Metformin XR

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Multiple MyelomaCardiovascularPolycystic Kidney DiseaseType 2 Diabetes (T2DM)

282 competitors in Multiple Myeloma

#DrugCompanyPhaseTrials

1

Belamaf

GSK

Phase 3

392

Xpovio

KKaryopharm Therapeutics Inc

Phase 3

293

BLENREP

GGlaxo Dba Glaxosmithkline

Phase 3

104

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 3

95

Mezigdomide

Bristol-Myers Squibb

Phase 3

116

Etentamig

AbbVie

Phase 3

87

Adriamycin

HHRYZ Biotech Co.

Phase 3

48

Cevostamab

Roche

Phase 3

99

Metformin XR

AstraZeneca

Phase 3

210

JNJ-79635322

Johnson & Johnson

Phase 3

4Show 26 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Metformin11 trials

BE Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin HCl XR Tablet Relative to a 5 mg Saxagliptin (Onglyza™) Tablet and a 500 mg Metformin HCl XR (Glifage® XR Marketed in Brazil by Merck S.A.) Tablet Co-Administered to Healthy Subjects in the Fasted and Fed States

Withdrawn·AstraZeneca·Phase 1·NCT01305551

PCOS Treatment Using DLBS3233, Metformin, and Combination of Both

Completed·DDexa Medica Group·Phase 3·NCT01999686·186 enrolled

Study To Evaluate 24 Hour Blood Sugar Control (24-hour Mean Weighted Glucose) In Subjects That Are Taking Saxagliptin 5 mg Added Onto Metformin XR 1500 XR mg Compared To Subjects Taking Metformin XR 1500 mg Up-titrated To Metformin XR 2000 mg

Completed·AstraZeneca·Phase 3·NCT00918138·219 enrolled

Show 8 more trials

A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components

Completed·Johnson & Johnson·Phase 1·NCT02073227·52 enrolled

A Study to Compare MP-513 20mg & Metformin XR 1000mg FDC With Coadministration of the Two Separate Drugs

Completed·HHandok Inc.·Phase 1·NCT03787017·36 enrolled

A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants

Completed·Johnson & Johnson·Phase 1·NCT02071368·3 enrolled

Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin XR Tablet (Manufactured in Mt Vernon, IN) Relative to 5 mg Saxagliptin Tablet and 500 mg Metformin XR Tablet (Manufactured in Evansville, IN)

Completed·AstraZeneca·Phase 1·NCT01192139·30 enrolled

An Efficacy & Safety Study of BMS-512148 in Combination With Metformin Extended Release Tablets

Completed·AstraZeneca·Phase 3·NCT00643851·994 enrolled

A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components

Completed·Johnson & Johnson·Phase 1·NCT02065752·2 enrolled

A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants

Completed·Johnson & Johnson·Phase 1·NCT02077803·47 enrolled

A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration

Completed·AstraZeneca·Phase 1·NCT01755494·64 enrolled

Type 2 Diabetes7 trials

An 18 Week Efficacy and Safety Study of Saxagliptin and Metformin XR Combination in Subjects With Type 2 Diabetes

Completed·AstraZeneca·Phase 3·NCT00960076·282 enrolled

Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes

Completed·Merck & Co.·Phase 4·NCT02252965·532 enrolled

Safety and Efficacy of Combination Saxagliptin & Dapagliflozin Added to Metformin to Treat Subjects With Type 2 Diabetes

Completed·AstraZeneca·Phase 3·NCT01606007·1,282 enrolled

Show 4 more trials

Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia

Completed·CCook County Health·Phase 4·NCT01267448·100 enrolled

Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes

Completed·Bristol-Myers Squibb·Phase 4·NCT01864174·1,736 enrolled

Study of Dapagliflozin in Combination With Metformin XR to Initiate the Treatment of Type 2 Diabetes

Completed·AstraZeneca·Phase 3·NCT00859898·1,093 enrolled

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Saxagliptin (BMS-477118) in Combination With Metformin IR or Metformin XR in Pediatric Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone

