Restasis

(Hyaluronic Acid)

ApprovedSmall molecule

Hyaluronic acid is used to reduce dry eye symptoms by lubricating the eyes, and it's also injected into joints to reduce arthritis pain and into the skin to add volume and reduce wrinkles.[2] Restasis is currently approved and in use across 32 indications[4].[1]

Restasis is one of 462 small molecule programs targeting Arthropathy. It is currently in Approved.

Indications

121

Total Trials

Active Trials

461

Competitors

Pipeline

Status by Indication[4][1]

Indication

ArthropathyActive, not recruiting

Wound HealingActive, not recruiting

Stenosing TenosynovitisActive, not recruiting

Lateral EpicondylitisActive, not recruiting

TendinitisActive, not recruiting

Shoulder PainActive, not recruiting

ArthralgiaActive, not recruiting

Periodontal DisorderActive, not recruiting

Hearing LossActive, not recruiting

PresbyopiaActive, not recruiting

ArthropathyPreclinical

Active, not recruiting

Wound HealingPreclinical

Active, not recruiting

Stenosing TenosynovitisPhase 1

Active, not recruiting

Lateral EpicondylitisPreclinical

Active, not recruiting

TendinitisPhase 3

Active, not recruiting

Shoulder PainPreclinical

Active, not recruiting

ArthralgiaPhase 2

Active, not recruiting

Periodontal DisorderPreclinical

Active, not recruiting

Hearing LossPhase 1/Phase 2

Active, not recruiting

PresbyopiaPhase 1

Active, not recruiting

Showing 10 of 30 indications

Competition

Competitive Landscape

778 competitors in Osteoarthritis

#DrugCompanyPhaseTrials

Restasis

TTaiwan Bio Therapeutics Inc.

Approved

29 2

Epidiolex

Jazz Pharmaceuticals

Preclinical

4 3

Toradol

Roche

Preclinical

1 4

Cataflam

Bayer Aspirin

Platelet Rich Plasma

25 7

Voltaren

CCerimon Pharmaceuticals

Preclinical

4 8

Enbrel

IImmunex

Preclinical

2 9

Paracetamol

GSK

Preclinical

4 10

Chirocaine

PPurdue Pharma LP

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 3Active, not recruiting

Osteoarthritis

NCT07102225

Q4 2026

N/ANot yet recruiting

Tooth Extraction

NCT07205640

PreclinicalRecruiting

Intraarticular

NCT07666347

N/ANot yet recruiting

Premature Ejaculation

NCT07236632

Phase 1/2Not yet recruiting

Hyaluronic Acid

NCT07012525

Q1 2027

Phase 1Not yet recruiting

Cystitis, Interstitial

NCT07658118

Clinical

Trials by Indication[1]

Osteoarthritis29 trials

Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells

Completed·RRed de Terapia Celular·Phase 1/2·NCT01586312·30 enrolled

Gait Patterns After Intraarticular Treatment of Patients With Osteoarthritis of the Knee

Completed·PPhilipps University Marburg·Phase 4·NCT00731289·60 enrolled

Intra-Articular, Single-shot Injection of Hyaluronic Acid and Corticosteroids in Knee Osteoarthritis

Unknown status·ZZhongda Hospital·Phase 1·NCT03047096·120 enrolled

Show 26 more trials

Treatment of Knee Osteoarthritis by Intra-articular Injection of Bone Marrow Mesenchymal Stem Cells

Completed·—·Phase 1/2·NCT02123368·30 enrolled

Ultrasound-guided Injection of Glucocorticoid Into Infrapatellar Fat Pad in Patients With Knee Osteoarthritis

Completed·ZZhujiang Hospital·Phase 4·NCT05291650·60 enrolled

Intra-articular Hyaluronic Acid in Mild to Moderate Knee Osteoarthritis

Completed·TTechnical University of Munich··NCT01239810·34 enrolled

Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis

Completed·UUniversity of Milan·Phase 4·NCT03211650·174 enrolled

The Role of Synovitis in Osteoarthritis

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03167333·100 enrolled

Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint

Completed·SSamsung Medical Center·Phase 3·NCT02211521·110 enrolled

Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis

Unknown status·MMeir Medical Center·Phase 2/3·NCT01270412·100 enrolled

Autologous Adipose-Derived Stromal Vascular Fraction Cells for Osteoarthritis Treatment

Completed·RRussian Academy of Medical Sciences·Phase 1/2·NCT02967874·27 enrolled

Intra-articular Adipose Tissue Injections for Osteoarthritis

Unknown status·UUniversity of Southern California·N/A·NCT03242707·54 enrolled

Multicenter Clinical Trial Comparing Treatment with Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control with Hyaluronic Acid in Patients with Knee Osteoarthritis.

