Gastroenterology

Inguinal Hernia

51

Pipeline Programs↗

12

Active Trials↗

21

Companies Involved↗

Inguinal hernia is a moderately active landscape with 51 programs across 21 companies. The most active players are Shanghai Hengrui Pharmaceutical Co., Ltd., AstraZeneca, Pacira Pharmaceuticals, Inc. 15 therapies are approved with 9 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

61/100

Pipeline Velocity

27/100

Mech. Concentration

12/100

Completion Rate

94/100

Attrition Rate

3/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Shanghai Hengrui Pharmaceutical Co., Ltd.

1 program

AstraZeneca

1 program

Pacira Pharmaceuticals, Inc

3 programs

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

1 program

Alnylam Pharmaceuticals

1 program

GSK

1 program

Pipeline

Programs by Phase

Preclinical18

Nalbuphine

Aultman Health Foundation

Morphine

Hikma Pharmaceuticals LLC

Propofol

Fresenius Kabi Oncology Ltd.

Rocuronium

Fresenius Kabi Oncology Ltd.

Aspirin

Bayer

Phase 15

Midazolam

Conrado Roberto Hoffmann Filho

Naropin

Taiwan Liposome Company

HR18034

Shanghai Hengrui Pharmaceutical Co., Ltd.

Fulvestrant

Fresenius Kabi Oncology Ltd.

Anastrazole

AstraZeneca

Phase 24

Fentanyl

Cephalon

Acetaminophen

Kenvue Brands

Pethidine

Kasr El Aini Hospital

SKY0402

Pacira Pharmaceuticals, Inc

Phase 39

Dexamethasone

Aspen Global Incorporated

Duloxetine

Alnylam Pharmaceuticals

Paracetamol

GSK

Pregabalin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Levobupivacaine

Purdue Pharma LP

Approved15

Gabapentin

Viatris Specialty LLC

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Ropivacaine

Fresenius Kabi Oncology Ltd.

Bupivacaine

Innocoll

Ibuprofen

Kenvue Brands

Analysis

Modality Breakdown

99%

Small molecule

66 of 67 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 67 classified programs, each share of the total. Modality classified for 100% of 67 pipeline programs.

Analysis

Trial Status

62

clinical trials

Completed34 · 55%

Unknown status14 · 23%

Recruiting6 · 10%

Not yet recruiting3 · 5%

Active, not recruiting3 · 5%

Withdrawn2 · 3%

Clinical Trials

Trial Activity

62 trials

Postoperative Ozonated Oil Dressing After Open Inguinal Hernia Repair: A Randomized Pilot Trial

Recruiting·NNigde Omer Halisdemir University·N/A·NCT07328698·60 enrolled

Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery

Recruiting·KKasr El Aini Hospital·Phase 2·NCT06326944·50 enrolled

PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)

Recruiting·TTampere University Hospital·N/A·NCT07423910·200 enrolled

Effect of Preoperative Erector Spinae Plane Block on Recovery Quality, Time to Return to Daily Activities, and Postoperative Pain Scores in Inguinal Hernia Surgery

Recruiting·Sanliurfa Education and Research Hospital·Preclinical·NCT07509957·60 enrolled

Reversing InGuinal Hernia Trial (RIGHT Trial): The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males

Recruiting·NNorthwestern University·Phase 1·NCT07604272·30 enrolled

WATCH IT TRIAL WAtchful Waiting Versus immediaTe Repair for Occult Contralateral Hernias Found During MIS Inguinal Hernia Repair Trial.

Recruiting·NNorthwestern University·Preclinical·NCT07461558·380 enrolled

No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Active, not recruiting·—·Phase 4·NCT05929937·904 enrolled

Ilioinguinal Nerve Block With Local Anesthetic vs. Placebo in Inguinal Hernia Repair Under Spinal Anesthesia

Active, not recruiting·MMakassed General Hospital·Phase 1·NCT07049835·100 enrolled

Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk

Active, not recruiting·PParc de Salut Mar·Phase 3·NCT06606067·294 enrolled

Comparing the Synergistic Effect of Caudal Dexmedetomidine and Propofol Versus Caudal Dexmedetomidine Only or Propofol Only in Prevention of Sevoflurane Related Emergence Agitation in Pediatric Patients Undergoing Congenital Inguinal Hernia Repair

Not yet recruiting·—·Phase 4·NCT06734195·90 enrolled

Perioperative Rehabilitation for Individuals Undergoing Inguinal Hernia Repair: A Randomized Controlled Trial

Not yet recruiting·UUniversity of Alberta·Preclinical·NCT07680777·98 enrolled

Analgesic Efficacy of Ultrasound-Guided Transversalis Fascia Plane Block Versus Surgical Wound Infiltration After Open Inguinal Hernia Surgery: A Randomized Controlled Trial

Not yet recruiting·OOndokuz Mayıs University·Preclinical·NCT07238829·104 enrolled

Transabdominal Plane (TAP) Blocks for Inguinal Hernia Repairs

Completed·IIcahn School of Medicine at Mount Sinai·Phase 2/3·NCT05672680·100 enrolled

The Addition of Hydromorphone to Local Anesthetics for the Repair of Inguinal Hernias in Elderly Patients

Completed·SSecond Hospital of Jilin University·N/A·NCT06218160·63 enrolled

Intrathecal Morphine for Inguinal Hernia Repair.

Completed·—·Phase 4·NCT02001948·46 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)