Completed·AstraZeneca·Phase 3·NCT01434186·32 enrolled

Multiple Myeloma2 trials

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Active, not recruiting·—·Phase 2·NCT04850846·60 enrolled

Phase II Trial, Open Label, Clinical Activity of Metformin in Combination With High-dose of Dexamethasone (HDdexa) in Patients With Relapsed/Refractory Multiple Myeloma

Terminated·UUniversity of Campinas, Brazil·Phase 2·NCT02967276·28 enrolled

Type 2 Diabetes Mellitus2 trials

A Study to Evaluate the Effectiveness, Safety, and Tolerability of Canagliflozin in Combination With Metformin in the Treatment of Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control With Diet and Exercise

Completed·Johnson & Johnson·Phase 3·NCT01809327·1,186 enrolled

A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289)

Completed·Merck & Co.·Phase 3·NCT01760447·223 enrolled

Polycystic Ovary Syndrome2 trials

Efficacy and Safety of DLBS3233 in Subjects With Polycystic Ovary Syndrome (PCOS)

Completed·DDexa Medica Group·Phase 3·NCT01733459·124 enrolled

Treatment of Infertility in Women With Polycystic Ovary Syndrome

Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 3·NCT00068861·678 enrolled

13 more indications

Polycystic Ovarian Syndrome (PCOS)2 trials

Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome

Completed·JJinnah Postgraduate Medical Centre·Phase 1·NCT07399535·116 enrolled

Effect of Nepeta Adenophyta Hedge Extract and Its Fractions on Polycystic Ovarian Syndrome (PCOS)

Completed·JJinnah Sindh Medical University·Phase 1·NCT07603505·116 enrolled

Body Weight1 trial

Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients

Completed·Bristol-Myers Squibb·Phase 4·NCT00778622·371 enrolled

Patients With Advanced Solid Tumors1 trial

A Pharmacodynamic Study of Sirolimus and Metformin in Patients With Advanced Solid Tumors

Completed·UUniversity of Chicago·Phase 1·NCT02145559·24 enrolled

Polycystic Kidney Disease1 trial

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

Recruiting·TThe University of Queensland·Phase 3·NCT04939935·1,174 enrolled

Homeostasis1 trial

Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis

Completed·WWoman's·Phase 3·NCT02022007·38 enrolled

Obesity1 trial

Effect of Dapagliflozin/Metformin XR vs Monotherapies on Anthropometric Indicators in Obesity

Unknown status·UUniversity of Guadalajara·Phase 4·NCT03710460·33 enrolled

Randomized1 trial

Randomized Sitagliptin Withdrawal Study (MK-0431-845)

Completed·Merck & Co.·Phase 3·NCT02738879·746 enrolled

Dapagliflozin1 trial

Bioavailability Study of Fixed Dose Combination (FDC) Formulations of Dapagliflozin and Metformin XR Versus Individual Component Coadministered to Healthy Subjects in a Fasted State

Completed·AstraZeneca·Phase 1·NCT01002807·15 enrolled

ART1 trial

A Study of LY900020 in Healthy Chinese Participants

Completed·Eli Lilly·Phase 1·NCT04047940·32 enrolled

Breast Cancer1 trial

Study of Safety and Efficacy of Dapagliflozin + Metformin XR Versus Metformin XR in Participants With HR+, HER2-, Advanced Breast Cancer While on Treatment With Alpelisib and Fulvestrant

Terminated·Novartis·Phase 2·NCT04899349·2 enrolled

Cardiovascular1 trial

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Recruiting·VVA Office of Research and Development·Phase 4·NCT02915198·7,410 enrolled

Concentration1 trial

Study of Saxagliptin, 5-Hydroxy Saxagliptin, and Metformin Concentrations/Levels in Pediatric Subjects With T2DM

Terminated·AstraZeneca·Phase 1·NCT01525225·4 enrolled

Type 2 Diabetes (T2DM)1 trial

A Double-Blind, Randomized, Active-Controlled Phase 2a Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of TriGlytza®-01 in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin Therapy

Not yet recruiting·MMyopharm Limited·Phase 2·NCT07139405·48 enrolled

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