Mecobalamin

Phase 3Small molecule

Eisai

Mecobalamin is one of 96 small molecule programs targeting Peripheral Neuropathy. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Peripheral NeuropathyUnknown status

Facial ParalysisActive, not recruiting

DeafnessActive, not recruiting

Diabetic Peripheral NeuropathyNot yet recruiting

Recurrent Laryngeal NerveNot yet recruiting

Efficacy and SafetyActive, not recruiting

NeuropathyRecruiting

Peripheral NeuropathyPhase 3

Unknown status

Facial ParalysisPreclinical

Active, not recruiting

DeafnessPreclinical

Active, not recruiting

Diabetic Peripheral NeuropathyPreclinical

Not yet recruiting

Recurrent Laryngeal NervePhase 3

Not yet recruiting

Efficacy and SafetyPhase 3

Active, not recruiting

NeuropathyPreclinical

Recruiting

Competition

Competitive Landscape

228 competitors in Efficacy and Safety

#DrugCompanyPhaseTrials

Tuoyi

SSun Yat-sen University

Phase 3

4 2

Busulfex

Akero Therapeutics

Phase 3

3 3

BESREMI

PPharmaEssentia

Phase 3

2 4

Avalglucosidase Alfa

Sanofi

Phase 3

1 5

Mecobalamin

Eisai

Phase 3

1 6

PLB1004

AAvistone Biotechnology Co., Ltd.

Phase 3

1 7

Tpoxx

SSIGA Technologies

Phase 3

1 8

Hemay005

GGanzhou Hemay Pharmaceutical Co., Ltd

Phase 3

2 9

KN057

SSuzhou Alphamab Co., Ltd.

Phase 3

2 10

IN-B00009

HHK inno.N Corporation

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Not yet recruiting

Neurovascular Coupling

NCT06813274

Q3 2027

Post-ApprovalRecruiting

Retinal Vein Occlusion

NCT07133438

PreclinicalNot yet recruiting

Diabetic Peripheral Neuropathy

NCT07771894

Q4 2027

PreclinicalRecruiting

Neuropathy

NCT07907536

Q4 2028

Phase 3Not yet recruiting

Recurrent Laryngeal Nerve

NCT07274696

Clinical

Trials by Indication[1]

Peripheral Neuropathy4 trials

Effect of Rotating Magnetic Therapy on Diabetic Peripheral Neuropathy

Unknown status·MMajianhua·N/A·NCT03983200·200 enrolled

Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy

Recruiting·QQinghai Red Cross Hospital·Phase 3·NCT07423390·326 enrolled

Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients

Unknown status·XXiangya Hospital of Central South University·Phase 4·NCT05184049·72 enrolled

Show 1 more trial

Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy

Completed·—·Phase 4·NCT02923388·88 enrolled

Mesenchymal Stem Cell Transplantation1 trial

Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm

Unknown status·XXinhua Hospital, Shanghai Jiao Tong University School of Medicine·Phase 1·NCT02853942·100 enrolled

Recurrent Laryngeal Nerve1 trial

Mecobalamin in Promoting Recurrent Laryngeal Nerve Function Recovery After Thyroid Surgery

Not yet recruiting·WWest China Hospital·Phase 3·NCT07274696·528 enrolled

Gastrectomy1 trial

Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy

Completed·YYonsei University·Phase 2·NCT00699478·30 enrolled

Injury1 trial

Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury

Unknown status·SSichuan Provincial People's Hospital·Phase 4·NCT06220929·40 enrolled

13 more indications

Neurotoxicity1 trial

Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients

Completed·—·Phase 2/3·NCT03593304·40 enrolled

Neurovascular Coupling1 trial

Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling

Not yet recruiting·HHejiang Ye·Phase 2·NCT06813274·160 enrolled

Facial Paralysis1 trial

Effect of Stellate Ganglion Block Combined With Facial Nerve Block on the Treatment of Idiopathic Facial Paralysis

Completed·ZZhuan Zhang·N/A·NCT04800666·80 enrolled

Deafness1 trial

Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness

Unknown status·ZZhuan Zhang·N/A·NCT05623384·90 enrolled

Fibromyalgia1 trial

Evaluation of the Efficiacy of Mecobalamine in the Treatment of Long-term Pain in Women Diagnosed With Fibromyalgia

Completed·LLinnaeus University·Phase 1/2·NCT05008042·40 enrolled

Retinal Vein Occlusion1 trial

Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment

Recruiting·FFirst Affiliated Hospital of Chongqing Medical University·Phase 4·NCT07133438·120 enrolled

Efficacy and Safety1 trial

The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome

Active, not recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 3·NCT05165069·234 enrolled

Type 2 Diabetes Mellitus1 trial

Lung Function in Patients With Early Type 2 Diabetes Mellitus

Completed·LLiaoning University of Traditional Chinese Medicine·Phase 2/3·NCT03167918·200 enrolled

Dementia1 trial

The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia.

Completed· Eisai logo

Eisai·Phase 4·NCT00165711

Thyroid Cancer1 trial

Oral Mecobalamin for the Treatment of Tyrosine Kinase Inhibitor-Associated Hand-Foot Syndrome in Patients With Advanced Thyroid Cancer: A Single-Center, Open-Label, Randomized Controlled Trial

Completed·LLi Zhihui·Phase 2·NCT07911891·100 enrolled

Neuropathy1 trial

Efficacy and Safety of Acupuncture at Xinshu (BL15), Jueyinshu (BL14) and Yishu (EX-B3) for Cardiac Autonomic Neuropathy in Patients With Type 2 Diabetes

Recruiting·TThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School·Preclinical·NCT07907536·60 enrolled

Bladder Cancer1 trial

Efficacy and Safety of Disitamab Vedotin Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder Cancer: A Single-Arm Clinical Study

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 1·NCT07853053·20 enrolled

Diabetic Peripheral Neuropathy1 trial

Mechanistic Study of Zuogui Jiangtang Shuluo Formula in Regulating Lipid Metabolism and Inhibiting Ferroptosis for the Prevention and Treatment of Diabetic Peripheral Neuropathy

Not yet recruiting·TThe First Affiliated Hospital of Hunan University of Traditional Chinese Medicine·Preclinical·NCT07771894·74 enrolled

Sources

References

[1]
ClinicalTrials.gov — 21 trial records for Mecobalamin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Mecobalamin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Mecobalamin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Eisai company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Eisai

Mecobalamin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q3 2027

Q4 2027

Q4 2028

Trials by Indication[1]

Peripheral Neuropathy4 trials

Mesenchymal Stem Cell Transplantation1 trial

Recurrent Laryngeal Nerve1 trial

Gastrectomy1 trial

Injury1 trial

Neurotoxicity1 trial

Neurovascular Coupling1 trial

Facial Paralysis1 trial

Deafness1 trial

Fibromyalgia1 trial

Retinal Vein Occlusion1 trial

Efficacy and Safety1 trial

Type 2 Diabetes Mellitus1 trial

Dementia1 trial

Thyroid Cancer1 trial

Neuropathy1 trial

Bladder Cancer1 trial

Diabetic Peripheral Neuropathy1 trial

References

Drug Info

Quick Facts

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