol

(Ketorolac)

Phase 3Small molecule

Ketorolac is a strong pain reliever used to treat moderate to severe pain, often after surgery or injury. It works quickly to reduce pain and inflammation without being an opioid.[1] Toradol is currently being investigated across 25 indications[3], with its most advanced program in Phase 3.[1]

Toradol is one of 400 small molecule programs targeting Ketorolac. It is currently in Phase 3.

Indications

210

Total Trials

Active Trials

399

Competitors

Pipeline

Status by Indication[3][1]

Indication

KetorolacCompleted

Eye InflammationUnknown

Hallux ValgusActive, not recruiting

ContraceptionActive, not recruiting

Obstructive Sleep ApneaActive, not recruiting

Macular Retinal EdemaActive, not recruiting

Rheumatic DiseaseUnknown

ToxicityActive, not recruiting

Shoulder Impingement SyndromeActive, not recruiting

AppendicitisActive, not recruiting

KetorolacPhase 3

Completed

Eye InflammationPreclinical

Unknown

Hallux ValgusPreclinical

Active, not recruiting

ContraceptionPreclinical

Active, not recruiting

Obstructive Sleep ApneaPreclinical

Active, not recruiting

Macular Retinal EdemaPreclinical

Active, not recruiting

Rheumatic DiseasePreclinical

Unknown

ToxicityPreclinical

Active, not recruiting

Shoulder Impingement SyndromePreclinical

Active, not recruiting

AppendicitisPreclinical

Active, not recruiting

Showing 10 of 25 indications

Competition

Competitive Landscape

744 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Toradol

JJavelin Pharmaceuticals

Phase 3

1 2

Lexiscan

Astellas

Preclinical

1 3

Voltaren

Novartis

Preclinical

1 4

Zolymbus

AbbVie

Preclinical

1 5

Blenoxane

Bristol-Myers Squibb

Preclinical

1 6

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 8

Duragesic-100

CCephalon

Preclinical

2 9

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 10

Spravato

WWim Janssens

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Recruiting

Nephrectomy

NCT05842044

Q4 2026

Phase 3Recruiting

Arthritis

NCT05992883

Phase 3Recruiting

Pain Control

NCT03823534

Q1 2027

ApprovedRecruiting

Extremity

NCT07773155

Q2 2027

Post-ApprovalRecruiting

Ketorolac

NCT04771156

Phase 2Active, not recruiting

Anterior Cruciate Ligament Rupture

NCT06973785

Clinical

Trials by Indication[1]

Ketorolac18 trials

An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 2·NCT04646967·100 enrolled

Oral Ketorolac for Arthroscopic Rotator Cuff Repair

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT03967847·44 enrolled

Valproate Versus Ketorolac Versus Metoclopramide

Completed·MMontefiore Medical Center·Phase 4·NCT01267864·330 enrolled

Show 15 more trials

Intramuscular Ketorolac at Two Single-Dose Regimens

Completed·WWilliam Beaumont Army Medical Center·Phase 4·NCT04763876·110 enrolled

The Use of Ketorolac in Surgical Neonates

Withdrawn·NNationwide Children's Hospital·Phase 2·NCT01667120

Adjuncts to IVRA, a Comparison Between Ketorolac and Paracetamol

Completed·—·Phase 3·NCT03485625·60 enrolled

Oral Ketorolac for Pain Relief During IUD Insertion

Completed·OOhioHealth·Phase 4·NCT03031795·71 enrolled

Comparing Intramuscular Fentanyl and Ketorolac With Nerve of Arnold (NOA) Block for Bilateral Myringotomy

Not yet recruiting·UUniversity of South Alabama·Phase 4·NCT07276906·300 enrolled

Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase

Completed·FFlorida Eye Microsurgical Institute·Phase 4·NCT00520260·42 enrolled

Ketorolac in Palatoplasty

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 4·NCT04771156·74 enrolled

Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections

Unknown status·SSt. Luke's Hospital, Pennsylvania·Phase 4·NCT02612272·448 enrolled

