Seroquel

(Quetiapine)

ApprovedSmall molecule

Quetiapine is used to treat schizophrenia, bipolar disorder, and depression. It works by helping to balance certain chemicals in the brain that affect mood and thinking.[2] Seroquel is currently approved and in use across 32 indications[4].[1]

Seroquel is one of 495 small molecule programs targeting Methamphetamine Dependence. It is currently in Approved.

Indications

256

Total Trials

Active Trials

494

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Methamphetamine DependenceApproved

Depressive DisorderApproved

Psychiatric DisorderRecruiting

Drug-Induced DyskinesiaApproved

Mental or Behavioural DisorderApproved

Attention Deficit Hyperactivity DisorderApproved

ParkinsonismCompleted

Schizoaffective DisorderCompleted

Parkinson DiseaseApproved

DeliriumCompleted

Methamphetamine DependenceApproved

Approved

Depressive DisorderApproved

Approved

Psychiatric DisorderPhase 3

Recruiting

Drug-Induced DyskinesiaApproved

Approved

Mental or Behavioural DisorderApproved

Approved

Attention Deficit Hyperactivity DisorderApproved

Approved

ParkinsonismApproved

Completed

Schizoaffective DisorderApproved

Completed

Parkinson DiseaseApproved

Approved

DeliriumApproved

Completed

Showing 10 of 32 indications

Competition

Competitive Landscape

174 competitors in Schizophrenia

#DrugCompanyPhaseTrials

Seroquel

EEngelhard Arzneimittel GmbH & Co.KG

Approved

33 2

Inapsine

Jazz Pharmaceuticals

Preclinical

1 3

Ozempic

Novo Nordisk

Preclinical

1 4

Resotran

Takeda

Preclinical

1 5

Depakote

Ibrance

Lunesta

3 8

Persantine

Boehringer Ingelheim

Preclinical

1 9

Luvox

SSolvay Pharmaceuticals

Preclinical

1 10

Catapres

Boehringer Ingelheim

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalNot yet recruiting

Delirium

NCT05085808

N/ARecruiting

Study completion

NCT05480150

Q1 2027

N/ANot yet recruiting

Sleep

NCT04728581

Post-ApprovalRecruiting

Medication

NCT05590637

Q2 2028

Phase 3Recruiting

Brain Injury

NCT06333990

Phase 3Recruiting

First-Line Treatment

NCT05973786

Clinical

Trials by Indication[1]

Schizophrenia28 trials

Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT02600741·296 enrolled

Efficacy of Bifeprunox in Patients With Schizophrenia

Terminated· Lundbeck logo

Lundbeck·Phase 3·NCT00704509·346 enrolled

Study Evaluating the Clinical Benefit of SEROQUEL XR in Subjects With Schizophrenia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00640601·331 enrolled

Show 25 more trials

Seroquel XR in Adults With Schizophrenia

Terminated· AstraZeneca logo

AstraZeneca·Phase 3·NCT00852631·28 enrolled

Fast Titration in the Treatment of Schizophrenia, Taiwan

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00304473·40 enrolled

Pilot Study to Evaluate the Efficacy and Safety of Quetiapine Fumarate Instant-Release (Seroquel IR) in Controlling Agitation and Aggressive Symptoms in the Acute Treatment of Patients With Schizophrenia

Unknown status·SSichuan University·Phase 4·NCT00838032·70 enrolled

Seroquel® Combined With Cognitive Remediation Therapy to Conventional Treatment in Patients With Schizophrenia

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00255515·85 enrolled

A Comparison of Seroquel vs. Risperidone in Schizophrenia

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00034905

Efficacy & Safety of Quetiapine Fumarate (SEROQUEL) & Placebo in the Treatment of Acutely Ill Patients With Schizophrenia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00085891·535 enrolled

Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Adolescent Patients With Schizophrenia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00090324·249 enrolled

A 4-week, Randomized, Rater-blinded, Parallel Study to Evaluate Quetiapine in Improving Sleep Quality of Schizophrenia

Completed·GGuang Dong Provincial Mental Health Institute·N/A·NCT00642369·60 enrolled

A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniform

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT02431702·337 enrolled

Twelve Month Study Comparing Paliperidone Palmitate and Select Oral Antipsychotics in Adults With Schizophrenia Who Have Been Recently Discharged From an Inpatient Psychiatric Hospital

Withdrawn· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT01193166

Antipsychotic Response in Schizophrenia

Completed·UUS Department of Veterans Affairs·Phase 4·NCT00018668

CATIE- Schizophrenia Trial

Completed·NNational Institute of Mental Health (NIMH)·Phase 4·NCT00014001·1,600 enrolled

Clinical Effectiveness of Newer Antipsychotics in Comparison With Conventional Antipsychotics in Schizophrenia

