Calan
(Verapamil)ApprovedSmall molecule
Verapamil is used to treat high blood pressure and certain heart rhythm problems by helping your heart beat more regularly and reducing pressure on blood vessel walls.[2] Calan is currently approved and in use across 33 indications[4].[1]
Calan is one of 719 small molecule programs targeting Ischemic Cardiomyopathy. It is currently in Approved.
33
Indications
68
Total Trials
10
Active Trials
718
Competitors
9
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 32 indications
Competition
Competitive Landscape
1931 competitors in COVID-19
#DrugCompanyPhaseTrials
1Calan
VVal Adams
Approved
Aldactone
PfizerPreclinical
Precedex
MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
Preclinical
SARS-COV-2 VACCINE
ModernaPreclinical
Statin
Bristol-Myers SquibbPreclinical
Biological Collection
AAssistance Publique - Hôpitaux de Paris
Preclinical
Antihypertensive Agents
NNational Heart, Lung, and Blood Institute (NHLBI)
Preclinical
Blood Taken
HHospices Civils de Lyon
Preclinical
Selenium
SSWOG Cancer Research Network
Preclinical
Vit D
PPost Graduate Institute of Medical Education and Research, Chandigarh
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Atrial Fibrillation4 trials
RATe Control in Atrial Fibrillation
Completed·—·Phase 3·NCT00313157·80 enrolled
Show 1 more trial
Interaction4 trials
Type 1 Diabetes3 trials
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
Recruiting·—·Phase 1/2·NCT07061574·120 enrolled
ART2 trials
47 more indications
Keloid2 trials
Osteoarthritis1 trial
Female1 trial
Ventricular Tachycardia1 trial
AIN1 trial
Adult Subject1 trial
Marfan syndrome1 trial
Comparison of Medical Therapies in Marfan Syndrome.
Completed·—·Phase 4·NCT01295047·18 enrolled
Lymphoma1 trial
Brentuximab Vedotin, Cyclosporine, and Verapamil Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Completed·—·Phase 1·NCT03013933·29 enrolled
Hypertrophic Cardiomyopathy1 trial
Atrioventricular Block1 trial
Atrioventricular Block and Cluster Headache (SEVA)
Active, not recruiting·—·Phase 4·NCT04406259·60 enrolled
Supraventricular tachycardia1 trial
Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting
Completed·—·N/A·NCT04203368·268 enrolled
General Anaesthesia1 trial
Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.
Unknown status·—·Phase 1·NCT04356196·135 enrolled
NAC1 trial
TIA1 trial
Erectile Dysfunction1 trial
Intracavernosal Injection of Papaverine/Verapamil Versus Papaverine/Phentolamine in Erectile Dysfunction
Completed·—··NCT03033537·20 enrolled
Ischemic stroke1 trial
CAR1 trial
NEC1 trial
Drug Interactions1 trial
Function1 trial
Targeting Beta Cell Dysfunction With Verapamil in Longstanding T1D
Completed·—·Phase 1·NCT05847413·10 enrolled
Idiopathic Ventricular Fibrillation1 trial
Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation
Unknown status·—·Phase 2·NCT05593757·24 enrolled
Ischemic Cardiomyopathy1 trial
Infants1 trial
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Recruiting·—··NCT03511118·1,600 enrolled
Acute Myocardial Infarction1 trial
Supraclavicular Brachial Plexus Block1 trial
Verapamil in Supraclavicular Brachial Plexus Block
Unknown status·—·N/A·NCT05183997·60 enrolled
Radiofrequency Ablation1 trial
Radiofrequency Ablation of Symptomatic Frequent Ventricular Premature Complexes in Pediatric Population
Unknown status·MMeshalkin Research Institute of Pathology of Circulation·Phase 2/3·NCT02772354·124 enrolled
Fed1 trial
Intraoperative Bleeding1 trial
Efficacy of Oral Verapamil and Oral Diltiazim on Reduction of Intraoperative Bleeding During Endoscopic Sinus Surgery Under General Anesthesia
Unknown status·—·Phase 1·NCT04790331·135 enrolled
Paroxysmal atrial fibrillation1 trial
Clinical Trial1 trial
Paroxysmal supraventricular tachycardia1 trial
Insulin Secretion1 trial
ST Elevation Myocardial Infarction1 trial
Intracoronary Administration of Epinephrine and Verapamil in the Refractory No-reflow Phenomenon in Patients With Acute Myocardial Infarction: The EPIVER Randomized Controlled Trial
Completed·TTomsk National Research Medical Center of the Russian Academy of Sciences·Preclinical·NCT04573751·104 enrolled
Unspecified6 trials
Is Verapamil In TransRadial Interventions OmittabLe?
Completed·—·N/A·NCT01402427·591 enrolled
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
ISOPTIN
NDA NDA018485
Mar 30, 1984
VERAPAMIL HYDROCHLORIDE
NDA NDA018925
Mar 30, 1984
CALAN
NDA NDA019038
Nov 23, 1987
ISOPTIN
NDA NDA018593
Feb 23, 1988
CALAN
NDA NDA018817
May 29, 1990
VERELAN
NDA NDA019614
Mar 6, 1991
CALAN SR
NDA NDA019152
Feb 26, 1996
COVERA-HS
NDA NDA020552
Nov 25, 1998
VERELAN PM
NDA NDA020943
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Calan drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Verapamil. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]