Active, not recruiting·FFundación Instituto de Estudios de Ciencias de la Salud de Castilla y León·Phase 3·NCT05086939·124 enrolled

Effect Of Plasma Rich In Growth Factors In Knee Osteoarthritis

Completed·FFundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias·Phase 3·NCT02039531·96 enrolled

Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid

Unknown status·HHumanitas Clinical and Research Center·Phase 3·NCT04426721·120 enrolled

The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid

Completed·CClinical Center of Vojvodina·Phase 4·NCT03825133·180 enrolled

Evaluation of Methods of Teaching Self-management Strategies to Patients With Symptomatic Knee Osteoarthritis

Completed·HHospital for Special Surgery, New York·Phase 4·NCT03245463·24 enrolled

Preparation Rich in Growth Factors (PRGF) Treatment for Osteoarthritis of the Knee

Completed·MMeir Medical Center·Phase 2/3·NCT00728611·60 enrolled

Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis.

Completed·TTanta University·N/A·NCT06710782·80 enrolled

Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis

Completed·HHospital for Special Surgery, New York·Phase 4·NCT02984228·70 enrolled

A Study to Assess Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells in Knee Osteoarthritis

Completed·FFrancisco Espinoza, MD·Phase 1/2·NCT02580695·30 enrolled

To Evaluate the Optimum Dose of Platelet Rich Plasma in Knee Osteoarthritis and Compare Efficacy With Hyaluronic Acid

Completed·—·Phase 2·NCT04198467·100 enrolled

Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis

Completed·RRush University Medical Center·N/A·NCT02588872·111 enrolled

Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis

Unknown status·NNational University of Malaysia·Phase 2·NCT01459640·50 enrolled

Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis

Unknown status·UUniversity of Wasit·Phase 3·NCT04980105·150 enrolled

Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management

Unknown status·IIndonesia University·Phase 1·NCT03800810·9 enrolled

Combination of Platelets Rich Plasma and Hyaluronic is an Effective Tool for Treatment of Knee Osteoarthritis

Completed·UUniversity of Karachi·N/A·NCT07089446·60 enrolled

PRP-HA Versus HA in Knee Osteoarthritis

Unknown status·SSingapore General Hospital·Phase 2/3·NCT05076526·132 enrolled

Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis.

Active, not recruiting·—·Phase 3·NCT07102225·56 enrolled

Hyaluronic Acid27 trials

Treatment of Osteoarthrosis of the Knee With Platelet Rich Plasma, Comparative Study With Hyaluronic Acid

Completed·KKarla Andrea Arias Varela·Phase 3·NCT03477630·28 enrolled

Hyaluronic Acid Injection in the Glans Penis Versus Selective Serotonin Reuptake Inhibitors for Lifelong Premature

Completed·NNew Valley University·N/A·NCT06451406·60 enrolled

Influence of Hyaluronic Acid on Bacillus Calmette-Guérin Local Side Effects

Completed·UUniversity of Rome Tor Vergata·Phase 2·NCT02207608·30 enrolled

Show 24 more trials

Role of Hyaluronic Acid in Bone Healing After Dental Extraction

Completed·—·N/A·NCT02330822·20 enrolled

A Comparison Between Sonoguided Injection Corticosteroid and Hyaluronic Acid Injection in Treatment of Trigger Finger