Pharmacokinetics of Intranasal Ketorolac in Children

Terminated·—·Phase 1·NCT02297906·18 enrolled

Paracetamol Compared With Ketorolac for Post-operative Analgetic

Completed·IIndonesia University·Phase 4·NCT05523102·85 enrolled

Effect of Spinal Ketorolac After Acute Opioid Exposure

Terminated·WWake Forest University·Phase 2·NCT00693160·30 enrolled

Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision

Completed·—·Phase 1·NCT02973958·30 enrolled

Intrathecal Ketorolac in Patients With Intrathecal Morphine Dose Escalation

Withdrawn·WWake Forest University Health Sciences·Phase 2·NCT00349401

Dosing of Ketorolac in the Emergency Department

Terminated·UUniversity of Missouri-Columbia·Phase 4·NCT03464461·289 enrolled

Intranasal Ketorolac Trial

Terminated·WWashington University School of Medicine·Phase 2·NCT06083571·41 enrolled

Pain Control10 trials

Efficacy of Pethidine, Ketorolac And Xylocaine Gel As Analgesics For Pain Control In Shockwave Lithotripsy

Completed·MMansoura University·Phase 4·NCT03032458·165 enrolled

Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK

Completed·CCenter For Excellence In Eye Care·Phase 4·NCT00347204·40 enrolled

Pain Control for Intrauterine Device Placement: A Trial of Ketorolac Prior to Intrauterine Device Placement

Completed·LLynn Ngo·N/A·NCT01664559·67 enrolled

Show 7 more trials

Pain Control After Lumbar Spine Fusion

Enrolling by invitation·RRothman Institute Orthopaedics·Phase 4·NCT06484192·428 enrolled

Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery

Completed·CCumberland Pharmaceuticals·Phase 4·NCT01901393·100 enrolled

Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study

Recruiting·UUniversity of Alberta·Phase 3·NCT06819956·30 enrolled

A Pilot Study on the Use of Methoxyflurane (Penthrox®) for Pain Control in the Emergency Department

Completed·HHospital Authority, Hong Kong·Phase 3·NCT04618497·40 enrolled

Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy

Completed·UUniversity of Utah·Phase 2·NCT03669081·64 enrolled

Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children

Unknown status·AAnica Crnkovic·Phase 4·NCT02653742·150 enrolled

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

Recruiting·SSt. Louis University·Phase 3·NCT03823534·60 enrolled

Post Operative Pain8 trials

Toradol v. Celecoxib for Postoperative Pain

Completed·—·Phase 2·NCT03331315·170 enrolled

Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy

Completed·MMayo Clinic·Phase 4·NCT00765128·17 enrolled

Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy

Completed·PPOZEN·Phase 2·NCT00293631·100 enrolled

Show 5 more trials

Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain

Unknown status·—·Phase 4·NCT04380298·40 enrolled

Use of Ketorolac in Management of Post-Operative Pain After Heart Surgery

Completed·WWeill Medical College of Cornell University·Phase 4·NCT00161577·25 enrolled

Ketorolac Effects on Post-operative Pain and Bone Healing

Terminated·—·N/A·NCT01133639·18 enrolled

Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy

Completed·SSt. Louis University·Phase 4·NCT05074056·142 enrolled

Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery

Completed·—·Phase 4·NCT02829944·84 enrolled

Total Knee Arthroplasty7 trials

A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

Completed·UUniversity of Aarhus·Phase 4·NCT00868348·60 enrolled

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

Withdrawn·HHoly Cross Hospital, Florida·Phase 4·NCT02765815

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Completed·SSeoul National University Hospital·Phase 4·NCT00901628·101 enrolled

Show 4 more trials

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Completed·—·Phase 4·NCT00562627·102 enrolled

Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty

Terminated·UUniversity of Southern California·Phase 4·NCT02987920·23 enrolled

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

Terminated·VVirginia Commonwealth University·Phase 4·NCT02570503·64 enrolled

Implementation of a Pain Management Protocol for Total Knee Arthroplasty

Completed·HHealth Sciences North Research Institute·Phase 4·NCT02474654·220 enrolled

Headache6 trials

Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children

Completed·—·Phase 3·NCT02358681·59 enrolled

Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

Not yet recruiting·—·Phase 1/2·NCT06729047·330 enrolled

Ketamine v. Ketorolac for Management of Generalized Tension Type Headache

Unknown status·—·Phase 4·NCT03221569·60 enrolled

Show 3 more trials

Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

Withdrawn·WWeill Medical College of Cornell University·Phase 1·NCT04353505

A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

Withdrawn·CCorewell Health South·Phase 4·NCT03472872

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Completed·—·Phase 3·NCT03081416·80 enrolled

