Propofol alone

ApprovedSmall molecule

WWashington University School of Medicine

Propofol alone is one of 108 small molecule programs targeting Sedation. It is currently in Approved.

Indications

Total Trials

Active Trials

107

Competitors

Pipeline

Status by Indication[3][1]

Indication

DeliriumActive, not recruiting

Inguinal HerniaActive, not recruiting

Acute LeukemiaActive, not recruiting

DeliriumPhase 1

Active, not recruiting

Inguinal HerniaApproved

Active, not recruiting

Acute LeukemiaPreclinical

Active, not recruiting

Competition

Competitive Landscape

173 competitors in Acute Leukemia

#DrugCompanyPhaseTrials

Cytosar

Teva

Phase 3

14 2

Trexall

Alnylam Pharmaceuticals

Phase 3

4 3

Cytoxan

BBaxter Healthcare Corporation

Phase 3

15 4

Decadron

AAspen Global Incorporated

Phase 3

3 5

Oncaspar

SServier

Phase 3

2 6

Rayos

RRoxane Laboratories

Phase 3

2 7

Deltasone

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Phase 3

1 8

Cerubidine

EEastern Cooperative Oncology Group

Phase 3

1 9

Wellcovorin

EEastern Cooperative Oncology Group

Phase 3

1 10

Levaquin

WWim Janssens

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 1Not yet recruiting

Delirium

NCT06756178

Q2 2028

Post-ApprovalNot yet recruiting

Inguinal Hernia

NCT06734195

Clinical

Trials by Indication[1]

Sedation3 trials

Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia

Completed·LLions Gate Hospital·Phase 3·NCT01211158·284 enrolled

Frontal Electroencephalography of Neonatal Patients Under Sedation With Opioids and General Anesthesia With Propofol.

Completed·PPontificia Universidad Catolica de Chile·N/A·NCT04904965·20 enrolled

Sedation in Patients Undergoing GIT Endoscopy

Unknown status·—·Phase 1·NCT05880459·60 enrolled

Inguinal hernia1 trial

Comparing the Synergistic Effect of Caudal Dexmedetomidine and Propofol Versus Caudal Dexmedetomidine Only or Propofol Only in Prevention of Sevoflurane Related Emergence Agitation in Pediatric Patients Undergoing Congenital Inguinal Hernia Repair

Not yet recruiting·—·Phase 4·NCT06734195·90 enrolled

Delirium1 trial

Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial

Not yet recruiting·—·Phase 1·NCT06756178·111 enrolled

Carbon Dioxide1 trial

Non-invasive Carbon Dioxide Monitoring and Endoscopic Retrograde Cholangiopancreatography Patients

Unknown status·—··NCT04481308·150 enrolled

Acute Leukemia1 trial

Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma

Completed·UUniversity of Wisconsin, Madison·N/A·NCT00214370·40 enrolled

1 more indication

High Risk1 trial

Propofol vs Propofol + Benzo/Opiates in High Risk Group

Terminated·WWashington University School of Medicine·N/A·NCT01315158·36 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Propofol alone. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Propofol alone compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Propofol alone. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Washington University School of Medicine company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: WWashington University School of Medicine

Propofol alone

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q2 2028

Trials by Indication[1]

Sedation3 trials

Inguinal hernia1 trial

Delirium1 trial

Carbon Dioxide1 trial

Acute Leukemia1 trial

High Risk1 trial

References

Drug Info

Quick Facts

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