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Senna

ApprovedSmall molecule

MMedtronic - MITG

Senna is one of 55 small molecule programs targeting Constipation. It is currently in Approved.

4

Indications

12

Total Trials

1

Active Trials

54

Competitors

Pipeline

Status by Indication[3][1]

Indication

ParalysisActive, not recruiting

Autism Spectrum DisorderActive, not recruiting

ParalysisApproved

Active, not recruiting

Autism Spectrum DisorderPreclinical

Active, not recruiting

Competition

Competitive Landscape

160 competitors in Autism Spectrum Disorder

#DrugCompanyPhaseTrials

Vraylar

Elavil

Bumex

VValidus Pharmaceuticals

Rexulti

Nuplazid

AACADIA Pharmaceuticals Inc.

Lithobid

SSolvay Pharmaceuticals

Glucophage

Hetlioz

VVanda Pharmaceuticals

Senna

MMedtronic - MITG

Circadin

NNeurim Pharmaceuticals Ltd.

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Post-ApprovalRecruiting

Surgery

NCT06825260

Clinical

Trials by Indication[1]

Constipation3 trials

A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation

Completed·HHong Kong Baptist University·Phase 2·NCT01695850·291 enrolled

RELISTOR's Effects on Opioid-Induced Constipation

Withdrawn·MMethodist Health System··NCT04930237

Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation

Completed·SShirley Ryan AbilityLab·N/A·NCT00662363·64 enrolled

Bowel Preparation2 trials

Bowel Preparation and Prokinetics in Capsule Endoscopy

Unknown status·LLondon North West Healthcare NHS Trust·Phase 3·NCT00275184·150 enrolled

Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Completed·MMedtronic - MITG·N/A·NCT02481219·122 enrolled

Efficacy1 trial

Efficacy of Linaclotide to Senna for CIC

Terminated·TTriHealth Inc.·N/A·NCT02239510·9 enrolled

Colorectal Surgery1 trial

Bowel Preparation in Elective Pediatric Colorectal Surgery

Unknown status·MMcMaster University·N/A·NCT03593252·81 enrolled

Autism Spectrum Disorder1 trial

An Interdisciplinary Approach to the Treatment of Encopresis in Children With Autism Spectrum Disorders

Completed·EEmory University·N/A·NCT02383758·22 enrolled

4 more indications

Pruritus1 trial

Evaluating the Effect of Senna in Uremic Pruritus

Completed·SShiraz University of Medical Sciences·N/A·NCT02008864·60 enrolled

Surgery1 trial

PEG3350 vs Senna After Urogyn Surgery

Recruiting·SSt. Joseph's Health, New York·Phase 4·NCT06825260·254 enrolled

Paralysis1 trial

Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids

Terminated·TTufts Medical Center·Phase 4·NCT02977286·12 enrolled

Unspecified1 trial

Gut Transit Effect on Enterohepatic Circulation

Completed·UUniversity Hospital Plymouth NHS Trust·N/A·NCT03501498·19 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Senna. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Senna compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Senna. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Medtronic - MITG company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: MMedtronic - MITG

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