Completed·—·Phase 4·NCT01164059·149 enrolled

Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy

Completed·NNorthwell Health·Phase 4·NCT00330863·357 enrolled

A Randomized Double-blind Trial With 6 Antipsychotic Drugs for Schizophrenia

Completed·—·N/A·NCT02192723·550 enrolled

Efficacy of Bifeprunox in Patients With Schizophrenia

Terminated· Lundbeck logo

Lundbeck·Phase 3·NCT00658645·227 enrolled

Switching Medication to Treat Schizophrenia

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT00044655·219 enrolled

Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

Completed·—·Phase 4·NCT00208143·20 enrolled

15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT01157351·450 enrolled

Completed·NNational Taiwan University Hospital·Phase 4·NCT00797927·30 enrolled

Effectiveness of Atypical Versus Conventional Antipsychotics in Treating Schizophrenia

Completed·YYale University·Phase 4·NCT00237861

Efficacy Study Exploring the Effects on Cognition of Sertindole Versus Comparator in Patients With Schizophrenia

Completed· Lundbeck logo

Lundbeck·Phase 3·NCT00654706·264 enrolled

Quetiapine Decreases Smoking in Patients With Chronic Schizophrenia

Unknown status·—·N/A·NCT00231101·40 enrolled

Schizophrenia Sensory Gating Deficit With Quetiapine

Completed·NNew Mexico VA Healthcare System··NCT00536783·20 enrolled

Neurobiological and Neurocognitive Disturbances in First-episode Schizophrenia

Completed·BBirte Glenthoj·N/A·NCT00207064·46 enrolled

Bipolar Disorder15 trials

A Double-Blind Randomized Placebo Controlled Study of Quetiapine for the Treatment of Depression in Adolescents With Bipolar Disorder

Completed·UUniversity of Cincinnati·Phase 3·NCT00232414·30 enrolled

A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder

Unknown status·GGuangzhou Mental Hospital·Phase 4·NCT00837343·120 enrolled

Efficacy and Safety of Quetiapine Compared With Valproate in the Treatment of Patients With Bipolar Disorder and Rapid Cycling

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00254774·44 enrolled

Show 12 more trials

Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD

Completed·UUniversity of South Florida·Phase 4·NCT00579280·224 enrolled

Quetiapine Sr as Adjunctive Treatment In Mixed States of Bipolar Disorder

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT01195363·28 enrolled

To Evaluate the Efficiency and Safety of Quetiapine Fumarate in the Treatment of Acute Manic Patients With Bipolar Disorder.

Unknown status·SShanghai Jiao Tong University School of Medicine·N/A·NCT00742638·70 enrolled

Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00672490·376 enrolled

Efficacy and Safety of Seroquel and Lithium as Monotherapy in Acute Mania Treatment in Bipolar Disorder Patients

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00448578·150 enrolled

Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00114686·350 enrolled

Quetiapine for Mania In Preschool Children 4 to 6 Years of Age With Bipolar Disorder

Completed·MMassachusetts General Hospital·Phase 4·NCT00181883·30 enrolled

Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 4·NCT02562287·54 enrolled

A Survey on Quetiapine Extended-release Tablets in Patients With Depression in Bipolar Disorder

Completed· Astellas logo

Astellas··NCT03403790·369 enrolled

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Terminated·UUniversity of New Mexico··NCT02893371·1,037,352 enrolled

Treatment and Outcome of Early Onset Bipolar Disorder

Completed·NNorthwell Health·Phase 4·NCT00048802·40 enrolled

Sequential Multiple Assignment Treatment for Bipolar Disorder

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT01588457·112 enrolled

TIA11 trials

Crossover Bioequivalence Study of Quetiapine Fumarate 300 mg Tablets Under Steady State Fasted Conditions

Completed·RRoxane Laboratories·N/A·NCT01570959·56 enrolled

Quetiapine and the Dopaminergic Epigenetic Control

Completed·UUniversity of Erlangen-Nürnberg Medical School·Phase 4·NCT00370500·100 enrolled

Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fed Conditions

Completed·RRoxane Laboratories·N/A·NCT01570894·42 enrolled

Show 8 more trials

Bioequivalence Study of Quetiapine Fumarate Tablets 300 mg Under Fasting Condition

Completed·—·Phase 1·NCT01566487·54 enrolled

Crossover Bioequivalence Study of Quetiapine Fumarate 25 mg Tablets Under Fasted Conditions

Completed·RRoxane Laboratories·N/A·NCT01570907·42 enrolled

Bioequivalence Study of Quetiapine Fumarate Tablets 25 mg Under Fed Condition

Completed·IIPCA Laboratories Ltd.·Phase 1·NCT01603186·54 enrolled

Bioequivalence Study of Quetiapine Fumarate Tablets 25 mg Under Fasting Condition

Completed·IIPCA Laboratories Ltd.·Phase 1·NCT01603173·54 enrolled

Quetiapine Fumarate Immediate Release (IR) Versus Extended Release (XR) Dose Escalation Comparison