104 more indications

Cataract4 trials

Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery

Completed·BBausch & Lomb Incorporated·Phase 4·NCT00904904·120 enrolled

Nepafenac Versus Ketorolac Eye Drops in Prevention of Intraoperative Miosis During Cataract Surgery

Unknown status·—·Phase 2·NCT03851172·75 enrolled

A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery

Completed· AbbVie logo

AbbVie·Phase 3·NCT00524264·248 enrolled

Show 1 more trial

Protein Profile of Immunoregulatory Factors in Diabetic Cataract

Completed·UUniversity of Zagreb·Phase 4·NCT01832311·61 enrolled

Opioid Analgesia4 trials

Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.

Completed·MMontefiore Medical Center·Phase 3·NCT03584373·119 enrolled

Nonopioid Analgesia After Arthroscopic Meniscus Surgery

Completed·HHenry Ford Health System·Phase 1·NCT03820193·61 enrolled

Nonopioid Analgesia After Rotator Cuff Repair

Completed·HHenry Ford Health System·Phase 2·NCT03818919·70 enrolled

Show 1 more trial

Nonopioid Analgesia After Labral Surgery

Recruiting·HHenry Ford Health System·Phase 2/3·NCT03825809·100 enrolled

Postoperative Analgesia4 trials

Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy

Withdrawn·MMansoura University·N/A·NCT03742180

Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia?

Completed·AASST Gaetano Pini-CTO·Phase 4·NCT02162121·64 enrolled

A Comparison of Bupivacaine and Ketorolac for Postoperative Analgesia After Iliac Crest Bone Harvesting

Completed·TThe Hospital for Sick Children·Phase 3·NCT00405262·54 enrolled

Show 1 more trial

Magnesium Sulfate Improves Postoperative Analgesia in Laparoscopic Gynecologic Surgeries

Completed·IInstituto do Cancer do Estado de São Paulo·Phase 4·NCT02508857·60 enrolled

Pain Management4 trials

Nitrous Oxide for Pain Management During In-office Transcervical Sterilization

Completed·UUniversity of New Mexico·N/A·NCT02312739·72 enrolled

Pain Management in Outpatient Urologic Procedures

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 1·NCT03393364·150 enrolled

Comparative Study Between the Effect of Diclofanic and Ketorolac in Post Tonsillectomy Pain Management

Completed·—·Phase 2/3·NCT03178539·100 enrolled

Show 1 more trial

The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA

Completed·—·N/A·NCT06112548·80 enrolled

Migraine4 trials

Comparison of Ketorolac Nasal Spray to Sumatriptan Nasal Spray and Placebo for Acute Treatment of Migraine

Completed·JJohns Hopkins University·Phase 4·NCT01807234·72 enrolled

Intravenous Fluids in Pediatric Migraine

Unknown status·—·N/A·NCT06182098·134 enrolled

A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents

Completed·UUniversity of Calgary·Phase 3·NCT05102591·22 enrolled

Show 1 more trial

Prochlorperazine Versus Prochlorperazine & Ketorolac in Treatment of Pediatric Migraine in the Emergency Department

Withdrawn·—·Phase 4·NCT01534806

Renal Colic4 trials

Morphine Versus Ketorolac in Renal Colic

Unknown status·LLoredana Ghinea·Phase 4·NCT02782273·100 enrolled

Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

Completed·SShahid Beheshti University of Medical Sciences·N/A·NCT02937896·40 enrolled

Comparison of IV 10, 20, and 30mg for Renal Colic Pain in the ED

Completed·TTehran University of Medical Sciences·Phase 1·NCT03665753·165 enrolled

Show 1 more trial

Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Unknown status·—·Phase 4·NCT03137498·60 enrolled

Treatment3 trials

Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment

Unknown status·UUniversity of Guadalajara·Phase 4·NCT05383820·24 enrolled

Pain Treatment With Combinations of NSAIDs

Completed·FFederal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty·N/A·NCT05994287·105 enrolled

