Senna

Phase 3Small molecule

MMedtronic - MITG

Senna is one of 85 small molecule programs targeting Colorectal Surgery. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Colorectal SurgeryUnknown status

Autism Spectrum DisorderActive, not recruiting

Bowel PreparationRecruiting

SurgeryRecruiting

Colorectal SurgeryPreclinical

Unknown status

Autism Spectrum DisorderPreclinical

Active, not recruiting

Bowel PreparationPreclinical

Recruiting

SurgeryPhase 3

Recruiting

Competition

Competitive Landscape

56 competitors in Autism Spectrum Disorder

#DrugCompanyPhaseTrials

Buspar

Bristol-Myers Squibb

Approved

4 2

Namenda

AbbVie

Approved

3 3

Marinol

Lioresal

Epidiolex

Aricept

Abilify

2 8

Neurontin

VViatris Specialty LLC

Approved

2 9

Strattera

MMap77

Approved

1 10

Bendopa

MMerz North America, Inc.

Approved

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Post-ApprovalRecruiting

Surgery

NCT06825260

Q4 2027

PreclinicalRecruiting

Bowel Preparation

NCT04113382

Clinical

Trials by Indication[1]

Constipation3 trials

Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation

Completed·SShirley Ryan AbilityLab·N/A·NCT00662363·64 enrolled

A Double-blinded,Double-dummy Clinical Trial of Chinese Herbal Medicine (MaZiRenWan) for Functional Constipation

Completed·HHong Kong Baptist University·Phase 2·NCT01695850·291 enrolled

RELISTOR's Effects on Opioid-Induced Constipation

Withdrawn·MMethodist Health System··NCT04930237

Bowel Preparation3 trials

Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Completed·MMedtronic - MITG·N/A·NCT02481219·122 enrolled

Bowel Preparation and Prokinetics in Capsule Endoscopy

Unknown status·LLondon North West Healthcare NHS Trust·Phase 3·NCT00275184·150 enrolled

A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 12 Months to Less Than 9 Years

Recruiting· Ferring logo

Ferring·Preclinical·NCT04113382·39 enrolled

Efficacy1 trial

Efficacy of Linaclotide to Senna for CIC

Terminated·TTriHealth Inc.·N/A·NCT02239510·9 enrolled

Autism Spectrum Disorder1 trial

An Interdisciplinary Approach to the Treatment of Encopresis in Children With Autism Spectrum Disorders

Completed·EEmory University·N/A·NCT02383758·22 enrolled

Paralysis1 trial

Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids

Terminated·TTufts Medical Center·Phase 4·NCT02977286·12 enrolled

4 more indications

Surgery1 trial

PEG3350 vs Senna After Urogyn Surgery

Recruiting·SSt. Joseph's Health, New York·Phase 4·NCT06825260·254 enrolled

Colorectal Surgery1 trial

Bowel Preparation in Elective Pediatric Colorectal Surgery

Unknown status·MMcMaster University·N/A·NCT03593252·81 enrolled

Pruritus1 trial

Evaluating the Effect of Senna in Uremic Pruritus

Completed·SShiraz University of Medical Sciences·N/A·NCT02008864·60 enrolled

Unspecified1 trial

Gut Transit Effect on Enterohepatic Circulation

Completed·UUniversity Hospital Plymouth NHS Trust·N/A·NCT03501498·19 enrolled

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for Senna. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Senna compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Senna. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Medtronic - MITG company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMedtronic - MITG

Senna

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2027

Trials by Indication[1]

Constipation3 trials

Bowel Preparation3 trials

Efficacy1 trial

Autism Spectrum Disorder1 trial

Paralysis1 trial

Surgery1 trial

Colorectal Surgery1 trial

Pruritus1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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