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT00702676·63 enrolled

Quetiapine Induced Neuroplasticity in First-episode Schizophrenic Patients

Completed·UUniversity of Regensburg·Phase 4·NCT00554658·30 enrolled

Fast Titration Of Quetiapine Versus Currently Approved Titration

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00254813·150 enrolled

Gao Bipolar Spectrum Lithium/Quetiapine Study

Terminated·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT01526148·42 enrolled

Major Depressive Disorder10 trials

Effects of Seroquel XR on Sleep Architecture in Patients With Major Depressive Disorder

Withdrawn·EEwha Womans University·Phase 2·NCT01189318

Efficacy of SEROQUEL in Selective Serotonin Reuptake Inhibitors (SSRI)-Resistant Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00733668

Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00351169·450 enrolled

Show 7 more trials

Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00320268·600 enrolled

Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00326144·310 enrolled

Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00321490·600 enrolled

Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorders

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00326105·450 enrolled

Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00278941·3,000 enrolled

Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00351910·494 enrolled

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

Recruiting·—·Phase 3·NCT05603104·1,254 enrolled

Bipolar Depression7 trials

Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 3·NCT00879307·100 enrolled

Efficacy of Quetiapine XR Versus Divalproex on Clinical Outcome Quality of Sleep and Quality of Life in Bipolar Depression

Withdrawn·BBo-Hyun Yoon·Phase 4·NCT01587066

Phase III/Seroquel SR Bipolar Depression Monotherapy - US

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00422214·400 enrolled

Show 4 more trials

Controlled Study of the Use of Quetiapine Fumarate in the Treatment of Patients With Bipolar Depression

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00083954·530 enrolled

Seroquel in Bipolar Depression Versus Lithium

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00206141·672 enrolled

Seroquel in Bipolar Depression Versus SSRI

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00119652·676 enrolled

Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Active, not recruiting·MMassachusetts General Hospital·Phase 4·NCT06433635·2,726 enrolled

69 more indications

Schizoaffective Disorder7 trials

A Study of the Cataractogenic Potential of Seroquel and Risperdal in the Treatment of Participants With Schizophrenia or Schizoaffective Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00206102·1,098 enrolled

Rapid Versus Conventional Titration of Quetiapine in Schizophrenia/Schizoaffective Disorder

Terminated· AstraZeneca logo

AstraZeneca·Phase 3·NCT00457899·234 enrolled

Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder

Completed·NNational Institute of Mental Health (NIMH)·Phase 4·NCT00423878·215 enrolled

Show 4 more trials

A Study of Relapse Prevention and the Effectiveness of Long-acting Injectable Risperidone and Quetiapine Tablets in the Treatment of Patients With Schizophrenia or Schizoaffective Disorder

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT00216476·753 enrolled

Comparison of Continuing Olanzapine to Switching to Quetiapine in Overweight or Obese Patients With Schizophrenia and Schizoaffective Disorder

Completed· Eli Lilly logo

Eli Lilly·Phase 4·NCT00090012·340 enrolled

A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adults With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical Antipsychotic

Completed· Otsuka logo

Otsuka·Phase 4·NCT03568500·44 enrolled

Quetiapine vs Haloperidol Decanoate for the Long Term Treatment of Schizophrenia and Schizoaffective Disorder

Completed·UUS Department of Veterans Affairs·N/A·NCT00018642

Delirium7 trials

Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients

Completed·UUniversity of Tennessee Graduate School of Medicine·Phase 4·NCT02612948·82 enrolled

Quetiapine as Prophylaxis for Delirium in CABG

Unknown status·—·N/A·NCT05801289·60 enrolled

A Double-blind, Randomized, Controlled Trial of Quetiapine Versus Haloperidol for the Treatment of Delirium

Terminated·—·Phase 3·NCT00954603·52 enrolled

Show 4 more trials

Quetiapine Treatment for Pediatric Delirium

Withdrawn·MMedical College of Wisconsin·Phase 2/3·NCT03572257

RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ)

Not yet recruiting·UUniversity of Southern California·Phase 4·NCT05085808·30 enrolled

Prophylactic Quetiapine on Delirium Prevention in Critically Ill Patients

Unknown status·SSeoul National University Hospital·Phase 3·NCT02297763·194 enrolled

Trazodone vs. Quetiapine for the Treatment of ICU Delirium

Recruiting·UUniversity of Southern California··NCT05307003·60 enrolled

Efficacy and Safety6 trials

Efficacy and Safety of Lu AA34893 in Patients With Bipolar Depression

Terminated· Lundbeck logo

Lundbeck·Phase 2·NCT00622245·166 enrolled

Study of the Efficacy and Safety of Quetiapine Fumarate Extended Release (Seroquel XR)

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00779506·96 enrolled

Study of Efficacy and Safety of Seroquel (Quetiapine Fumarate) as Mono-Therapy for Acute Schizophrenic

