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Other/Bupivacaine

Bupivacaine

27

Pipeline Programs↗

37

Active Trials↗

10

Companies Involved↗

Bupivacaine is an emerging landscape with 27 programs across 10 companies. 5 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

34/100

Mech. Concentration

25/100

Completion Rate

78/100

Attrition Rate

15/100

Pipeline

Programs by Phase

Preclinical19

Intrathecal Morphine With Fentanyl

Makerere University

Bupivacaine Hydrocloride

Roswell Park Cancer Institute

Dexmedetomidine 0.4 Added

Menoufia University

Dexmedetomidine 0.6 Added

Menoufia University

Proparacaine

Vitae Pharmaceuticals Inc., an Allergan affiliate

Phase 12

Hyaluronidase

Antares Pharma Inc.

Ketamine

Aultman Health Foundation

Phase 21

Iopamidol

Bracco Diagnostics, Inc

Phase 35

Bupivacain

Istanbul University

Bupivacaine Liposomes(bl)

Huazhong University of Science and Technology

Sensorcaine With Epinephrine

Amin Javer

Liposomal Bupivacaine

TLC Biopharmaceuticals, Inc.

Epinephrine

Samson Clinical Operations Pty Ltd

Approved

No programs

Analysis

Modality Breakdown

96%

Small molecule

24 of 25 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 25 classified programs, each share of the total. Modality classified for 93% of 27 pipeline programs.

Analysis

Trial Status

245

clinical trials

Completed140 · 57%

Unknown status29 · 12%

Recruiting22 · 9%

Terminated21 · 9%

Withdrawn15 · 6%

Not yet recruiting9 · 4%

Other9 · 4%

Clinical Trials

Trial Activity

245 trials

Determination of the Optimal Volume of Liposomal Bupivacaine in Single-Shot Adductor Canal Block for Knee Joint Surgery-A Phase I/II Trial

Recruiting·NNanjing First Hospital, Nanjing Medical University·Approved·NCT06942689·80 enrolled

The Effect of Different Doses of Dexmedetomidine as an Adjuvant to Bupivacaine for Parturients Having Dural Puncture Epidural Technique to Elaborate Labor Pain

Recruiting·MMenoufia University·Preclinical·NCT07506044·140 enrolled

Effect of Bupivacaine Liposomes or Bupivacaine for Ultrasound-guided CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery: a Prospective, Single Blind, Completely Randomized, Active Controlled Clinical Trial

Recruiting·HHuazhong University of Science and Technology·Approved·NCT06737341·60 enrolled

Local LevoBupivacaine for Pain Relief After Endoscopic Submucosal Dissection for Esophageal Lesions

Recruiting·—·N/A·NCT06611176·88 enrolled

Efficacy of EXPAREL vs. Bupivacaine

Recruiting·EEmory University·Phase 3·NCT07212114·104 enrolled

Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

Recruiting·UUniversity of Chicago·Phase 2·NCT06635889·116 enrolled

Bupivacaine and Epinephrine Injection Study

Recruiting·—·Phase 2/3·NCT06456255·80 enrolled

Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine

Recruiting·TThe Cooper Health System·Phase 4·NCT03906617·34 enrolled

Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery

Recruiting·GGeorge Washington University·Phase 3·NCT06810375·120 enrolled

Liposomal Bupivacaine vs Ropivacaine for TAPBs

Recruiting·SSun Yat-sen University·Phase 3·NCT06430112·74 enrolled

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Recruiting·—·Phase 3·NCT06284434·60 enrolled

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

Recruiting·UUniversity of North Carolina, Chapel Hill·Phase 3·NCT06179004·100 enrolled

Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy

Recruiting·HHartford Hospital·Phase 4·NCT05224089·114 enrolled

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

Recruiting·MMilton S. Hershey Medical Center·Phase 4·NCT03737292·40 enrolled

Liposomal Bupivacaine and Transoral Robotic Surgery

Recruiting·GGeisinger Clinic·N/A·NCT05862792·80 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)