Post-Operative Treatment With Ketorolac After Abdominal Myomectomy

Completed·—·N/A·NCT00845754·112 enrolled

Hysterectomy3 trials

Ibuprofen Versus Ketorolac for Perioperative Pain Control After Open Hysterectomy

Completed·—·N/A·NCT05610384·100 enrolled

ICE-T Pain Regimen for Total Laparoscopic Hysterectomy

Completed·MMetroHealth Medical Center·Phase 4·NCT03987022·66 enrolled

Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy

Completed·SState University of New York at Buffalo·Phase 3·NCT04429022·68 enrolled

Total Hip Arthroplasty3 trials

Pain Control Following Total Hip Arthroplasty

Completed·SSt. Mary's Research Center, Canada·Phase 1·NCT05062356·240 enrolled

Use of Local Infiltration Analgesia Following Total Hip Arthroplasty

Completed·UUniversity of Aarhus·Phase 4·NCT01344395·80 enrolled

Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular

Completed·MMayo Clinic·Phase 4·NCT02242201·165 enrolled

Acute Pancreatitis3 trials

Ketorolac in Acute Pancreatitis

Unknown status·UUniversity of Cincinnati·Phase 4·NCT04282200·60 enrolled

Treatment of Acute Pancreatitis With Ketorolac

Terminated·—·Phase 4·NCT02885441·56 enrolled

"NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?

Unknown status·HHayatabad Medical Complex·Phase 1·NCT05756504·130 enrolled

Postoperative Pain Control3 trials

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT04246541·48 enrolled

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

Withdrawn·RRush University Medical Center·Phase 4·NCT03119038

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 3·NCT04246554·49 enrolled

Dexamethasone2 trials

TPI Medication Comparison - Ketorolac, Lidocaine, or Dexamethasone

Terminated·UUniversity of Utah·Phase 4·NCT03028012·10 enrolled

Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders

Terminated·NNYU Langone Health·Phase 3·NCT02266433·245 enrolled

Effectiveness2 trials

Effectiveness of Corticosteroid vs. Ketorolac Shoulder Injections: A Prospective Double-Blinded Randomized Trial

Terminated·MMichael Khazzam·Phase 4·NCT04115644·82 enrolled

Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections

Withdrawn·MMichael Khazzam·Phase 4·NCT04895280

Low back pain2 trials

A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain.

Completed·MMontefiore Medical Center·Phase 4·NCT03861611·198 enrolled

Morphine Versus Ketorolac in Low Back Pain

Unknown status·LLoredana Ghinea·Phase 4·NCT02782286·100 enrolled

Cesarean Section2 trials

Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial

Completed·TTufts Medical Center·Phase 3·NCT03678675·148 enrolled

Preemptive Ketorolac for Shoulder Tip Pain During Cesarean Section

Completed·—·Phase 4·NCT02380898·200 enrolled

Laparoscopic Cholecystectomy2 trials

Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia

Unknown status·FFederal University of São Paulo·Phase 4·NCT02953210·40 enrolled

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT02327923·90 enrolled

Post-cesarean Pain2 trials

Dosing of Ketorolac Impacts Post-cesarean paiN manaGemenet (KING)

Completed·OOhio State University·Phase 4·NCT05248984·92 enrolled

Comparison of Two Dosing Regimens of Intravenous Ketorolac for Post-Cesarean Pain Control

Recruiting·—·N/A·NCT07244757·126 enrolled

Ibuprofen2 trials

Ibuprofen Versus Ketorolac for Pain Relief During Hysterosalpingogram

Terminated·MMadigan Army Medical Center·Phase 4·NCT05190341·12 enrolled

Intramuscular Ketorolac Versus Oral Ibuprofen for Pain Relief in First Trimester Suction Curettage

Completed·PPlanned Parenthood League of Massachusetts·N/A·NCT01595282·94 enrolled

Outcome2 trials

Total Knee Prosthesis With Continuous Block of Adductor Canal and Outcome

Withdrawn·AASST Gaetano Pini-CTO·Phase 4·NCT02082067

Inflammatory Markers in Trauma Patient Outcomes

Completed·AArun Aneja·Phase 1·NCT03671746·70 enrolled

Sickle Cell Disease2 trials

Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease

Terminated·—·Phase 4·NCT00115336·10 enrolled

Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease

Not yet recruiting·—·Phase 4·NCT06579703·102 enrolled

Shoulder Arthroplasty2 trials

Multimodal Analgesia in Shoulder Arthroplasty

Withdrawn·RRush University Medical Center·Phase 3·NCT03586934

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Active, not recruiting·HHenry Ford Health System·Phase 4·NCT05488847·83 enrolled