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00428350·120 enrolled

Show 3 more trials

Efficacy and Safety of Quetiapine Fumarate in the Treatment of Schizophrenic Patients

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00882518·388 enrolled

Evaluate the Efficacy and Safety of Quetiapine Fumarate (SEROQUEL) Extended Release as Monotherapy in the Treatment of Patients With Bipolar Depression

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT01256177·361 enrolled

Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression

Terminated· Lundbeck logo

Lundbeck·Phase 2·NCT00771134·105 enrolled

Psychosis6 trials

Dose Finding of Quetiapine Fumarate 200mg vs 400mg in First Episode Psychosis

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00449397·150 enrolled

Comparative Study of Aripiprazole, Quetiapine and Ziprasidone in the Treatment of First Episode Nonaffective Psychosis

Completed·FFundación Marques de Valdecilla·Phase 4·NCT02305823·203 enrolled

Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 1-year Follow-up

Completed·FFundación Marques de Valdecilla·Phase 4·NCT02534363·136 enrolled

Show 3 more trials

Antipsychotic to Treat Psychosis Syndrome

Unknown status·—·N/A·NCT02137616·300 enrolled

A Comparative Study of New Medications for Psychosis in Adolescents

Completed·UUniversity of Minnesota·N/A·NCT00222495·30 enrolled

Comparative Study of Aripiprazole, Quetiapine and Ziprasidone in Treatment of First Episode Psychosis: 3-year Follow-up

Completed·FFundación Marques de Valdecilla·Phase 4·NCT02526030·203 enrolled

Generalized Anxiety Disorder4 trials

Efficacy and Safety Study of Seroquel SR in the Treatment of Generalized Anxiety Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00322595·800 enrolled

Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo & Active Control in Generalized Anxiety Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00329446·800 enrolled

Generalized Anxiety Disorder Adjunct Study

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00534599·409 enrolled

Show 1 more trial

Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Generalized Anxiety Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00329264·876 enrolled

Fibromyalgia4 trials

A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome

Completed·DDr Alexander McIntyre Inc.·Phase 4·NCT00675896·120 enrolled

Quetiapine Compared With Placebo in the Management of Fibromyalgia

Completed·—·Phase 4·NCT01458964·42 enrolled

Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study

Completed·UUniversité de Sherbrooke·Phase 4·NCT00983320·52 enrolled

Show 1 more trial

Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia

Completed·UUniversidad de Granada·Phase 4·NCT00766350·90 enrolled

Antipsychotics4 trials

Use, Effects and Side-effects of Second-generation Antipsychotics in a Naturalistic Setting

Completed·UUniversity of Bergen·Phase 4·NCT00932529·226 enrolled

Atypical Antipsychotics Influence on the Safety of the Heart and Monitoring Indicators Model Building

Unknown status·SShanghai Mental Health Center·Phase 4·NCT04446234·350 enrolled

A Study to Compare Capillary and Venous Whole Blood and Plasma Concentrations of Five Antipsychotics

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01607762·31 enrolled

Show 1 more trial

Switch Study of Existing Atypical Antipsychotics to Bifeprunox

Completed·SSolvay Pharmaceuticals·Phase 3·NCT00347425·286 enrolled

Depression3 trials

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 2·NCT04521478·389 enrolled

Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms

Terminated·MMassachusetts General Hospital·Phase 4·NCT00955474·32 enrolled

Treatment of Depression With Quetiapine

Terminated·RRush University Medical Center·Phase 3·NCT00174603·60 enrolled

Insomnia3 trials

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

Terminated·VVA Connecticut Healthcare System·Phase 4·NCT01662297·1 enrolled

Quetiapine for Primary Insomnia Patients : A Randomized Controlled Trial

Completed·KKhon Kaen University·N/A·NCT00328822·16 enrolled

Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders

Completed·MMichael E. DeBakey VA Medical Center·Phase 2/3·NCT00462618·32 enrolled

Postpartum Depression3 trials

The Safety, Tolerability, and Effectiveness of Quetiapine in Postpartum Depression

Active, not recruiting·VVerinder Sharma·Phase 1·NCT04950868·22 enrolled

Quetiapine Versus Trazadone in Women With Postpartum Depression

Not yet recruiting·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 1·NCT06546358·50 enrolled

Quetiapine in Postpartum Depression

Terminated· AstraZeneca logo

AstraZeneca·Phase 2·NCT00681668·5 enrolled

Medication3 trials

A Study to Assess the Clinical Utility of Antipsychotic Medication Levels in Plasma as Determined by Liquid Chromatography-Tandem Mass Spectrometry

Terminated· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT02462473·9 enrolled

Comparison of the Pharmacokinetics of Three Generic Medications and Their Respective Brand Preparations

