selective alpha 1-blockers

PreclinicalSmall molecule

SSamsung Medical Center

selective alpha 1-blockers is one of 141 small molecule programs targeting Cognition. It is currently in Preclinical.

Indications

Total Trials

Active Trials

140

Competitors

Pipeline

Status by Indication[3][1]

Indication

CognitionActive, not recruiting

Post-Traumatic Stress DisorderActive, not recruiting

Major Depressive DisorderActive, not recruiting

Virtual RealityNot yet recruiting

CognitionPreclinical

Active, not recruiting

Post-Traumatic Stress DisorderPreclinical

Active, not recruiting

Major Depressive DisorderPreclinical

Active, not recruiting

Virtual RealityPreclinical

Not yet recruiting

Competition

Competitive Landscape

120 competitors in Major Depressive Disorder

#DrugCompanyPhaseTrials

Seroquel

EEngelhard Arzneimittel GmbH & Co.KG

Phase 3

12 2

Ketalar

Boehringer Ingelheim

Phase 3

3 3

Lithobid

SSolvay Pharmaceuticals

Phase 3

1 4

Clozaril

LLife Extension Foundation Inc.

Phase 3

1 5

Sunosi

AAxsome Therapeutics, Inc.

Phase 3

1 6

Psilocybin

COMPASS Pathways

Phase 3

11 7

Esketamine Hydrochloride

TThe Second Hospital of Anhui Medical University

Phase 3

2 8

Aticaprant

Johnson & Johnson

Phase 3

4 9

Selective Serotonin Reuptake Inhibitor

Johnson & Johnson

Phase 3

2 10

CYB003

CCybin IRL Limited

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

N/ANot yet recruiting

Virtual Reality

NCT07452341

Q4 2028

N/ANot yet recruiting

Major Depressive Disorder

NCT07390981

Clinical

Trials by Indication[1]

Major Depressive Disorder2 trials

Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder

Completed·—·Phase 4·NCT05181527·60 enrolled

Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder

Not yet recruiting·FFirst People's Hospital of Hangzhou·N/A·NCT07390981·114 enrolled

Benign Prostatic Hyperplasia1 trial

The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia

Withdrawn·SSamsung Medical Center·Phase 4·NCT00687388

Overactive Bladder1 trial

Efficacy and Safety of Selective Serotonin Reuptake Inhibitor (SSRI) in Overactive Bladder Patients

Completed·SSamsung Medical Center·Phase 4·NCT00902421·40 enrolled

Cohort Study1 trial

Prospective Clinical Cohort Study of Depression

Unknown status·SSir Run Run Shaw Hospital··NCT05775809·300 enrolled

Cognition1 trial

Effects of Menopause Hormonal Therapy and Selective Serotonin Reuptake Inhibitor on Cognition, Sexual Function and Quality of Life

Completed·FFaculdade de Medicina do ABC··NCT05050981·74 enrolled

2 more indications

Virtual Reality1 trial

Effect of Virtual Reality on Depression in Adolescent Females

Not yet recruiting·—·N/A·NCT07452341·48 enrolled

Post-Traumatic Stress Disorder1 trial

Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) Therapy Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the Treatment of Post-Traumatic Stress Disorder

Active, not recruiting·AAsad Ullah Jan·N/A·NCT06955845·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for selective alpha 1-blockers. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — selective alpha 1-blockers compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for selective alpha 1-blockers. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Samsung Medical Center company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: SSamsung Medical Center

selective alpha 1-blockers

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q4 2028

Trials by Indication[1]

Major Depressive Disorder2 trials

Benign Prostatic Hyperplasia1 trial

Overactive Bladder1 trial

Cohort Study1 trial

Cognition1 trial

Virtual Reality1 trial

Post-Traumatic Stress Disorder1 trial

References

Drug Info

Quick Facts

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