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT01950793·36 enrolled

Intraarticular Glucose Versus Hyaluronic Acid Injection for Knee Osteoarthrosis

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03690232·100 enrolled

Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human

Completed·FFederal University of Minas Gerais·Phase 1/2·NCT02709525·16 enrolled

The Effect of Hyaluronic Acid Gel on Relieving Post-Implantation Pain

Completed·—·N/A·NCT05776290·11 enrolled

Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars

Unknown status·—·Phase 3·NCT05116306·36 enrolled

Hyaluronic Acid Gel in Ridge Preservation

Completed·—·Phase 4·NCT06176937·24 enrolled

A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction

Completed·EEmory University·Phase 4·NCT01524913·102 enrolled

Effect of Hyaluronic Acid on Perimplantitis

Completed·UUniversidad de Granada·Phase 4·NCT03157193·61 enrolled

the Effect of Topical Application of Hyaluronic Acid on Immediate Dental Implant

Completed·IIbrahim Samy Kalboush·Phase 4·NCT03691467·24 enrolled

The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline

Unknown status·—·N/A·NCT05161403·39 enrolled

Hyaluronic Acid, Corticosteroid and Electrotherapy in Subacromial Impingement Syndrome

Completed·ŞŞeyhmus KAPLAN·N/A·NCT04833738·90 enrolled

Insulin Versus Hyaluronic Acid in Management of Periodontal Defects

Unknown status·OOctober University for Modern Sciences and Arts·Phase 3·NCT05746676·30 enrolled

What Factors Are Associated With Prognosis of Rotator Cuff Disorder After Subacromial Hyaluronic Acid Injection

Unknown status·TTaipei Veterans General Hospital, Taiwan·N/A·NCT03677895·200 enrolled

Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy

Completed·UUniversidad Complutense de Madrid·Phase 4·NCT04110587·54 enrolled

Role of Hyaluronic Acid in the Prevention of Post-operative Adhesions: a RCT

Unknown status·SServices Institute of Medical Sciences, Pakistan·Phase 3·NCT02790177·150 enrolled

Clinical and Radiographic Evaluation of the Effect of Hyaluronic Acid Surface Treatment Versus Sandblasted Acid Etched on Stability of Delayed Dental Implant in Posterior Maxilla.

Unknown status·—·N/A·NCT06033989·20 enrolled

Hyaluronic Acid Application Following Frenectomy

Completed·GGazi University·N/A·NCT03920553·40 enrolled

EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders

Recruiting·BBasel khaled mohamed·Phase 1/2·NCT06694532·30 enrolled

Application of Hyaluronic Acid in Diabetes

Unknown status·—·N/A·NCT05543434·26 enrolled

Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections

Completed·—·N/A·NCT03761472·40 enrolled

Clinical Evaluation of Photobiomodulated Hyaluronic Acid Therapy for Interdental Papillary Loss: Minimal Invasive Blind Split Mouth Technique

Not yet recruiting·—·Phase 1/2·NCT07012525·14 enrolled

MEBO Ointment and Hyaluronic Acid Gel in the Management of Pain After Free Gingival Graft Harvesting

Unknown status·—·Phase 1/2·NCT03728244·30 enrolled

Injection of Hyaluronic Acid Versus Corticosteroid for Treatment of Trigger Finger

Unknown status·DDubai Health Authority·Phase 1·NCT04645303·100 enrolled

Wound Healing4 trials

Randomized, Controlled, Multicenter Study of Extracellular Vesicles From Human Adipose Tissue Promoting Wound Healing

Unknown status·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·N/A·NCT06253975·20 enrolled

Effect of Hyaluronic Acid and Single Dose Corticosteroid Injection to Improve Wound Healing in Controlled Diabetic Patients Post Tooth Extraction.

Completed·RRimsha Rasheed·Phase 4·NCT06637384·128 enrolled

Palatal Wound Healing Evaluation After Application of Platelet Rich Fibrin Versus 0.2% Hyaluronic Acid Dressings

Completed·—·Phase 4·NCT04390100·30 enrolled

Show 1 more trial

Comparison of I-PRF, T-PRF, and 0.8% Hyaluronic Acid Applications in Wound Healing After Gingivectomy.

Active, not recruiting·SSaglik Bilimleri Universitesi·N/A·NCT06865092·60 enrolled

Periodontitis3 trials

''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis

Completed·EEhab Haider Hassan El-emam·Phase 4·NCT05834517·28 enrolled

Clinical and Immunological Evaluation of HA in Treatment of Periodontitis

Not yet recruiting·SSana'a University·N/A·NCT06324474·24 enrolled

Hyaluronic Acid Versus Red Injectable Platelet Rich Fibrin in Treatment of Periodontitis

Completed·—·Phase 4·NCT05768243·75 enrolled

Mesenchymal Stem Cells3 trials

Safety Study of Filler Agent Composed of Umbilical Cord Mesenchymal Stem Cells and Hyaluronic Acid