Bunion2 trials

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

Completed·CConcentric Analgesics·Phase 2·NCT03885596·36 enrolled

Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients

Completed·CConcentric Analgesics·Phase 2·NCT03599089·147 enrolled

Spinal Fusion2 trials

Ketorolac on Posterior Thoracolumbar Spinal Fusions

Unknown status·HHenry Ford Health System·Phase 4·NCT03278691·600 enrolled

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

Completed·HHospital for Special Surgery, New York·N/A·NCT02700451·178 enrolled

Laparoscopic2 trials

Atropine in Laparoscopic Gynaecological Surgery

Unknown status·CClinica Santa Maria·Phase 4·NCT02769325·150 enrolled

Modified Thoracoabdominal Nerves Block Through Perichondrial Approach: a New Strategy With a Wide Range of Utilization in Laparoscopic Gynecological Surgeries.

Completed·—·Phase 2·NCT06039423·60 enrolled

Pancreatitis2 trials

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Terminated·—·Phase 2·NCT04291599·23 enrolled

A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis

Withdrawn·UUniversity of California, San Francisco·Phase 4·NCT02465138

Prostatectomy2 trials

Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy

Withdrawn·WWake Forest University Health Sciences·Phase 2/3·NCT04939987

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

Suspended·WWake Forest University Health Sciences·Phase 2/3·NCT05597878·100 enrolled

Knee Arthroplasty2 trials

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Completed·KKootenai Health·Phase 4·NCT02543801·239 enrolled

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT02540070·135 enrolled

Hernia2 trials

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT02128646·19 enrolled

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Unknown status·—·N/A·NCT03041948·88 enrolled

Cystoid Macular Edema2 trials

Treatment of Acute Pseudophakic Cystoid Macular Edema: Bromfenac 0.09% Versus Diclofenac Sodium 0.1% Versus Ketorolac Tromethamine 0.5%

Completed·BBp Consulting, Inc·Phase 4·NCT00595543·166 enrolled

Anti-inflammatory Efficacy for Prophylaxis of Cystoid Macular Edema (CME) After Phacoemulsification

Completed·—·Phase 4·NCT02084576·40 enrolled

Tonsillectomy2 trials

Effect of Ketorolac on Post Adenotonsillectomy Pain

Completed·EEmory University·Phase 4·NCT03467750·63 enrolled

Opioid-Free Anesthetic for Tonsillectomy

Terminated·—·Phase 4·NCT04528173·35 enrolled

Keratoconus1 trial

Pain Management in Corneal Collagen Crosslinking for Keratoconus

Completed·IInstituto de Oftalmología Fundación Conde de Valenciana·Phase 4·NCT02867176·25 enrolled

Bone Fracture1 trial

RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child

Completed·IIRCCS Burlo Garofolo·Phase 4·NCT00560443·133 enrolled

Platelet Function1 trial

Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers

Completed·JJavelin Pharmaceuticals·Phase 1·NCT00548678·30 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

Completed·HHenry Ford Health System·Phase 2/3·NCT03818932·90 enrolled

Enhanced Recovery1 trial

Enhanced Recovery at Cesarean Birth to Improve Postoperative Outcomes and Reduce Postoperative Length of Stay

Completed·MMontefiore Medical Center·Phase 2·NCT02956616·118 enrolled

Healing1 trial

Effect of Toradol on Post-operative Foot and Ankle Healing

Completed·RRothman Institute Orthopaedics·Phase 4·NCT03727048·128 enrolled

Ovarian Cancer1 trial

Evaluation of GTPase Inhibition by Post-operative Intravenous Ketorolac in Ovarian Cancer Patients

Completed·NNew Mexico Cancer Research Alliance·N/A·NCT02470299·21 enrolled

Appendicitis1 trial

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

Completed·—·N/A·NCT02881996·90 enrolled

Nerve Block1 trial

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Pediatric Patients1 trial

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

Recruiting·—·N/A·NCT06326983·58 enrolled

Hysteroscopy1 trial

Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT06653400·60 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of IV Diclofenac (DIC075V) for Pain After Abdominal or Pelvic Surgery

