Pentothal

(Thiopental)

ApprovedSmall molecule

AAbbott

Pentothal is one of 110 small molecule programs targeting Intracranial Hypertension. It is currently in Approved.

Indications

Total Trials

Active Trials

109

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Intracranial HypertensionActive, not recruiting

Alcohol DependenceActive, not recruiting

Septic ShockActive, not recruiting

MemoryActive, not recruiting

Intracranial HypertensionPhase 3

Active, not recruiting

Alcohol DependencePreclinical

Active, not recruiting

Septic ShockPhase 3

Active, not recruiting

MemoryApproved

Active, not recruiting

Competition

Competitive Landscape

224 competitors in Septic Shock

#DrugCompanyPhaseTrials

Pentothal

AAbbott

Approved

1 2

Primaxin

Pfizer

Preclinical

2 3

Intropin

Pfizer

Preclinical

2 4

Zyvox

Pfizer

Preclinical

1 5

Doribax

Avastin

1 7

Ultiva

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 8

Glucophage

EMD Serono

Preclinical

1 9

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 10

Tygacil

PPrism Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Propofol1 trial

Onset Time of Thiopental Versus Propofol in the Elderly

Completed·RRigshospitalet, Denmark·Phase 4·NCT00965107·78 enrolled

Alcohol Dependence1 trial

GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence

Completed·YYale University·N/A·NCT00611767·73 enrolled

IVF Outcome1 trial

Comparative Effect of Theipoental and Propofol in IVF Outcome

Completed·—·Phase 4·NCT02377778·180 enrolled

Memory1 trial

Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Terminated·WWeill Medical College of Cornell University·Phase 4·NCT00504894·60 enrolled

Nitric Oxide1 trial

The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes

Completed·MMelike Cengiz·N/A·NCT06485388·12 enrolled

3 more indications

Septic Shock1 trial

Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock

Completed·—·Phase 3·NCT03104140·26 enrolled

Remifentanil1 trial

The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children

Completed·HHallym University Medical Center·N/A·NCT02486926·102 enrolled

Intracranial Hypertension1 trial

Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension

Terminated·HHospital Universitari Son Dureta·Phase 3·NCT00622570·44 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

PENTOTHAL

NDA NDA011679

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Thiopental. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Thiopental compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Thiopental. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA011679). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Abbott company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: AAbbott

Pentothal

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Propofol1 trial

Alcohol Dependence1 trial

IVF Outcome1 trial

Memory1 trial

Nitric Oxide1 trial

Septic Shock1 trial

Remifentanil1 trial

Intracranial Hypertension1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

Related News