Unknown status·SSouth China Research Center for Stem Cell and Regenerative Medicine·Phase 1·NCT02698813·30 enrolled

The Comparison of Efficacy and Safety of the Mesenchymal Stem Cells From Adipose and Hyaluronic Acid

Unknown status·PPeking University People's Hospital·N/A·NCT03357575·14 enrolled

RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):

Completed·—·Phase 1·NCT04326985·20 enrolled

45 more indications

Hyaluronate2 trials

Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic for Internal Derangement

Unknown status·—·Phase 4·NCT06426199·20 enrolled

Functional Improvement and UTC of the Achilles Tendon After Sodium Hyaluronate Injection for Plantaris Syndrome

Unknown status·FFortius Clinic·Phase 4·NCT03077009·33 enrolled

Hearing Loss2 trials

Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss

Not yet recruiting·SSeoul National University Hospital·Phase 1/2·NCT06437054·26 enrolled

Verification of the Efficacy/safety of the Intratympanic Drug Delivery for Hearing Loss

Completed·SSeoul National University Hospital·Phase 1/2·NCT04766853·15 enrolled

Gingival Recession2 trials

Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession

Completed·OOrdu University·Phase 1/2·NCT07437885·20 enrolled

Effect of Hyaluronic Acid on Gingival Recession Treatment

Unknown status·KKrishnadevaraya College of Dental Sciences & Hospital·Phase 4·NCT04692558·20 enrolled

Adhesive Capsulitis2 trials

Efficacy of Intra-articular Hyaluronate Injection for Adhesive Capsulitis

Completed·TTri-Service General Hospital·N/A·NCT05983081·46 enrolled

The Efficacy of Ultrasound-guided Hydrodilatation With Hyaluronic Acid for Patients With Adhesive Capsulitis

Completed·TTaipei Veterans General Hospital, Taiwan·N/A·NCT02708706·62 enrolled

Periodontal Pocket2 trials

Effect of Hyaluronic Acid in the Treatment of Periodontal Pockets

Completed·—·N/A·NCT02170857·30 enrolled

Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment

Completed·UUniversity of Roma La Sapienza·N/A·NCT04702334·144 enrolled

Bursitis2 trials

Effect of Ultrasound-guided Hyaluronic or Corticosteroid Injections in Patients With Chronic Subacromial Bursitis

Completed·SShin Kong Wu Ho-Su Memorial Hospital·N/A·NCT02702206·207 enrolled

Additional Effect of Steroid on Hyaluronic Acid in Subdeltoid Bursitis

Not yet recruiting·SShin Kong Wu Ho-Su Memorial Hospital·Phase 4·NCT06935877·60 enrolled

Premature Ejaculation2 trials

Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study

Not yet recruiting·—·N/A·NCT07236632·80 enrolled

Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation

Completed·—·Phase 3·NCT03459833·30 enrolled

Intraarticular2 trials

Intraarticular Injections of Platelet-rich Plasma in Pain's Treatment of the Osteoarthritic Knee

Completed·FFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud·Phase 3·NCT02448407·52 enrolled

Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis

Recruiting·TTanta University·Preclinical·NCT07666347·50 enrolled

Complication2 trials

Comparing Methylprednisolone And Hyaluronic Acid To Reduce Wisdom Tooth Surgery Complications

Enrolling by invitation·SSana'a University·Phase 3·NCT07317596·40 enrolled

Controlling Post-extraction Complications of Impacted Mandibular Third Molar

Completed·—·N/A·NCT04816253·72 enrolled

Growth2 trials

Treatment of Knee Arthrosis With Platelet-derived Growth Factors vs. Hyaluronic Acid.