Completed·JJavelin Pharmaceuticals·Phase 3·NCT00448110·331 enrolled

Corticosteroids1 trial

The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF

Terminated·UUniversity of Nebraska·Phase 3·NCT04650893·33 enrolled

Premedication1 trial

Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block

Completed·—·N/A·NCT05097768·250 enrolled

Unknown status·SShady Grove Fertility Reproductive Science Center·Phase 1·NCT06026553·400 enrolled

ART1 trial

Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation

Recruiting·TThe University of Hong Kong·Phase 4·NCT07006168·56 enrolled

Polytrauma1 trial

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

Recruiting·MMassachusetts General Hospital·Phase 4·NCT06201676·458 enrolled

Breast Cancer1 trial

Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)

Recruiting·JJules Bordet Institute·Phase 2·NCT06150898·112 enrolled

Sacro Iliac Joint Pain1 trial

Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain

Not yet recruiting·MMcMaster University·Phase 1·NCT06081101·20 enrolled

Shoulder Impingement Syndrome1 trial

Subacromial Injection With Corticosteroid Versus Nonsteroidal Anti-inflammatory Drugs (NSAID) in Shoulder Impingement Syndrome

Withdrawn·MMadigan Army Medical Center·N/A·NCT01449448

Conditioning1 trial

A Brain Imaging Study of Opioid (Morphine) and Non-opioid (Ketorolac) Conditioning Effects

Completed·MMassachusetts General Hospital·N/A·NCT01576276·51 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

MPA1 trial

Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation

Withdrawn·UUniversity of Wisconsin, Madison·Phase 1·NCT03066115

Prevention1 trial

Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)

Completed·SState University of New York - Downstate Medical Center·Phase 2·NCT02344225·14 enrolled

Dental Implant1 trial

Intranasal Ketorolac for Postsurgical Pain in Dental Implant Patients

Completed·HHersh, Elliot V., DMD, MS, PhD·Phase 4·NCT01490931·28 enrolled

Spine Fusion1 trial

Efficacy Parecoxib and Ketorolac as Preemptive Analgesia in Spine Fusion

Completed·PPrince of Songkla University·Phase 4·NCT01859585·96 enrolled

Hematoma1 trial

The Effect of Intra-operative Ketorolac on Hematoma Rates in Breast Reduction Surgery

Unknown status·—·Phase 4·NCT03535116·100 enrolled

Liposomal Bupivacaine1 trial

TAP Block With Liposomal Bupivacaine Versus Pre-incisional Wound Infiltration With Bupivacaine for Postoperative Pain

Terminated·UUniversity of Tennessee·Phase 1·NCT02400645·69 enrolled

Thoracic Surgery1 trial

Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery

Completed·WWake Forest University Health Sciences·N/A·NCT02112448·78 enrolled

Lumbar Erector Spinae Plane Block1 trial

Lumbar Erector Spinae Plane Block for Back Surgery

Unknown status·DDr M. B. Breebaart·Phase 3·NCT03825198·80 enrolled

Steroid1 trial

Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients

Withdrawn·MMilton S. Hershey Medical Center·Phase 4·NCT03319784

Acute Pain1 trial

Ibuprofen Versus Ketorolac by Mouth in the Treatment of Acute Pain From Osteoarticular Trauma

Completed·IIRCCS Burlo Garofolo·Phase 3·NCT04133623·212 enrolled

Clinical Trial1 trial

KITS Study -Ketorolac In Tonsillectomy Surgery: a Double Blinded, Randomized Clinical Trial

Terminated·UUniversity of Alberta·Phase 2·NCT01498796·121 enrolled

Vitreoretinal Surgery1 trial

Topical 0.4% Ketorolac and Vitreoretinal Surgery

Completed·EEmory University·Phase 2/3·NCT00576329·76 enrolled

Oxycodone1 trial

Ketorolac vs Oxycodone for Great Toe Arthrodesis

Unknown status·MMedstar Health Research Institute·Phase 1·NCT05054868·40 enrolled

Endoscopy1 trial

Study of Ketorolac Versus Opioid for Pain After Endoscopy

Completed·TThe Cleveland Clinic·Phase 4·NCT03888144·81 enrolled

Post-craniotomy1 trial

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Unknown status·—·Phase 4·NCT04141319·100 enrolled

Methylprednisolone1 trial

Efficacy of Methylprednisolone for Pain Control After ACL Repair

Recruiting·SSt. Louis University·Phase 4·NCT07158476·90 enrolled

Erector Spinae Plane Block1 trial

Erector Spinae Plane Block in Scoliotic Adolescents

Completed·KKasr El Aini Hospital·Phase 2·NCT03968146·30 enrolled

Superficial Cervical Plexus Block1 trial

Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding Ketorolac to it.

