VivoSeq
Other

Cognition

171

Pipeline Programs↗

33

Active Trials↗

68

Companies Involved↗

Cognition is a highly competitive landscape with 171 programs across 68 companies. The most active players are Roche, Eisai, Nxera Pharma UK Limited. 48 therapies are approved with 10 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

78/100

Pipeline Velocity

34/100

Mech. Concentration

5/100

Completion Rate

86/100

Attrition Rate

11/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Roche logo

Roche

3 programs

Phase 1Eisai logo

Eisai

1 program

Phase 1N

Nxera Pharma UK Limited

1 program

Phase 1Boehringer Ingelheim logo

Boehringer Ingelheim

1 program

Phase 1U

United BioPharma

1 program

Phase 1A

Advanz Pharma

1 program

Phase 1

Pipeline

Programs by Phase

Preclinical51

Semaglutide

Novo Nordisk

Lorazepam

Bausch Health Americas, Inc.

Dexamethasone

Aspen Global Incorporated

Olanzapine

MODAG GmbH

Metformin

EMD Serono

Phase 129

Hydrocortisone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Sevoflurane

AbbVie

Ketamine Hydrochloride

Boehringer Ingelheim

Topiramate

Wim Janssens

AZD7325

AstraZeneca

Phase 233

Curcumin

Merck & Co.

Osimertinib

AstraZeneca

Pimavanserin

ACADIA Pharmaceuticals Inc.

LDV/SOF

Gilead

Rosiglitazone

Alnylam Pharmaceuticals

Phase 310

Tamoxifen

AstraZeneca

Risperidone

Wim Janssens

Caffeine

Hikma Pharmaceuticals LLC

Modafinil

Nuvo Research GmbH

Lamotrigine

Glaxo Dba Glaxosmithkline

Approved48

Oxytocin

Retrophin

Atropine

Fresenius Kabi Oncology Ltd.

Fentanyl

Cephalon

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Zolpidem

Purdue Pharma LP

Analysis

Modality Breakdown

99%

Small molecule

189 of 191 classified programs — the dominant modality here.

1%ALL OTHERSProtein / enzyme1<1%Peptide1<1%

Small molecule leads; the ring shows all 191 classified programs, each share of the total. Modality classified for 100% of 192 pipeline programs.

Analysis

Trial Status

198

clinical trials

Completed129 · 65%
Recruiting16 · 8%
Unknown status15 · 8%
Terminated14 · 7%
Active, not recruiting9 · 5%
Withdrawn7 · 4%
Other8 · 4%

Clinical Trials

Trial Activity

198 trials

Effect of CAFfeine on Cognition in Alzheimer's Disease
Recruiting·UUniversity Hospital, Lille·Phase 3·NCT04570085·248 enrolled
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
Recruiting·—·N/A·NCT03372317·105 enrolled
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
Recruiting·TTata Memorial Centre·Phase 3·NCT06275035·101 enrolled
Nitrous Oxide and EMOtional Cognition
Recruiting·UUniversity of Oxford·N/A·NCT06557642·88 enrolled
Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
Recruiting·JJohns Hopkins University·Phase 2·NCT05282550·100 enrolled
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Recruiting·IInstitut d'Investigació Biomèdica de Girona Dr. Josep Trueta·N/A·NCT04841668·136 enrolled
Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy
Recruiting·RRenJi Hospital·Phase 4·NCT05255211·90 enrolled
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Recruiting·MMedical College of Wisconsin·Phase 2·NCT05045950·53 enrolled
Cannabis Use, Cognition, and the Endocannabinoid System in HIV
Recruiting·UUniversity of California, San Diego·Phase 1·NCT04883255·138 enrolled
HNC: Human Neural Circuits Electrophysiology During Cognition
Recruiting·SStanford University·Phase 1·NCT05962424·120 enrolled
Pimavanserin and Aggression and Social Cognition.
Recruiting·OOhio State University·Phase 2·NCT05895513·35 enrolled
Ketamine in OCD: Efficacy and Effects on Stress and Cognition
Recruiting·MMedical University of Vienna·N/A·NCT05577585·60 enrolled
Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis
Recruiting·AAssistance Publique - Hôpitaux de Paris·N/A·NCT04280497·1,800 enrolled
Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study
Recruiting·UUniversity of Florida·Preclinical·NCT05090267·80 enrolled
A Randomized, Triple-blind, Placebo-controlled, Parallel, Proof of Concept Clinical Trial to Investigate the Safety and Efficacy of AP-Brain on Cognitive Performance at Varying Dosages in Healthy Middle-aged and Older Adults With Self-reported Memory Problems
Recruiting·RRousselot BVBA·Preclinical·NCT07388043·120 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)