Depacon

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

SchizophreniaPneumoniaMigraineDeliriumAlcohol DependenceEnuresisTIPSWithdrawalAmblyopia

174 competitors in Schizophrenia

#DrugCompanyPhaseTrials

1

Depacon

AbbVie

Approved

12

Ozempic

Novo Nordisk

Preclinical

13

Resotran

Takeda

Preclinical

14

Inapsine

Jazz Pharmaceuticals

Preclinical

15

Depakote

AbbVie

Preclinical

—6

Ibrance

Pfizer

Preclinical

—7

Lunesta

Akero Therapeutics

Preclinical

38

Luvox

SSolvay Pharmaceuticals

Preclinical

19

Catapres

Boehringer Ingelheim

Preclinical

110

Rapamune

PPrism Pharmaceuticals

Preclinical

1Show 31 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Bipolar Disorder6 trials

Add-on Dextromethorphan in Bipolar Disorders

Completed·NNational Cheng-Kung University Hospital·Phase 3·NCT01188265·300 enrolled

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Completed·NNational Institute of Mental Health (NIMH)·N/A·NCT00012558·5,000 enrolled

Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders

Completed·—·Phase 3·NCT00221403·46 enrolled

Show 3 more trials

ABLE: Abilify in Bipolar Disorder for Long-term Effectiveness

Completed·KKorea Otsuka International Asia Arab·Phase 4·NCT00484471·127 enrolled

Decision-Making in Bipolar Disorder

Completed·EEmory University·N/A·NCT01463111·37 enrolled

A Phase 3, Open-label Extension Study to Assess the Long-term Safety of KarXT for the Treatment of Mania or Mania With Mixed Features in Bipolar-I Disorder (BALSAM-3)

Recruiting·Bristol-Myers Squibb·Phase 3·NCT06929273·450 enrolled

Seizure2 trials

Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures

Completed·MMazandaran University of Medical Sciences·Phase 4·NCT03940326·103 enrolled

A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures

Completed·CCerebral Therapeutics LLC·Phase 1/2·NCT02899611·6 enrolled

Withdrawal2 trials

The Effect of Valproate on Benzodiazepine Withdrawal Severity

Completed·UUniversity of Helsinki·N/A·NCT00570219·30 enrolled

Treatment of Polydrug-Using Opiate Dependents During Withdrawal

Completed·SSorlandet Hospital HF·Phase 4·NCT00367874·12 enrolled

Status Epilepticus2 trials

Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus

Unknown status·XXuanwu Hospital, Beijing·Phase 2·NCT03025906·120 enrolled

Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures

Unknown status·HHillel Yaffe Medical Center··NCT01268904·50 enrolled

Adolescent2 trials

Valproate Response in Aggressive Autistic Adolescents

Unknown status·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 3·NCT00065884·30 enrolled

Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents

Completed·WWashington University School of Medicine·Phase 3·NCT00057681·379 enrolled

27 more indications

Bipolar I Disorder2 trials

Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder

Completed·Eli Lilly·Phase 3·NCT00266630·139 enrolled

Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder

Completed·Otsuka·Phase 3·NCT00665366·493 enrolled

Pneumonia1 trial

Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium

Withdrawn·UUniversity of Miami·Phase 4·NCT04513314

Migraine1 trial

Zolmitriptane as Prophylaxis for Chilhood Migraine

Unknown status·TTanta University·Phase 4·NCT06089356·90 enrolled

Drug1 trial

Antiepileptic Drugs and Vascular Risk Markers

Terminated·TThomas Jefferson University·N/A·NCT00774306·52 enrolled

Enuresis1 trial

Sleep Architecture in Valproate-induced Nocturnal Enuresis in Primary School and Preschool Children.

Completed·MMansoura University Hospital··NCT04191863·260 enrolled

Schizophrenia1 trial

Valproate in Late Life Schizophrenia

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT00194025·20 enrolled

Ketorolac1 trial

Valproate Versus Ketorolac Versus Metoclopramide

Completed·MMontefiore Medical Center·Phase 4·NCT01267864·330 enrolled

Effectiveness1 trial

Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)

Unknown status·JJoseph Blader·Phase 4·NCT00794625·270 enrolled

TIPS1 trial

Determining Metabolic Effects of Valproate and Antipsychotic Therapy

Completed·WWashington University School of Medicine·N/A·NCT00167934·164 enrolled

Dementia1 trial

Valproate in Dementia (VALID)

Completed·AAlzheimer's Disease Cooperative Study (ADCS)·Phase 3·NCT00071721·313 enrolled

Epilepsy1 trial

Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed Epilepsy

Completed·UCB·Phase 3·NCT00175903·1,701 enrolled

Acceptability1 trial

Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania

Unknown status·GGuiyun Xu·Phase 4·NCT01893229·120 enrolled

Brain Metastases1 trial

Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT00513162·8 enrolled

Diffuse Large B-Cell Lymphoma1 trial

Valproate as First Line Therapy in Combination With Rituximab and CHOP in Diffuse Large B-cell Lymphoma

Completed·LLund University Hospital·Phase 1/2·NCT01622439·50 enrolled

Maintenance Treatment1 trial

Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode

Completed·UUniversity of British Columbia·Phase 3·NCT01977300·159 enrolled

Delirium1 trial

Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy

Recruiting·MM.D. Anderson Cancer Center·Phase 2/3·NCT05431595·42 enrolled

Alcohol Use Disorders1 trial

Treatment Strategy for Alcohol Use Disorders in Veterans With TBI

Completed·VVA Office of Research and Development·Phase 3·NCT01342549·62 enrolled

Morbidity1 trial

Valproate Efficacy in Cocaine-Bipolar Comorbidity

Completed·UUniversity of Miami·Phase 1/2·NCT00240110·152 enrolled

Agitation1 trial

Haloperidol vs. Valproate in Agitation

Completed·SShahid Beheshti University of Medical Sciences·Phase 3·NCT01750541·56 enrolled

Tics1 trial

A Study on the Effects of Valproate on the Pharmacokinetics of RO4917838 in Healthy Volunteers

Completed·Roche·Phase 1·NCT01495104·18 enrolled

Chronic Lymphocytic Leukemia1 trial

Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic Leukemia

Completed·LLund University Hospital·Phase 1·NCT02144623·4 enrolled

Interaction1 trial

Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate

Completed·Haisco Pharmaceutical Group Co., Ltd.·Phase 1·NCT05181007·41 enrolled

Bipolar Depression1 trial

Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression

Withdrawn·EEwha Womans University·Phase 2·NCT01543139

Glioblastoma1 trial

Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma

Terminated·UUniversity of Virginia·Phase 1·NCT02648633·4 enrolled

Alcohol Dependence1 trial

Prospective Assessment of Valproate on Ethanol Withdrawal

Terminated·CCAMC Health System·Approved·NCT03235531·3 enrolled

Amblyopia1 trial

Valproate for the Treatment of Residual Amblyopia

Recruiting·BBoston Children's Hospital·Preclinical·NCT07226141·28 enrolled

Mania1 trial

A Phase 3, Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Individuals With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

Recruiting·Bristol-Myers Squibb·Phase 3·NCT07140913·424 enrolled

Regulatory

FDA Approval Timeline[4]

Details

Drug Info

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