Citanest

(Prilocaine)

PreclinicalSmall molecule

DDentsply International

Citanest is one of 85 small molecule programs targeting Prostate Carcinoma. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Prostate CarcinomaActive, not recruiting

Intrathecal InjectionCompleted

Cesarean SectionActive, not recruiting

Prostate CarcinomaPreclinical

Active, not recruiting

Intrathecal InjectionPreclinical

Completed

Cesarean SectionPreclinical

Active, not recruiting

Competition

Competitive Landscape

230 competitors in Cesarean Section

#DrugCompanyPhaseTrials

Marcaine

IInnocoll

Preclinical

21 2

Pitocin

RRetrophin

Preclinical

16 3

Naropin

FFresenius Kabi Oncology Ltd.

Preclinical

12 4

Neo-Synephrine

EExela Pharma Sciences, LLC.

Preclinical

11 5

Proamatine

Takeda

Preclinical

1 6

Duragesic

CCephalon

Preclinical

6 7

Versed

CConrado Roberto Hoffmann Filho

Preclinical

4 8

Catapres

Boehringer Ingelheim

Preclinical

4 9

Xylocaine

MMEDRx USA, Inc.

Preclinical

4 10

Ancef

BBaxter Healthcare Corporation

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

PreclinicalActive, not recruiting

Prostate Carcinoma

NCT07683182

Clinical

Trials by Indication[1]

Hyperbaric Bupivacaine3 trials

Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine in Spinal Anaesthesia

Active, not recruiting·NNational University Hospital, Singapore·Phase 4·NCT07329582·50 enrolled

Hyperbaric Prilocaine Compared With Hyperbaric Bupivacaine in Cervical Cerclage?

Recruiting·GGuy's and St Thomas' NHS Foundation Trust·Phase 4·NCT04394533·135 enrolled

Comparison of Hyperbaric Prilocaine 2% 50 Mg and Hyperbaric Bupivacaine 0.5% 12.5 Mg Against Spinal Anesthesia Recovery Time in Cystoscopy Procedure

Unknown status·IIndonesia University·Phase 4·NCT05610007·66 enrolled

Spinal Anesthesia2 trials

Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl

Completed·—·Phase 4·NCT01880775·50 enrolled

Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine

Completed·AAZ St.-Dimpna Geel··NCT02813382·101 enrolled

Prilocaine2 trials

Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine

Completed·GGaleno Desenvolvimento de Pesquisas Clínicas·Phase 1·NCT03441841·48 enrolled

Spinal Prilocaine for Caesarian Sections

Completed·UUniversity Hospital, Antwerp·N/A·NCT03219086·182 enrolled

Caesarean Section1 trial

Effect of Prilocaine on Motor Block During Caesarean Section

Completed·—·Phase 4·NCT06133881·40 enrolled

Cesarean Section1 trial

Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section

Completed·SSouth Valley University·N/A·NCT06290583·120 enrolled

9 more indications

Geriatric Patients1 trial

Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients

Completed·—·Phase 3·NCT06165679·112 enrolled

Infiltration1 trial

Anesthetic Efficacy of Liposomal Prilocaine in Maxillary Infiltration Anesthesia

Completed·UUniversity of Campinas, Brazil·Phase 1·NCT01073371·32 enrolled

Arteriovenous Fistula1 trial

Comparison of Infraclavicular Brachial Plexus Block and Local Anesthesia in Arteriovenous Fistula Surgeries and Their Effects on Tissue Oxygen Saturation

Completed·—·N/A·NCT06416111·60 enrolled

Bupivacaine1 trial

Unilateral Intrathecal Bupivacaine Versus Prilocaine on Postoperative Spontaneous Voiding

Completed·TTheodor Bilharz Research Institute·Phase 4·NCT07262398·70 enrolled

Femoral Nerve Block1 trial

Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy

Completed·AASST Gaetano Pini-CTO·Phase 4·NCT02384915·100 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Local Anesthesia1 trial

EEG and Auditory Evoked Potentials During Local Anesthesia

Unknown status·TTechnical University of Munich·Phase 4·NCT00408941·15 enrolled

Prostate Carcinoma1 trial

The Effect of Intraprostatic Local Anesthesia on Pain Perception During Transperineal Prostate Biopsy Under Local Anesthesia

Active, not recruiting·MMarmara University·Preclinical·NCT07683182·50 enrolled

Intrathecal Injection1 trial

Comparison Between Intrathecal Injection of Hyperbaric Prilocaine Versus Hyperbaric Bupivacaine for Cystoscopic Procedures: A Prospective Randomized Controlled Trial

Completed·HHelwan University·Preclinical·NCT07664618·100 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

CITANEST

NDA NDA014763

Jan 1, 1982

CITANEST PLAIN DENTAL

NDA NDA021382

Sources

References

[1]
ClinicalTrials.gov — 18 trial records for Prilocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Prilocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Prilocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA014763). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Dentsply International company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: DDentsply International

Citanest

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Trials by Indication[1]

Hyperbaric Bupivacaine3 trials

Spinal Anesthesia2 trials

Prilocaine2 trials

Caesarean Section1 trial

Cesarean Section1 trial

Geriatric Patients1 trial

Infiltration1 trial

Arteriovenous Fistula1 trial

Bupivacaine1 trial

Femoral Nerve Block1 trial

Blood Pressure1 trial

Local Anesthesia1 trial

Prostate Carcinoma1 trial

Intrathecal Injection1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

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