Completed·FFondazione IRCCS Policlinico San Matteo di Pavia·Phase 2·NCT02958761·58 enrolled

Microbial Growth in the Suture Thread, After Application of Different Antiseptic Gels in Mandibular Third Molars Extraction

Completed·UUniversity of Santiago de Compostela·Phase 4·NCT03188289·21 enrolled

Tranexamic Acid1 trial

Use of Tranexamic Acid in Facial Fillers

Withdrawn·UUniversity of Wisconsin, Madison·Phase 4·NCT04373603

Prospective1 trial

EuroPainClinics® Study II (Prospective Trial)

Completed·EEPC Education s.r.o.·N/A·NCT02459392·300 enrolled

Hysteroscopy1 trial

Pharmacological Preparation of the Cervix for Hysteroscopy

Completed·JJagiellonian University·N/A·NCT05783479·96 enrolled

Articular Cartilage1 trial

Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration

Completed·KKuala Lumpur Sports Medicine Centre·Phase 2·NCT01076673·50 enrolled

Urinary Tract Infection1 trial

Intravesical Instillation of Hyaluronic Acid to Decrease Incidence of Urinary Tract Infection

Withdrawn·RRabin Medical Center·Phase 4·NCT02034890

Proctitis1 trial

Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis

Completed·—·Phase 1/2·NCT06469216·44 enrolled

Trial1 trial

Hylenex-Assisted Resuscitation in Kenya (HARK) Trial for the Management of Dehydration

Completed·MMassachusetts General Hospital·Phase 2·NCT02265575·51 enrolled

Injury1 trial

Development of Novel Strategy for Treatment of Anterior Cruciate Ligament (ACL) Injury Using Stem Cell

Completed·SSamsung Medical Center·N/A·NCT02755376·30 enrolled

Carcinoma1 trial

Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma

Completed·AAyhman Al Afif·Phase 2·NCT04525066·39 enrolled

Oral Submucous Fibrosis1 trial

Evaluation of Efficacy of Aloevera in the Treatment of Oral Submucous Fibrosis- A Clinical Study

Completed·TThe Oxford Dental College, Hospital and Research Center, Bangalore, India·Phase 3·NCT02714543·74 enrolled

Rotator Cuff Tear1 trial

The Effect of Platelet Rich Plasma Injection Combined With Exercise Rehabilitation in Patients With Rotator Cuff Tear

Completed·TTaipei Veterans General Hospital, Taiwan·Phase 1·NCT03548662·30 enrolled

Lateral Epicondylitis1 trial

Injection Therapy in Patients With Lateral Epicondylitis

Completed·HHacettepe University·N/A·NCT04395417·32 enrolled

Randomized Controlled Trial1 trial

Early Viscosupplementation After Partial Meniscectomy: a Randomized Controlled Trial

Completed·IIstituto Ortopedico Rizzoli·Phase 4·NCT02629380·90 enrolled

Oral Mucositis1 trial

Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy

Completed·YYuzuncu Yil University·Phase 4·NCT05818007·40 enrolled

Outcome1 trial

Voice and Swallow Outcomes After Office-based Injection Laryngoplasty in Patients With Glottal Insufficiency

Unknown status·SSohag University·N/A·NCT06161064·10 enrolled

Shoulder pain1 trial

Hemiplegic Shoulder Pain and Rotator Cuff Injuries

Completed·—·N/A·NCT02465853·42 enrolled

Ultrasound1 trial

Efficacy of Ultrasound Guided Hyaluronic Injection in Treatment of Trigger Finger

Unknown status·MMahidol University·Phase 2/3·NCT03131882·120 enrolled

Arthralgia1 trial

Trial of Oral Hyaluronic Acid for the Prevention of Aromatase Inhibitor-Associated Arthralgias

Withdrawn·EErin Newton·Phase 2·NCT03384095

Pregnancy1 trial

the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome

Recruiting·—·Phase 2·NCT06937645·120 enrolled

Thyroid Eye Disease1 trial

Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease

Terminated·UUniversity of California, Los Angeles·Phase 4·NCT01738243·2 enrolled

Medication1 trial

New Vital Pulpotomy Medications in Primary Molars

Active, not recruiting·MMansoura University·N/A·NCT05937100·48 enrolled

Musculoskeletal1 trial

Orthobiological Therapies in Musculoskeletal Disorders

Not yet recruiting·PPROREGEN·Phase 1·NCT07434115·300 enrolled

Platelet-rich Fibrin1 trial

Comparison of Hyaluronic Acid, Injectable Platelet-Rich Fibrin, and Prolotherapy in TMJ Arthrocentesis

Completed·OOndokuz Mayıs University·N/A·NCT07479693·36 enrolled

Surgical1 trial

Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy

Unknown status·IInstitute of Dental Sciences, Bareilly, Uttar Pradesh, India·N/A·NCT04070729·120 enrolled

Atrophy1 trial

A Comparison of Hyaluronic Acid and Estradiol Treatment in Vulvovaginal Atrophy.