Unknown status·UUniversity of Ottawa·Phase 1·NCT01400165·30 enrolled

Comparing Antipsychotic Medications in LBD Over Time

Recruiting·TThe University of Texas Health Science Center at San Antonio·Phase 4·NCT05590637·94 enrolled

Bipolar I Disorder3 trials

Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00107731·710 enrolled

Quetiapine Fumarate (SEROQUEL) in the Treatment of Adolescent Patients With Schizophrenia and Bipolar I Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00227305·381 enrolled

A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder

Completed· Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logo

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 3·NCT00309699·493 enrolled

Monotherapy3 trials

Seroquel in Acute Mania: Study to Investigate if Valproate Add-On Therapy is Superior to Quetiapine Monotherapy in Acutely Manic Patients

Terminated· AstraZeneca logo

AstraZeneca·Phase 4·NCT00139074·17 enrolled

Phase 3 /Seroquel SR Acute Mania Monotherapy - US

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00422123·447 enrolled

Quetiapine Fumarate Bipolar Maintenance Monotherapy

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00314184·1,255 enrolled

Treatment3 trials

A Study of Quetiapine and Mirtazapine for the Treatment of Alcohol Dependency

Completed·—·Phase 2·NCT01165541·20 enrolled

The Role of miR-30 Family Dysregulation in Response to Antipsychotic Treatment

Unknown status·SShanxi Medical University·Phase 1/2·NCT02650102·200 enrolled

The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Public Speaking Environment

Completed·UUniversity of Minnesota·Phase 4·NCT00407199·20 enrolled

Obsessive-Compulsive Disorder3 trials

Quetiapine Augmentation in Severe Obsessive Compulsive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00254735·44 enrolled

Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients

Completed·UUniversity of Sao Paulo·Phase 4·NCT00564564·21 enrolled

Addition of Quetiapine in Obsessive Compulsive Disorder - Westenberg Study

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00318539·90 enrolled

Adult3 trials

Adult Bipolar Mania

Completed· AstraZeneca logo

AstraZeneca·Phase 4·NCT00931723·356 enrolled

Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes

Completed·UUniversity of California, San Diego·Phase 4·NCT00397020·30 enrolled

Levomilnacipran ER vs. Adjunctive Quetiapine for Adults With Inadequate Relief With SSRIs in MDD

Completed·—·Phase 3·NCT02720198·60 enrolled

Social Anxiety Disorder3 trials

Adjunctive Quetiapine in the Treatment of Refractory Social Anxiety Disorder in Adults

Completed·CCambridge Health Alliance·Phase 4·NCT01224067·40 enrolled

Quetiapine in Social Anxiety Disorder

Completed·—·Phase 2/3·NCT00215254·15 enrolled

Efficacy of Quetiapine in Generalised Social Anxiety Disorder

Terminated· AstraZeneca logo

AstraZeneca·Phase 3·NCT00302770·50 enrolled

AIN2 trials

Quetiapine for the Reduction of Cocaine Use

Completed·SSeattle Institute for Biomedical and Clinical Research·N/A·NCT00631748·60 enrolled

Bioequivalence Study of Two Extended Release Formulations Containing 50 mg of Quetiapine.

Completed·LLaboratorio Elea Phoenix S.A.·Phase 4·NCT03317236·24 enrolled

Borderline personality disorder2 trials

Verkes Borderline Study: The Effect of Quetiapine on Borderline Personality Disordered Patients

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00254748·40 enrolled

Quetiapine Treatment for Symptoms Associated With Borderline Personality Disorder

Completed·UUniversity of Medicine and Dentistry of New Jersey·Phase 3·NCT00122070·15 enrolled

Brain Injury2 trials

Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)

Recruiting·FFoundation for Advancing Veterans' Health Research·Phase 3·NCT06333990·146 enrolled

Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT04280965·28 enrolled

Effectiveness2 trials

Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT00498628·224 enrolled

A Comparison of the Effectiveness of Seroquel XR and Seroquel XR Plus Lithium in Patients With Acute Bipolar Mania: An Open-label, Randomized, Parallel Groups, Rater-blinded, 4 Week, Multicenter, Comparative,Study

Terminated· AstraZeneca logo

AstraZeneca·Phase 4·NCT01254721·131 enrolled

Agitation2 trials

Seroquel- Agitation Associated With Dementia

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00621647·333 enrolled

A Comparison of Two Standard Therapies in the Management of Dementia With Agitation

Completed·EEmory University·Phase 4·NCT00208819·50 enrolled

Anxiety2 trials

A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and of Quetiapine Fumarate (Seroquel®) as Potentiation SSRI's, and SNRI's Treatment in Major Depression With Anxiety

Completed·DDr Alexander McIntyre Inc.·Phase 4·NCT00229645·60 enrolled

Anxiety in Recovering Opiate Dependence

Terminated·—·Phase 4·NCT00668265·14 enrolled

Interaction2 trials

Cannabidiol as a Different Type of an Antipsychotic: Drug Delivery and Interaction Study