Completed·SSohag University·Phase 2·NCT05180214·46 enrolled

Pilot Study1 trial

Relieving Acute Pain (RAP) Study: A Pilot Study

Terminated·UUniversity of Maryland, Baltimore·Phase 2·NCT03426137·3 enrolled

Phase 21 trial

Phase 2 Herniorrhaphy Study for Opioid Elimination

Completed·HHeron Therapeutics·Phase 2·NCT03695367·63 enrolled

Abdominal Surgeries1 trial

Combined Ketorolac Bupivacaine Versus Bupivacaine Alone for TAP Block in Children Undergoing Lower Abdominal Surgeries

Completed·SSohag University·Phase 2·NCT06267820·90 enrolled

Complication1 trial

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT02509312·70 enrolled

Back pain1 trial

Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department

Completed·SSan Antonio Military Medical Center·N/A·NCT03996564·26 enrolled

Laparoscopic Donor Nephrectomy1 trial

Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy

Completed·MMayo Clinic·Phase 4·NCT00765232·111 enrolled

Third Molar1 trial

Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction

Completed·UUnited States Naval Medical Center, San Diego·Phase 1·NCT06484439·80 enrolled

Orthopedic Surgery1 trial

Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing in Orthopedic Surgery

Completed·—·Phase 1·NCT05695664·100 enrolled

Tension-type headache1 trial

Metoclopramide Versus Ketorolac for Tension-type Headache

Completed·MMontefiore Medical Center·Phase 4·NCT01011673·123 enrolled

Glaucoma1 trial

Steroids After Laser Trabeculoplasty for Glaucoma

Completed·SStanford University·Phase 4·NCT00981435·97 enrolled

Total Joint Arthroplasty1 trial

Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)

Completed·UUniversity of Miami·Phase 3·NCT05291598·223 enrolled

Epidural Analgesia1 trial

Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery

Unknown status·OOspedale San Raffaele·N/A·NCT02647047·40 enrolled

Postoperative Pain Management1 trial

ON-Q Pump Infusion of Ketorolac and Ropivacaine at the Wound Site for Postoperative Pain Management

Completed·MMaimonides Medical Center·Phase 4·NCT00638508·67 enrolled

Infiltration1 trial

Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia

Completed·MMansoura University·N/A·NCT02691572·80 enrolled

Chlorhexidine1 trial

Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist

Completed·AAmirhossein Farahmand·Phase 2/3·NCT03836781·2 enrolled

Macular Edema1 trial

Topic Antiinflammatory Therapy Added to Selective Photocoagulation in Macular Edema

Completed·HHospital Juarez de Mexico·Phase 2·NCT00900887·84 enrolled

Arthritis1 trial

NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis

Recruiting·MMayo Clinic·Phase 3·NCT05992883·240 enrolled

Nephrectomy1 trial

NSAID Use After Robotic Partial Nephrectomy

Recruiting·UUniversity of Miami·Phase 2·NCT05842044·110 enrolled

Procedural Pain1 trial

Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement

Recruiting·—·Phase 4·NCT05875571·18 enrolled

Toxicity1 trial

Tolerability and Toxicity of Topically Applied Nepafenac 0.3% vs Ketorolac 0.5%

Completed·MMDbackline, LLC·N/A·NCT02752646·200 enrolled

Tenosynovitis1 trial

Betamethasone Versus Ketorolac Injection for the Treatment of DeQuervains Tenosynovitis

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT02604537·64 enrolled

Randomized Controlled Trial1 trial

Prospective Randomized Controlled Trial for Pain Relief After Office Ureteral Stent Removal

Completed·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT04112160·125 enrolled

