Noradrenaline

Phase 3Small molecule

IInstitute of Liver and Biliary Sciences, India

Noradrenaline is one of 271 small molecule programs targeting Liver Transplant. It is currently in Phase 3.

Indications

Total Trials

Active Trials

270

Competitors

Pipeline

Status by Indication[3][1]

Indication

Liver TransplantActive, not recruiting

Brain InjuryActive, not recruiting

Septic ShockActive, not recruiting

Chronic Kidney DiseaseActive, not recruiting

InteractionCompleted

Cesarean DeliveryCompleted

ARTRecruiting

Tracheal IntubationRecruiting

Liver TransplantPreclinical

Active, not recruiting

Brain InjuryPreclinical

Active, not recruiting

Septic ShockPreclinical

Active, not recruiting

Chronic Kidney DiseasePreclinical

Active, not recruiting

InteractionPreclinical

Completed

Cesarean DeliveryPreclinical

Completed

ARTPhase 3

Recruiting

Tracheal IntubationPhase 3

Recruiting

Competition

Competitive Landscape

169 competitors in Chronic Kidney Disease

#DrugCompanyPhaseTrials

Noradrenaline

IInstitute of Liver and Biliary Sciences, India

Phase 3

1 2

Uloric

Takeda

Preclinical

2 3

Vemlidy

Gilead

Preclinical

1 4

Lorelco

Sanofi

Preclinical

1 5

Sovaldi

Gilead

Preclinical

1 6

Glucotrol

Pfizer

Preclinical

1 7

Activase

Flomax

Tradjenta

1 10

Verquvo

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 3Recruiting

ART

NCT05931601

Clinical

Trials by Indication[1]

Septic Shock3 trials

To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02468063·184 enrolled

Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT01836224·84 enrolled

Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock

Not yet recruiting·GGeneral and Teaching Hospital Celje·N/A·NCT06853574·30 enrolled

Hypotension2 trials

Therapeutic Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery

Completed·NNantes University Hospital·Phase 3·NCT05335954·211 enrolled

The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension

Completed·TTanta University·N/A·NCT05774054·64 enrolled

Tracheal Intubation1 trial

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

Recruiting·UUniversity of Turin, Italy·Phase 3·NCT05014581·420 enrolled

Cesarean Delivery1 trial

Prophylactic Perioperative Infusion of Ephedrine Versus Noradrenaline in Patients Undergoing Cesarean Delivery Under Spinal Anesthesia

Completed·TTanta University·N/A·NCT07067944·100 enrolled

Sepsis1 trial

Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis

Unknown status·OOnze Lieve Vrouwe Gasthuis·Phase 4·NCT00484133·80 enrolled

8 more indications

Hemodynamic1 trial

Comparison of Hemodynamic Results of Two Different Fluid Managements

Unknown status·IIstanbul University·N/A·NCT05733403·40 enrolled

Chronic Kidney Disease1 trial

Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.

Completed·—··NCT02987465·29 enrolled

Hepatorenal Syndrome1 trial

TYPE 2 HEPATORENAL SYNDROME

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT01637454·46 enrolled

Injury1 trial

Acute Renal Injury After Major Elective Non-Cardiac Surgery

Completed·IIstanbul University··NCT04600271·425 enrolled

Brain Injury1 trial

The Influence of Noradrenaline on Coagulation and Fibrinolysis in Severe Isolated Brain Injury

Unknown status·UUniversity Medical Centre Ljubljana··NCT04515420·60 enrolled

Interaction1 trial

Interaction of Apelin and Angiotensin in the Human Forearm Circulation

Completed·UUniversity of Edinburgh·N/A·NCT00901745·12 enrolled

ART1 trial

Early Initiated Vasopressor Therapy in the Emergency Department

Recruiting·OOdense University Hospital·Phase 3·NCT05931601·320 enrolled

Liver Transplant1 trial

The Effect of Norepinephrine on Cardiac Output in Patients Undergoing Liver Transplant .

Completed·—·N/A·NCT04376281·31 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for Noradrenaline. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Noradrenaline compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Noradrenaline. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Institute of Liver and Biliary Sciences, India company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: IInstitute of Liver and Biliary Sciences, India

Noradrenaline

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Trials by Indication[1]

Septic Shock3 trials

Hypotension2 trials

Tracheal Intubation1 trial

Cesarean Delivery1 trial

Sepsis1 trial

Hemodynamic1 trial

Chronic Kidney Disease1 trial

Hepatorenal Syndrome1 trial

Injury1 trial

Brain Injury1 trial

Interaction1 trial

ART1 trial

Liver Transplant1 trial

References

Drug Info

Quick Facts

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