Completed·—·Phase 1·NCT02051387·74 enrolled

Interaction Between Cocaine and Quetiapine - 1

Unknown status·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT00087750·12 enrolled

First-line Treatment1 trial

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Recruiting·—·Phase 3·NCT05973786·418 enrolled

TIPS1 trial

Antipsychotic Therapy and First Episode

Completed·TThe University of Hong Kong·Phase 4·NCT00334035·169 enrolled

Pneumonia1 trial

Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium

Withdrawn·UUniversity of Miami·Phase 4·NCT04513314

Efficacy1 trial

A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room

Completed·UUniversity of Southern California·Phase 4·NCT00457366·72 enrolled

Craving1 trial

Quetiapine for Cocaine Use and Cravings

Completed·SSeattle Institute for Biomedical and Clinical Research·Phase 4·NCT00232336·42 enrolled

Metabolic Syndrome1 trial

SGA-induced Metabolic Syndrome in Bipolar Youth

Completed·UUniversity of Cincinnati·Phase 3·NCT01858948·19 enrolled

Adolescent1 trial

Quetiapine Fumarate (SEROQUEL) Compared to Placebo in the Treatment of Children & Adolescents With Bipolar I Mania

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00090311·220 enrolled

Multiple Sclerosis1 trial

Safety and Tolerability of Quetiapine in Multiple Sclerosis

Completed·UUniversity of Calgary·Phase 1/2·NCT02087631·14 enrolled

Partial Response1 trial

Study of the Broad Clinical Benefit for Seroquel XR With Flexible Dose as an add-on Therapy in the Treatment of Acute Bipolar Mania Patients With Partial Response to Current Therapy

Terminated· AstraZeneca logo

AstraZeneca·Phase 4·NCT01128114·32 enrolled

Cognition1 trial

Effect of Quetiapine on Negative Symptoms and Cognition

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00305422·45 enrolled

Post-Traumatic Stress Disorder1 trial

Use of Quetiapine as an Add on Therapy in the Treatment of Post Traumatic Stress Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00306540·90 enrolled

Safety and Efficacy1 trial

Safety and Efficacy Maintenance Study of Quetiapine SR to Treat GAD Patients.

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00314210·575 enrolled

Drug1 trial

An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308)

Completed·OOrganon and Co··NCT01498770·42 enrolled

Sedation1 trial

Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine

Terminated·AACADIA Pharmaceuticals Inc.·Phase 2·NCT04164758·11 enrolled

Alcohol Abuse1 trial

Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00223249·115 enrolled

Tics1 trial

Synergistic Effect of Vitamin E & D in Reducing Risk of Effects Associated With Atypical Anti-psychotics

Completed·DDr Rabia Arshad·N/A·NCT06200584·140 enrolled

Major Depression1 trial

Effect of Quetiapine XR on Sleep in Patients With Major Depression, as Compared With Mirtazapine

Completed·TTechnical University of Munich·Phase 3·NCT00782405·40 enrolled

Weight Change1 trial

Compare the Effects of Bifeprunox and Quetiapine on Weight Changes in Stable Schizophrenic Patients

Terminated·SSolvay Pharmaceuticals·Phase 3·NCT00396214·83 enrolled

Cocaine Dependence1 trial

An Add-On Trial of Quetiapine in Patients With Bipolar Disorder and Cocaine Dependence

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00223210·100 enrolled

Substance Use Disorders1 trial

Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

Completed·—·Phase 4·NCT02845453·24 enrolled

Pregnancy1 trial

Pharmacokinetics of Quetiapine Across Pregnancy and Postpartum

Completed·NNorthwestern University··NCT02978534·4 enrolled

Metabolism1 trial

Glucose and Lipid Metabolism on Antipsychotic Medication

Completed·WWashington University School of Medicine·N/A·NCT00515723·96 enrolled

Mood Disorder1 trial

A Study of Quetiapine for the Treatment of Mood Disorders in Adolescents

Completed·UUniversity of Cincinnati·Phase 3·NCT00221468·20 enrolled

Dementia1 trial

Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients

Withdrawn·UUniversity of Cincinnati·Phase 4·NCT00375557

Alcohol Dependence1 trial

Quetiapine for Bipolar Disorder and Alcohol Dependence

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00457197·90 enrolled

Cognitive impairment1 trial

A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication

Completed· Astellas logo

Astellas·Phase 2·NCT03557931·233 enrolled

Benzodiazepines1 trial

Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines

Terminated·WWeill Medical College of Cornell University·Phase 4·NCT01244711·1 enrolled

Movement Disorder1 trial

Movement Disorders Caused by Antipsychotic Drugs in Older Patients

Completed·UUniversity of California, San Diego·Phase 1·NCT00255879·250 enrolled

Sleep1 trial

Improving Sleep After TKA Using Mirtazapine and Quetiapine

Not yet recruiting·SSt. Anna Ziekenhuis, Geldrop, Netherlands·N/A·NCT04728581·165 enrolled