Thyroid Surgery1 trial

The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery

Completed·YYeungnam University College of Medicine·N/A·NCT02039427·192 enrolled

Abdominal pain1 trial

Sublingual Analgesia for Acute Abdominal Pain in Children

Completed·IIRCCS Burlo Garofolo·Phase 3·NCT02465255·210 enrolled

Analgesic1 trial

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03472469·1,561 enrolled

AIN1 trial

Status Migrainosus - Differentiating Between Responders and Non-responders

Unknown status·HHartford HealthCare·Phase 1/2·NCT03066544·50 enrolled

Intravenous1 trial

Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries

Recruiting·MMansoura University·N/A·NCT05543785·76 enrolled

Primary Peritoneal Cancer1 trial

Availability & Effect of Post-OP Ketorolac on Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Completed·NNew Mexico Cancer Research Alliance·Phase 1·NCT01670799·29 enrolled

IUD Insertion Pain1 trial

Timing of Oral Ketorolac for Pain Reduction in IUD Insertion: A Double-Blind Randomized Controlled Trial

Enrolling by invitation·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT06853327·108 enrolled

Aortic dissection1 trial

Efficacy and Safety of Ketorolac in Improving Prognosis of Stanford Type A Aortic Dissection: a Multicenter, Randomised, Double-blind, Controlled Clinical Trial

Recruiting·TThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School·Phase 3·NCT06968806·1,346 enrolled

Anterior Cruciate Ligament Rupture1 trial

Non-Narcotic Pain Control After ACL Reconstruction

Active, not recruiting·TThe Cleveland Clinic·Phase 2·NCT06973785·30 enrolled

Extremity1 trial

A Pilot Study to Assess Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Recruiting·UUniversity of Chicago·Approved·NCT07773155·120 enrolled

Sources

References

[1]
ClinicalTrials.gov — 210 trial records for Ketorolac. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ketorolac compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ketorolac. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Javelin Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cyclooxygenase Inhibitor[2]
Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: JJavelin Pharmaceuticals

Toradol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Q2 2027

Trials by Indication[1]

Ketorolac18 trials

Pain Control10 trials

Post Operative Pain8 trials

Total Knee Arthroplasty7 trials

Headache6 trials

Cataract4 trials

Opioid Analgesia4 trials

Postoperative Analgesia4 trials

Pain Management4 trials

Migraine4 trials

Renal Colic4 trials

Treatment3 trials

Hysterectomy3 trials

Total Hip Arthroplasty3 trials

Acute Pancreatitis3 trials

Postoperative Pain Control3 trials

Dexamethasone2 trials

Effectiveness2 trials

Low back pain2 trials

Cesarean Section2 trials

Laparoscopic Cholecystectomy2 trials

Post-cesarean Pain2 trials

Ibuprofen2 trials

Outcome2 trials

Sickle Cell Disease2 trials

Shoulder Arthroplasty2 trials

Bunion2 trials

Spinal Fusion2 trials

Laparoscopic2 trials

Pancreatitis2 trials

Prostatectomy2 trials

Knee Arthroplasty2 trials

Hernia2 trials

Cystoid Macular Edema2 trials

Tonsillectomy2 trials

Keratoconus1 trial

Bone Fracture1 trial

Platelet Function1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Enhanced Recovery1 trial

Healing1 trial

Ovarian Cancer1 trial

Appendicitis1 trial

Nerve Block1 trial

Pediatric Patients1 trial

Hysteroscopy1 trial

Efficacy and Safety1 trial

Corticosteroids1 trial

Premedication1 trial

Multimodal Pain Management1 trial

Elective Cardiac Surgery1 trial

Oocyte Retrieval1 trial

ART1 trial

Polytrauma1 trial

Breast Cancer1 trial

Sacro Iliac Joint Pain1 trial

Shoulder Impingement Syndrome1 trial

Conditioning1 trial

Perioperative Pain Control1 trial

MPA1 trial

Prevention1 trial

Dental Implant1 trial

Spine Fusion1 trial

Hematoma1 trial

Liposomal Bupivacaine1 trial

Thoracic Surgery1 trial

Lumbar Erector Spinae Plane Block1 trial

Steroid1 trial

Acute Pain1 trial

Clinical Trial1 trial

Vitreoretinal Surgery1 trial