Completed·KKoru Health Groups·N/A·NCT06144814·300 enrolled

Treatment Outcome1 trial

Local Application of Hyaluronic Acid (HYADENT BG) With Free Soft Tissue Grafing Improves Treatment Outcomes.

Completed·JJordan University of Science and Technology·Phase 2/3·NCT04821804·24 enrolled

Arthropathy1 trial

Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy

Completed·TTri-Service General Hospital·N/A·NCT02601170·22 enrolled

Tooth Extraction1 trial

Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid

Not yet recruiting·—·N/A·NCT07205640·36 enrolled

Efficacy1 trial

Evaluation of Clinical Efficacy of Different Injection Therapies for Treating Humeral Epicondylopathy

Unknown status·WWroclaw Medical University·Phase 4·NCT04521387·120 enrolled

Thyroid Surgery1 trial

Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery

Completed·NNational Taiwan University Hospital·Phase 1·NCT05851560·45 enrolled

Tendinitis1 trial

Benefit of a Subacromial Injection Combining Corticosteroid and Hyaluronic Acid Versus Corticosteroid Alone in Supraspinatus Tendinopathy

Recruiting·CCentre Hospitalier Departemental Vendee·Phase 3·NCT06376981·132 enrolled

Palatal Donor Site Wound Healing1 trial

COMPARİSON OF HYPOCHLOROUS ACİD, HYALURONİC ACİD, AND CHLORHEXİDİNE MOUTHRİNSES ON PALATAL DONOR SİTE HEALİNG FOLLOWİNG FREE GİNGİVAL GRAFT SURGERY: A SİNGLE-BLİND CONTROLLED CLİNİCAL TRİAL

Completed·YYuzuncu Yil University·Preclinical·NCT07689695·54 enrolled

Osteoarthritis, Knee1 trial

A Phase IIb Study to Evaluate the Efficacy and Safety of Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)

Completed·TTaiwan Bio Therapeutics Inc.·Phase 2·NCT05027581·72 enrolled

Cystitis, Interstitial1 trial

A Pilot Open-Label Prospective Study of Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Not yet recruiting·SSverdlovsk Regional Clinical Hospital No.1·Phase 1·NCT07658118·15 enrolled

Unspecified1 trial

Humectant Activity of a New Formulation of Gynomunal® Vaginalgel

Completed·DDerming SRL·Phase 4·NCT01948583·28 enrolled

Sources

References

[1]
ClinicalTrials.gov — 121 trial records for Hyaluronic Acid. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Restasis drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Hyaluronic Acid compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Hyaluronic Acid. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Taiwan Bio Therapeutics Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: TTaiwan Bio Therapeutics Inc.

Restasis

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Trials by Indication[1]

Osteoarthritis29 trials

Hyaluronic Acid27 trials

Wound Healing4 trials

Periodontitis3 trials

Mesenchymal Stem Cells3 trials

Hyaluronate2 trials

Hearing Loss2 trials

Gingival Recession2 trials

Adhesive Capsulitis2 trials

Periodontal Pocket2 trials

Bursitis2 trials

Premature Ejaculation2 trials

Intraarticular2 trials

Complication2 trials

Growth2 trials

Tranexamic Acid1 trial

Prospective1 trial

Hysteroscopy1 trial

Articular Cartilage1 trial

Urinary Tract Infection1 trial

Proctitis1 trial

Trial1 trial

Injury1 trial

Carcinoma1 trial

Oral Submucous Fibrosis1 trial

Rotator Cuff Tear1 trial

Lateral Epicondylitis1 trial

Randomized Controlled Trial1 trial

Oral Mucositis1 trial

Outcome1 trial

Shoulder pain1 trial

Ultrasound1 trial

Arthralgia1 trial

Pregnancy1 trial

Thyroid Eye Disease1 trial

Medication1 trial

Musculoskeletal1 trial

Platelet-rich Fibrin1 trial

Surgical1 trial

Atrophy1 trial

Treatment Outcome1 trial

Arthropathy1 trial

Tooth Extraction1 trial

Efficacy1 trial

Thyroid Surgery1 trial

Tendinitis1 trial

Palatal Donor Site Wound Healing1 trial

Osteoarthritis, Knee1 trial

Cystitis, Interstitial1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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