Treatment Resistant Depression1 trial

Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression

Unknown status·—·Phase 4·NCT04936126·150 enrolled

Function1 trial

Functional and Neurochemical Brain Changes in First-episode Bipolar Mania

Completed·UUniversity of Cincinnati··NCT00609193·81 enrolled

Alzheimer's Disease1 trial

CATIE-Alzheimer's Disease Trial

Completed·NNational Institute of Mental Health (NIMH)·N/A·NCT00015548·450 enrolled

Chronic Kidney Disease1 trial

Sleep Disorders in Chronic Kidney Disease Patients

Unknown status·—·Phase 1·NCT05240261·60 enrolled

Psychotropic Drugs1 trial

Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs

Completed·SSeoul National University Hospital·Phase 1·NCT01871701·40 enrolled

Anorexia Nervosa1 trial

A Double Blind, Placebo Controlled Trial of Quetiapine in Anorexia Nervosa, a Dual Site Study

Terminated·UUniversity of South Florida·Phase 2·NCT00584688·24 enrolled

Depressed1 trial

Quetiapine Prolong, Escitalopram and Hypothalamic-pituitary-adrenocortical (HPA) Axis Activity in Depressed Patients

Completed·LLudwig-Maximilians - University of Munich·Phase 3·NCT00953108·60 enrolled

Maintenance Treatment1 trial

Quetiapine (Seroquel) Maintenance Treatment in Early Onset Bipolar Spectrum Disorders

Completed·MMood Disorders Center of Ottawa·Phase 3·NCT00252226·100 enrolled

PET1 trial

Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders

Unknown status·—··NCT05840861·59 enrolled

Treatment Refractory Schizophrenia1 trial

High Dose of Quetiapine in Treating Subjects With Treatment Refractory Schizophrenia or Schizoaffective Disorder

Completed·MManhattan Psychiatric Center·Phase 2/3·NCT00297947·60 enrolled

Psychiatric Disorder1 trial

Efficacy of Melatonin, Low-dose Quetiapine, or Placebo in Patients With Psychiatric Disorders and Comorbid Insomnia

Recruiting·LLone Baandrup·Phase 2/3·NCT06062953·255 enrolled

Oral1 trial

Study in Schizophrenic In-patients Treated With Quetiapine Prolong or Oral Risperidone at Flexible Dose

Terminated· AstraZeneca logo

AstraZeneca·Phase 3·NCT00660595·29 enrolled

Drug Therapy1 trial

Treatment of Mania Symptoms With Drug Therapy

Completed·PPalo Alto Veterans Institute for Research·Phase 3·NCT00183443·75 enrolled

Pilot Study1 trial

Quetiapine in the Treatment of Psychotic Depression - a Pilot Study

Completed·RRuhr University of Bochum·Phase 3·NCT00751504·16 enrolled

Bipolar II Disorder1 trial

Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder

Completed·MMassachusetts General Hospital·Phase 4·NCT00182013·106 enrolled

Unspecified3 trials

Chinese Longitudinal and Systematic Study of Bioplar Disorder

Recruiting·FFirst Affiliated Hospital of Zhejiang University·N/A·NCT05480150·10,000 enrolled

Seroquel STACK Study in Schizophrenic or Schizoaffective Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00328978·330 enrolled

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 26, 1997

SEROQUEL

NDA NDA020639

Feb 23, 1998

SEROQUEL

NDA NDA020639

May 8, 1998

SEROQUEL

NDA NDA020639

Dec 20, 1998

SEROQUEL

NDA NDA020639

Jul 7, 2000

SEROQUEL

NDA NDA020639

Jul 26, 2000

SEROQUEL

NDA NDA020639

Nov 6, 2000

SEROQUEL

NDA NDA020639

Jan 24, 2001

SEROQUEL

NDA NDA020639

Mar 19, 2001

SEROQUEL

NDA NDA020639

Mar 27, 2001

SEROQUEL

NDA NDA020639

Nov 16, 2001

SEROQUEL

NDA NDA020639

Dec 6, 2002

SEROQUEL

NDA NDA020639

Jan 12, 2004

SEROQUEL

NDA NDA020639

Jan 12, 2004

SEROQUEL

NDA NDA020639

Jul 21, 2004

SEROQUEL

NDA NDA020639

Feb 7, 2006

SEROQUEL

NDA NDA020639

Sep 20, 2006

SEROQUEL

NDA NDA020639

Oct 20, 2006

SEROQUEL

NDA NDA020639

May 17, 2007

SEROQUEL XR

NDA NDA022047

May 17, 2007

SEROQUEL XR

NDA NDA022047

Jul 30, 2007

SEROQUEL

NDA NDA020639

Jan 28, 2008

SEROQUEL

NDA NDA020639

Jan 28, 2008

SEROQUEL

NDA NDA020639

Mar 13, 2008

SEROQUEL XR

NDA NDA022047

May 13, 2008

SEROQUEL

NDA NDA020639

May 13, 2008

SEROQUEL

NDA NDA020639

May 13, 2008

SEROQUEL

NDA NDA020639

May 13, 2008

SEROQUEL

NDA NDA020639

May 21, 2008

SEROQUEL XR

NDA NDA022047

Aug 11, 2008

SEROQUEL XR

NDA NDA022047

Aug 14, 2008

SEROQUEL

NDA NDA020639

Aug 14, 2008

SEROQUEL XR

NDA NDA022047

Oct 8, 2008

SEROQUEL XR

NDA NDA022047

Oct 8, 2008

SEROQUEL XR

NDA NDA022047

Oct 8, 2008

SEROQUEL XR

NDA NDA022047

Oct 24, 2008

SEROQUEL

NDA NDA020639

Dec 2, 2009

SEROQUEL XR

NDA NDA022047

Dec 2, 2009

SEROQUEL XR

NDA NDA022047

Dec 2, 2009

SEROQUEL

NDA NDA020639

Dec 2, 2009

SEROQUEL XR

NDA NDA022047

Dec 2, 2009

SEROQUEL XR

NDA NDA022047

Dec 2, 2009

SEROQUEL XR

NDA NDA022047

Dec 2, 2009

SEROQUEL

NDA NDA020639

Dec 1, 2010

SEROQUEL XR

NDA NDA022047

Dec 1, 2010

SEROQUEL

NDA NDA020639

May 17, 2011

SEROQUEL XR

NDA NDA022047

May 17, 2011

SEROQUEL

NDA NDA020639

Jul 8, 2011

SEROQUEL XR

NDA NDA022047

Jul 8, 2011

SEROQUEL

NDA NDA020639

Jul 8, 2011

SEROQUEL

NDA NDA020639

Jul 8, 2011

SEROQUEL XR

NDA NDA022047

Nov 9, 2011

SEROQUEL XR

NDA NDA022047

Nov 9, 2011

SEROQUEL

NDA NDA020639

Apr 30, 2013

SEROQUEL

NDA NDA020639

Apr 30, 2013

SEROQUEL XR

NDA NDA022047

Apr 30, 2013

SEROQUEL XR

NDA NDA022047

Apr 30, 2013

SEROQUEL

NDA NDA020639

Apr 30, 2013

SEROQUEL XR

NDA NDA022047

Apr 30, 2013

SEROQUEL

NDA NDA020639

Apr 30, 2013

SEROQUEL XR

NDA NDA022047

Apr 30, 2013

SEROQUEL

NDA NDA020639

Oct 29, 2013

SEROQUEL

NDA NDA020639

Oct 29, 2013

SEROQUEL XR

NDA NDA022047

Jan 26, 2015

SEROQUEL XR

NDA NDA022047

Jun 17, 2016

SEROQUEL

NDA NDA020639

Jun 17, 2016

SEROQUEL XR

NDA NDA022047

Feb 23, 2017

SEROQUEL XR

NDA NDA022047

Feb 23, 2017

SEROQUEL

NDA NDA020639

Nov 29, 2018

SEROQUEL

NDA NDA020639

Nov 29, 2018

SEROQUEL XR

NDA NDA022047

Nov 29, 2018

SEROQUEL XR

NDA NDA022047

Nov 29, 2018

SEROQUEL

NDA NDA020639

Aug 26, 2019

SEROQUEL

NDA NDA020639

Aug 26, 2019

SEROQUEL XR

NDA NDA022047

Feb 5, 2020

SEROQUEL

NDA NDA020639

Feb 5, 2020

SEROQUEL XR

NDA NDA022047

Mar 27, 2020

SEROQUEL XR

NDA NDA022047

Mar 27, 2020

SEROQUEL

NDA NDA020639

Sep 18, 2020

SEROQUEL

NDA NDA020639

Sep 18, 2020

SEROQUEL XR

NDA NDA022047

Sep 18, 2020

SEROQUEL XR

NDA NDA022047

Jan 27, 2022

SEROQUEL

NDA NDA020639

Jan 27, 2022

SEROQUEL XR

NDA NDA022047

Jan 22, 2025

SEROQUEL XR

NDA NDA022047

Jan 22, 2025

SEROQUEL

NDA NDA020639

Sources

References

[1]
ClinicalTrials.gov — 256 trial records for Quetiapine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Seroquel drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Quetiapine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Quetiapine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022047). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Engelhard Arzneimittel GmbH & Co.KG company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Serotonin 2a (5-Ht2a) Receptor Antagonist; Dopamine D2 Receptor Antagonist; Serotonin 2c (5-Ht2c) Receptor Antagonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: EEngelhard Arzneimittel GmbH & Co.KG